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1. 发明授权

US5569452A Pharmaceutical formulation having enhanced bile acid binding affinity 失效
标题翻译：具有增强的胆汁酸结合亲和力的药物制剂
公开(公告)号：US5569452A
公开(公告)日：1996-10-29
申请号：US453438
申请日：1995-05-30
申请人： Gordon L. Amidon , Lizbeth B. Sherman , John R. Crison
发明人： Gordon L. Amidon , Lizbeth B. Sherman , John R. Crison
IPC分类号： A61K31/785 , A61K38/38 , A61K45/06 , A61K31/74 , B29C49/00
CPC分类号： A61K45/06 , A61K31/785 , A61K38/38
摘要： A pharmaceutical formulation comprising a polymeric resin having bile acid binding properties in combination with at least one bile acid binding material which enhances the bile acid binding affinity and/or capacity of the formulation, methods for preparing the formulations and methods for using the formulations.
摘要翻译：一种药物制剂，其包含具有胆汁酸结合性质的聚合物树脂与至少一种胆汁酸结合材料的组合，其增强了制剂的胆汁酸结合亲和力和/或能力，制备制剂的方法和使用制剂的方法。

2. 发明授权

US06207191B1 Multi-stage drug delivery system 失效
标题翻译：多期药物输送系统
公开(公告)号：US06207191B1
公开(公告)日：2001-03-27
申请号：US09372913
申请日：1999-08-12
申请人： John R. Crison , Gordon L. Amidon
发明人： John R. Crison , Gordon L. Amidon
IPC分类号： A61K922
CPC分类号： A61J3/071 , A61K9/0004 , A61K9/4808
摘要： A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16). A pump mechanism, reactive with the external environment of the capsule half (12), causes an increase in pressure within the inner chamber (16) and forces the plug (28) out of the passageway (26) to release the drug (18) from the inner chamber (16) and out of the passageway (26). Thusly, after initial release of drug from a second capsule half (14) releasably mounted on the first capsule half (12), the first capsule half (12) provides a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system (10) and method by which the drug delivery system (10) provides the drug to a body.
摘要翻译：药物递送系统（10）包括具有在其中容纳药物（18）的内室（16）的第一胶囊半部（12）。插塞（28）设置在胶囊半部（12）的通道（26）中，用于堵塞其开口（24）。在从内腔（16）内施加压力时，塞子（28）可从通道开口（24）释放。与胶囊一半（12）的外部环境反应的泵机构引起内室（16）内的压力增加并迫使塞子（28）离开通道（26）以释放药物（18）从内室16排出通道26。因此，在从可释放地安装在第一胶囊半部（12）上的第二胶囊半部（14）初次释放药物之后，第一胶囊半部（12）在胶囊初次摄入之后的预定时间提供药物释放的第二脉冲。本发明还提供了一种制备药物递送系统（10）的方法和药物递送系统（10）将药物提供给身体的方法。

3. 发明授权

US06669954B2 Controlled release of drugs 失效
公开(公告)号：US06669954B2
公开(公告)日：2003-12-30
申请号：US09768852
申请日：2001-01-24
申请人： John R. Crison , Gordon L. Amidon
发明人： John R. Crison , Gordon L. Amidon
IPC分类号： A61K922
CPC分类号： A61K9/2072
摘要： A device for controlled release of pharmaceutical agents and a method for use of the device. The drug delivery device comprises a covered container with an aperture and an aperture cover, containing a pharmaceutical agent and an excipient formulation.

4. 发明授权

US5686133A Water soluble pharmaceutical coating and method for producing coated pharmaceuticals 失效
标题翻译：水溶性药物涂层及其制备方法
公开(公告)号：US5686133A
公开(公告)日：1997-11-11
申请号：US594814
申请日：1996-01-31
申请人： Gordon L. Amidon , John R. Crison
发明人： Gordon L. Amidon , John R. Crison
IPC分类号： A61K9/16 , A61K9/40 , A61K9/50 , A61K47/24 , A61K47/26 , A61K47/42 , B05D3/00 , A61J3/06 , B01J13/12 , B05D7/00
CPC分类号： A61K9/5015 , A61K9/1676 , A61K9/5057
摘要： A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.
摘要翻译：公开了制备药物组合物的方法。该方法包括使至少一种药物成分与基本上由明胶和卵磷脂组成的混合物接触以增加水不溶性药物成分的溶解速率的步骤。还公开了用于增加水不溶性药物成分的溶解速率的药物赋形剂涂层。涂层基本上由明胶和卵磷脂组成。

5. 发明授权

US5674530A Method for making a multi-stage drug delivery system 失效
标题翻译：制备多期药物递送系统的方法
公开(公告)号：US5674530A
公开(公告)日：1997-10-07
申请号：US383830
申请日：1995-02-06
申请人： Gordon L. Amidon , John R. Crison
发明人： Gordon L. Amidon , John R. Crison
IPC分类号： A61K9/00 , A61K9/48 , A61K9/52 , A61K9/22
CPC分类号： A61K9/0092 , A61K9/0004 , A61K9/4808
摘要： A method of making a drug delivery system (10) includes the steps of filling a first water permeable capsule half with a drug and an osmotic agent and plugging an open-end (24) of the capsule (12). The method further includes the steps of disposing a water permeable film (30) over the capsule (12) and plug (28), filling a second capsule half (14) with a drug (18), and releasably mounting an open end (34) of the second capsule half (14) over the plugged end (24) of the first capsule half (12).
摘要翻译：制备药物递送系统（10）的方法包括以下步骤：用药物和渗透剂填充第一透水性胶囊半部，并堵塞胶囊（12）的开口端（24）。该方法还包括以下步骤：在胶囊（12）和塞子（28）上方设置透水膜（30），用药物（18）填充第二胶囊半部（14），并可释放地安装开口端）在第一胶囊半部（12）的插入端（24）上方。

6. 发明授权

US6048551A Microsphere encapsulation of gene transfer vectors 失效
标题翻译：微球包裹基因转移载体
公开(公告)号：US6048551A
公开(公告)日：2000-04-11
申请号：US824997
申请日：1997-03-27
申请人： John M. Hilfinger , Beverly L. Davidson , Steven J. Beer , John R. Crison , Gordon L. Amidon
发明人： John M. Hilfinger , Beverly L. Davidson , Steven J. Beer , John R. Crison , Gordon L. Amidon
IPC分类号： A61K9/16 , B01J13/02 , A61K9/50 , A61F2/02 , B32B5/16
CPC分类号： B01J13/02 , A61K9/1647 , Y10T428/2985
摘要： A controlled release delivery system includes a functional gene vector in a biodegradable polymeric microsphere encapsulating the vector. The present invention further provides a method of making a controlled release delivery system by encapsulating the functional gene vector in a biologically degradable polymeric microsphere.
摘要翻译：控制释放递送系统包括封装载体的生物可降解聚合物微球中的功能基因载体。本发明还提供了通过将功能基因载体包封在生物可降解聚合物微球体中来制备控制释放递送系统的方法。

7. 发明授权

US5993858A Method and formulation for increasing the bioavailability of poorly water-soluble drugs 失效
标题翻译：提高水溶性差的药物的生物利用度的方法和制剂
公开(公告)号：US5993858A
公开(公告)日：1999-11-30
申请号：US867161
申请日：1997-06-13
申请人： John R. Crison , Gordon L. Amidon
发明人： John R. Crison , Gordon L. Amidon
IPC分类号： A61K9/107 , A61K9/48 , A61K9/10
CPC分类号： A61K9/4858 , A61K9/1075 , Y10S514/937
摘要： A self-microemulsifying excipient formulation for increasing the bioavailability of a drug which includes an emulsion including an oil or other lipid material, a surfactant, and a hydrophilic co-surfactant. A method for making a drug delivery system for increasing the bioavailability of a drug by emulsifying at least one drug with a self-microemulsifying excipient comprising an oil or other lipid material, a surfactant, and a hydrophilic co-surfactant and drugs formulated thereby.
摘要翻译：一种用于增加药物的生物利用度的自微乳化赋形剂制剂，其包括包含油或其它脂质材料，表面活性剂和亲水性辅助表面活性剂的乳液。通过用包含油或其它脂质材料，表面活性剂和亲水性辅助表面活性剂的自微乳化赋形剂乳化至少一种药物来制备用于提高药物生物利用度的药物递送系统的方法。

8. 发明授权

US5976571A Method for making a multi-stage drug delivery system 失效
标题翻译：制备多期药物递送系统的方法
公开(公告)号：US5976571A
公开(公告)日：1999-11-02
申请号：US946515
申请日：1997-10-07
申请人： John R. Crison , Gordon L. Amidon
发明人： John R. Crison , Gordon L. Amidon
IPC分类号： A61K9/22 , A61K9/00 , A61K9/48 , A61K9/52 , A61K47/30
CPC分类号： A61J3/071 , A61K9/0004 , A61K9/4808
摘要： A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) for containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16). A pump mechanism, reactive with the external environment of the capsule half (12), causes an increase in pressure within the inner chamber (16) and forces the plug (28) out of the passageway (26) to release the drug (18) from the inner chamber (16) and out of the passageway (26). Thusly, after initial release of drug from a second capsule half (14) releasably mounted on the first capsule half (12), the first capsule half (12) provides a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system (10) and method by which the drug delivery system (10) provides the drug to a body.
摘要翻译：药物输送系统（10）包括具有用于在其中容纳药物（18）的内室（16）的第一胶囊半部（12）。插塞（28）设置在胶囊半部（12）的通道（26）中，用于堵塞其开口（24）。在从内腔（16）内施加压力时，塞子（28）可从通道开口（24）释放。与胶囊一半（12）的外部环境反应的泵机构引起内室（16）内的压力增加并迫使塞子（28）离开通道（26）以释放药物（18）从内室16排出通道26。因此，在从可释放地安装在第一胶囊半部（12）上的第二胶囊半部（14）初次释放药物之后，第一胶囊半部（12）在胶囊初次摄入之后的预定时间提供药物释放的第二脉冲。本发明还提供了一种制备药物递送系统（10）的方法和药物递送系统（10）将药物提供给身体的方法。

9. 发明授权

US5851275A Water soluble pharmaceutical coating and method for producing coated pharmaceuticals 失效
标题翻译：水溶性药物涂层及其制备方法
公开(公告)号：US5851275A
公开(公告)日：1998-12-22
申请号：US790737
申请日：1997-01-27
申请人： Gordon L. Amidon , John R. Crison
发明人： Gordon L. Amidon , John R. Crison
IPC分类号： A61K9/16 , A61K9/40 , A61K9/50 , A61K47/24 , A61K47/26 , A61K47/42 , C08H1/00 , C08L89/00
CPC分类号： A61K9/5015 , A61K9/1676 , A61K9/5057
摘要： A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.
摘要翻译：公开了制备药物组合物的方法。该方法包括使至少一种药物成分与基本上由明胶和卵磷脂组成的混合物接触以增加水不溶性药物成分的溶解速率的步骤。还公开了用于增加水不溶性药物成分的溶解速率的药物赋形剂涂层。涂层基本上由明胶和卵磷脂组成。

10. 发明授权

US5834022A Water soluble pharmaceutical coating and method for producing coated pharmaceuticals 失效
公开(公告)号：US5834022A
公开(公告)日：1998-11-10
申请号：US790570
申请日：1997-01-29
申请人： Gordon L. Amidon , John R. Crison
发明人： Gordon L. Amidon , John R. Crison
IPC分类号： A61K9/16 , A61K9/40 , A61K9/50 , A61K47/24 , A61K47/26 , A61K47/42 , A61K9/14
CPC分类号： A61K9/5015 , A61K9/1676 , A61K9/5057
摘要： A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.

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