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    • 4. 发明申请
    • Neural stimulation device employing renewable chemical stimulation
    • 采用可再生化学刺激的神经刺激装置
    • US20060009805A1
    • 2006-01-12
    • US11114976
    • 2005-04-26
    • Ralph JensenCarmen ScholzLuke Theogarajan
    • Ralph JensenCarmen ScholzLuke Theogarajan
    • A61N1/00
    • A61N1/0543A61K9/0004A61K9/0051A61L27/50A61L2430/32A61N1/0551
    • A variety of neural stimulation devices are disclosed. The devices comprise an uptake component comprising means for selectively transporting a stimulating species into the device; a release component comprising means for releasing the stimulating species; and means for producing a concentration gradient of a second species. The concentration gradient of the second species provides energy to transport the stimulating species into the device. The stimulating species may be an ion, e.g., a potassium ion, or a neurotransmitter. In a preferred embodiment of the invention the stimulating species is a potassium ion. In a second preferred embodiment the stimulating species is dopamine. In certain embodiments of the invention countertransport across an uptake component comprising a synthetic ABA polymer membrane is achieved using a carboxylic acid crown ether. The gradient of the second species may be provided by means of a chemical reaction that takes place inside the device. The substrate for the chemical reaction is transported into the device from the external environment. In certain embodiments the neural stimulation device comprises light-sensitive elements that comprise light-sensitive proton pumps. The proton pumps translocate protons into the device in response to light, thereby triggering release of the stimulating species. In certain embodiments the neural stimulation device comprises electronic components that receive a signal and send an activating input to the device, thereby triggering release of the stimulating species.
    • 公开了各种神经刺激装置。 所述装置包括吸收组分,其包括用于将刺激物质选择性地输送到装置中的装置; 释放组件,包括用于释放刺激物种的装置; 以及用于产生第二种类的浓度梯度的装置。 第二种物质的浓度梯度提供能量以将刺激物质运送到装置中。 刺激物质可以是离子,例如钾离子或神经递质。 在本发明的优选实施方案中,刺激物质是钾离子。 在第二优选实施方案中,刺激物质是多巴胺。 在本发明的某些实施方案中,通过使用羧酸冠醚实现包含合成ABA聚合物膜的吸收组分的反运送。 第二种类的梯度可以通过发生在装置内部的化学反应来提供。 用于化学反应的基材从外部环境输送到装置中。 在某些实施例中,神经刺激装置包括包含光敏质子泵的光敏元件。 质子泵响应于光将质子转移到器件中,从而引发刺激物质的释放。 在某些实施例中,神经刺激装置包括接收信号并向装置发送激活输入的电子部件,由此触发刺激物质的释放。