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1. 发明申请

US20150037832A1 METHODS OF FACILITATING THE BIOCONVERSION OF CRUDE BIODIESEL-DERIVED GLYCEROL BY MICROORGANISMS 审中-公开
标题翻译：通过微生物促进原生质体衍生的甘露醇生物合成的方法
公开(公告)号：US20150037832A1
公开(公告)日：2015-02-05
申请号：US14342515
申请日：2012-09-01
申请人： Carmen Scholz , Keerthi Prasad Venkataramanan , Geoffrey D. Bothun
发明人： Carmen Scholz , Keerthi Prasad Venkataramanan , Geoffrey D. Bothun
IPC分类号： C12P7/16 , C07C29/76
CPC分类号： C12P7/16 , C07C29/76 , C12N1/32 , C12P7/20 , Y02E50/10
摘要： The present disclosure generally pertains to a method of facilitating the bioconversion of glycerol by microorganisms. In one embodiment, biodiesel derived crude glycerol is purified by removing fatty acids through acid precipitation. The fatty acid-free crude glycerol is then utilized as a carbon source for the culture of microorganisms and the production of value added substances. Additionally, the unsaturated fatty acids within the biodiesel-derived crude glycerol are converted to saturated fatty acids, allowing for fermentation behavior similar to that of pure glycerol. Both the cultured microorganisms and the culture media containing the purified crude glycerol may be analyzed for crude glycerol bioconversion products. The disclosure also relates to a method of increasing product yield through the addition of a second carbon source to the microorganism culture media.
摘要翻译：本公开一般涉及促进甘油由微生物进行生物转化的方法。在一个实施方案中，生物柴油衍生的粗甘油通过酸沉淀除去脂肪酸来纯化。然后将不含脂肪酸的粗甘油用作微生物培养和生产附加值物质的碳源。此外，生物柴油衍生的粗甘油中的不饱和脂肪酸转化成饱和脂肪酸，允许发酵行为与纯甘油相似。培养的微生物和含有纯化粗甘油的培养基都可以分析粗甘油生物转化产物。本公开还涉及通过向微生物培养基中加入第二碳源来提高产物产率的方法。

2. 发明申请

US20090131589A1 CONTROLLED MOLECULAR WEIGHT AMINO ACID POLYMERS HAVING FUNCTIONALIZABLE BACKBONES AND END GROUPS AND PROCESSES FOR PREPARING THE SAME 审中-公开
标题翻译：具有功能性的背景和末端组的控制分子量的氨基酸聚合物及其制备方法
公开(公告)号：US20090131589A1
公开(公告)日：2009-05-21
申请号：US12260440
申请日：2008-10-29
申请人： Carmen Scholz , Willy Vayaboury
发明人： Carmen Scholz , Willy Vayaboury
IPC分类号： C08G69/10 , C08G69/04
CPC分类号： C07K14/001 , C08G69/00
摘要： The present disclosure relates to processes for preparing metal-free, mono-dispersed polymers of amino acids. The polymers include homopolymers, random copolypeptides, block copolypeptides, block copolymers with at least one peptidyl block, grafted copolypeptides, and polypetidyl dendrimers. The disclosed process does not make use of a heavy metal catalyst, inter alia, copper or nickel containing reagents. The disclosed process encompasses a “living polymerization” such that the growth of each polymer chain is not truncated or otherwise halted by undesirable side reactions or limitations due to the length or size of the growing polymer chain, provides amino acid comprising polymers having a narrow polydispersity, is conducted at lower temperatures, and avoids the premature secondary folding that inhibits the formation of polymers having a low polydispersity index. This abstract is intended to provide key words and search terms for use in searching patent and patent application data bases and is not intended to limit the subject matter of the disclosure.
摘要翻译：本公开涉及制备无金属，单分散的氨基酸聚合物的方法。聚合物包括均聚物，无规共聚肽，嵌段共聚肽，与至少一个肽基嵌段的嵌段共聚物，接枝的共聚肽和多聚酰胺树枝状聚合物。所公开的方法不使用重金属催化剂，尤其是含铜或镍的试剂。所公开的方法包括“活性聚合”，使得每个聚合物链的生长不会由于不期望的副反应而被截短或以其它方式停止或由于生长的聚合物链的长度或尺寸而限制，提供了包含具有窄多分散性的聚合物的氨基酸，在较低的温度下进行，避免过早的二次折叠，从而抑制多分散性指数低的聚合物的形成。本摘要旨在提供用于搜索专利和专利申请数据库的关键词和搜索术语，并不旨在限制本公开的主题。

3. 发明授权

US5925720A Heterotelechelic block copolymers and process for producing the same 失效
标题翻译：异丙烯嵌段共聚物及其制备方法
公开(公告)号：US5925720A
公开(公告)日：1999-07-20
申请号：US930898
申请日：1997-12-18
申请人： Kazunori Kataoka , Carmen Scholz , Michihiro Iijima , Takahito Kutsuna , Yukio Nagasaki , Masao Kato , Teruo Okano
发明人： Kazunori Kataoka , Carmen Scholz , Michihiro Iijima , Takahito Kutsuna , Yukio Nagasaki , Masao Kato , Teruo Okano
IPC分类号： A61K9/51 , A61K47/48 , C08G63/66 , C08G63/664 , C08G65/26 , C08G65/32 , C08G65/332 , C08L71/02 , C08G63/08
CPC分类号： A61K9/1075 , A61K47/48215 , C08G63/664 , C08G65/2609 , C08G65/3324 , C08L71/02 , Y10S525/922
摘要： This invention provides a heterotelechelic oligomer or polymer which is represented by formula below: ##STR1## wherein R.sup.1 and R.sup.2 form an acetal, or, combined with each other, denote oxy (.dbd.O),p, m, n and q each denote a certain integer,L is a group which forms an ester, andZ denotes a certain functional group.This invention a so provides a process to produce the above oligomer or polymer by means of living polymeri-zation. Since this oligomer or polymer forms a high- molecular micelle which is stable in an aqueous solvent, said oligomer or polymer will be useful as a carrier for drug delivery.
摘要翻译： PCT No.PCT / JP96 / 01057 Sec。 371 1997年12月18日第 102（e）1997年12月18日PCT PCT 1996年4月18日PCT公布。出版物WO96 / 33233 日本特开1996年10月24日本发明提供了由下式表示的杂多炔类低聚物或聚合物：其中R1和R2形成缩醛，或彼此组合表示氧（= O），p，m，n和q各自表示一个整数，L是形成酯的基团，Z表示某一官能团。本发明提供了通过活性聚合制备上述低聚物或聚合物的方法。由于该低聚物或聚合物形成在水性溶剂中稳定的高分子胶束，因此所述低聚物或聚合物可用作药物递送的载体。

4. 发明申请

US20180208950A1 METHODS OF FACILITATING THE BIOCONVERSION OF CRUDE BIODIESEL-DERIVED GLYCEROL BY MICROORGANISMS 审中-公开
公开(公告)号：US20180208950A1
公开(公告)日：2018-07-26
申请号：US15924935
申请日：2018-03-19
申请人： Carmen Scholz , Keerthi Prasad Venkataramanan , Geoffrey D. Bothun
发明人： Carmen Scholz , Keerthi Prasad Venkataramanan , Geoffrey D. Bothun
IPC分类号： C12P7/16 , C12P7/20 , C07C29/76 , C12N1/32
CPC分类号： C12P7/16 , C07C29/76 , C12N1/32 , C12P7/20 , Y02E50/10
摘要： The present disclosure generally pertains to a method of facilitating the bioconversion of glycerol by microorganisms. In one embodiment, biodiesel derived crude glycerol is purified by removing fatty acids through acid precipitation. The fatty acid-free crude glycerol is then utilized as a carbon source for the culture of microorganisms and the production of value added substances. Additionally, the unsaturated fatty acids within the biodiesel-derived crude glycerol are converted to saturated fatty acids, allowing for fermentation behavior similar to that of pure glycerol. Both the cultured microorganisms and the culture media containing the purified crude glycerol may be analyzed for crude glycerol bioconversion products. The disclosure also relates to a method of increasing product yield through the addition of a second carbon source to the microorganism culture media.

5. 发明申请

US20060009805A1 Neural stimulation device employing renewable chemical stimulation 审中-公开
标题翻译：采用可再生化学刺激的神经刺激装置
公开(公告)号：US20060009805A1
公开(公告)日：2006-01-12
申请号：US11114976
申请日：2005-04-26
申请人： Ralph Jensen , Carmen Scholz , Luke Theogarajan
发明人： Ralph Jensen , Carmen Scholz , Luke Theogarajan
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61K9/0004 , A61K9/0051 , A61L27/50 , A61L2430/32 , A61N1/0551
摘要： A variety of neural stimulation devices are disclosed. The devices comprise an uptake component comprising means for selectively transporting a stimulating species into the device; a release component comprising means for releasing the stimulating species; and means for producing a concentration gradient of a second species. The concentration gradient of the second species provides energy to transport the stimulating species into the device. The stimulating species may be an ion, e.g., a potassium ion, or a neurotransmitter. In a preferred embodiment of the invention the stimulating species is a potassium ion. In a second preferred embodiment the stimulating species is dopamine. In certain embodiments of the invention countertransport across an uptake component comprising a synthetic ABA polymer membrane is achieved using a carboxylic acid crown ether. The gradient of the second species may be provided by means of a chemical reaction that takes place inside the device. The substrate for the chemical reaction is transported into the device from the external environment. In certain embodiments the neural stimulation device comprises light-sensitive elements that comprise light-sensitive proton pumps. The proton pumps translocate protons into the device in response to light, thereby triggering release of the stimulating species. In certain embodiments the neural stimulation device comprises electronic components that receive a signal and send an activating input to the device, thereby triggering release of the stimulating species.
摘要翻译：公开了各种神经刺激装置。所述装置包括吸收组分，其包括用于将刺激物质选择性地输送到装置中的装置; 释放组件，包括用于释放刺激物种的装置; 以及用于产生第二种类的浓度梯度的装置。第二种物质的浓度梯度提供能量以将刺激物质运送到装置中。刺激物质可以是离子，例如钾离子或神经递质。在本发明的优选实施方案中，刺激物质是钾离子。在第二优选实施方案中，刺激物质是多巴胺。在本发明的某些实施方案中，通过使用羧酸冠醚实现包含合成ABA聚合物膜的吸收组分的反运送。第二种类的梯度可以通过发生在装置内部的化学反应来提供。用于化学反应的基材从外部环境输送到装置中。在某些实施例中，神经刺激装置包括包含光敏质子泵的光敏元件。质子泵响应于光将质子转移到器件中，从而引发刺激物质的释放。在某些实施例中，神经刺激装置包括接收信号并向装置发送激活输入的电子部件，由此触发刺激物质的释放。

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