专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060264805A1 Permeabilization of biological membranes 审中-公开
标题翻译：生物膜的渗透性
公开(公告)号：US20060264805A1
公开(公告)日：2006-11-23
申请号：US11433664
申请日：2006-05-11
申请人： Parminder Singh , Gary Cleary
发明人： Parminder Singh , Gary Cleary
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61M37/00 , A61N1/0424 , A61N1/044
摘要： In one embodiment of the invention, electrodes are brought into the vicinity of a biological membrane such as human skin. Through those electrodes, a current is driven. As a result of that current, at one electrode there occurs a reaction in which the pH of the water or other fluid in a small area of the membrane is lowered or raised. The lowered or raised pH causes substances present in the membrane to denature or decompose, resulting in the formation of a channel in the membrane. In another embodiment of the invention, a high volatility fluid is applied to a membrane from the outside. A small area of the membrane is heated. The high volatility fluid expands and then vaporizes. As a result of the expansion and vaporization of the fluid, a channel is created in the membrane.
摘要翻译：在本发明的一个实施例中，电极被引入诸如人皮肤的生物膜附近。通过这些电极驱动电流。作为该电流的结果，在一个电极处发生反应，其中在膜的小区域中的水或其它流体的pH降低或升高。降低或升高的pH导致膜中存在的物质变性或分解，导致在膜中形成通道。在本发明的另一个实施方案中，高挥发性流体从外部施加到膜上。膜的一小部分被加热。高挥发性液体膨胀然后汽化。由于流体的膨胀和蒸发，在膜中产生通道。

2. 发明申请

US20060034905A1 Adhesive composition 有权
标题翻译：粘合剂组合物
公开(公告)号：US20060034905A1
公开(公告)日：2006-02-16
申请号：US11198468
申请日：2005-08-04
申请人： Parminder Singh , Gary Cleary , Valery Kulichikhin , Sergey Antonov
发明人： Parminder Singh , Gary Cleary , Valery Kulichikhin , Sergey Antonov
IPC分类号： A61K9/66 , A61K9/70
CPC分类号： A61L15/585 , A61K9/006 , A61K9/06 , A61K9/7007 , A61K9/7053 , A61K47/02 , C08K3/346 , C08L53/02 , C08L71/02 , C08L2666/02 , C08L2666/24 , C09J139/06 , C09J153/02 , C09J155/02
摘要： An adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use as blister pads and wound dressings.
摘要翻译：描述了具有改善的初始粘性，长期粘附性，吸水性和半透明特性的粘合剂组合物，并且可以通过熔体挤出制备。还描述了这些组合物的用途，例如它们用作起泡垫和伤口敷料。

3. 发明申请

US20050215727A1 Water-absorbent adhesive compositions and associated methods of manufacture and use 审中-公开
标题翻译：吸水粘合剂组合物及其相关的制造和使用方法
公开(公告)号：US20050215727A1
公开(公告)日：2005-09-29
申请号：US11028702
申请日：2005-01-03
申请人： Mikhail Feldstein , Danir Bairamov , Mikhail Novikov , Valery Kulichikhin , Nicolai Plate , Gary Cleary , Parminder Singh
发明人： Mikhail Feldstein , Danir Bairamov , Mikhail Novikov , Valery Kulichikhin , Nicolai Plate , Gary Cleary , Parminder Singh
IPC分类号： A61K8/04 , A61K8/81 , A61K8/86 , A61Q11/00 , C08F293/00 , C08L33/04 , C08L39/06 , C08L71/02
CPC分类号： B05D5/10 , A61K8/042 , A61K8/8152 , A61K8/8176 , A61K8/8182 , A61K8/86 , A61K47/32 , A61K2800/262 , A61K2800/54 , A61L15/42 , A61L15/585 , A61Q11/00 , C08K5/06 , C08K5/11 , C08L33/04 , C08L39/06 , C08L71/02 , C09J133/14 , C08L2666/02
摘要： An adhesive composition is provided that is water-insoluble yet water-absorbent, i.e., capable of absorbing up to 15 wt. % water or more. The composition is composed of a film-forming hydrophilic polymer with at least one linear segment having a plurality of recurring polar groups along the polymer backbone, a complementary multifunctional polymer with a plurality of recurring functional groups that noncovalently bind to the polar groups on the film-forming polymer, and a plasticizer. A method for manufacturing the adhesive composition is provided as well.
摘要翻译：提供了一种粘合剂组合物，其是不溶于水的吸水剂，即能够吸收高达15wt。％水或更多。该组合物由具有至少一个线性区段的成膜亲水性聚合物组成，所述至少一个线性区段沿着聚合物主链具有多个重复极性基团，具有多个与膜上的极性基团非共价结合的重复官能团的互补多官能聚合物形成聚合物和增塑剂。还提供了制造粘合剂组合物的方法。

4. 发明申请

US20050113510A1 Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components 审中-公开
标题翻译：使用聚合物组分之间的相互作用机理制备聚合物粘合剂组合物的方法
公开(公告)号：US20050113510A1
公开(公告)日：2005-05-26
申请号：US10936887
申请日：2004-09-08
申请人： Mikhail Feldstein , Danir Bairamov , Nicolai Plate , Valery Kulichikhin , Anatoly Chalykh , Gary Cleary , Parminder Singh
发明人： Mikhail Feldstein , Danir Bairamov , Nicolai Plate , Valery Kulichikhin , Anatoly Chalykh , Gary Cleary , Parminder Singh
IPC分类号： A61C19/06 , A61K6/00 , A61K8/04 , A61K8/22 , A61K8/73 , A61K8/81 , A61K8/86 , A61L15/60 , A61Q11/00 , C08F20/10
CPC分类号： A61Q11/00 , A61C19/066 , A61K6/0067 , A61K8/0208 , A61K8/042 , A61K8/22 , A61K8/731 , A61K8/8152 , A61K8/817 , A61K8/8176 , A61K8/86 , A61K9/7007 , A61K2800/262 , A61K2800/54 , A61K2800/5422 , A61K2800/5424 , A61L15/585 , A61L15/60 , C08L2312/00 , C08L53/00
摘要： A method of selecting components for use in water-absorbing pressure-sensitive adhesive compositions is provided. The method involves selecting a film-forming polymer, a ladder-like non-covalent crosslinker that is capable of forming a ladder-like interpolymer complex with the film-forming polymer selected, and selecting a carcass-like non-covalent crosslinker that is capable of forming a carcass-like complex with at least one of the film-forming polymer selected or the ladder-like non-covalent crosslinker selected. The adhesive hydrogels provide high adhesion in a swollen state and bridge the gap between conventional pressure sensitive adhesives and bioadhesives. Methods for preparing and using the resulting compositions are also disclosed.
摘要翻译：提供了一种选择用于吸水压敏粘合剂组合物中的组分的方法。该方法包括选择成膜聚合物，能够与选择的成膜聚合物形成梯状共聚体络合物的阶梯状非共价交联剂，并且选择能够形成的胎体状非共价交联剂与选择的成膜聚合物中的至少一种或阶梯状非共价交联剂形成胎体状络合物。粘合剂水凝胶在膨胀状态下提供高粘合性并桥接常规压敏粘合剂和生物粘合剂之间的间隙。还公开了制备和使用所得组合物的方法。

5. 发明申请

US20050208110A1 Rapidly dissolving film for delivery of an active agent 有权
标题翻译：快速溶解膜用于递送活性剂
公开(公告)号：US20050208110A1
公开(公告)日：2005-09-22
申请号：US11047964
申请日：2005-01-31
申请人： Parminder Singh , Sri Mudumba , Danir Bairamov , Valery Kulichikhin , Mikhail Feldstein , Gary Cleary
发明人： Parminder Singh , Sri Mudumba , Danir Bairamov , Valery Kulichikhin , Mikhail Feldstein , Gary Cleary
IPC分类号： A61K9/00 , A61K9/70
CPC分类号： A61K9/7007 , A61K9/0014 , A61K9/0056 , A61K9/006
摘要： A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent.
摘要翻译：提供快速溶解的膜用于将活性剂递送到潮湿的身体表面，例如粘膜组织。膜包括成膜粘合剂，快速溶解的聚合物材料和活性剂。

6. 发明申请

US20070051376A1 Composition for cushions, wounds dressings and other skin-contacting products 有权
标题翻译：用于靠垫，伤口敷料和其他皮肤接触产品的组合物
公开(公告)号：US20070051376A1
公开(公告)日：2007-03-08
申请号：US11594461
申请日：2006-11-07
申请人： Valery Kulichikhin , Shoreh Parandoosh , Mikhail Feldstein , Sergey Antonov , Gary Cleary
发明人： Valery Kulichikhin , Shoreh Parandoosh , Mikhail Feldstein , Sergey Antonov , Gary Cleary
IPC分类号： A61F13/06
CPC分类号： A61L15/585 , A61L24/043 , C08L1/08
摘要： A skin-contacting adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use in wound dressings, adhesive cushions, and transdermal drug delivery devices.
摘要翻译：描述了皮肤接触的粘合剂组合物，其具有改善的初始粘性，长期粘附性，吸水性和半透明性，并且可以通过熔体挤出制备。还描述了这些组合物的用途，例如它们在伤口敷料，粘合剂垫和透皮药物递送装置中的用途。

7. 发明申请

US20050228340A1 Transdermal delivery device 有权
标题翻译：透皮递送装置
公开(公告)号：US20050228340A1
公开(公告)日：2005-10-13
申请号：US11088829
申请日：2005-03-24
申请人： Gary Cleary , Steven Klemm
发明人： Gary Cleary , Steven Klemm
IPC分类号： A61B17/20 , A61M37/00
CPC分类号： A61B17/205 , A61M37/0015 , A61M2037/0023
摘要： A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.
摘要翻译：皮肤，透皮，粘膜或经粘膜递送装置包括覆盖含有成分的储存器的背衬层，并且具有连接到其上的微突出阵列，用于储存器的盖具有穿过其中的至少一个开口，粘合剂层和衬垫层。在去除衬里层时，可以将装置放置在皮肤或粘膜的期望区域上并粘附施加于其上，从而允许成分从储存器流过至少一个开口至皮肤或粘膜。

8. 发明申请

US20050152957A1 Compositions and delivery systems for administration of a local anesthetic agent 审中-公开
标题翻译：用于给予局部麻醉剂的组合物和递送系统
公开(公告)号：US20050152957A1
公开(公告)日：2005-07-14
申请号：US11077593
申请日：2005-03-10
申请人： Gary Cleary , Sri Mudumba , Shoreh Parandoosh , Colin Cleary , Raj Birudaraj , Pathamar Park
发明人： Gary Cleary , Sri Mudumba , Shoreh Parandoosh , Colin Cleary , Raj Birudaraj , Pathamar Park
IPC分类号： A61K9/00 , A61K9/70 , A61K31/165 , A61K31/245 , A61K47/00 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/40 , A61K31/24 , A61L15/16
CPC分类号： A61K9/0014 , A61K9/7015 , A61K31/165 , A61K31/245 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/40
摘要： A pharmaceutical composition is provided for topical administration of a local anesthetic agent. The composition comprises (a) a therapeutically effective amount of a local anesthetic agent and (b) a pharmaceutically acceptable, nonliposomal carrier comprised of a monohydric alcohol, a penetration enhancer, and polymer, which may be a hydrophilic polymer, a hydrophobic polymer or a combination thereof. The composition can be in the form of a gel, or it may form a film following application to a patient's body surface and evaporation of the monohydric alcohol. The composition provides rapid onset of local anesthesia as well as penetration of the active agent into the skin. Methods and drug delivery systems for administration of local anesthetic agents are also provided.
摘要翻译：提供用于局部施用局部麻醉剂的药物组合物。组合物包含（a）治疗有效量的局部麻醉剂和（b）由一元醇，渗透增强剂和聚合物组成的药学上可接受的非脂质载体，其可以是亲水性聚合物，疏水性聚合物或的组合。组合物可以是凝胶的形式，或者可以在施用于患者的身体表面并蒸发一元醇后形成膜。该组合物可快速开始局部麻醉以及活性剂渗入皮肤。还提供了用于施用局部麻醉剂的方法和药物递送系统。

9. 发明申请

US20050049365A1 Method for preparing a two-phase water-absorbent bioadhesive composition 有权
标题翻译：二相吸水生物粘合剂组合物的制备方法
公开(公告)号：US20050049365A1
公开(公告)日：2005-03-03
申请号：US10964431
申请日：2004-10-12
申请人： Gary Cleary , Mikhail Feldstein , Valery Kulichikhin , Danir Bairamov
发明人： Gary Cleary , Mikhail Feldstein , Valery Kulichikhin , Danir Bairamov
IPC分类号： A61K9/70 , A61L15/22 , A61L15/30 , A61L15/44 , A61L15/46 , A61L15/58 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C09J123/22 , C08F8/00
CPC分类号： A61K9/7053 , A61L15/44 , A61L15/46 , A61L15/585 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C08L2312/00 , C08L2666/20 , C09J123/22 , C08L23/22
摘要： A method is provided for preparing an adhesive composition that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
摘要翻译：提供了一种制备含有疏水相和亲水相的粘合剂组合物的方法，其中疏水相由交联的疏水聚合物组合物组成，亲水相是亲水性聚合物和互补低聚物的吸水共混物能够通过氢键，离子键合和/或共价键来交联亲水性聚合物。该组合物可用作生物粘附剂，用于将药物递送系统，伤口敷料，绷带，垫子等固定在身体表面如皮肤或粘膜组织上。

10. 发明申请

US20050048103A1 Two-phase, water-absorbent bioadhesive composition for delivery of an active agent to a patient 审中-公开
标题翻译：用于将活性剂递送至患者的两相吸水生物粘合剂组合物
公开(公告)号：US20050048103A1
公开(公告)日：2005-03-03
申请号：US10964379
申请日：2004-10-12
申请人： Gary Cleary , Mikhail Feldstein , Valery Kulichikhin , Danir Bairamov
发明人： Gary Cleary , Mikhail Feldstein , Valery Kulichikhin , Danir Bairamov
IPC分类号： A61K9/70 , A61L15/22 , A61L15/30 , A61L15/44 , A61L15/46 , A61L15/58 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C09J123/22 , A61F13/02 , A61L15/16
CPC分类号： A61K9/7053 , A61L15/44 , A61L15/46 , A61L15/585 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C08L2312/00 , C08L2666/20 , C09J123/22 , C08L23/22
摘要： An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
摘要翻译：提供了含有疏水相和亲水相的粘合剂组合物，其中疏水相由交联的疏水聚合物组合物组成，亲水相是亲水性聚合物和能够交联的亲水性聚合物和互补低聚物的吸水共混物亲水性聚合物通过氢键，离子键和/或共价键。该组合物可用作生物粘附剂，用于将药物递送系统，伤口敷料，绷带，垫子等固定在身体表面如皮肤或粘膜组织上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式