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1. 发明公开

EP2490013A1 MEASURING DEVICE 审中-公开
标题翻译：测量工具
公开(公告)号：EP2490013A1
公开(公告)日：2012-08-22
申请号：EP10823178.8
申请日：2010-10-08
申请人： Panasonic Corporation , Agency for Science, Technology and Research
发明人： NAKATANI, Masaya , YOBAS, Levent , REBOUD, Julien
IPC分类号： G01N27/28 , C12M1/00 , G01N27/00 , G01N27/416
CPC分类号： G01N27/44756 , B01L3/5027 , B01L2200/0694 , B01L2300/0816 , B01L2300/0867 , B01L2400/0472
摘要： In order to attain the aim of improving the measuring efficiency of a measuring device, there is provided a measuring device including: a first substrate 11; and a second substrate 12 bonded on the first substrate 11, the second substrate 12 having at least two inflow ports 13, at least two outflow ports 14, and a injection port 15, wherein the two inflow ports 13, the two outflow ports 14, and the injection port 15 penetrate the second substrate, wherein the first substrate 11 includes: partition wall portions 19 opposing to each other, and forming a first cavity 16 between the partition wall portions 19, and forming at least two second cavities 21 close against one of the partition wall portions 19, wherein each second cavity 21 is provided adjacent to the first cavity 16; and through holes 20 provided in the respective partition wail portions 19 to connect the first cavity 16 and the second cavity 21 each other, and the through holes 20 are adapted to capture an object 23 to-be-tested introduced in the first cavity 16, wherein the first cavity 16 is connected to the external environment through at least two inflow ports 13 and at least two outflow ports 14, and the second cavity 21 is connected to an external environment through the injection port 15.
摘要翻译：为了实现提高测量装置的测量效率的目的，提供了一种测量装置，包括：第一基板11; 以及结合在第一基板11上的第二基板12，第二基板12具有至少两个流入口13，至少两个流出口14和喷射口15，其中两个流入口13，两个流出口14，并且注入口15贯穿第二基板，其中第一基板11包括：彼此相对的分隔壁部分19，并且在分隔壁部分19之间形成第一空腔16，并形成至少两个第二空腔21，其中每个第二腔体21设置在第一腔体16附近; 以及设置在各个分隔壁部19中的通孔20，以将第一腔体16和第二腔体21彼此连接，并且通孔20适于捕获被引入第一腔体16中的待测物体23，其中第一腔体16通过至少两个流入端口13和至少两个流出端口14连接到外部环境，并且第二腔体21通过注入端口15连接到外部环境。

2. 发明申请

WO2011102804A1 AN ELECTRO-FLUIDIC INTERFACE TO A MULTI-WELL PLATE 审中-公开
标题翻译：对多孔板的电磁流体界面
公开(公告)号：WO2011102804A1
公开(公告)日：2011-08-25
申请号：PCT/SG2010/000064
申请日：2010-02-22
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YOBAS, Levent , REBOUD, Julien , PENG, Shuling , SIM, Poh Chuen Steven
发明人： YOBAS, Levent , REBOUD, Julien , PENG, Shuling , SIM, Poh Chuen Steven
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/50853 , B01L2200/0689 , B01L2300/046 , B01L2300/0829 , B01L2400/0415 , B01L2400/0478 , G01N33/48728
摘要： In an embodiment, an electro-fluidic interface to a multi-well plate may be provided. The multi-well plate may include at least one first well and at least one second well, the at least one first well may be connected to the at least one second well via at least one channel. The electro-fluidic interface may include a sealing portion configured to be inserted into the at least one first well and to thereby seal the at least one first well; at least one electrode configured to be inserted through the sealing portion; and at least one biasing structure; wherein the at least one biasing structure may be positioned relative to the sealing portion and the at least one electrode so as to allow movement of the sealing portion relative to the at least one electrode so as to induce a change in pressure in the at least one first well, thereby allowing fluid to be transported away or into the at least one first well.
摘要翻译：在一个实施例中，可以提供到多孔板的电流界面。多孔板可以包括至少一个第一阱和至少一个第二阱，所述至少一个第一阱可以经由至少一个通道连接到所述至少一个第二阱。电流体界面可以包括密封部分，该密封部分构造成插入到至少一个第一孔中并且从而密封至少一个第一孔; 至少一个电极构造成插入穿过所述密封部分; 和至少一个偏置结构; 其中所述至少一个偏置结构可以相对于所述密封部分和所述至少一个电极定位，以允许所述密封部分相对于所述至少一个电极移动，以便引起所述至少一个电极中的压力变化第一井，从而允许流体被运送或者进入至少一个第一井。

3. 发明申请

WO2011053254A1 PROBE ELEMENT AND METHOD OF FORMING A PROBE ELEMENT 审中-公开
标题翻译：探索元素和形成探测元素的方法
公开(公告)号：WO2011053254A1
公开(公告)日：2011-05-05
申请号：PCT/SG2010/000419
申请日：2010-10-29
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YOBAS, Levent , AGARWAL, Ajay , BADAM, Ramana Murthy , KOTLANKA, Rama Krishna , FOO, Xiang Jie Cyrus
发明人： YOBAS, Levent , AGARWAL, Ajay , BADAM, Ramana Murthy , KOTLANKA, Rama Krishna , FOO, Xiang Jie Cyrus
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/0478 , A61B5/685 , A61N1/0551
摘要： A probe element and a method of forming a probe element are provided. The probe element includes a carrier comprising biodegradable and/or bioactive material; and at least one electrode coupled to the carrier.
摘要翻译：提供探针元件和形成探针元件的方法。探针元件包括包含可生物降解和/或生物活性材料的载体; 以及耦合到所述载体的至少一个电极。

4. 发明申请

WO2006088427A1 MICROFLUIDICS PACKAGE AND METHOD OF FABRICATING THE SAME 审中-公开
标题翻译：微流控封装及其制造方法
公开(公告)号：WO2006088427A1
公开(公告)日：2006-08-24
申请号：PCT/SG2005/000038
申请日：2005-02-15
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , CHONG, Ser, Choong , XIE, Ling , JI, Hongmiao , LI, Jing , CHEN, Yu , YOBAS, Levent
发明人： CHONG, Ser, Choong , XIE, Ling , JI, Hongmiao , LI, Jing , CHEN, Yu , YOBAS, Levent
IPC分类号： B81B1/00 , B01L3/00
CPC分类号： B81B7/0061 , B01F5/0603 , B01F13/0059 , B01L3/502707 , B01L3/502715 , B01L9/527 , B01L2200/028 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B81B2201/051 , B81B2201/058
摘要： A microfluidics package (1) comprising a substrate (6) having a top surface, said top surface comprises at least one fluid channel (11, 12), at least one fluidic chip (2) having a top surface, a bottom surface, at least one side surface, and at least one passage to allow a fluid to traverse from the top surface or any side surface to the bottom surface of the chip; and a sheet (4) of which both sides are adhesive, wherein the first adhesive side of the sheet (4) is secured to the substrate (6), and the at least one fluidic chip (2) is secured by the second adhesive side of the sheet (4), said fluidic chip (2) being arranged such that the at least one passage of the fluidic chip is in fluid communication with the at least one fluid channel (11, 12) of the substrate.
摘要翻译：一种微流体封装（1），包括具有顶表面的衬底（6），所述顶表面包括至少一个流体通道（11,12），至少一个流体芯片（2），其具有顶表面，底表面至少一个侧表面和至少一个通道，以允许流体从所述芯片的顶表面或任何侧表面穿过所述底表面; 和其中两侧是粘合剂的片材（4），其中片材（4）的第一粘合剂侧固定到基底（6）上，并且至少一个流体碎片（2）由第二粘合剂侧所述流体芯片（2）布置成使得流体芯片的至少一个通道与基板的至少一个流体通道（11,12）流体连通。

5. 发明申请

WO2007108779A1 MICROFLUIDIC DEVICE FOR ANALYZING THE STATUS OF A PARTICLE 审中-公开
标题翻译：用于分析颗粒状态的微流体装置
公开(公告)号：WO2007108779A1
公开(公告)日：2007-09-27
申请号：PCT/SG2007/000080
申请日：2007-03-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ONG, Wee Liat , YOBAS, Levent , TANG, Kim Cheong , AGARWAL, Ajay , RANGANATHAN, Nagarajan
发明人： ONG, Wee Liat , YOBAS, Levent , TANG, Kim Cheong , AGARWAL, Ajay , RANGANATHAN, Nagarajan
IPC分类号： G01N33/487 , B01L3/00 , G01N1/10
CPC分类号： G01N33/48728 , B01L3/5027
摘要： The present invention provides a device for analyzing the status of a biological entity. The device comprises a base substrate having a recess defined therein by two opposing lateral walls and a base wall, a filler member having at least a portion thereof occupying the recess, and a channel defined in the portion of the filler member occupying the recess, wherein the channel comprises a first aperture and a second aperture, the first aperture being arranged on a first lateral wall of the filler member, and the second aperture being arranged on a second lateral wall of the filler member, said first lateral wall of the filler member being arranged in opposing relationship with the second lateral wall of the filler member, and at least a portion of the first and the second lateral walls of the filler member being at least substantially perpendicular to the opposing lateral walls defining the recess.
摘要翻译：本发明提供了一种用于分析生物实体的状态的装置。该装置包括基底，其具有通过两个相对的侧壁和底壁限定的凹部，填充构件具有占据凹部的至少一部分，以及限定在占据凹部的填充构件的部分中的通道，其中所述通道包括第一孔和第二孔，所述第一孔布置在所述填充构件的第一侧壁上，并且所述第二孔布置在所述填充构件的第二侧壁上，所述填充构件的所述第一侧壁被布置成与填充构件的第二侧壁相对的关系，并且填充构件的第一和第二侧壁的至少一部分至少基本上垂直于限定凹部的相对侧壁。

6. 发明申请

WO2007050040A1 IMMOBILIZATION UNIT AND DEVICE FOR ISOLATION OF NUCLEIC ACID MOLECULES 审中-公开
标题翻译：固定单元和用于分离核酸分子的装置
公开(公告)号：WO2007050040A1
公开(公告)日：2007-05-03
申请号：PCT/SG2005/000374
申请日：2005-10-28
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , JI, Hongmiao , YOBAS, Levent , CHEN, Yu , HUI, Wing Cheong , HENG, Chew Kiat , LIM, Tit Meng
发明人： JI, Hongmiao , YOBAS, Levent , CHEN, Yu , HUI, Wing Cheong , HENG, Chew Kiat , LIM, Tit Meng
IPC分类号： C12Q1/68 , C12N15/00 , G01N33/50 , C12M1/40 , G01N33/48
CPC分类号： B01F5/0647 , B01F5/0646 , B01F13/0059 , B01L3/502746 , B01L2200/0631 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2400/0487 , G01N1/34 , G01N1/405
摘要： An immobilization unit (820) for the detection of dexoyribonucleic acid (DNA) and ribonucleic acid (RNA) molecules capable of immobilizing nucleic molecules, said immobilization unit comprising a channel of a given depth, width and length and having at least one surface. The surface is adapted to immobilize nucleic molecules under suitable conditions. The channel has at least one straight portion and at least one meandering portion. The at least one meandering portion is essentially u-shaped and the at least one straight portion is an arm of the u-shaped meandering portion.
摘要翻译：一种用于检测能够固定核酸分子的核酸核酸（DNA）和核糖核酸（RNA）分子的固定单元（820），所述固定单元包括给定深度，宽度和长度的通道，并具有至少一个表面。表面适于在合适的条件下固定核酸分子。通道具有至少一个直线部分和至少一个曲折部分。至少一个曲折部分基本上是U形的，并且至少一个直线部分是U形曲折部分的臂。

7. 发明公开

EP2008093A1 MICROFLUIDIC DEVICE FOR ANALYZING THE STATUS OF A PARTICLE 审中-公开
标题翻译：微流体装置及其制造方法
公开(公告)号：EP2008093A1
公开(公告)日：2008-12-31
申请号：EP07716167.7
申请日：2007-03-23
申请人： Agency for Science, Technology and Research
发明人： ONG, Wee Liat , YOBAS, Levent , TANG, Kim Cheong , AGARWAL, Ajay , RANGANATHAN, Nagarajan
IPC分类号： G01N33/487 , B01L3/00 , G01N1/10
CPC分类号： G01N33/48728 , B01L3/5027
摘要： The present invention provides a device for analyzing the status of a biological entity. The device comprises a base substrate having a recess defined therein by two opposing lateral walls and a base wall, a filler member having at least a portion thereof occupying the recess, and a channel defined in the portion of the filler member occupying the recess, wherein the channel comprises a first aperture and a second aperture, the first aperture being arranged on a first lateral wall of the filler member, and the second aperture being arranged on a second lateral wall of the filler member, said first lateral wall of the filler member being arranged in opposing relationship with the second lateral wall of the filler member, and at least a portion of the first and the second lateral walls of the filler member being at least substantially perpendicular to the opposing lateral walls defining the recess.

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