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1. 发明授权

US4324894A Aminoisoquinoline derivatives 失效
标题翻译：氨基异喹啉衍生物
公开(公告)号：US4324894A
公开(公告)日：1982-04-13
申请号：US138843
申请日：1980-04-10
申请人： Pal Benko , Andras Gelleri , Gyorgy Hajos , Andras Messmer , Laszlo Pallos , Lujza Petocz , Ibolya Kosoczky , Katalin Grasser , Peter Gorog , Eniko Szirt nee Kiszelly
发明人： Pal Benko , Andras Gelleri , Gyorgy Hajos , Andras Messmer , Laszlo Pallos , Lujza Petocz , Ibolya Kosoczky , Katalin Grasser , Peter Gorog , Eniko Szirt nee Kiszelly
IPC分类号： A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61P25/00 , A61P25/04 , C07D217/22 , C07D217/24 , C07D401/12 , C07D413/04 , C07D403/14
CPC分类号： C07D217/22 , C07D217/24
摘要： Novel aminoisoquinoline derivatives of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sub.2 represents a hydrogen atom,R.sub.3 represents a hydrogen atom,R.sub.4 represents a morpholinyl group or a piperazinyl group substituted with a pyridyl group, andpharmaceutically acceptable acid addition salts and quaternary derivatives thereof have been prepared. The novel compounds exert narcosis potentiating effects.
摘要翻译：通式（I）的新型氨基异喹啉衍生物其中R 1表示氢原子或C 1-4烷基，R 2表示氢原子，R 3表示氢原子，R 4表示吗啉基或哌嗪基已经制备了被吡啶基取代的基团，以及其药学上可接受的酸加成盐和其季衍生物。新型化合物发挥麻醉加强作用。

2. 发明授权

US4871846A Process for the preparation of condensed as-triazine derivatives 失效
标题翻译：缩合的三嗪衍生物的制备方法
公开(公告)号：US4871846A
公开(公告)日：1989-10-03
申请号：US43600
申请日：1987-04-28
申请人： Sandor Batori , Gyorgy Hajos , Andras Messmer , Pal Benko , Laszlo Pallos , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Szirt nee Kiszelly
发明人： Sandor Batori , Gyorgy Hajos , Andras Messmer , Pal Benko , Laszlo Pallos , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Szirt nee Kiszelly
IPC分类号： C07D215/12 , C07D215/58 , C07D217/16 , C07D217/18 , C07D471/04
CPC分类号： C07D471/04 , C07D215/58 , C07D217/18
摘要： A process for the preparation of condensed as-triazinium derivatives of the formula I ##STR1## and isomers thereof, wherein R.sub.1 inter alia is an alkyl group, R.sub.2 inter alia is hydrogen or an alkyl group and R.sub.3 is hydrogen and where Z is a group of the formula a or b ##STR2## which comprises reacting a compound of the formula II ##STR3## where Y is a group of the formula c or d ##STR4## with a compound of the formula IIaNH.sub.2 --CO--R.sub.2 (IIa)in the presence of a dehydrating agent. The advantage of the process is that it consists of fewer reaction steps and provides higher yields than the known methods. The compounds of formula I are pharmaceutically active known derivatives.
摘要翻译：一种制备式I（I）的缩合的三嗪鎓衍生物及其异构体的方法，其中R1特别是烷基，R 2特别是氢或烷基，R 3是氢，并且其中Z 是式a或b的基团（a）（b），其包括使式II的化合物（II）其中Y是式c的基团或d （c）在脱水剂存在下，用式IIa NH 2 -CO-R 2（IIa）化合物与（d）化合物反应。该方法的优点在于其由较少的反应步骤组成，并提供比已知方法更高的产率。式I的化合物是药学活性的已知衍生物。

3. 发明授权

US4753938A Condensed as-triazine derivatives 失效
标题翻译：浓缩的三嗪衍生物
公开(公告)号：US4753938A
公开(公告)日：1988-06-28
申请号：US787704
申请日：1985-10-15
申请人： Andras Messmer , Sandor Batori , Gyorgy Hajos , Pal Benko , Laszlo Pallos , Lujza Petocz , Katalin Grasser , Eniko Szirt nee Kiszelly
发明人： Andras Messmer , Sandor Batori , Gyorgy Hajos , Pal Benko , Laszlo Pallos , Lujza Petocz , Katalin Grasser , Eniko Szirt nee Kiszelly
IPC分类号： A61K31/53 , A61P9/06 , A61P25/02 , A61P25/24 , A61P29/00 , A61P43/00 , C07D471/04 , C07D253/08
CPC分类号： C07D471/04
摘要： The invention relates to new compounds of the general Formula I ##STR1## and isomers thereof wherein R.sub.1 is C.sub.1-10 alkyl, C.sub.3-6 cycloalkyl or phenyl, naphthyl or phenyl-(C.sub.1-4 alkyl), wherein the aryl ring of the three latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy substituent(s);R.sub.2 stands for hydrogen, halogen, hydroxy, oxo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl or naphthyl, wherein the two latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy substituent(s);R.sub.3 represents hydrogen, hydroxy or C.sub.1-4 alkoxy;Z is buta-1,3-dienyl or a group of the general Formula (a) ##STR2## or (b) ##STR3## and X is hydrogen or halogen.The compounds of the general Formula I possess useful pharmacological properties, particularly antidepressant and antiarrhythmial effect.
摘要翻译：本发明涉及通式I（I）的新化合物及其异构体，其中R 1为C 1-10烷基，C 3-6环烷基或苯基，萘基或苯基 - （C 1-4烷基），其中芳基环三个后面的基团可任选地带有一个或多个卤素，硝基，三氟甲基，氨基，羟基，C 1-4烷基和/或C 1-4烷氧基取代基; R2代表氢，卤素，羟基，氧代，C1-4烷基，C1-4烷氧基，苯基或萘基，其中后两个基团可任选地具有一个或多个卤素，硝基，三氟甲基，氨基，羟基，C 1-4烷基和/或C 1-4烷氧基取代基; R3表示氢，羟基或C1-4烷氧基; Z是丁-1,3-二烯基或通式（a）的基团（a）或（b）图像（b），X是氢或卤素。通式I的化合物具有有用的药理学特性，特别是抗抑郁药和抗心律失常作用。

4. 发明授权

US4419355A Condensed as-triazine derivatives and method of using the same 失效
标题翻译：缩合三嗪衍生物及其使用方法
公开(公告)号：US4419355A
公开(公告)日：1983-12-06
申请号：US283971
申请日：1981-07-16
申请人： Ibolya Kosoczky , Eva Toncsev, nee Ravasz , Pal Benko , Laszlo Pallos , Lujza Petocz , Sandor Batori , Gyorgy Hajos , Andras Messmer , Katalin Grasser
发明人： Ibolya Kosoczky , Eva Toncsev, nee Ravasz , Pal Benko , Laszlo Pallos , Lujza Petocz , Sandor Batori , Gyorgy Hajos , Andras Messmer , Katalin Grasser
IPC分类号： C07D471/04 , A61K31/53 , A61P25/24 , A61P25/26 , C07D253/10 , C07D487/04 , C07D253/08
CPC分类号： C07D487/04
摘要： The invention relates to new condensed as-triazine derivatives of the general formula (I) ##STR1## wherein Z represents a buta-1,3-dienyl group or a group of the formula (a), (b), (c) or (d) ##STR2## R.sub.1 denotes a C.sub.1-10 alkyl group, an oxo group or a C.sub.6-10 aryl or C.sub.6-10 aryl-(C.sub.1-3 alkyl) group optionally substituted by one or more identical or different substituents selected from the group consisting of amino, nitro, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and halogen,R.sub.2 stands for hydrogen, C.sub.1-10 alkyl or amino,R.sub.3 represents hydrogen, C.sub.1-10 alkyl or C.sub.6-10 aryl or C.sub.6-10 aryl-(C.sub.1-3 alkyl) optionally substituted by one or more identical or different substituents selected from the group consisting of nitro, amino, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and halogen,X.sup.- denotes an anion, andn is 0 or 1,with the proviso that if n is O, R.sub.1 is other than an oxo group and R.sub.1 ' and R.sub.2 ' form together a double bond, and with the further provisos that if n is 1, R.sub.1 represents an oxo group and the symbols R.sub.1 ' and R.sub.2 ' are not present, and if Z is a buta-1,3-dienyl group and R.sub.1 denotes an oxo group, R.sub.3 is other than unsubstituted phenyl.The new compounds of the general formula (I) can be prepared by cyclizing the compounds of the general formula (II) or (V), wherein R.sub.1, Z, R.sub.3 and X.sup.- have the above defined meanings, R.sub.4 is a leaving group and R.sub.7 represents hydrogen or C.sub.1-10 alkyl.The new compounds of the general formula (I) possess a valuable antidepressant effect and can advantageously be used in the therapy.
摘要翻译：本发明涉及通式（I）的新的缩合的三嗪衍生物，其中Z代表丁-1,3-二烯基或式（a），（b），（ c）或（d）R1表示任选被一个或多个相同的C 1-6烷基，氧代基或C 6-10芳基或C 6-10芳基 - （C 1-3烷基）或选自氨基，硝基，C 1-6烷基，C 1-6烷氧基，羟基和卤素的不同取代基，R 2代表氢，C 1-10烷基或氨基，R 3表示氢，C 1-10烷基或C 6- 芳基或任选被一个或多个相同或不同的选自硝基，氨基，C 1-6烷基，C 1-6烷氧基，羟基和卤素的取代基取代的芳基或C 6-10芳基 - （C 1-3烷基）表示阴离子，n为0或1，条件是如果n为O，则R1不是氧代基，R1'和R2'一起形成双键，另外条件是，如果n为1， R1代表氧代基团， mbols R1'和R2'不存在，并且如果Z是丁-1,3-二烯基并且R 1表示氧代基，则R 3不是未取代的苯基。通式（I）的新化合物可以通过使通式（II）或（V）的化合物环化来制备，其中R1，Z，R3和X具有上述定义，R4是离去基团， R 7表示氢或C 1-10烷基。通式（I）的新化合物具有有价值的抗抑郁作用，可有利地用于治疗。

5. 发明授权

US4994448A Condensed quinolinium and isoquinolinium derivatives 失效
标题翻译：浓缩的喹啉和异喹啉衍生物
公开(公告)号：US4994448A
公开(公告)日：1991-02-19
申请号：US251445
申请日：1988-09-30
申请人： Andras Messmer , Gyorgy Hajos , Zsuzsa Juhasz nee Riedl , Pal Benko , Laszlo Pallos , Lujza Petocz , Eniko Szirt nee Kiszelly , Gabor Gigler , Istvan Gyertyan , Maria Hegedus
发明人： Andras Messmer , Gyorgy Hajos , Zsuzsa Juhasz nee Riedl , Pal Benko , Laszlo Pallos , Lujza Petocz , Eniko Szirt nee Kiszelly , Gabor Gigler , Istvan Gyertyan , Maria Hegedus
IPC分类号： A61K31/53 , A61P25/02 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/26 , C07D471/04
CPC分类号： C07D471/04
摘要： The new compounds of the general Formula I ##STR1## (wherein R.sub.1 stands for C.sub.1-4 alkyl or aralkyl; andR.sub.2 represents hydroxy; orR.sub.1 and R.sub.2 together form a valency bond;R.sub.3 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl, amino, alkylthio or a group of the Formula --NR.sub.7 R.sub.8 in which R.sub.7 and R.sub.8 may be the same or different and stand for hydrogen, C.sub.1-4 alkyl, phenyl-C.sub.1-4 alkyl, hydroxy-C.sub.1-4 alkyl or di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl or together with the nitrogen atom they are attached to form a 6-membered heterocyclic ring which may optionally contain a further nitrogen, oxygen or sulfur atom; orR.sub.2 and R.sub.3 together form an oxo (.dbd.O) or thixo (.dbd.S) group;R.sub.4 represents hydrogen, C.sub.1-4 alkyl or phenyl which may optionally bear one or two halogen or nitro substituent(s);Z is a group of the Formula (a) or (b) ##STR2## A.sup.- represents an anion) and isomers thereof possess useful local anaesthetic, antidepressant, tranquillo-sedative and smooth muscle relaxant properties accompanied by a weaker analgesic effect and are useful in therapy.
摘要翻译：通式I的新化合物Ⅰ（其中R1代表C1-4烷基或芳烷基，R2代表羟基;或R1和R2一起形成价键; R3是氢，C1-4烷基，C1- 烷氧基，苯基，氨基，烷硫基或式-NR7R8的基团，其中R 7和R 8可以相同或不同，代表氢，C 1-4烷基，苯基-C 1-4烷基，羟基-C 1-4烷基或二 - （C 1-4烷基） - 氨基-C 1-4烷基或与它们连接的氮原子一起形成可任选地含有另外的氮，氧或硫原子的6元杂环;或R 2和R 3 一起形成氧代（= O）或触变（= S）基团; R4代表氢，C1-4烷基或苯基，其可任选地带有一个或两个卤素或硝基取代基; Z是式（a ）或（b）和A-表示阴离子）及其异构体具有有用的局部麻醉剂，抗抑郁药，镇痛镇痛和平滑肌松弛剂性质，伴随较弱的镇痛剂 c效应，可用于治疗。

6. 发明授权

US4697013A Condensed as-triazine derivatives 失效
标题翻译：浓缩的三嗪衍生物
公开(公告)号：US4697013A
公开(公告)日：1987-09-29
申请号：US652613
申请日：1984-09-20
申请人： Andras Messmer , Sandor Batori , Gyorgy Hajos , Pal Benko , Laszlo Pallos , Lujza Petocz , Grasser Katalin , Ibolya Kosoczky
发明人： Andras Messmer , Sandor Batori , Gyorgy Hajos , Pal Benko , Laszlo Pallos , Lujza Petocz , Grasser Katalin , Ibolya Kosoczky
IPC分类号： C07D253/08 , C07D471/04
CPC分类号： C07D471/04
摘要： A one step process for the preparation of compounds having antidepressant activity of the formula I ##STR1## and isomers thereof, wherein R.sub.1, R.sub.2, Z and A.sup.- have the meanings indicated in the claims, which process comprises: heating a compound of the formula II ##STR2## wherein Z, A.sup.-, R.sub.1 and R.sub.2 have the meanings set out in the claims and R.sub.3 stands for hydrogen or C.sub.1-4 alkyl, in the presence of a dehydrating agent to split off a compound of the formula R.sub.3 OH. The invention is also directed to compounds of the formula I, wherein R.sub.2 is halogen and to compositions containing a compound of the formula I which exhibit antidepressant activity.
摘要翻译：制备具有式I的抗抑郁活性的化合物及其异构体的一步法，其中R1，R2，Z和A具有权利要求中所示的含义，该方法包括：将式II其中Z，A，R 1和R 2具有权利要求中所述的含义，R 3代表氢或C 1-4烷基，在脱水剂的存在下分离式R 3 OH的化合物。本发明还涉及式I化合物，其中R 2是卤素，以及含有表现出抗抑郁活性的式I化合物的组合物。

7. 发明授权

US4652562A Quinoline derivatives and pharmaceutical compositions 失效
标题翻译：喹啉衍生物和药物组合物
公开(公告)号：US4652562A
公开(公告)日：1987-03-24
申请号：US870396
申请日：1986-06-04
申请人： Edit Berenyi nee Poldermann , Laszlo Varga , Laszlo Pallos , Lujza Petocz , Laszlo Ladanyi , Peter Tompe , Eva Hartai nee Zsorzs , Agnes Kovacs nee Palotai
发明人： Edit Berenyi nee Poldermann , Laszlo Varga , Laszlo Pallos , Lujza Petocz , Laszlo Ladanyi , Peter Tompe , Eva Hartai nee Zsorzs , Agnes Kovacs nee Palotai
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61P35/00 , A61P43/00 , C07D215/42 , C07D215/46 , C07D401/12 , C07D405/12 , C07D413/12
CPC分类号： C07D401/12 , C07D215/46 , C07D405/12
摘要： The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy;n is an integer of 1, 2 or 3;R.sup.1 represents hydrogen andR.sup.2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, ##STR2## wherein Z stands for --O--, --S--, --NH-- or --N(lower alkyl)--; the dotted lines represent optional bonds; andm is 0 or 1; orR.sup.1 and R.sup.2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted),and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.
摘要翻译：本发明涉及通式Ⅰ（I）的新喹啉衍生物（其中X代表氢，卤素或低级烷氧基; n是1,2或3的整数; R1代表氢，R2代表羟基低级烷基或低级烷氧基 - 低级烷基或通式Ⅳ的基团，其中Z代表-O - ， - S - ， - NH-或-N（低级烷基） - ;虚线表示任选的键;并且m为0或1;或者R1和R2与相邻的氮原子一起连接，形成可任选地含有另外的氧，氮或硫杂原子的5-或6-元杂环基，并且可以任选取代）及其药学上可接受的酸加成盐。本发明的新化合物显示放射增敏作用，使低氧细胞对辐射高度敏感，并可用于放射治疗。

8. 发明授权

US4097668A 2-�(P-Methoxy-benzoyl)-hydrazono-formyl!-quinoxaline-1,4-dioxide 失效
标题翻译： 2- {8（对 - 甲氧基 - 苯甲酰基） - 肼基 - 甲酰基{9-喹喔啉-1,4-二氧化物
公开(公告)号：US4097668A
公开(公告)日：1978-06-27
申请号：US775998
申请日：1977-03-09
申请人： Pal Benko , Ildiko Simonek , Laszlo Pallos , Jeno Kovacs , Karoly Magyar
发明人： Pal Benko , Ildiko Simonek , Laszlo Pallos , Jeno Kovacs , Karoly Magyar
IPC分类号： C07D241/52 , C07D241/00 , A61K31/085 , A61K31/165 , A61K31/495
CPC分类号： C07D241/52
摘要： The invention provides 2-�(p-methoxy-benzoyl)-hydrazono-formyl!-quinoxaline-1,4-dioxide. This compound is indicated for use as a potent antibacterial agent having a low toxicity.
摘要翻译：本发明提供了2 - [（对 - 甲氧基 - 苯甲酰基） - 肼基 - 甲酰基] - 喹喔啉-1,4-二氧化物。

9. 发明授权

US4746678A Phenanthrene derivatives 失效
标题翻译：菲衍生物
公开(公告)号：US4746678A
公开(公告)日：1988-05-24
申请号：US870402
申请日：1986-06-04
申请人： Pal Benko , Tibor Zsolnai , Marta Kininczky , Laszlo Pallos , Iren Zsolnai nee Csillag , Peter Tetenyi , Jeno Bernath
发明人： Pal Benko , Tibor Zsolnai , Marta Kininczky , Laszlo Pallos , Iren Zsolnai nee Csillag , Peter Tetenyi , Jeno Bernath
IPC分类号： A61K31/265 , A01N37/16 , A01N37/34 , A01N37/38 , A01N37/44 , A01N37/48 , A01N47/06 , A01N47/24 , A61K31/27 , A61K31/275 , A61P31/04 , C07C67/00 , C07C249/12 , C07C251/44 , C07C325/00 , C07C329/06 , A61K31/15
CPC分类号： A01N47/06 , A01N37/16 , A01N47/24 , C07C2103/26
摘要： The invention relates to new phenanthrene derivatives wherein R stand for C.sub.1-10 alkylamino; C.sub.1-10 alkylthio; C.sub.1-5 alkoxy; or phenyl or phenylamino, the two latter groups being optionally substituted on the phenyl ring by one or more identical or different C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, cyano and/or halogen substituent(s) .The compounds of the present invention possess valuable fungicidal properties and may be used in agriculture, horticulture and therapy as active ingredient of fungicidal or antifungal compositions.The compounds of the general Formula I ##STR1## may be prepared by acylating 9,10-phenanthrene-dione-9-oxime or an alkali or alkali earth metal salt thereof.
摘要翻译：本发明涉及新的菲衍生物，其中R代表C1-10烷基氨基; C 1-10烷硫基; C 1-5烷氧基或苯基或苯基氨基，后两个基团在苯环上任选被一个或多个相同或不同的C 1-4烷基，C 1-4烷氧基，硝基，氨基，氰基和/或卤素取代基取代。本发明的化合物具有有价值的杀真菌性质，可用作农业，园艺和治疗用作杀真菌剂或抗真菌组合物的有效成分。通式Ⅰ（I）的化合物可以通过酰化9,10-菲 - 二酮-9-肟或其碱金属或碱土金属盐来制备。

10. 发明授权

US4511717A 2-Hydroxymethyl-quinoxaline-1,4-dioxide derivatives, a process for preparing same and compositions containing same 失效
标题翻译： 2-羟甲基 - 喹喔啉-1,4-二氧化物衍生物，其制备方法和含有它们的组合物
公开(公告)号：US4511717A
公开(公告)日：1985-04-16
申请号：US593204
申请日：1984-03-27
申请人： Pal Benko , Ildiko Ratz nee Simonek , Laszlo Pallos , Karoly Magyar , Jeno Kovacs , Erzsebet Matrai , Janos Gundel , Albert Balogh
发明人： Pal Benko , Ildiko Ratz nee Simonek , Laszlo Pallos , Karoly Magyar , Jeno Kovacs , Erzsebet Matrai , Janos Gundel , Albert Balogh
IPC分类号： A23K1/16 , A61K31/498 , A61P31/00 , C07D241/00 , C07D241/52 , C07D307/00 , C07D401/00 , C07D405/00 , A61K31/495 , C07D401/12 , C07D403/12
CPC分类号： C07D241/52
摘要： The invention relates to new 2-hydroxymethyl-quinoxaline-1,4-dioxide derivatives of the general formula (I) ##STR1## wherein A represents an amino group, or a group of the general formula --NH--COOR.sub.1, wherein R.sub.1 stands for a C.sub.2-4 alkyl group, or a group of the general formula --NH--CX--NH.sub.2, whereinX denotes an oxygen or sulfur atom, or a group of the formula --NH--C(NH)--NH.sub.2, or a group of the general formula --NH--R.sub.2, wherein R.sub.2 represents a C.sub.1-6 alkyl, a phenyl, a benzyl, a hydroxyl or a hydroxy-(C.sub.2-4 alkyl) group, or a group of the general formula --NH--CO--R.sub.3, wherein R.sub.3 stands for a C.sub.1-20 alkyl group or a phenyl group optionally substituted by one, two or three identical or different substituent(s) selected from the group consisting of nitro, hydroxyl, amino, C.sub.1-3 alkoxy and halogen; a naphtyl group optionally substituted by a hydroxyl group, a phenyl-(C.sub.1-3 alkyl) group, a pyridyl, a piperidyl, a pyrazinyl, a pyrimidyl, a 1,2,4-triazinyl, a furyl, a nitrofuryl or an .alpha.,.alpha.-diphenyl-.alpha.-hydroxymethyl group.Due to their antimicrobial and weight-gain increasing effects, the new compounds of the general formula (I) can serve as active ingredients of pharmaceutical or veterinary compositions, particularly fodder concentrates, fodder additives and fodders.The invention relates also to the preparation of the new compounds of the general formula (I) and the compositions containing same.
摘要翻译： PCT No.PCT / HU81 / 00038 Sec。 371日期1982年5月7日 102（e）日期1982年5月7日PCT提交1981年9月11日PCT公布。出版物WO82 / 01001 日本1982年4月1日。本发明涉及通式（I）的新的2-羟甲基 - 喹喔啉-1,2-二氧化物衍生物，其中A表示氨基，或一般为式-NH-COOR1，其中R1表示C2-4烷基，或通式为-NH-CX-NH2的基团，其中X表示氧或硫原子，或式-NH-C （NH）-NH 2或通式为-NH-R 2的基团，其中R 2表示C 1-6烷基，苯基，苄基，羟基或羟基 - （C 2-4烷基）基团，或一组通式为-NH-CO-R3，其中R3代表C1-20烷基或任选被一个，两个或三个相同或不同的取代基取代的苯基，所述取代基选自硝基，羟基，氨基，C 1-3烷氧基和卤素; 任选被羟基取代的萘基，苯基 - （C 1-3烷基）基，吡啶基，哌啶基，吡嗪基，嘧啶基，1,2,4-三嗪基，呋喃基，硝基呋喃基或α ，α-二苯基-α-羟甲基。由于其抗微生物和增重增加的作用，通式（I）的新化合物可用作药物或兽药组合物，特别是饲料浓缩物，饲料添加剂和饲料的有效成分。本发明还涉及通式（I）的新化合物和含有其的组合物的制备。

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