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1. 发明授权

US4511717A 2-Hydroxymethyl-quinoxaline-1,4-dioxide derivatives, a process for preparing same and compositions containing same 失效
标题翻译： 2-羟甲基 - 喹喔啉-1,4-二氧化物衍生物，其制备方法和含有它们的组合物
公开(公告)号：US4511717A
公开(公告)日：1985-04-16
申请号：US593204
申请日：1984-03-27
申请人： Pal Benko , Ildiko Ratz nee Simonek , Laszlo Pallos , Karoly Magyar , Jeno Kovacs , Erzsebet Matrai , Janos Gundel , Albert Balogh
发明人： Pal Benko , Ildiko Ratz nee Simonek , Laszlo Pallos , Karoly Magyar , Jeno Kovacs , Erzsebet Matrai , Janos Gundel , Albert Balogh
IPC分类号： A23K1/16 , A61K31/498 , A61P31/00 , C07D241/00 , C07D241/52 , C07D307/00 , C07D401/00 , C07D405/00 , A61K31/495 , C07D401/12 , C07D403/12
CPC分类号： C07D241/52
摘要： The invention relates to new 2-hydroxymethyl-quinoxaline-1,4-dioxide derivatives of the general formula (I) ##STR1## wherein A represents an amino group, or a group of the general formula --NH--COOR.sub.1, wherein R.sub.1 stands for a C.sub.2-4 alkyl group, or a group of the general formula --NH--CX--NH.sub.2, whereinX denotes an oxygen or sulfur atom, or a group of the formula --NH--C(NH)--NH.sub.2, or a group of the general formula --NH--R.sub.2, wherein R.sub.2 represents a C.sub.1-6 alkyl, a phenyl, a benzyl, a hydroxyl or a hydroxy-(C.sub.2-4 alkyl) group, or a group of the general formula --NH--CO--R.sub.3, wherein R.sub.3 stands for a C.sub.1-20 alkyl group or a phenyl group optionally substituted by one, two or three identical or different substituent(s) selected from the group consisting of nitro, hydroxyl, amino, C.sub.1-3 alkoxy and halogen; a naphtyl group optionally substituted by a hydroxyl group, a phenyl-(C.sub.1-3 alkyl) group, a pyridyl, a piperidyl, a pyrazinyl, a pyrimidyl, a 1,2,4-triazinyl, a furyl, a nitrofuryl or an .alpha.,.alpha.-diphenyl-.alpha.-hydroxymethyl group.Due to their antimicrobial and weight-gain increasing effects, the new compounds of the general formula (I) can serve as active ingredients of pharmaceutical or veterinary compositions, particularly fodder concentrates, fodder additives and fodders.The invention relates also to the preparation of the new compounds of the general formula (I) and the compositions containing same.
摘要翻译： PCT No.PCT / HU81 / 00038 Sec。 371日期1982年5月7日 102（e）日期1982年5月7日PCT提交1981年9月11日PCT公布。出版物WO82 / 01001 日本1982年4月1日。本发明涉及通式（I）的新的2-羟甲基 - 喹喔啉-1,2-二氧化物衍生物，其中A表示氨基，或一般为式-NH-COOR1，其中R1表示C2-4烷基，或通式为-NH-CX-NH2的基团，其中X表示氧或硫原子，或式-NH-C （NH）-NH 2或通式为-NH-R 2的基团，其中R 2表示C 1-6烷基，苯基，苄基，羟基或羟基 - （C 2-4烷基）基团，或一组通式为-NH-CO-R3，其中R3代表C1-20烷基或任选被一个，两个或三个相同或不同的取代基取代的苯基，所述取代基选自硝基，羟基，氨基，C 1-3烷氧基和卤素; 任选被羟基取代的萘基，苯基 - （C 1-3烷基）基，吡啶基，哌啶基，吡嗪基，嘧啶基，1,2,4-三嗪基，呋喃基，硝基呋喃基或α ，α-二苯基-α-羟甲基。由于其抗微生物和增重增加的作用，通式（I）的新化合物可用作药物或兽药组合物，特别是饲料浓缩物，饲料添加剂和饲料的有效成分。本发明还涉及通式（I）的新化合物和含有其的组合物的制备。

2. 发明授权

US4618623A Carbazic acid derivatives, process for their preparation and compositions containing the same 失效
标题翻译：咔唑酸衍生物，其制备方法和含有它们的组合物
公开(公告)号：US4618623A
公开(公告)日：1986-10-21
申请号：US737388
申请日：1985-05-23
申请人： Zoltan Budai , Pal Benko , Ildiko Ratz nee Simonek , Eva Rakoczy nee Pinter , Karoly Magyar , Jozsef Kelemen , Attila Mandi
发明人： Zoltan Budai , Pal Benko , Ildiko Ratz nee Simonek , Eva Rakoczy nee Pinter , Karoly Magyar , Jozsef Kelemen , Attila Mandi
IPC分类号： C07C281/02 , A23K1/16 , A23K1/18 , C07C67/00 , C07C239/00 , C07C281/04 , A61K31/27
CPC分类号： A23K50/30 , A23K20/105 , A23K20/111
摘要： The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same. The new compounds according to the invention correspond to the formula (I)R.sup.1 .dbd.N--NH--COOR.sup.3 (I)wherein R.sup.1 stands for a C.sub.7-12 cycloalkylidene group, an indanylidene group or a group of the formula (IX) ##STR1## wherein A represents a phenyl group optionally carrying one or more identical or different substituents selected from the group consisting of halo, nitro, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, amino or C.sub.1-4 alkoxycarbonylhydrazino; phenyl-(C.sub.1-4 alkyl), C.sub.1-16 alkyl, C.sub.3-7 cycloalkyl or indolyl, or a C.sub.3 -C.sub.6 cycloalkyl group substituted by a C.sub.3 -C.sub.6 cycloalkyl group; R.sup.2 denotes a hydrogen atom, a C.sub.1-16 alkyl or a C.sub.3-7 cycloalkyl group; and R.sup.3 represents a C.sub.1-4 alkyl group.
摘要翻译：本发明涉及新的卡巴酸衍生物，其制备方法和组合物 - 特别是饲料添加剂和含有它们的动物饲料。根据本发明的新化合物对应于式（I）R 1 = N-NH-COOR 3（I）其中R 1表示C 7-12亚环烷基，亚茚基或式（Ⅸ）的基团）（IX）其中A表示任选携带一个或多个相同或不同的取代基的苯基，所述取代基选自卤素，硝基，羟基，C 1-4烷氧基，C 1-4烷基，氨基或C 1-4烷氧基羰基肼; 苯基 - （C 1-4烷基），C 1-16烷基，C 3-7环烷基或吲哚基，或被C 3 -C 6环烷基取代的C 3 -C 6环烷基; R2表示氢原子，C1-16烷基或C3-7环烷基; 并且R 3表示C 1-4烷基。

3. 发明授权

US4824670A Carbazates 失效
标题翻译： Car子
公开(公告)号：US4824670A
公开(公告)日：1989-04-25
申请号：US808352
申请日：1985-12-11
申请人： Ildiko Ratz nee Simonek , Pal Benko , Edit Bernenyi nee Poldermann , Karoly Magyar
发明人： Ildiko Ratz nee Simonek , Pal Benko , Edit Bernenyi nee Poldermann , Karoly Magyar
IPC分类号： C07C281/00 , A23K1/16 , A23K1/18 , A61K31/27 , A61P3/00 , C07C67/00 , C07C239/00 , C07C281/02 , C07D231/56 , C07D307/71 , A23L1/30
CPC分类号： C07D231/56 , A23K20/105 , A23K20/111 , A23K20/116 , A23K50/30 , C07D307/71
摘要： The present invention relates to new carbazates of the general formula (I), ##STR1## wherein A is C.sub.3-10 alkyl, C.sub.3-10 alkenyl, C.sub.2-10 haloalkyl, trifluoromethyl, phenyl-C.sub.1-3 alkyl, phenyl-C.sub.2-3 -alkenyl, naphthyl-C.sub.1-3 alkyl; phenyl optionally substituted by one or more identical or different substituent(s) selected from C.sub.1-4 alkyl, halogen, C.sub.1-4 alkoxy and hydroxy; C.sub.3-7 cycloalkyl-C.sub.1-3 alkyl; optionally nitro-substituted furyl; diphenyl-hydroxy-methyl or indazolyl optionally substituted by one or more C.sub.1-4 alkoxy group(s) andR represents C.sub.1-4 alkyl,with the proviso that if R stands for ethyl, A is other than tertiary butyl, and acid addition salts thereof, a process for the preparation thereof and feed-additives comprising the same.The compounds of the general formula (I) may be used in animal husbandry due to their weight-gain increasing and fodder utilization improving effect.
摘要翻译：本发明涉及通式（I）的新的肼基甲酸酯，其中A为C 3-10烷基，C 3-10烯基，C 2-10卤代烷基，三氟甲基，苯基-C 1-3烷基，苯基-C 2 -3-烯基，萘基-C 1-3烷基; 任选被一个或多个相同或不同的选自C 1-4烷基，卤素，C 1-4烷氧基和羟基的取代基取代的苯基; C 3-7环烷基-C 1-3烷基; 任选硝基取代的呋喃基; 任选被一个或多个C 1-4烷氧基取代的二苯基 - 羟基 - 甲基或吲唑基，R表示C 1-4烷基，条件是如果R代表乙基，则A不是叔丁基，而酸加成盐其制备方法和包含其的饲料添加剂。通式（I）的化合物可以用于畜牧业，因为它们的增重和饲料利用率的改善效果。

4. 发明授权

US4883907A Carbazates 失效
标题翻译： Car子
公开(公告)号：US4883907A
公开(公告)日：1989-11-28
申请号：US179595
申请日：1988-04-11
申请人： Ildiko Ratz nee Simonek , Pal Benko , Edit Berenyi nee Foldermann , Karoly Magyar
发明人： Ildiko Ratz nee Simonek , Pal Benko , Edit Berenyi nee Foldermann , Karoly Magyar
IPC分类号： A23K1/16 , A23K1/18 , C07D231/56 , C07D307/71
CPC分类号： C07D231/56 , A23K20/105 , A23K20/111 , A23K20/116 , A23K50/30 , C07D307/71
摘要： The present invention relates to new carbazates of the formula (I) ##STR1## wherein A is C.sub.3 to C.sub.10 alkenyl, C.sub.2 to C.sub.10 haloalkyl, trifluoromethyl, phenyl-C.sub.1 to C.sub.3 alkyl, phenyl-C.sub.2 to C.sub.3 alkenyl, naphthyl-C.sub.1 to C.sub.3 alkyl, C.sub.3 to C.sub.7 cycloalkyl-C.sub.1 to C.sub.3 alkyl, furyl which can be nitro-substituted, diphenyl-hydroxymethyl or indazolyl which can be substituted by one or more C.sub.1 to C.sub.4 alkoxy groups; andR is C.sub.1 to C.sub.4 alkyl,and acid addition salts thereof, a process for the preparation thereof and feed additives comprising the same.The compounds of formula (I) may be used in animal husbandry due to their weight-gain increasing and fodder utilization improving effect.
摘要翻译：本发明涉及式（I）的新的肼基甲酸酯其中A为C 3至C 10烯基，C 2至C 10卤代烷基，三氟甲基，苯基-C 1至C 3烷基，苯基-C 2至C 3烯基， C 1 -C 3烷基，C 3至C 7环烷基-C 1至C 3烷基，可被硝基取代的呋喃基，可被一个或多个C 1至C 4烷氧基取代的二苯基 - 羟甲基或吲唑基; 和R是C1-C4烷基，及其酸加成盐，其制备方法和含有它们的饲料添加剂。由于其增重和饲料利用率的改善效果，式（I）化合物可用于畜牧业。

5. 发明授权

US4587261A Cycloalkane derivatives and fodder compositions containing the same 失效
标题翻译：含有它们的环烷烃衍生物和饲料组合物
公开(公告)号：US4587261A
公开(公告)日：1986-05-06
申请号：US491083
申请日：1983-05-03
申请人： Zoltan Budai , Pal Benko , Ildiko Ratz nee Simonek , Eva Rakoczy nee Pinter , Karoly Magyar , Jozsef Kelemen , Attila Mandi
发明人： Zoltan Budai , Pal Benko , Ildiko Ratz nee Simonek , Eva Rakoczy nee Pinter , Karoly Magyar , Jozsef Kelemen , Attila Mandi
IPC分类号： A23K1/16 , A23K1/18 , A23K1/22 , A61K31/15 , C07C67/00 , C07C239/00 , C07C241/00 , C07C251/84 , C07C281/02 , C07C281/04 , C07C125/065 , A61K31/27 , C07C125/067
CPC分类号： C07C251/72 , A23K20/105 , A23K50/30
摘要： The invention relates to new cycloalkane derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same.The new compounds of the present invention correspond to the general formula I ##STR1## wherein n is 3, 4, 5 or 6;R denotes a phenyl group optionally carrying one or more substituent/s/ selected from the group consisting of halogen, lower alkoxy and lower alkyl;R.sup.1 and R.sup.2 each represent hydrogen or form together a valence bond;R.sup.3 represents lower alkoxy or a phenyl optionally substituted by one or more C.sub.1-12 alkoxy.The fodder additives and fodders according to the invention contain as active ingredient an amount of 1 ppm to 85% by weight of a compound of the general formula I in admixture with inert solid or liquid carriers or diluents and can be used to advantage in animal husbandry.
摘要翻译：本发明涉及新的环烷烃衍生物，其制备方法和组合物，特别是饲料添加剂和含有它们的动物饲料。本发明的新化合物对应于通式I其中n为3,4,5或6; R表示任选携带一个或多个选自卤素，低级烷氧基和低级烷基的取代基的苯基; R1和R2各自表示氢或一起形成价键; R3表示低级烷氧基或任选被一个或多个C 1-12烷氧基取代的苯基。根据本发明的饲料添加剂和饲料以惰性固体或液体载体或稀释剂的混合物的形式含有1至85重量％的通式I化合物作为活性成分，并可用于畜牧业。

6. 发明授权

US4097668A 2-�(P-Methoxy-benzoyl)-hydrazono-formyl!-quinoxaline-1,4-dioxide 失效
标题翻译： 2- {8（对 - 甲氧基 - 苯甲酰基） - 肼基 - 甲酰基{9-喹喔啉-1,4-二氧化物
公开(公告)号：US4097668A
公开(公告)日：1978-06-27
申请号：US775998
申请日：1977-03-09
申请人： Pal Benko , Ildiko Simonek , Laszlo Pallos , Jeno Kovacs , Karoly Magyar
发明人： Pal Benko , Ildiko Simonek , Laszlo Pallos , Jeno Kovacs , Karoly Magyar
IPC分类号： C07D241/52 , C07D241/00 , A61K31/085 , A61K31/165 , A61K31/495
CPC分类号： C07D241/52
摘要： The invention provides 2-�(p-methoxy-benzoyl)-hydrazono-formyl!-quinoxaline-1,4-dioxide. This compound is indicated for use as a potent antibacterial agent having a low toxicity.
摘要翻译：本发明提供了2 - [（对 - 甲氧基 - 苯甲酰基） - 肼基 - 甲酰基] - 喹喔啉-1,4-二氧化物。

7. 发明授权

US4091206A Quinoxaline-1,4-dioxide derivatives 失效
标题翻译：喹喔啉-1,4-二氧化物衍生物
公开(公告)号：US4091206A
公开(公告)日：1978-05-23
申请号：US775999
申请日：1977-03-09
申请人： Pal Benko , Ildiko Simonek , Laszlo Pallos , Jeno Kovacs , Karoly Magyar
发明人： Pal Benko , Ildiko Simonek , Laszlo Pallos , Jeno Kovacs , Karoly Magyar
IPC分类号： C07D241/52 , C07D241/00 , C07D401/12 , C07D405/12
CPC分类号： C07D241/52
摘要： The invention relates to new quinoxaline-1,4-dione derivatives of the formula ##STR1## wherein R is pyridyl, 5-nitrofuryl or 1-naphthylmethyl group. The new compounds of formula I have weight-gain increasing effects.
摘要翻译：本发明涉及式（I）的新的喹喔啉-1,4-二酮衍生物，其中R是吡啶基，5-硝基呋喃基或1-萘基甲基。

8. 发明授权

US4373101A Quinoxaline-2-yl ethenyl ketones 失效
标题翻译：喹喔啉-2-基乙烯基酮
公开(公告)号：US4373101A
公开(公告)日：1983-02-08
申请号：US269721
申请日：1981-06-02
申请人： Pal Benko , Daniel Bozsing , Janos Gundel , Karoly Magyar
发明人： Pal Benko , Daniel Bozsing , Janos Gundel , Karoly Magyar
IPC分类号： A23K1/16 , A23K1/17 , A61K31/495 , A61K31/498 , A61P3/00 , A61P21/06 , A61P31/04 , C07D241/52 , C07D401/06 , C07D405/06 , C09B55/00
CPC分类号： C07D241/52 , A23K20/116 , A23K20/195
摘要： The invention relates to novel quinoxaline-2-yl ethenyl ketones, their preparation and compositions containing them.The novel quinoxaline-2-yl ethenyl ketones of the general formula I ##STR1## wherein R.sub.1 represents an aryl group or a heterocyclic group comprising one or more nitrogen and/or oxygen and/or sulfur atoms wherein both the aryl and heterocyclic groups are optionally substituted by one or more identical or different substituents,R.sub.2 stands for a hydrogen atom or a C.sub.1-4 alkyl group, are prepared by reacting an acetylquinoxaline derivative of the general formula II ##STR2## wherein R.sub.2 is as stated above, with an aldehyde of the general formula IIIR.sub.1 --CHO (III) wherein R.sub.1 is as stated above.The novel compounds of the general formula I possess valuable antibacterial effect and promote the growth of animals. Thus, the novel compounds can be incorporated in animal feeds.
摘要翻译：本发明涉及新型喹喔啉-2-基乙烯基酮，其制备方法和含有它们的组合物。通式Ⅰ（I）的新型喹喔啉-2-基乙烯基酮其中R 1表示芳基或包含一个或多个氮和/或氧和/或硫原子的杂环基，其中芳基和杂环基团任选地被一个或多个相同或不同的取代基取代，R2代表氢原子或C1-4烷基，是通过使通式II的乙酰基喹喔啉衍生物（II）（其中R 2如所述）而制备的与通式III的R 1 -CH（III）的醛反应，其中R 1如上所述。通式Ⅰ的新型化合物具有有价值的抗菌作用，促进动物的生长。因此，新化合物可以并入动物饲料中。

9. 发明授权

US4373100A Methyl-quinoxaline-1,4-dioxide derivatives 失效
标题翻译：甲基 - 喹喔啉-1,4-二氧化物衍生物
公开(公告)号：US4373100A
公开(公告)日：1983-02-08
申请号：US269720
申请日：1981-06-02
申请人： Pal Benko , Daniel Bozsing , Janos Gundel , Karoly Magyar
发明人： Pal Benko , Daniel Bozsing , Janos Gundel , Karoly Magyar
IPC分类号： A23K1/16 , A23K1/17 , A23K1/18 , A61K31/495 , A61K31/498 , A61P3/00 , A61P21/06 , A61P31/04 , C07D237/36 , C07D241/42 , C07D241/52 , C07D277/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/06 , C07D417/06 , C09B23/00 , C09B25/00
CPC分类号： C07D403/06 , A23K20/116 , A23K20/137 , A23K20/195 , A23K50/30 , C07D241/42 , C07D241/52 , C07D413/06 , C07D417/06
摘要： The invention relates to fodder additives, fodder concentrates and fodders with weight gain increasing and fodder utilization improving effects, which contain as active agent a new compound of the general formula (I), ##STR1## The invention also relates to a process for the preparation of compounds having the general formula (I) by reacting a compound of the general formula (II), ##STR2## wherein Z is oxygen atom or represents two lower alkoxy groups and R.sup.1 is as defined above, with a compound of the general formula (III), ##STR3## wherein Q, A, B and n are as defined above, and, if desired, converting the resulting compound of the general formula (I) into another compound of the general formula (I) by well-known reactions.The compounds of the general formula (I) are new.
摘要翻译：本发明涉及饲料添加剂，饲料浓缩物和具有增重增重和饲料利用改善效果的饲料，其含有作为活性剂的通式（I）的新化合物，（I）本发明还涉及一种方法通过使通式（II）的化合物，其中Z是氧原子，或表示两个低级烷氧基并且R 1如上所定义的化合物与式（I）的化合物反应，制备具有通式（I）的化合物与通式（III）的化合物，其中Q，A，B和n如上所定义，如果需要，将得到的通式（I）的化合物转化为通式公式（I）通过众所周知的反应。通式（I）的化合物是新的。

10. 发明授权

US4404204A Pyridazino[4,5-b]quinoxaline-5,10-dioxide derivatives, a process for preparing same and anti-microbial compositions containing same 失效
标题翻译：哒嗪并[4,5-b]喹喔啉-5,10-二氧化物衍生物，其制备方法和含有其的抗微生物组合物
公开(公告)号：US4404204A
公开(公告)日：1983-09-13
申请号：US275393
申请日：1981-06-19
申请人： Pal Benko , Daniel Bozsing , Janos Gundel , Karoly Magyar
发明人： Pal Benko , Daniel Bozsing , Janos Gundel , Karoly Magyar
IPC分类号： A23K1/16 , A23K1/17 , A23K1/18 , A61K31/498 , A61K31/50 , A61K31/5025 , A61P1/00 , A61P31/00 , A61P31/04 , C07D487/04 , A61K31/495 , C07D241/52 , C07D401/12
CPC分类号： C07D487/04 , A23K20/116 , A23K50/30
摘要： The invention relates to fodder concentrates, fodder additives and fodders having antimicrobial and/or weight-gain increasing effects which comprise as active ingredient a new compound of the general formula (I) ##STR1## wherein R represents a C.sub.1-20 alkyl, a C.sub.1-6 alkoxy group, an optionally substituted C.sub.6-10 aryl group, a phenyl-(C.sub.1-3 alkyl), a C.sub.3-7 cycloalkyl or a 5 or 6 membered heterocyclic group containing one or two nitrogen and/or oxygen and/or sulfur atom(s),or a biologically acceptable acid addition salt of a basic compound of the general formula (I) together with a suitable inert, solid or liquid carrier or diluent.The invention relates also to the preparation of the new compounds of the general formula (I).
摘要翻译：本发明涉及具有抗微生物和/或增重增加效果的饲料浓缩物，饲料添加剂和饲料，其包含作为活性成分的通式（I）的新化合物，其中R表示C 1-20烷基，C 1-6烷氧基，任选取代的C 6-10芳基，苯基 - （C 1-3烷基），C 3-7环烷基或含有一个或两个氮和/或氧的5或6元杂环基，以及 /或硫原子，或通式（I）的碱性化合物的生物可接受的酸加成盐以及合适的惰性，固体或液体载体或稀释剂。本发明还涉及通式（I）的新化合物的制备。

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