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    • 4. 发明申请
    • PHARMACEUTICAL FORMULATION FOR SULFUR-CONTAINING DRUGS IN LIQUID DOSAGE FORMS
    • 液体药物中含硫药物的药物制剂
    • WO2007067331A1
    • 2007-06-14
    • PCT/US2006/044828
    • 2006-11-17
    • CHILDREN'S MEDICAL CENTER CORPORATIONCHEN, Wen, G.SHANNON, MichaelUMPRAIN, VimonratLO, Whe-YongWEINRICH, Karl, P.
    • CHEN, Wen, G.SHANNON, MichaelUMPRAIN, VimonratLO, Whe-YongWEINRICH, Karl, P.
    • A61K31/095
    • A61K45/06A61K31/095A61K31/195A61K2300/00
    • The pharmaceutical formulations of the invention for masking the odor from the sulfur-containing active agent comprise at least one sulfur-containing active agent, an effective amount of at least one flavoring agent. Any flavoring agent or combinations of flavoring agents may be used in the pharmaceutical formulation of the invention. The flavoring agent may be natural flavors, natural fruit flavors; artificial flavors, and mixtures thereof. The pharmaceutical formulation may contain an artificial sweetener, a natural sweetener or mixtures thereof. The pharmaceutical formulations are provided in liquid dosage form or a dry powder dosage form for reconstitution in water. Stabilizer added as one of expicients can extend the stability of the pharmaceutical formulation liquid dosage form for a period of at least 30 days when the formulation is stored below room temperature. The pharmaceutical formulations of the invention are palatable and particularly useful for the administration of sulfur-containing drugs to very small children that are in need of such medications. Methods of forming a liquid dosage form of pharmaceutical formulation by adding water to the dry powder form, methods to prepare an odor-masking pharmaceutical formulation and methods for treating lead poisoning or Wilson's, disease using the odor-masking pharmaceutical formulation are also provided.
    • 用于掩蔽来自含硫活性剂的气味的本发明的药物制剂包含至少一种含硫活性剂,有效量的至少一种调味剂。 任何调味剂或调味剂的组合可用于本发明的药物制剂中。 调味剂可以是天然香料,天然水果香料; 人造香料及其混合物。 药物制剂可以含有人造甜味剂,天然甜味剂或其混合物。 药物制剂以液体剂型或干粉剂型提供,用于在水中重构。 作为顾客之一添加的稳定剂可以将制剂储存在室温以下时将药物制剂液体剂型的稳定性延长至少30天。 本发明的药物制剂是可口的,并且特别可用于向需要这种药物的非常小的儿童施用含硫药物。 还提供了通过向干粉形式中加入水形成药物制剂的液体剂型的方法,制备气味掩蔽药物制剂的方法和使用气味掩蔽药物制剂治疗铅中毒或威尔逊病的方法。