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1. 发明申请

WO2010012770A1 PROCESS FOR THE CONTINUOUS PRODUCTION OF POLYESTERS 审中-公开
标题翻译：连续生产聚酯的方法
公开(公告)号：WO2010012770A1
公开(公告)日：2010-02-04
申请号：PCT/EP2009/059806
申请日：2009-07-29
申请人： PURAC BIOCHEM BV , SULZER CHEMTECH AG , HAAN, Robert Edgar , JANSEN, Peter Paul , DE VOS, Siebe Cornelis , VAN BREUGEL, Jan , KREIS, Peter Willi , LANFRANCHI, Sarah
发明人： HAAN, Robert Edgar , JANSEN, Peter Paul , DE VOS, Siebe Cornelis , VAN BREUGEL, Jan , KREIS, Peter Willi , LANFRANCHI, Sarah
IPC分类号： C08G63/78
CPC分类号： C08G63/785 , C08G63/08
摘要： Continuous process for the ring-opening polymerisation of cyclic ester monomers to form aliphatic polyesters at a temperature between 100-240°C which comprises the steps of : a) continuously providing cyclic ester monomer and polymerisation catalyst to a continuous mixing reactor, the reactor being operated at conditions effective for polymerisation to form a pre-polymerised reaction mixture, b) continuously removing pre-polymerised reaction mixture from the continuous mixing reactor and continuously providing pre-polymerised reaction mixture to a plug flow reactor, the plug flow reactor being operated under polymerisation conditions, wherein the reaction mixture is polymerised to a degree of polymerisation of at least 90%, to form polymer c) continuously removing polymer from the plug flow reactor.
摘要翻译：在100-240℃的温度下环状酯单体的开环聚合的连续方法，其包括以下步骤：a）连续向连续混合反应器提供环酯单体和聚合催化剂，反应器为在有效聚合以形成预聚合的反应混合物的条件下操作，b）从连续混合反应器中连续除去预聚合的反应混合物，并连续地将预聚合反应混合物提供给活塞流反应器，活塞流反应器在聚合条件，其中反应混合物聚合至至少90％的聚合度，以形成聚合物c）从活塞流反应器中连续除去聚合物。

2. 发明申请

WO2011045365A1 FERMENTATION PROCESS AT REDUCED PRESSURE 审中-公开
标题翻译：降低压力的发酵过程
公开(公告)号：WO2011045365A1
公开(公告)日：2011-04-21
申请号：PCT/EP2010/065395
申请日：2010-10-14
申请人： PURAC BIOCHEM BV , VAN BREUGEL, Jan , GROOT, Willem Jacob , JANSEN, Peter Paul
发明人： VAN BREUGEL, Jan , GROOT, Willem Jacob , JANSEN, Peter Paul
IPC分类号： C12P1/00 , C12P7/46 , C12P7/56
CPC分类号： C12P1/00 , C12P7/46 , C12P7/56
摘要： The present invention pertains to a fermentation process wherein a carbohydrate source is contacted under fermentation conditions with a microorganism in an aqueous fermentation broth to form a fermentation product which is a salt or a product with a boiling point above the boiling point of water, wherein the fermentation process is carried out aτ; a pressure which is below atmospheric pressure and at least at the value where the reaction medium is at its boiling point at the fermentation temperature, with water being evaporated and removed from the reactor during the fermentation in an amount which is at least 20% of the volume of liquid present in the reactor at the start of the fermentation. It has been found that effecting a fermentation process at reduced pressure while removing a substantial amount of water has a number of advantages. It solves the problem of having a surplus of water in the system, it ensures removal of reaction heat, and may lead to improved fermentation quality.
摘要翻译：本发明涉及一种发酵方法，其中碳水化合物源在发酵条件下与含水发酵液中的微生物接触以形成发酵产物，其为沸点高于水沸点的盐或产物，其中发酵过程在压力低于大气压，至少在反应介质处于发酵温度沸点的温度下，在发酵期间蒸发和从反应器中除去水的量至少为发酵温度的20％在发酵开始时反应器中存在的液体体积。已经发现，在减少大量水的同时在减压下进行发酵过程具有许多优点。解决了系统中多余的水分问题，确保了反应热的去除，可以提高发酵品质。

3. 发明申请

WO2013025107A1 RECOVERY OF CARBOXYLIC ACID FROM THEIR MAGNESIUM SALTS BY PRECIPITATION USING HYDROCHLORIC ACID, USEFUL FOR FERMENTATION BROTH WORK-UP 审中-公开
标题翻译：通过使用氢氯酸还原从其镁盐中回收羧酸，有用于发酵工作
公开(公告)号：WO2013025107A1
公开(公告)日：2013-02-21
申请号：PCT/NL2012/050574
申请日：2012-08-16
申请人： PURAC BIOCHEM B.V. , DE HAAN, André Banier , VAN BREUGEL, Jan , VAN DER WEIDE, Paulus Loduvicus Johannes , JANSEN, Peter Paul , VIDAL LANCIS, José María , CERDÀ BARÓ, Agustín
发明人： DE HAAN, André Banier , VAN BREUGEL, Jan , VAN DER WEIDE, Paulus Loduvicus Johannes , JANSEN, Peter Paul , VIDAL LANCIS, José María , CERDÀ BARÓ, Agustín
IPC分类号： C01B7/03 , C01F5/10 , C07C51/02 , C07C51/43 , C07C55/10 , C07C57/13 , C07C57/15 , C07C59/265
CPC分类号： C07C51/02 , C01B7/035 , C01F5/06 , C01F5/10 , C01F5/16 , C01F5/30 , C07C51/42 , C07C51/43 , C07D307/60 , C07D307/68 , C07C55/10
摘要： The invention provides a method for preparing a carboxylic acid, which method comprises the steps of - providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate has a solubility in water at 20 °C of 80 g/100 g water or less; - acidifying the magnesium carboxylate with HCl, thereby obtaining a solution comprising carboxylic acid and magnesium chloride (Mg Cl 2 ); - optionally a concentration step, wherein the solution comprising carboxylic acid and Mg Cl 2 is concentrated; - precipitating the carboxylic acid from the solution comprising the carboxylic acid and MgCl 2 , thereby obtaining a carboxylic acid precipitate and a MgCl 2 solution. The inventors found that the addition of HCl to a magnesium salt of the carboxylic acid and subsequent precipitation of the carboxylic acid from the solution leads to a very efficient separation of the carboxylic acid from a magnesium carboxylate solution.
摘要翻译：本发明提供一种制备羧酸的方法，该方法包括以下步骤： - 提供羧酸镁，其中与羧酸盐相对应的羧酸在20℃下在水中的溶解度为80g / 100g水或更少; - 用HCl酸化羧酸镁，从而得到包含羧酸和氯化镁（MgCl 2）的溶液; - 任选的浓缩步骤，其中将包含羧酸和MgCl 2的溶液浓缩; - 从包含羧酸和MgCl 2的溶液中沉淀羧酸，由此得到羧酸沉淀和MgCl 2溶液。本发明人发现向羧酸的镁盐中加入HCl并随后从溶液中沉淀羧酸导致羧酸与羧酸镁溶液的非常有效的分离。

4. 发明申请

WO2013025106A1 RECOVERY OF CARBOXYLIC ACID FROM THEIR MAGNESIUM SALTS BY PRECIPITATION USING HYDROCHLORIC ACID, USEFUL FOR FERMENTATION BROTH WORK-UP 审中-公开
标题翻译：通过使用氢氯酸还原从其镁盐中回收羧酸，有用于发酵加工
公开(公告)号：WO2013025106A1
公开(公告)日：2013-02-21
申请号：PCT/NL2012/050573
申请日：2012-08-16
申请人： PURAC BIOCHEM B.V , DE HAAN, André Banier , VAN BREUGEL, Jan , VAN DER WEIDE, Paulus Loduvicus Johannes , JANSEN, Peter Paul , VIDAL LANCIS, José María , CERDÀ BARÓ, Agustín
发明人： DE HAAN, André Banier , VAN BREUGEL, Jan , VAN DER WEIDE, Paulus Loduvicus Johannes , JANSEN, Peter Paul , VIDAL LANCIS, José María , CERDÀ BARÓ, Agustín
IPC分类号： C01B7/03 , C01F5/10 , C07C51/02 , C07C51/43 , C07C55/10 , C07C57/13 , C07C57/15 , C07C59/265
CPC分类号： C07C51/02 , C01B7/03 , C01B7/035 , C01F5/10 , C01F5/30 , C07C51/43 , C07D307/68 , C07C55/10
摘要： The invention provides a method for preparing a carboxylic acid, which method comprises the steps of providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate is selected from the group consisting of 2,5-furandicarboxylic acid, fumaric acid, adipic acid, itaconic acid, citric acid, glutaric acid, maleic acid, malonic acid, oxalic acid and fatty acids having more than 10 carbon atoms; acidifying the magnesium carboxylate with hydrogen chloride (HC1), thereby obtaining a solution comprising carboxylic acid and magnesium chloride (MgCb); optionally a concentration step, wherein the solution comprising carboxylic acid and MgCb is concentrated; precipitating the carboxylic acid from the solution comprising the carboxylic acid and MgCb, thereby obtaining a carboxylic acid precipitate and a MgCb solution. The inventors found that the addition of HC1 to a magnesium salt of the carboxylic acid and subsequent precipitation of the carboxylic acid from the solution leads to a very efficient separation of the carboxylic acid from a magnesium carboxylate solution.
摘要翻译：本发明提供一种制备羧酸的方法，该方法包括提供羧酸镁的步骤，其中对应于羧酸酯的羧酸选自2,5-呋喃二羧酸，富马酸，己二酸，衣康酸酸，柠檬酸，戊二酸，马来酸，丙二酸，草酸和具有10个以上碳原子的脂肪酸; 用氯化氢（HCl）酸化羧酸镁，从而得到包含羧酸和氯化镁（MgCl 3）的溶液; 任选的浓缩步骤，其中将包含羧酸和MgCl 2的溶液浓缩; 从包含羧酸和MgCb的溶液中沉淀羧酸，由此得到羧酸沉淀物和MgCl 2溶液。本发明人发现向羧酸的镁盐中加入HCl并随后从溶液中沉淀羧酸导致羧酸与羧酸镁溶液的非常有效的分离。

5. 发明授权

EP2310437B1 PROCESS FOR THE CONTINUOUS PRODUCTION OF POLYESTERS 有权转让
标题翻译： PROCESS聚酯连续生产
公开(公告)号：EP2310437B1
公开(公告)日：2015-10-14
申请号：EP09781236.6
申请日：2009-07-29
申请人： PURAC Biochem BV , Sulzer Chemtech AG
发明人： HAAN, Robert Edgar , JANSEN, Peter Paul , DE VOS, Siebe Cornelis , VAN BREUGEL, Jan , KREIS, Peter Willi , LANFRANCHI, Sarah
IPC分类号： C08G63/78
CPC分类号： C08G63/785 , C08G63/08
摘要： Continuous process of forming aliphatic polyesters The process includes continuously providing cyclic ester monomer and polymerization catalyst to a continuous mixing loop reactor (CMLR) having static mixing elements and operated at a temperature between 100 and 240° C. to form a pre-polymerized reaction mixture. The conversion is between 40 and less than 90 wt. %, wherein the cyclic ester monomer comprises lactide having a free acid content lower than 50 milli-equivalents per kg. The pre-polymerized reaction mixture is continuously provided to a plug flow reactor that is a static mixer reactor having static mixing elements and is operated at a temperature between 110-240° C., wherein the reaction mixture is polymerized to a conversion of at least 90%, to form polymer wherein the flow ratio of the CMLR and the plug flow reactor is between 1.5 an d50. The process includes continuously removing polymer from the plug flow reactor devolitizing the polymer.

6. 发明公开

EP2310437A1 PROCESS FOR THE CONTINUOUS PRODUCTION OF POLYESTERS 有权转让
标题翻译： VERFAHREN ZUR KONTINUIERLICHEN HERSTELLUNG VON POLYESTERN
公开(公告)号：EP2310437A1
公开(公告)日：2011-04-20
申请号：EP09781236.6
申请日：2009-07-29
申请人： PURAC Biochem BV , Sulzer Chemtech AG
发明人： HAAN, Robert Edgar , JANSEN, Peter Paul , DE VOS, Siebe Cornelis , VAN BREUGEL, Jan , KREIS, Peter Willi , LANFRANCHI, Sarah
IPC分类号： C08G63/78
CPC分类号： C08G63/785 , C08G63/08
摘要： Continuous process of forming aliphatic polyesters The process includes continuously providing cyclic ester monomer and polymerization catalyst to a continuous mixing loop reactor (CMLR) having static mixing elements and operated at a temperature between 100 and 240° C. to form a pre-polymerized reaction mixture. The conversion is between 40 and less than 90 wt. %, wherein the cyclic ester monomer comprises lactide having a free acid content lower than 50 milli-equivalents per kg. The pre-polymerized reaction mixture is continuously provided to a plug flow reactor that is a static mixer reactor having static mixing elements and is operated at a temperature between 110-240° C., wherein the reaction mixture is polymerized to a conversion of at least 90%, to form polymer wherein the flow ratio of the CMLR and the plug flow reactor is between 1.5 an d50. The process includes continuously removing polymer from the plug flow reactor devolitizing the polymer.
摘要翻译：在100-240℃的温度下环状酯单体开环聚合以形成脂族聚酯的连续方法，其包括a）连续地向连续混合反应器提供环状酯单体和聚合催化剂，反应器在有效聚合以形成预聚合的反应混合物的条件，b）从连续混合反应器中连续除去预聚合的反应混合物，并将连续提供预聚合的反应混合物连续提供给活塞流反应器，活塞流反应器在聚合条件下操作其中反应混合物聚合至至少90％的聚合度，以形成聚合物，和c）从活塞流反应器中连续除去聚合物。

7. 发明申请

WO2013025105A8 RECOVERY OF CARBOXYLIC ACID FROM THEIR MAGNESIUM SALTS BY PRECIPITATION USING HYDROCHLORIC ACID, USEFUL FOR FERMENTATION BROTH WORK-UP 审中-公开
公开(公告)号：WO2013025105A8
公开(公告)日：2013-02-21
申请号：PCT/NL2012/050572
申请日：2012-08-16
申请人： PURAC BIOCHEM B.V. , DE HAAN, André Banier , VAN BREUGEL, Jan , VAN DER WEIDE, Paulus Loduvicus Johannes , JANSEN, Peter Paul , VIDAL LANCIS, José María , CERDÀ BARÓ, Agustín
发明人： DE HAAN, André Banier , VAN BREUGEL, Jan , VAN DER WEIDE, Paulus Loduvicus Johannes , JANSEN, Peter Paul , VIDAL LANCIS, José María , CERDÀ BARÓ, Agustín
IPC分类号： C01B7/03 , C01F5/10 , C07C51/02 , C07C51/43 , C07C55/10 , C07C57/13 , C07C57/15 , C07C59/265
摘要： The invention provides a method for preparing a succinic acid, which method comprises the steps of - providing magnesium succinate; - acidifying the magnesium succinate with hydrochloric acid (HC1), thereby obtaining a solution comprising succinic acid and magnesium chloride (M g C1 2 ); - optionally a concentration step, wherein the solution comprising succinic acid and M g C1 2 is concentrated; - precipitating succinic acid from the solution comprising succinic acid and M g C1 2 , thereby obtaining a succinic acid precipitate and a M g C1 2 solution. The inventors found that the addition of HC1 to a magnesium salt of succinic acid and subsequent precipitation of succinic acid from the solution leads to a very efficient separation of succinic acid from a magnesium succinate solution.

8. 发明授权

EP2812304B1 CARBOXYLATE ACIDIFICATION 有权
标题翻译：羧酸酯酸化
公开(公告)号：EP2812304B1
公开(公告)日：2018-04-11
申请号：EP13705419.3
申请日：2013-02-08
申请人： PURAC Biochem BV
发明人： CERDÀ BARÓ, Agustín , VAN BREUGEL, Jan , GROOT, Willem Jacob , DE HAAN, André Banier , JANSEN, Peter Paul
IPC分类号： C07C51/02 , C07C53/122 , C07C55/10 , C07C55/14 , C07C57/04 , C07C57/13 , C07C57/145 , C07C57/15 , C07C59/01 , C07C59/08 , C07C59/195 , C07C59/265 , C07C61/20
CPC分类号： C07C51/02 , C07C59/08 , C12P7/56 , C07C53/122 , C07C55/10 , C07C55/14 , C07C57/04 , C07C57/13 , C07C57/145 , C07C57/15 , C07C59/01 , C07C59/195 , C07C59/265 , C07C61/20
摘要： A method for preparing a carboxylic acid by acidification of a liquid feed including a carboxylate salt, which method includes the steps of providing a liquid feed including magnesium carboxylate; providing a gas feed including gaseous hydrogen chloride; and acidifying the carboxylate to carboxylic acid by bringing the liquid feed into contact with the gas feed, thereby forming a liquid effluent including carboxylic acid and magnesium chloride, wherein the gas feed including gaseous hydrogen chloride is derived from a thermal decomposition step wherein an aqueous liquid including magnesium chloride is subjected to a temperature of at least 300° C., thereby decomposing magnesium chloride into magnesium oxide and hydrogen chloride, thus obtaining a solid including magnesium oxide and a gas comprising gaseous hydrogen chloride.

9. 发明公开

EP2812304A1 CARBOXYLATE ACIDIFICATION 有权
标题翻译：羧酸乙酯，SÄUERUNG
公开(公告)号：EP2812304A1
公开(公告)日：2014-12-17
申请号：EP13705419.3
申请日：2013-02-08
申请人： PURAC Biochem BV
发明人： CERDÀ BARÓ, Agustín , VAN BREUGEL, Jan , GROOT, Willem Jacob , DE HAAN, André Banier , JANSEN, Peter Paul
IPC分类号： C07C51/02 , C07C53/122 , C07C55/10 , C07C55/14 , C07C57/04 , C07C57/13 , C07C57/145 , C07C57/15 , C07C59/01 , C07C59/08 , C07C59/195 , C07C59/265 , C07C61/20
CPC分类号： C07C51/02 , C07C59/08 , C12P7/56 , C07C53/122 , C07C55/10 , C07C55/14 , C07C57/04 , C07C57/13 , C07C57/145 , C07C57/15 , C07C59/01 , C07C59/195 , C07C59/265 , C07C61/20
摘要： A method for preparing a carboxylic acid by acidification of a liquid feed including a carboxylate salt, which method includes the steps of providing a liquid feed including magnesium carboxylate; providing a gas feed including gaseous hydrogen chloride; and acidifying the carboxylate to carboxylic acid by bringing the liquid feed into contact with the gas feed, thereby forming a liquid effluent including carboxylic acid and magnesium chloride, wherein the gas feed including gaseous hydrogen chloride is derived from a thermal decomposition step wherein an aqueous liquid including magnesium chloride is subjected to a temperature of at least 300° C., thereby decomposing magnesium chloride into magnesium oxide and hydrogen chloride, thus obtaining a solid including magnesium oxide and a gas comprising gaseous hydrogen chloride.

10. 发明授权

EP3322688B1 METHOD FOR MANUFACTURING SUCCINIC ACID 有权
公开(公告)号：EP3322688B1
公开(公告)日：2019-09-11
申请号：EP16739125.9
申请日：2016-07-14
申请人： PURAC Biochem BV
发明人： VAN BREUGEL, Jan , JANSEN, Peter Paul , VIDAL LANCIS, José María , ÐEKIC ZIVKOVIC, Tanja , KON, Adriaan Dirk
IPC分类号： C07C51/02 , C07C51/43 , C07C51/47 , C01B9/02 , C01B7/03 , C01F5/10 , C01F5/30 , C12P7/46

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