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1. 发明申请

WO2015010137A3 BIOCHEMICAL MARKERS OF PLATELET STORAGE 审中-公开
标题翻译：生物化学标记物储存
公开(公告)号：WO2015010137A3
公开(公告)日：2015-03-19
申请号：PCT/US2014047489
申请日：2014-07-21
申请人： PUGET SOUND BLOOD CT
发明人： ZIMRING JAMES CHARLES , SLICHTER SHERRILL J
IPC分类号： A61K35/14 , C12Q1/00 , G01N29/00 , G01N33/50 , G01N33/96
CPC分类号： G01N33/492 , C40B30/02 , G01N33/5308 , G01N33/80 , G01N2800/7066
摘要： Compositions and methods determines post-transfusion survival of platelets and the suitability of platelet units for transfusion by measuring the levels of one or more markers in a platelet sample. A method determines post-transfusion survival of platelets (PL T) prior to transfusion, the method comprising the steps of: a) measuring the levels of one or more markers in a PL T sample selected from the group consisting of adenine, 13-HODE/9-HODE, Caprylate, Laurate, C-glycosyltryptophan, andro steroid monsulfate 2, and Unelucidated Compounds (UC) 1-4; b) comparing the level of the one or more markers in the PLT sample with the level of the one or more markers present in a control sample, wherein a higher or lower level of the one or more markers in the PL T sample is indicative of post-transfusion survival of platelets.
摘要翻译：组合物和方法通过测量血小板样品中一种或多种标记物的水平来确定血小板的输血后存活和血小板单位适用于输血。一种方法确定在输血前血小板（PL T）的输血后存活，所述方法包括以下步骤：a）测量PLT样品中一种或多种标记物的水平，所述PLT样品选自腺嘌呤，13-HODE / 9-HODE，辛酸盐，月桂酸盐，C-糖基色氨酸，类固醇甾类单硫酸盐2和未化合化合物（UC）1-4; b）将PLT样品中的一种或多种标记物的水平与对照样品中存在的一种或多种标志物的水平进行比较，其中PL T样品中的一种或多种标记物的较高或较低水平表示输血后血小板存活。

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