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1. 发明申请

WO2006001954A3 METHODS FOR PROMOTING THE FORMATION OF PLATELETS AND FOR TREATING BLOOD AND BONE MARROW DISORDERS 审中-公开
标题翻译：促进血小板形成和治疗血液和骨骼疾病的方法
公开(公告)号：WO2006001954A3
公开(公告)日：2006-03-23
申请号：PCT/US2005017735
申请日：2005-05-20
申请人： PUGET SOUND BLOOD CT AND PROGR , DRACHMAN JONATHAN G , LANNUTTI BRIAN J , GANDHI MANISH
发明人： DRACHMAN JONATHAN G , LANNUTTI BRIAN J , GANDHI MANISH
IPC分类号： A61K31/404 , A61P7/00 , A61P35/02
CPC分类号： A61K31/404
摘要： The invention provides methods for promoting the differentiation of megakaryocytes, methods for forming platelets, and methods for reducing the number of abnormal or malignant cells in bone marrow. In some embodiments, the methods comprise the step of contacting megakaryocyte progenitors with an amount of a 3-(cyclohexanoheteroarylidenyl)-2-indolinone compound effective to promote their differentiation. In some embodiments, the 3-(cyclohexanoheteroarylidenyl)-2-indolinone compound is 2-oxo-3-(4, 5, 6, 7-tetrahydro-lH-indol-2-ylmethylene)-2,3-dihydro-lH-indole-5-sulfonic acid dimethylamide (SU6656). The invention also provides methods for treating blood and bone marrow disorders.
摘要翻译：本发明提供促进巨核细胞分化的方法，形成血小板的方法以及减少骨髓中异常或恶性细胞数量的方法。在一些实施方案中，所述方法包括使巨核细胞祖细胞与一定量的有效促进其分化的3-（环己烷酰基亚芳基）-2-二氢吲哚酮化合物接触的步骤。在一些实施方案中，3-（环己烷酰基亚芳基）-2-二氢吲哚酮化合物是2-氧代-3-（4,5,6,7-四氢-1H-吲哚-2-基亚甲基）-2,3-二氢-1H- 吲哚-5-磺酸二甲基酰胺（SU6656）。本发明还提供了治疗血液和骨髓疾病的方法。

2. 发明申请

WO2011060371A3 FACTOR VIII T CELL EPITOPE VARIANTS HAVING REDUCED IMMUNOGENICITY 审中-公开
标题翻译：因子VIII T细胞表位变异体具有降低的免疫原性
公开(公告)号：WO2011060371A3
公开(公告)日：2011-07-28
申请号：PCT/US2010056730
申请日：2010-11-15
申请人： PUGET SOUND BLOOD CT , PRATT KATHLEEN , ETTINGER RUTH
发明人： PRATT KATHLEEN , ETTINGER RUTH
IPC分类号： A61K38/37
CPC分类号： C07K14/755 , A61K38/00
摘要： Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.
摘要翻译：本文提供了用于在患有血友病A的患者中预防或降低对因子VIII的初始免疫应答，以及用于降低具有预形成的针对因子VIII的抑制剂抗体的患者的免疫应答强度的方法和组合物。

3. 发明申请

WO2011060372A3 FACTOR VIII B CELL EPITOPE VARIANTS HAVING REDUCED IMMUNOGENICITY 审中-公开
标题翻译：因子VIII B细胞表位变异体具有降低的免疫原性
公开(公告)号：WO2011060372A3
公开(公告)日：2011-07-21
申请号：PCT/US2010056732
申请日：2010-11-15
申请人： PUGET SOUND BLOOD CT , PRATT KATHLEEN , ETTINGER RUTH
发明人： PRATT KATHLEEN , ETTINGER RUTH
IPC分类号： A61K38/37
CPC分类号： C07K14/755 , A61K38/00
摘要： Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.
摘要翻译：本文提供了用于在患有血友病A的患者中预防或降低对因子VIII的初始免疫应答，以及用于降低具有预形成的针对因子VIII的抑制剂抗体的患者的免疫应答强度的方法和组合物。

4. 发明申请

WO2014036183A2 BIOCHEMICAL MARKERS OF RED BLOOD CELL STORAGE AND TOXICITY 审中-公开
标题翻译：红血球细胞储存和毒性的生物化学标记
公开(公告)号：WO2014036183A2
公开(公告)日：2014-03-06
申请号：PCT/US2013057149
申请日：2013-08-28
申请人： PUGET SOUND BLOOD CT
发明人： ZIMRING JAMES CHARLES
IPC分类号： G01N33/53
CPC分类号： G01N33/5005 , G01N33/53 , G01N33/80 , G01N2800/7066
摘要： Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.
摘要翻译：提供了通过测量红细胞样品中一种或多种标记物的水平来确定红血球的输血后存活或毒性的红血球单元用于输血的组合物和方法。

5. 发明申请

WO2015010137A3 BIOCHEMICAL MARKERS OF PLATELET STORAGE 审中-公开
标题翻译：生物化学标记物储存
公开(公告)号：WO2015010137A3
公开(公告)日：2015-03-19
申请号：PCT/US2014047489
申请日：2014-07-21
申请人： PUGET SOUND BLOOD CT
发明人： ZIMRING JAMES CHARLES , SLICHTER SHERRILL J
IPC分类号： A61K35/14 , C12Q1/00 , G01N29/00 , G01N33/50 , G01N33/96
CPC分类号： G01N33/492 , C40B30/02 , G01N33/5308 , G01N33/80 , G01N2800/7066
摘要： Compositions and methods determines post-transfusion survival of platelets and the suitability of platelet units for transfusion by measuring the levels of one or more markers in a platelet sample. A method determines post-transfusion survival of platelets (PL T) prior to transfusion, the method comprising the steps of: a) measuring the levels of one or more markers in a PL T sample selected from the group consisting of adenine, 13-HODE/9-HODE, Caprylate, Laurate, C-glycosyltryptophan, andro steroid monsulfate 2, and Unelucidated Compounds (UC) 1-4; b) comparing the level of the one or more markers in the PLT sample with the level of the one or more markers present in a control sample, wherein a higher or lower level of the one or more markers in the PL T sample is indicative of post-transfusion survival of platelets.
摘要翻译：组合物和方法通过测量血小板样品中一种或多种标记物的水平来确定血小板的输血后存活和血小板单位适用于输血。一种方法确定在输血前血小板（PL T）的输血后存活，所述方法包括以下步骤：a）测量PLT样品中一种或多种标记物的水平，所述PLT样品选自腺嘌呤，13-HODE / 9-HODE，辛酸盐，月桂酸盐，C-糖基色氨酸，类固醇甾类单硫酸盐2和未化合化合物（UC）1-4; b）将PLT样品中的一种或多种标记物的水平与对照样品中存在的一种或多种标志物的水平进行比较，其中PL T样品中的一种或多种标记物的较高或较低水平表示输血后血小板存活。

6. 发明申请

WO2013066986A8 ANTIBODY RESPONSE PHENOTYPING 审中-公开
标题翻译：抗体反应
公开(公告)号：WO2013066986A8
公开(公告)日：2013-08-08
申请号：PCT/US2012062766
申请日：2012-10-31
申请人： PUGET SOUND BLOOD CT
发明人： PRATT KATHLEEN , LEWIS KENNETH B
IPC分类号： G01N33/53
CPC分类号： G01N33/48735 , A61K49/00 , B82Y30/00 , C12Q1/00 , G01N33/48 , G01N33/483 , G01N33/5306 , G01N33/54373 , G01N33/564 , G01N33/86 , G06F19/18 , G06F19/24
摘要： Disclosed herein are methods, systems, mediums, and kits for use in phenotyping antibody responses via devices such as surface plasmon resonance devices. Such phentypes can include total target-specific antibody titers, quantitative isotype distribution of the target-specific antibodies, and/or epitope specificity of the target-specific antibodies. Other methods, systems, mediums, and kits are also disclosed.
摘要翻译：本文公开了用于通过诸如表面等离子体共振装置的装置进行表型抗体反应的方法，系统，培养基和试剂盒。这样的鉴定可以包括总目标特异性抗体滴度，靶特异性抗体的定量同种型分布和/或靶特异性抗体的表位特异性。还公开了其它方法，系统，介质和试剂盒。

7. 发明申请

WO2013013220A3 PHOTONIC BLOOD TYPING 审中-公开
公开(公告)号：WO2013013220A3
公开(公告)日：2013-04-11
申请号：PCT/US2012047745
申请日：2012-07-20
申请人： UNIV WASHINGTON CT COMMERCIALI , PUGET SOUND BLOOD CT , RATNER DANIEL M , JOHNSEN JILL M , KIRK JAMES T , LOPEZ JOSE A , BRAULT NORMAN D , JIANG SHAOYI
发明人： RATNER DANIEL M , JOHNSEN JILL M , KIRK JAMES T , LOPEZ JOSE A , BRAULT NORMAN D , JIANG SHAOYI
IPC分类号： G01N33/52 , G01N33/53 , G01N33/80
CPC分类号： G01N33/54373 , G01N21/75 , G01N33/80
摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
摘要翻译：提供了用于检测生物溶液（例如全血）中的分析物的光子器件，系统和方法。代表性的光子器件是具有纳米尺度特征和微米尺寸直径的光学环形谐振器。由于这些器件的紧凑尺寸，许多谐振器可以被布置在单个衬底上，并且当样品通过器件时同时测试。典型的分析物包括血细胞，抗体和病原体，以及指示存在血细胞或病原体的化合物（例如血清学）。在某些实施方案中，可以通过使用血细胞直接检测和血清学的组合的光子感测来确定血型。通过组合多个装置的检测信号，可以确定血液的类型。

8. 发明申请

WO2014075033A3 PROTEIN STABILIZING FACTORS 审中-公开
标题翻译：蛋白质稳定因子
公开(公告)号：WO2014075033A3
公开(公告)日：2014-10-30
申请号：PCT/US2013069545
申请日：2013-11-12
申请人： PUGET SOUND BLOOD CT
发明人： CHUNG DOMINIC , LOPEZ JOSE ARON , LING MINHUA , CHEN JUNMEI , FU XIAOYUN
IPC分类号： A61K38/00 , A61L29/00
CPC分类号： A61K9/0019 , A61K38/00 , A61K47/42 , A61L29/048 , A61L29/085 , A61L29/143 , A61L29/16 , A61L31/10 , A61L31/143 , A61L31/16 , A61L2300/424 , A61L2400/18 , C07K14/755 , C07K14/775
摘要： Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and absorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.
摘要翻译：描述了用于预防或减少由于蛋白质聚集，变性和表面吸收引起的蛋白质损失的组合物和方法。还描述了用于防止或减少与血液接触的医疗装置例如导管的结垢或堵塞的组合物和方法。还描述了治疗由微血管激活引起的疾病的方法。

9. 发明公开

EP2734841A4 PHOTONIC BLOOD TYPING 失效转让
标题翻译：光子血液类别判断
公开(公告)号：EP2734841A4
公开(公告)日：2015-03-18
申请号：EP12814998
申请日：2012-07-20
申请人： UNIV WASHINGTON THROUGH ITS CT FOR COM IZATION , PUGET SOUND BLOOD CT , JIANG SHAOYL
发明人： BRAULT NORMAN D , JIANG SHAOYI , RATNER DANIEL M , JOHNSEN JILL M , KIRK JAMES T , LOPEZ JOSE A
IPC分类号： G01N33/543 , G01N33/80
CPC分类号： G01N33/54373 , G01N21/75 , G01N33/80

10. 发明公开

EP2498804A4 FACTOR VIII B CELL EPITOPE VARIANTS HAVING REDUCED IMMUNOGENICITY 审中-公开
标题翻译：因子VIII的B细胞表位的变体具有降低的免疫原性
公开(公告)号：EP2498804A4
公开(公告)日：2013-05-08
申请号：EP10830867
申请日：2010-11-15
申请人： PUGET SOUND BLOOD CT , JAMES EDDIE ARTHUR
发明人： PRATT KATHLEEN , ETTINGER RUTH , JAMES EDDIE ARTHUR
IPC分类号： A61K38/37
CPC分类号： C07K14/755 , A61K38/00

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