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1. 发明申请

WO2006042039A2 CONTINUOUS FIELD TOMOGRAPHY 审中-公开
标题翻译：连续现场测量
公开(公告)号：WO2006042039A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036035
申请日：2005-10-06
申请人： PROTEUS BIOMEDICAL, INC. , SAVAGE, George, M. , ZDEBLICK, Mark , COSTELLO, Ben , THOMPSON, Todd , COLLIOU, Olivier , ROBERTSON, Timothy
发明人： SAVAGE, George, M. , ZDEBLICK, Mark , COSTELLO, Ben , THOMPSON, Todd , COLLIOU, Olivier , ROBERTSON, Timothy
IPC分类号： A61B8/02
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。使用感测元件检测所施加的连续场的特性，以评估组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

2. 发明申请

WO2004052182A2 METHOD AND SYSTEM FOR MONITORING AND TREATING HEMODYNAMIC PARAMETERS 审中-公开
标题翻译：用于监测和处理血液动力学参数的方法和系统
公开(公告)号：WO2004052182A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039524
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL, INC.
发明人： ZDEBLICK, Mark , SAVAGE, George, M.
IPC分类号： A61B
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. The carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a second addressable sensor in the network to obtain data.
摘要翻译：复用的医疗载体提供用于感测一个或多个患者参数和/或通过单独识别的效应器递送能量。载体包括主体和与至少两个效应器耦合的至少两个电导体。效应器可以是传感器，致动器或两者的任何组合。传感器可以测量诸如压力，氧含量，体积，电导率，流体流速或任何其它化学或物理参数的参数。例如，可以使用致动器来调节心脏，刺激肌肉或神经组织，广播超声能量，发射光，热或其他形式的辐射，或递送任何形式的能量或物质。一种用于从患者收集医学数据的方法包括询问驻留在患者的并行导体上的复用传感器网络，包括寻址网络中的第一可寻址传感器以获得数据并寻址网络中的第二可寻址传感器以获得数据。

3. 发明申请

WO2007021804A3 EVALUATION OF DEPOLARIZATION WAVE CONDUCTION VELOCITY 审中-公开
公开(公告)号：WO2007021804A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/031152
申请日：2006-08-09
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , ROBERTSON, Timothy , SAVAGE, George, M.
发明人： ZDEBLICK, Mark , ROBERTSON, Timothy , SAVAGE, George, M.
IPC分类号： A61N1/00
摘要： A method for measuring the conduction velocity of a depolarization wave in a tissue employs a first satellite located within the tissue and a second that satellite is located within the tissue a distance away from the first satellite, e.g., by using the time of depolarization wave as reported from each satellite and the distance to determine velocity of the wave. Also provided are systems and kits that find use in accordance with the invention.

4. 发明申请

WO2006069322A3 IMPLANTABLE ADDRESSABLE SEGMENTED ELECTRODES 审中-公开
公开(公告)号：WO2006069322A3
公开(公告)日：2006-06-29
申请号：PCT/US2005/046811
申请日：2005-12-22
申请人： PROTEUS BIOMEDICAL, INC. , JENSEN, Marc , COSTELLO, Benedict, J. , THOMPSON, Todd , ZDEBLICK, Mark , FRANK, Jeremy , LEI, Dino , ADDIS, Bruce , COLLIOU, Olivier , SAVAGE, George, M.
发明人： JENSEN, Marc , COSTELLO, Benedict, J. , THOMPSON, Todd , ZDEBLICK, Mark , FRANK, Jeremy , LEI, Dino , ADDIS, Bruce , COLLIOU, Olivier , SAVAGE, George, M.
IPC分类号： A61N5/04
摘要： Implantable addressable segmented electrode devices, as well as methods for making and using the same, are provided. The subject devices include segmented electrode structures made up of an integrated circuit (403) electrically coupled to two or more electrodes (409A, 409B, 4D9C, 409D), where each electrode can be Individually activated. Also provided are implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures.

5. 发明申请

WO2006050385A3 CARDIAC MOTION CHARACTERIZATION BY STRAIN MEASUREMENT 审中-公开
公开(公告)号：WO2006050385A3
公开(公告)日：2006-05-11
申请号：PCT/US2005/039535
申请日：2005-10-31
申请人： PROTEUS BIOMEDICAL, INC. , JENSON, Marc , THOMPSON, Todd , COLLIOU, Olivier , SAVAGE, George, M. , ZDEBLICK, Mark , FRANK, Jeremy , ARNE, Lawrence , WHITE, Robert
发明人： JENSON, Marc , THOMPSON, Todd , COLLIOU, Olivier , SAVAGE, George, M. , ZDEBLICK, Mark , FRANK, Jeremy , ARNE, Lawrence , WHITE, Robert
IPC分类号： A61N1/39
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

6. 发明公开

EP1799113A2 CONTINUOUS FIELD TOMOGRAPHY 审中-公开
标题翻译：连续场断层摄影
公开(公告)号：EP1799113A2
公开(公告)日：2007-06-27
申请号：EP05811836.5
申请日：2005-10-06
申请人： Proteus Biomedical, Inc.
发明人： SAVAGE, George, M. , ZDEBLICK, Mark , COSTELLO, Benedict , THOMPSON, Todd , COLLIOU, Olivier , ROBERTSON, Timothy
IPC分类号： A61B8/02
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

7. 发明公开

EP1581102A2 METHOD AND SYSTEM FOR MONITORING AND TREATING HEMODYNAMIC PARAMETERS 审中-公开
标题翻译： SYSTEM FOR监测和治疗血液动力学参数
公开(公告)号：EP1581102A2
公开(公告)日：2005-10-05
申请号：EP03812966.4
申请日：2003-12-11
申请人： Proteus Biomedical, Inc.
发明人： ZDEBLICK, Mark , SAVAGE, George, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier (100) provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors (106). The carrier (100) includes a body (102) and at least two electrical conductors (104) coupled with at least two effectors (106). Effectors (106) may be any combination of sensors (206), actuators (206) or both. Sensors (206) may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators (206) may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors (106) residing on parallel conductors in the patient, including addressing a first addressable sensor (106) in the network to obtain data and addressing a second addressable sensor (106) in the network to obtain data.

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