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1. 发明申请

WO2006002100A2 DIAGNOSTIC AND SCREENING METHODS AND KITS ASSOCIATED WITH PROTEOLYTIC ACTIVITY 审中-公开
标题翻译：诊断和筛查方法以及与蛋白活性相关的试剂盒
公开(公告)号：WO2006002100A2
公开(公告)日：2006-01-05
申请号：PCT/US2005/021819
申请日：2005-06-21
申请人： PROGENRA INC. , BUTT, Tauseef, R. , BERNAL, Alejandro
发明人： BUTT, Tauseef, R. , BERNAL, Alejandro
IPC分类号： C12Q1/37
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/916
摘要： Methods and kits for assessing proteolytic enzyme activity and a modulator’s effect thereof employ a Ubiquitin or Ubiquitin-like Protein and a signal producing structure. The corresponding fusion polynucleotide is employed for production of transgenic cells, plants and animals that may be produced by stably transfection, optionally transforming the cell, plant or animal with a Ubiquitin-,UBL-or their C-terminal binding functional fragment-Reporter fusion polynucleotide. A method of diagnosing a disease or condition, comprises contacting or administering a sample obtained from a subject suspected of being afflicted with the disease or condition with the cell, plant or animal, detecting any signal produced by the reporter in the presence of the sample and comparing the signal to controls for 0% and 100% signals.
摘要翻译：用于评估蛋白水解酶活性和其调节剂效应的方法和试剂盒使用泛素或泛素样蛋白和信号产生结构。相应的融合多核苷酸用于产生可通过稳定转染产生的转基因细胞，植物和动物，任选地用泛素 - ，UBL-或其C-末端结合功能片段 - 报道子融合多核苷酸转化细胞，植物或动物。诊断疾病或病症的方法包括将从怀疑患有疾病或病症的受试者获得的样品与细胞，植物或动物接触或施用，检测在样品存在下由报道分子产生的任何信号，和将信号与控制0％和100％信号进行比较。

2. 发明申请

WO2006062701A2 SPHINGOSINE KINASE-1 MEDIATES GENE EXPRESSION REGULATION OF A MONOCYTE CHEMOATTRACTANT PROTEIN-1 GENE 审中-公开
标题翻译： SPHINGOSINE KINASE-1介导单核细胞化学反应蛋白-1基因的基因表达调控
公开(公告)号：WO2006062701A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/041375
申请日：2005-11-16
申请人： JANSSEN PHARMACEUTICA N.V. , BERNAL, Alejandro , DERIAN, Claudia, K.
发明人： BERNAL, Alejandro , DERIAN, Claudia, K.
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/6863 , C12Q1/485 , G01N33/5064 , G01N2333/91215 , G01N2500/00
摘要： The present invention relates to methods of identifying, monitoring, and using compounds that regulate the biological activity of Sphingosine kinase-1.
摘要翻译：本发明涉及鉴定，监测和使用调节鞘氨醇激酶-1生物活性的化合物的方法。

3. 发明公开

EP1792181A2 DIAGNOSTIC AND SCREENING METHODS AND KITS ASSOCIATED WITH PROTEOLYTIC ACTIVITY 有权
标题翻译：检查和诊断方法和试剂盒均与蛋白水解活性CONNECTION
公开(公告)号：EP1792181A2
公开(公告)日：2007-06-06
申请号：EP05762260.7
申请日：2005-06-21
申请人： Progenra Inc.
发明人： BUTT, Tauseef R. , BERNAL, Alejandro
IPC分类号： G01N33/53 , C12Q1/37
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/916
摘要： Methods and kits for assessing proteolytic enzyme activity and a modulator’s effect thereof employ a Ubiquitin or Ubiquitin-like Protein and a signal producing structure. The corresponding fusion polynucleotide is employed for production of transgenic cells, plants and animals that may be produced by stably transfection, optionally transforming the cell, plant or animal with a Ubiquitin-,UBL-or their C-terminal binding functional fragment-Reporter fusion polynucleotide. A method of diagnosing a disease or condition, comprises contacting or administering a sample obtained from a subject suspected of being afflicted with the disease or condition with the cell, plant or animal, detecting any signal produced by the reporter in the presence of the sample and comparing the signal to controls for 0% and 100% signals.

4. 发明授权

EP1792181B1 DIAGNOSTIC AND SCREENING METHODS AND KITS ASSOCIATED WITH PROTEOLYTIC ACTIVITY 有权
标题翻译：检查和诊断方法和试剂盒均与蛋白水解活性CONNECTION
公开(公告)号：EP1792181B1
公开(公告)日：2010-11-17
申请号：EP05762260.7
申请日：2005-06-21
申请人： Progenra Inc.
发明人： BUTT, Tauseef R. , BERNAL, Alejandro
IPC分类号： G01N33/53 , C12Q1/37
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/916
摘要： Methods and kits for assessing proteolytic enzyme activity and a modulator’s effect thereof employ a Ubiquitin or Ubiquitin-like Protein and a signal producing structure. The corresponding fusion polynucleotide is employed for production of transgenic cells, plants and animals that may be produced by stably transfection, optionally transforming the cell, plant or animal with a Ubiquitin-,UBL-or their C-terminal binding functional fragment-Reporter fusion polynucleotide. A method of diagnosing a disease or condition, comprises contacting or administering a sample obtained from a subject suspected of being afflicted with the disease or condition with the cell, plant or animal, detecting any signal produced by the reporter in the presence of the sample and comparing the signal to controls for 0% and 100% signals.

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