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1. 发明申请

WO2006062389A3 METHODS USING MITOCHONDRIAL NUCLEIC ACID FOR DETERMINING A HEALTH STATUS OF AN INDIVIDUAL 审中-公开
标题翻译：使用麻醉核酸测定个体健康状况的方法
公开(公告)号：WO2006062389A3
公开(公告)日：2006-10-19
申请号：PCT/NL2005000771
申请日：2005-10-28
申请人： PRIMAGEN HOLDING BV , UMC UTRECHT HOLDING BV , PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERAR , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
发明人： PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERAR , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6865 , C12Q2545/101
摘要： The invention describes means and methods for determining mitochondrion bound nucleic acid and describes the use thereof in diagnostics. Preferable cell free mitochondrion bound nucleic acid is determined.
摘要翻译：本发明描述了用于确定线粒体结合核酸的方法和方法，并描述了其在诊断中的用途。测定优选的无细胞线粒体结合核酸。

2. 发明专利

CA2585587C METHODS USING MITOCHONDRIAL NUCLEIC ACID FOR DETERMINING A HEALTH STATUS OF AN INDIVIDUAL 未知
公开(公告)号：CA2585587C
公开(公告)日：2016-02-16
申请号：CA2585587
申请日：2005-10-28
申请人： PRIMAGEN HOLDING BV , UMC UTRECHT HOLDING BV
发明人： PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERARDA IRENE MARTINA , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
IPC分类号： C12Q1/68
摘要： The invention describes means and methods for determining mitochondrion bound nucleic acid and describes the use thereof in diagnostics. Preferable cell free mitochondrion bound nucleic acid is determined.

3. 发明专利

AU2005312402B2 Methods using mitochondrial nucleic acid for determining a health status of an individual 未知
公开(公告)号：AU2005312402B2
公开(公告)日：2012-03-08
申请号：AU2005312402
申请日：2005-10-28
申请人： PRIMAGEN HOLDING BV , UMC UTRECHT HOLDING BV
发明人： MAAS HENRIETTE CATHARINA GERARDA IRENE MARTINA , DE BAAR MARINUS PETRUS , PENNING MAARTEN TJERK , VOEST EMILE EUGENE
IPC分类号： C12Q1/68
摘要： The invention describes means and methods for determining mitochondrion bound nucleic acid and describes the use thereof in diagnostics. Preferable cell free mitochondrion bound nucleic acid is determined.

4. 发明专利

CA2585587A1 METHODS USING MITOCHONDRIAL NUCLEIC ACID FOR DETERMINING A HEALTH STATUS OF AN INDIVIDUAL 未知
公开(公告)号：CA2585587A1
公开(公告)日：2006-06-15
申请号：CA2585587
申请日：2005-10-28
申请人： UMC UTRECHT HOLDING BV , PRIMAGEN HOLDING BV
发明人： PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERAR , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
IPC分类号： C12Q1/68

5. 发明专利

PL1807532T3 Sposoby zastosowania mitochondrialnego kwasu nukleinowego do określania stanu zdrowia osobnika 未知
公开(公告)号：PL1807532T3
公开(公告)日：2015-08-31
申请号：PL05797967
申请日：2005-10-28
申请人： PRIMAGEN HOLDING BV , UMC UTRECHT HOLDING BV
发明人： PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERARDA IRENE MARTINA , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
IPC分类号： C12Q1/68

6. 发明专利

DK1807532T3 FREMGANGSMÅDER MED ANVENDELSE AF MITOKONDRIE-NUKLEINSYRE TIL BESTEMMELSE AF ET INDIVIDS SUNDHEDSTILSTAND 未知
公开(公告)号：DK1807532T3
公开(公告)日：2015-06-22
申请号：DK05797967
申请日：2005-10-28
申请人： UMC UTRECHT HOLDING BV , PRIMAGEN HOLDING BV
发明人： PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERARDA IRENE MARTINA , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
IPC分类号： C12Q1/68

7. 发明申请

WO2005003392A2 HMG COENZYME A REDUCTASE INHIBITORS AFFECT THE MITOCHONDRIAL DNA CONTENT OF CELLS 审中-公开
标题翻译： HMG COENZYME一种还原酶抑制剂影响细胞的MITOCHONDRIAL DNA含量
公开(公告)号：WO2005003392A2
公开(公告)日：2005-01-13
申请号：PCT/NL2004000468
申请日：2004-07-01
申请人： PRIMAGEN HOLDING BV , VAN GEMEN BOB , DE BAAR MARINUS PETRUS
发明人： VAN GEMEN BOB , DE BAAR MARINUS PETRUS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/16
摘要： Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.
摘要翻译：他汀类药物广泛用于治疗高胆固醇水平。在本发明中，他汀类药物对线粒体核酸和线粒体活化状态的影响用于确定受试者是否处于发展他汀类药物治疗副作用的风险的方法中，用于治疗与线粒体降低相关的临床症状的方法功能。进一步提供的试剂盒等包括用于检测线粒体核酸的方法或用于上述方法中的线粒体的活化。

8. 发明专利

DE60327980D1 未知
公开(公告)号：DE60327980D1
公开(公告)日：2009-07-30
申请号：DE60327980
申请日：2003-07-03
申请人： PRIMAGEN HOLDING BV
发明人： DE ROOIJ ESTHER REGINA , DE BAAR MARINUS PETRUS
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/70 , G01N33/569
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 mu l, more preferably at least 250 mu l of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

9. 发明专利

CA2491495C STORING AND DETECTING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 未知
公开(公告)号：CA2491495C
公开(公告)日：2014-08-26
申请号：CA2491495
申请日：2003-07-03
申请人： PRIMAGEN HOLDING BV
发明人： DE ROOIJ ESTHER REGINA , DE BAAR MARINUS PETRUS
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/70 , G01N33/569
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 ~l , more preferably at least 250 ~l of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

10. 发明专利

NZ537498A Storing and quantifying nucleic acid administered to a solid carrier 未知
公开(公告)号：NZ537498A
公开(公告)日：2009-04-30
申请号：NZ53749803
申请日：2003-07-03
申请人： PRIMAGEN HOLDING BV
发明人： DE ROOIJ ESTHER REGINA , DE BAAR MARINUS PETRUS
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/70 , G01N33/569 , C12Q1/68
摘要： A method for quantifying a nucleic acid of interest in at least one blood sample, comprising: - administering said sample to a solid carrier capable of at least in part absorbing said sample, resulting in at least one spot; - drying said carrier; - excising at least one spot from said solid carrier, said at least one spot comprising at least 250 microIitres of sample; - administering said at least one spot to a chaotropic nucleic acid isolation lysis buffer; so that nucleic acid is extracted from said carrier; - further purifying the nucleic acid present in said lysis buffer; - performing a nucleic acid amplification step; and - quantifying said nucleic acid of interest.

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