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1. 发明申请

WO2006015306A3 METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES 审中-公开
标题翻译：方法，组合物和装置，包括微流体装置，包装涂覆的疏水性表面
公开(公告)号：WO2006015306A3
公开(公告)日：2008-10-16
申请号：PCT/US2005027225
申请日：2005-07-29
申请人： PREDICANT BIOSCIENCES INC , CHAPMAN ROBERT G , ZHAO MINGQI , NI JING , BOOSSE LUC J , STULTS JOHN T , YANG SAY , RUDOLF ROGER
发明人： CHAPMAN ROBERT G , ZHAO MINGQI , NI JING , BOOSSE LUC J , STULTS JOHN T , YANG SAY , RUDOLF ROGER
IPC分类号： B32B9/04 , B05D1/36 , B05D7/00
CPC分类号： G01N33/6848 , B01L3/5027 , H01J49/0018 , H01J49/165
摘要： Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices. Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.
摘要翻译：公开了用于涂覆至少一部分疏水表面的方法，包括塑料或其它聚合物的表面。这种方法包括使用与疏水表面相互作用的第一涂层和/或区域，尽管不需要在第一涂层和疏水表面之间形成化学键。然后随后的层可以与第一涂层和/或区域的至少一部分化学或非化学相互作用。这种涂覆的表面可以是包括微流体装置的装置或装置的一部分。微流体装置向质谱仪提供物质。微流体装置包括具有至少一个微通道的衬底，布置在微通道表面上的盖和至少一个电势源。一些实施例包括在出口处加宽的微通道。其他实施例将电势源沿着盖的表面定位。其他实施例包括其中设置电极和膜的阱。各种实施方案提供物质从微流体装置到质谱仪的稳定的电喷雾电离。

2. 发明申请

WO2004094994A3 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO2004094994A3
公开(公告)日：2005-06-23
申请号：PCT/US2004006918
申请日：2004-03-04
申请人： PREDICANT BIOSCIENCES INC , HELLER JONATHAN , STULTS JOHN , SRINIVASAN UTHARA , BOUSSE LUC , ZHAO MINGQI , NI JING
发明人： HELLER JONATHAN , STULTS JOHN , SRINIVASAN UTHARA , BOUSSE LUC , ZHAO MINGQI , NI JING
IPC分类号： F15C1/04 , F16L58/04 , G01N20060101 , H01J49/04 , H01J49/16
CPC分类号： H01J49/0018 , H01J49/165 , Y10T137/0402 , Y10T137/2082 , Y10T137/2191 , Y10T137/2224 , Y10T137/7036 , Y10T436/2575
摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.
摘要翻译：微流体装置向质谱仪提供物质。微流体装置包括第一和第二表面，由表面形成的至少一个微通道和表面边缘处的出口。一些实施例还包括具有一个或多个表面特征的尖端表面，用于帮助将物质从装置的出口引向质谱仪。在一些实施例中，表面特征包括凹槽，其可以沿其长度的全部或部分亲水。亲水表面和/或疏水表面还可以帮助将物质引出出口和/或朝向质谱仪。在一些实施例中，出口和/或尖端表面从边缘的相邻部分向后凹陷。电势源可以帮助物质通过微通道，分离物质和/或提供电喷雾电离。

3. 发明申请

WO2006034432A3 ELECTROSPRAY APPARATUS WITH AN INTEGRATED ELECTRODE 审中-公开
标题翻译：具有集成电极的电绝缘装置
公开(公告)号：WO2006034432A3
公开(公告)日：2006-08-17
申请号：PCT/US2005034093
申请日：2005-09-21
申请人： PREDICANT BIOSCIENCES INC , BOUSSE LUC J , ZHAO MINGQI
发明人： BOUSSE LUC J , ZHAO MINGQI
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/167 , B05B5/025 , B05B5/0533 , H01J49/0018 , Y10T29/494
摘要： The invention provides related apparatus and methods of making an integrated electrospray tip (102) by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate (104) to the surface of a second planar substrate (105), wherein a surface on at least one of the substrates includes one or more microfluidic channels (109, 112) and/or reservoirs ((108, 113, 114) which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels (109, 112) within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices (101) with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel (109, 112) containing a conductive material selected from a variety of solutions and gels.
摘要翻译：本发明提供了通过将离子和/或电子导体材料沉积到平面基底上来制造集成电喷雾尖端（102）的相关装置和方法。本发明还具有形成电喷射装置的方法，包括将第一平面基底（104）耦合到第二平面基底（105）的表面，其中至少一个基底上的表面包括一个或多个微流体通道（109， 112）和/或至少部分或完全封闭在其间的储存器（（108,113,114））。设备的导电区域优选地不与装置的其它部分内的微流体通道（109,112）相交。本发明还提供了用于制造和使用具有用于电喷雾离子化的集成电极的微流体装置（101）的相关装置和方法。一些实施例中的电喷射装置可以包括由微流体通道（109,112）形成的电子导体电极或离子导体电极），其含有选自多种溶液和凝胶的导电材料。

4. 发明申请

WO2005019804A3 MICROFLUIDIC CHIP WITH ENHANCED TIP FOR STABLE ELECTROSPRAY IONIZATION 审中-公开
标题翻译：微波芯片，增强了稳定的电泳放电
公开(公告)号：WO2005019804A3
公开(公告)日：2006-01-26
申请号：PCT/US2004027774
申请日：2004-08-25
申请人： PREDICANT BIOSCIENCES INC , ZHAO MINGQI , BLAGA LULIU , BOUSSE LUC , STULTS JOHN
发明人： ZHAO MINGQI , BLAGA LULIU , BOUSSE LUC , STULTS JOHN
IPC分类号： H01J49/04 , H03H19/00 , B01D59/44 , B01L3/00 , B01L3/02 , B81B1/00 , G01D5/20 , G01N20060101 , G01N27/447
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/027 , B81B1/008 , B81B2201/058 , G01N27/44717 , H01J49/0018
摘要： A microfluidic chip (10) formed with multiple fluid channels (12) terminating at a tapered electrospray ionization tip (14) for mass spectrometric analysis. The fluid channels (12) may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip (15) can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels (12) may terminate at an open-tip region (18) of the electrospray tip (15). A covering plate (5) may substantially enclose most portions of the fluid channels (12) formed on the channel plate except for the open-tip region (18). Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels (12) in a single microfluidic chip (10) that is formed with a tapered electrospray tip (14) having an open-tip region (18).
摘要翻译：形成有多个流体通道（12）的微流体芯片（10），其终止于锥形电喷雾离子化尖端（14），用于质谱分析。流体通道（12）可以形成在与相应的储存器流体连通的通道板上。电喷雾头（15）可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。流体通道（12）可以终止于电喷雾头（15）的开口尖端区域（18）。覆盖板（5）可以基本上封闭除了开口尖端区域（18）之外形成在通道板上的流体通道（12）的大部分。本发明的另一方面提供了用于对流过单个微流体芯片（10）中的各个流体通道（12）的多个样品进行质谱分析的方法，所述单个微流体芯片（10）由具有开口尖端区域（18）的锥形电喷枪尖端）。

5. 发明专利

CA2523094A1 MICROFLUIDIC DEVICES AND METHODS 未知
公开(公告)号：CA2523094A1
公开(公告)日：2004-11-04
申请号：CA2523094
申请日：2004-03-04
申请人： PREDICANT BIOSCIENCES INC
发明人： BOUSSE LUC , NI JING , ZHAO MINGQI , SRINIVASAN UTHARA , STULTS JOHN , HELLER JONATHAN
IPC分类号： F15C1/04 , F16L58/04 , G01N20060101 , H01J49/04 , H01J49/16
摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surface s. Some embodiments also include a tip surface with one or more surface feature s for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfac es and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

6. 发明专利

AU2004233154A1 Microfluidic devices and methods 未知
公开(公告)号：AU2004233154A1
公开(公告)日：2004-11-04
申请号：AU2004233154
申请日：2004-03-04
申请人： PREDICANT BIOSCIENCES INC
发明人： SRINIVASAN UTHARA , HELLER JONATHAN , NI JING , STULTS JOHN , BOUSSE LUC , ZHAO MINGQI
IPC分类号： F15C1/04 , F16L58/04 , G01N20060101 , H01J49/04 , H01J49/16
摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces which is recessed back from an adjacent portion of the edge. Hydrophilic surfaces and/or hydrophobic surfaces guide substances out of the outlet. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

7. 发明公开

EP1620651A4 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译： MICRO DEVICES流体和程序
公开(公告)号：EP1620651A4
公开(公告)日：2007-12-05
申请号：EP04717504
申请日：2004-03-04
申请人： PREDICANT BIOSCIENCES INC
发明人： HELLER JONATHAN , STULTS JOHN , SRINIVASAN UTHARA , BOUSSE LUC , ZHAO MINGQI , NI JING
IPC分类号： F15C1/04 , F16L58/04 , G01N20060101 , H01J49/04 , H01J49/16
CPC分类号： H01J49/0018 , H01J49/165 , Y10T137/0402 , Y10T137/2082 , Y10T137/2191 , Y10T137/2224 , Y10T137/7036 , Y10T436/2575
摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

8. 发明申请

WO02099410A9 SENSOR DEVICE AND METHOD FOR INDICATING OXYGEN CONSUMPTION 审中-公开
标题翻译：用于显示氧气消耗的传感器装置和方法
公开(公告)号：WO02099410A9
公开(公告)日：2004-04-15
申请号：PCT/US0217923
申请日：2002-06-04
申请人： ACLARA BIOSCIENCES INC , BERRIEN LA SHAUN , BINYAMIN GARY , LACKRITZ HILARY S , VANYSEK PETR , ZHAO MINGQI
发明人： BERRIEN LA SHAUN , BINYAMIN GARY , LACKRITZ HILARY S , VANYSEK PETR , ZHAO MINGQI
IPC分类号： G01N27/49 , G01N33/18
CPC分类号： G01N27/404 , G01N33/1806
摘要： A sensor device for measuring electrochemical, chemical, or biological oxygen demand in a sample is disclosed. The device includes a measurement chamber (14) having at least one chamber dimension of less than 1 millimeter. Also included in the device are working (56) and counter (60) electrodes, and possibly a reference electrode (58) adapted for electrical contact with liquid contained in the chamber. Measurement is accomplished under conditions of electron transfer to or from the components or intermediary to or from the working electrode (56), an electrical circuit connecting this electrode to the counter electrode (60) and possibly the reference electrode (58) and having a power source for applying a voltage potential between the working and counter electrodes, and possibly the working and reference electrodes. A current-responsive means is included in the circuit for measuring the instantaneous or time-averaged electrical current or for integrating the charge flowing through the circuit over a defined period of time, the current or charge being related to the total oxidizable or reducible bio/organic components contained in the sample with the measurement chamber.
摘要翻译：公开了一种用于测量样品中电化学，化学或生物需氧量的传感器装置。该装置包括具有小于1毫米的至少一个室尺寸的测量室（14）。设备中还包括工作（56）和计数器（60）电极，以及可能的参考电极（58），其适于与容纳在腔室中的液体电接触。测量是在电子转移到或来自组件或介于工作电极（56）的电子转移条件下完成的，电路将该电极连接到对电极（60）和可能的参考电极（58）并且具有功率用于在工作电极和对电极之间施加电压电位的源，以及可能的工作电极和参考电极。电流响应装置包括在电路中，用于测量瞬时或时间平均的电流或者用于在限定的时间段内积分流过电路的电荷，该电流或电荷与总可氧化或可还原的生物/ 包含在样品中的有机组分与测量室。

9. 发明申请

WO2007035658A3 INFUSION PUMPS WITH A POSITION DETECTOR 审中-公开
标题翻译：带位置检测器的输液泵
公开(公告)号：WO2007035658A3
公开(公告)日：2007-11-01
申请号：PCT/US2006036330
申请日：2006-09-18
申请人： LIFESCAN INC , ZHAO MINGQI , KRULEVITCH PETER
发明人： ZHAO MINGQI , KRULEVITCH PETER
IPC分类号： G01F25/00 , A61M1/00
CPC分类号： A61M5/14244 , A61M5/1452 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/702
摘要： An infusion pump (e.g., an electrokinetic infusion pump) includes an infusion pump module and an engine that can drive a moveable piston non-mechanically. In addition, the infusion pump module includes a position detector configured for sensing a dispensing state of the infusion pump module. Such information can be utilized in a control scheme to control fluid displacement within and out of the pump. Descriptions of different types of position detectors, such as magnetic sensors (e.g., an anisotropic magnetic resistive sensor), and their implementation in detecting infusion pump fluid displacement are described.
摘要翻译：输液泵（例如电动输液泵）包括输液泵模块和可以非机械地驱动可移动活塞的发动机。另外，输液泵模块包括配置用于感测输液泵模块的分配状态的位置检测器。这样的信息可以用于控制方案中以控制泵内部和外部的流体排量。描述了不同类型的位置检测器（诸如磁性传感器（例如，各向异性磁阻传感器））的描述以及它们在检测输注泵流体位移中的实施方式。

10. 发明申请

WO2007035563A2 MALFUNCTION DETECTION VIA PRESSURE PULSATION 审中-公开
标题翻译：通过压力脉冲进行故障检测
公开(公告)号：WO2007035563A2
公开(公告)日：2007-03-29
申请号：PCT/US2006036164
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
发明人： KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和液体流失状况（例如，断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中形成阻塞，这可能破坏从泵分散的流体的控制。同样，输液器断开连接也会导致液体损失，这可能是破坏性的。对于控制输液泵的系统而言，这种中断可能会很麻烦，例如闭环控制器。相应地，本文描述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，可以使用位置传感器来监测来自输液泵的流体流量，将测量值与期望值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其他算法。

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