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1. 发明申请

WO2007035563A2 MALFUNCTION DETECTION VIA PRESSURE PULSATION 审中-公开
标题翻译：通过压力脉冲进行故障检测
公开(公告)号：WO2007035563A2
公开(公告)日：2007-03-29
申请号：PCT/US2006036164
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
发明人： KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和液体流失状况（例如，断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中形成阻塞，这可能破坏从泵分散的流体的控制。同样，输液器断开连接也会导致液体损失，这可能是破坏性的。对于控制输液泵的系统而言，这种中断可能会很麻烦，例如闭环控制器。相应地，本文描述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，可以使用位置传感器来监测来自输液泵的流体流量，将测量值与期望值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其他算法。

2. 发明申请

WO2007035564A3 MALFUNCTION DETECTION WITH DERIVATIVE CALCULATION 审中-公开
标题翻译：导数计算的失效检测
公开(公告)号：WO2007035564A3
公开(公告)日：2007-07-12
申请号：PCT/US2006036165
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGGI , ANEX DEON
发明人： KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGGI , ANEX DEON
IPC分类号： B01D57/02
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和液体流失状况（例如，断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中形成阻塞，这可能破坏从泵分散的流体的控制。同样，输液器断开连接也会导致液体损失，这可能是破坏性的。对于控制输液泵的系统而言，这种中断可能会很麻烦，例如闭环控制器。相应地，本文描述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，可以使用位置传感器来监测来自输液泵的流体流量，将测量值与期望值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其他算法。

3. 发明申请

WO2007035658A3 INFUSION PUMPS WITH A POSITION DETECTOR 审中-公开
标题翻译：带位置检测器的输液泵
公开(公告)号：WO2007035658A3
公开(公告)日：2007-11-01
申请号：PCT/US2006036330
申请日：2006-09-18
申请人： LIFESCAN INC , ZHAO MINGQI , KRULEVITCH PETER
发明人： ZHAO MINGQI , KRULEVITCH PETER
IPC分类号： G01F25/00 , A61M1/00
CPC分类号： A61M5/14244 , A61M5/1452 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/702
摘要： An infusion pump (e.g., an electrokinetic infusion pump) includes an infusion pump module and an engine that can drive a moveable piston non-mechanically. In addition, the infusion pump module includes a position detector configured for sensing a dispensing state of the infusion pump module. Such information can be utilized in a control scheme to control fluid displacement within and out of the pump. Descriptions of different types of position detectors, such as magnetic sensors (e.g., an anisotropic magnetic resistive sensor), and their implementation in detecting infusion pump fluid displacement are described.
摘要翻译：输液泵（例如电动输液泵）包括输液泵模块和可以非机械地驱动可移动活塞的发动机。另外，输液泵模块包括配置用于感测输液泵模块的分配状态的位置检测器。这样的信息可以用于控制方案中以控制泵内部和外部的流体排量。描述了不同类型的位置检测器（诸如磁性传感器（例如，各向异性磁阻传感器））的描述以及它们在检测输注泵流体位移中的实施方式。

4. 发明申请

WO2007035666A3 ELECTROKINETIC INFUSION PUMP SYSTEM 审中-公开
标题翻译：电动输液泵系统
公开(公告)号：WO2007035666A3
公开(公告)日：2007-10-04
申请号：PCT/US2006036340
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BENETT WILLIAM , ROBERTS NEIL E , BOHM SEBASTIAN , SIEH ZARA
发明人： KRULEVITCH PETER , BENETT WILLIAM , ROBERTS NEIL E , BOHM SEBASTIAN , SIEH ZARA
IPC分类号： A61M31/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Various methods and devices are provided for delivering an infusion liquid using an electrokinetic infusion pump. The electrokinetic infusion pump can generally include an infusion housing having an infusion reservoir. The infusion reservoir has an infusion outlet and is capable of containing an infusion liquid. A plunger is movably coupled to the infusion housing and is adapted to be manually displaced relative to the infusion housing to load the infusion reservoir with infusion liquid. A movable partition can be disposed within the infusion housing and has a first surface in communication with an electrokinetic solution and a second surface, isolated from the first surface, in communication with the infusion reservoir. The electrokinetic infusion pump can further include an electrokinetic engine integrated within the plunger and adapted to selectively deliver electric potential across an electrokinetic porous media to cause the electrokinetic solution within the electrokinetic engine to displace the movable partition to effect delivery of at least a portion of the infusion liquid through the infusion outlet.
摘要翻译：提供用于使用电动输液泵输送输液的各种方法和装置。电动输液泵通常可以包括具有输注储器的输液罩。输注槽具有输液口，并且能够容纳输液。柱塞可移动地联接到输注壳体，并且适于相对于输注壳体手动移位以用输注液体加载输注储存器。可移动隔板可以设置在输注外壳内，并且具有与电动溶液连通的第一表面和与第一表面隔离的与输注储存器连通的第二表面。电动输液泵还可以包括集成在柱塞内的电动发动机，并适于选择性地跨电动多孔介质输送电势，以使电动发动机内的电动溶液移动可动隔板，从而实现至少一部分输液通过输液口。

5. 发明申请

WO2007035658A9 INFUSION PUMPS WITH A POSITION DETECTOR 审中-公开
公开(公告)号：WO2007035658A9
公开(公告)日：2007-05-18
申请号：PCT/US2006036330
申请日：2006-09-18
申请人： LIFESCAN INC , ZHAO MINGQI , KRULEVITCH PETER
发明人： ZHAO MINGQI , KRULEVITCH PETER
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/1452 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/702
摘要： An infusion pump (e.g., an electrokinetic infusion pump) includes an infusion pump module and an engine that can drive a moveable piston non-mechanically. In addition, the infusion pump module includes a position detector configured for sensing a dispensing state of the infusion pump module. Such information can be utilized in a control scheme to control fluid displacement within and out of the pump. Descriptions of different types of position detectors, such as magnetic sensors (e.g., an anisotropic magnetic resistive sensor), and their implementation in detecting infusion pump fluid displacement are described.

6. 发明申请

WO2011047298A3 PALM ACTIVATED DRUG DELIVERY DEVICE 审中-公开
标题翻译： PALM激活药物递送装置
公开(公告)号：WO2011047298A3
公开(公告)日：2011-08-25
申请号：PCT/US2010052894
申请日：2010-10-15
申请人： CENTOCOR ORTHO BIOTECH INC , OLSON LORIN P , KRULEVITCH PETER , GLENCROSS JAMES , WANG JINGLI , FOLEY NICHOLAS , ZHAO MINGQI
发明人： OLSON LORIN P , KRULEVITCH PETER , GLENCROSS JAMES , WANG JINGLI , FOLEY NICHOLAS , ZHAO MINGQI
IPC分类号： A61M5/32
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译：公开了用于胃肠外递送药物例如药物的装置。该装置包括上壳体和下壳体，其中上壳体构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下壳体移动。

7. 发明申请

WO2010009382A3 ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：分析测量和管理设备及相关方法
公开(公告)号：WO2010009382A3
公开(公告)日：2012-08-02
申请号：PCT/US2009050971
申请日：2009-07-17
申请人： LIFESCAN INC , SIEH ZARA , HORWITZ DAVID , PRICE DAVID , KRULEVITCH PETER , SAVAGE DONNA , SHARTLE ROBERT
发明人： SIEH ZARA , HORWITZ DAVID , PRICE DAVID , KRULEVITCH PETER , SAVAGE DONNA , SHARTLE ROBERT
IPC分类号： A61B5/00
CPC分类号： A61B5/4839 , A61B5/14532 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： Various embodiments of a diabetes management system are provided. One exemplary system may include an analyte measurement device and a therapeutic agent delivery device. The measurement device includes a measurement unit, display, and first wireless module. The therapeutic agent delivery device has a delivery device housing, delivery mechanism disposed in the housing that delivers a dosage of the agent to the user upon actuation by the user or health care provider, and a second wireless module. The second module, automatically, without prompting from a user or any active input or action by the user, transmits a signal to the first wireless module indicative of: (a) type of therapeutic agent delivered; and (b) amount of therapeutic agent delivered to the user; or (c) type of therapeutic agent device from which the therapeutic agent was administered. Also described are diabetes management devices and methods.
摘要翻译：提供了糖尿病管理系统的各种实施例。一个示例性系统可以包括分析物测量装置和治疗剂递送装置。测量装置包括测量单元，显示器和第一无线模块。治疗剂递送装置具有输送装置壳体，设置在壳体中的输送机构，其在用户或医疗保健提供者致动时将剂量的剂量递送给使用者，以及第二无线模块。自动地，第二模块在不提示用户或用户的任何有效输入或动作的情况下，向第一无线模块发送指示：（a）递送的治疗剂的类型; 和（b）递送给使用者的治疗剂量; 或（c）施用治疗剂的治疗剂装置的类型。还描述了糖尿病管理装置和方法。

8. 发明专利

JP2010179100A Flexible indwelling biosensor, flexible indwelling biosensor insertion device, and related methods 有权
标题翻译：柔性生物传感器，柔性生物传感器插入装置及相关方法
公开(公告)号：JP2010179100A
公开(公告)日：2010-08-19
申请号：JP2010022930
申请日：2010-02-04
申请人： Lifescan Inc , ライフスキャン・インコーポレイテッドLifescan,Inc.
发明人： KRULEVITCH PETER , SAVAGE DONNA , OLSON LORIN P , BOWMAN LEIF
IPC分类号： A61B5/145
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/6848 , A61B5/6849
摘要： PROBLEM TO BE SOLVED: To provide an indwelling biosensor, related insertion device, and related methods.
SOLUTION: A flexible indwelling biosensor includes an elongated framework formed from a flexible material (e.g., a Nitinol strip) with a body portion, a sharp head, a distal end, and a proximal end. The flexible indwelling sensor further includes a biosensor (such as a tissue fluid glucose sensor) integrated with the elongated framework and having a sensor element disposed over (for example, on or suspended over) at least either body portion of the elongated framework or sharp head. Moreover, the sharp head is disposed at the terminal end of the elongated framework and the sharp head and at least the sensor element of the biosensor are configured for insertion into a target site (for example, a subcutaneous target site).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供留置生物传感器，相关插入装置及相关方法。解决方案：柔性留置生物传感器包括由具有主体部分，尖头，远端和近端的柔性材料（例如，镍钛诺带）形成的细长骨架。柔性留置传感器还包括与细长骨架集成的生物传感器（例如组织液葡萄糖传感器），并且具有设置在细长框架或尖头的至少任一身体部分（例如，在其上或悬挂在上面）上的传感器元件。此外，尖头设置在细长框架的终端处，并且尖锐头部，并且生物传感器的至少传感器元件构造成用于插入目标部位（例如，皮下靶位点）。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2009106754A Integrated conduit insertion medical device 有权
标题翻译：集成电路插入式医疗器械
公开(公告)号：JP2009106754A
公开(公告)日：2009-05-21
申请号：JP2008278919
申请日：2008-10-29
申请人： Lifescan Inc , ライフスキャン・インコーポレイテッドLifescan,Inc.
发明人： KRULEVITCH PETER , CICHOCKI FRANK , OLSON LORIN P
IPC分类号： A61M5/158 , A61L29/00 , A61M5/145 , A61M5/32
CPC分类号： A61M5/158 , A61M5/3286 , A61M5/3287 , A61M5/329 , A61M25/00 , A61M25/0068 , A61M2005/1585 , A61M2005/1587 , A61M2205/0266
摘要： PROBLEM TO BE SOLVED: To provide a small medical device facilitating insertion into a user's target site so that it is easily applied to any location on the body that can be touched by the user. SOLUTION: A medical device 900 includes a medical device flexible conduit 902 that has an elongated Nitinol strip with a distal end, a proximal end, a longitudinal axis running from the distal end to the proximal end, a sharp head extending from the distal end, and a channel etched therein. Moreover, the channel is dispositioned along the longitudinal axis. The medical device flexible conduit also has a flexible tube at least partially jacketing the elongated Nitinol strip between the distal end and the proximal end, with the channel and the flexible tube defining a conduit. The medical device also includes an insertion mechanism configured to insert a portion of the flexible conduit, including the sharp head, into a user's target site such that the conduit provides fluid communication to the target site. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供便于插入用户的目标站点的小型医疗设备，使得其容易地应用于身体上可被用户触摸的任何位置。解决方案：医疗装置900包括医疗装置柔性导管902，其具有细长的镍钛诺带，其具有远端，近端，从远端延伸到近端的纵向轴线，从头部远端和在其中蚀刻的通道。此外，通道沿着纵向轴线布置。医疗器械柔性导管还具有柔性管，其至少部分地将细长的镍钛诺带夹在远端和近端之间，通道和柔性管限定导管。该医疗装置还包括插入机构，该插入机构构造成将包括尖头的柔性导管的一部分插入使用者的目标部位，使得导管向目标部位提供流体连通。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2009106758A Method for inserting flexible conduit into user's target site in medical device 有权
标题翻译：将柔性管道插入医疗设备中的用户目标站点的方法
公开(公告)号：JP2009106758A
公开(公告)日：2009-05-21
申请号：JP2008280114
申请日：2008-10-30
申请人： Lifescan Inc , ライフスキャン・インコーポレイテッドLifescan,Inc.
发明人： KRULEVITCH PETER , CICHOCKI FRANK , OLSON LORIN P
IPC分类号： A61M5/158 , A61L31/00 , A61M5/145 , A61M5/32
CPC分类号： A61M5/158 , A61M5/3286 , A61M5/3287 , A61M5/329 , A61M25/00 , A61M25/0068 , A61M2005/1585 , A61M2005/1587 , A61M2205/0266
摘要： PROBLEM TO BE SOLVED: To provide a method which will facilitates partial insertion of a conduit into a user's target site so that it is easily applied to any location on the body. SOLUTION: The method includes adhering a medical device to a user with the medical device including a flexible conduit 902 of a medical device 900 and an insertion mechanism, and inserting a medical device flexible conduit into a user's target site. The medical device flexible conduit has an elongated Nitinol strip with a distal end, a proximal end, a longitudinal axis running from the distal end to the proximal end, a sharp head extending from the distal end, and a channel etched therein. The channel is dispositioned along the longitudinal axis. The medical device flexible conduit also includes a flexible tube at least partially jacketing the elongated Nitinol strip between the distal end and the proximal end, the channel and flexible tube defining a conduit. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种方法，其将有助于将导管部分地插入到用户的目标部位中，使得其容易地应用于身体上的任何位置。解决方案：该方法包括使医疗装置将医疗装置粘贴到包括医疗装置900的柔性导管902和插入机构，以及将医疗装置柔性导管插入到使用者的目标部位中。医疗器械柔性导管具有细长的镍钛诺带，其具有远端，近端，从远端延伸到近端的纵向轴线，从远端延伸的尖锐头部以及在其中蚀刻的通道。通道沿纵向轴线布置。医疗器械柔性导管还包括柔性管，其至少部分地夹持在远端和近端之间的细长镍钛诺条，通道和柔性管限定导管。版权所有（C）2009，JPO＆INPIT

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