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1. 发明申请

WO0209690A3 PHARMACEUTICAL COMPOSITION COMPRISING A PHOTOCHEMOTHERAPEUTIC AGENT AND A MUCOADHESIVE AGENT 审中-公开
标题翻译：包含光化学治疗剂和麻醉剂的药物组合物
公开(公告)号：WO0209690A3
公开(公告)日：2002-08-08
申请号：PCT/GB0103338
申请日：2001-07-25
申请人： PHOTOCURE ASA , KLAVENESS JO , HANSSON VIDAR , GODAL ASLAK , GOLDING LOUISE
发明人： KLAVENESS JO , HANSSON VIDAR , GODAL ASLAK
IPC分类号： A61K47/02 , A61K9/00 , A61K9/70 , A61K31/122 , A61K31/197 , A61K31/22 , A61K31/24 , A61K31/37 , A61K31/409 , A61K45/08 , A61K47/20 , A61K47/24 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61P1/02 , A61P1/04 , A61P11/00 , A61P11/02 , A61P15/00 , A61P15/02 , A61P17/00 , A61P17/06 , A61P27/02 , A61P27/16 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/22 , A61P35/00 , A61P43/00 , A61K31/195 , A61K31/221 , G01N33/50
CPC分类号： A61K41/0061 , A61K9/006 , A61K9/70
摘要： The present invention relates to a pharmaceutical composition for use as a medicament, preferably for the treatment or diagnosis of disorders or abnormalities of epithelial-lined surfaces, preferably mucosa-lined surfaces, comprising a photochemotherapeutic agent together with a mucoadhesive agent, optionally together with at lest one surface penetration assisting agent and optionally with one or more chelating agents, and products and kits for performing the invention.
摘要翻译：本发明涉及用作药物的药物组合物，优选用于治疗或诊断上皮内衬表面，优选粘膜内衬表面的病症或异常，包括光化学治疗剂以及粘膜粘附剂，任选地与免除一种表面渗透助剂和任选的一种或多种螯合剂，以及用于实施本发明的产品和试剂盒。

2. 发明申请

WO0209690A8 PHARMACEUTICAL COMPOSITION COMPRISING A PHOTOCHEMOTHERAPEUTIC AGENT AND A MUCOADHESIVE AGENT 审中-公开
标题翻译：包含光化学治疗剂和麻醉剂的药物组合物
公开(公告)号：WO0209690A8
公开(公告)日：2004-04-15
申请号：PCT/GB0103338
申请日：2001-07-25
申请人： PHOTOCURE ASA , KLAVENESS JO , HANSSON VIDAR , GODAL ASLAK
发明人： KLAVENESS JO , HANSSON VIDAR , GODAL ASLAK
IPC分类号： A61K47/02 , A61K9/00 , A61K9/70 , A61K31/122 , A61K31/197 , A61K31/22 , A61K31/24 , A61K31/37 , A61K31/409 , A61K45/08 , A61K47/20 , A61K47/24 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61P1/02 , A61P1/04 , A61P11/00 , A61P11/02 , A61P15/00 , A61P15/02 , A61P17/00 , A61P17/06 , A61P27/02 , A61P27/16 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/22 , A61P35/00 , A61P43/00 , A61K31/195 , A61K31/221 , G01N33/50
CPC分类号： A61K41/0061 , A61K9/006 , A61K9/70
摘要： The present invention relates to a pharmaceutical composition for use as a medicament, preferably for the treatment or diagnosis of disorders or abnormalities of epithelial-lined surfaces, preferably mucosa-lined surfaces, comprising a photochemotherapeutic agent together with a mucoadhesive agent, optionally together with at lest one surface penetration assisting agent and optionally with one or more chelating agents, and products and kits for performing the invention.
摘要翻译：本发明涉及用作药物的药物组合物，优选用于治疗或诊断上皮内衬表面，优选粘膜内衬表面的病症或异常，包括光化学治疗剂以及粘膜粘附剂，任选地与免除一种表面渗透助剂和任选的一种或多种螯合剂，以及用于实施本发明的产品和试剂盒。

3. 发明申请

WO2009074811A3 USE OF 5-AMINOLEVULINIC ACID AND DERIVATIVES IN A SOLID FORM FOR PHOTODYNAMIC TREATMENT AND DIAGNOSIS 审中-公开
标题翻译：用于光化学治疗和诊断的固体形式中的5-氨基酸和衍生物的使用
公开(公告)号：WO2009074811A3
公开(公告)日：2009-08-06
申请号：PCT/GB2008004113
申请日：2008-12-12
申请人： PHOTOCURE ASA , GOLDING LOUISE , KLAVENESS JO , STENSRUD GRY , GODAL ASLAK , BRAENDEN JON ERIK , KLEM BJOERN
发明人： KLAVENESS JO , STENSRUD GRY , GODAL ASLAK , BRAENDEN JON ERIK , KLEM BJOERN
IPC分类号： A61K41/00 , A61K9/02 , A61K9/28 , A61K9/48 , A61K31/197 , A61K49/00 , A61P35/00
CPC分类号： A61K9/02 , A61K9/0031 , A61K9/0034 , A61K9/0075 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2013 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/48 , A61K9/4858 , A61K9/4891 , A61K9/5042 , A61K9/5073 , A61K31/197 , A61K31/221 , A61K41/0057 , A61K41/0061 , A61K49/00 , A61K49/0021
摘要： The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non- cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.
摘要翻译：本发明涉及使用5-ALA或其前体或衍生物（例如ALA酯）的光敏剂在制造用于癌症的光动力学治疗或诊断的药物产品中，与癌症或治疗或诊断非癌症状况，其中所述药物产品为固体形式。本发明还涉及用于这些方法的固体药物产品，例如。栓剂，阴道栓剂，片剂，丸剂和胶囊，其包含5-ALA或其前体或衍生物（例如ALA酯）和至少一种药学上可接受的载体或赋形剂。这些产品特别适用于光动力学治疗或诊断胃肠系统下部或女性生殖系统中的癌性或非癌性病症。在结直肠癌或宫颈癌的治疗或诊断中。

4. 发明申请

WO2010072419A2 ENEMA PREPARATIONS AND THEIR USE 审中-公开
标题翻译： ENEMA制剂及其使用
公开(公告)号：WO2010072419A2
公开(公告)日：2010-07-01
申请号：PCT/EP2009009293
申请日：2009-12-23
申请人： PHOTOCURE ASA , GODAL ASLAK , KLAVENESS JO
发明人： GODAL ASLAK , KLAVENESS JO
IPC分类号： A61K9/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20
CPC分类号： A61K9/0031 , A61K41/0061 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/34 , A61K47/38
摘要： This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester. Such preparations may further comprise one or more viscosity enhancing agents, mucoadhesive or mucolytic agents, penetration enhancers or chelating agents. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing cancer and non-cancerous conditions in the colon and/or rectum.
摘要翻译：本发明涉及光动力学治疗和诊断癌症和非癌症病症的改进方法，特别是涉及用于这些方法的改善的灌肠剂制剂，所述灌肠制剂包含5-氨基乙酰丙酸（5-ALA）的光敏剂或其前体或衍生物，例如一种5-ALA酯。这样的制剂可以进一步包含一种或多种粘度增强剂，粘膜粘附或粘液溶解剂，渗透增强剂或螯合剂。本文所述的方法和制剂特别适用于治疗和/或诊断结肠和/或直肠癌和非癌症病症的光动力学方法。

5. 发明申请

WO2008084241A2 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2008084241A2
公开(公告)日：2008-07-17
申请号：PCT/GB2008000086
申请日：2008-01-11
申请人： PHOTOCURE ASA , GOLDING LOUISE , WULF HANS CHRISTIAN , GODAL ASLAK , KLAVENESS JO
发明人： WULF HANS CHRISTIAN , GODAL ASLAK , KLAVENESS JO
IPC分类号： A61K31/221 , A61K31/197 , A61K41/00 , A61P17/10 , A61P35/00
CPC分类号： A61K41/0061 , A61K31/221 , A61N5/062
摘要： The invention provides the use of a photosensitiser which is 5- aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10 % wt (e.g. 0.5 to 8 %wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm 2 (e.g. 5 to 40 mW/cm 2 ), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).
摘要翻译：本发明提供了5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如酯）或其药学上可接受的盐的光敏剂在制备用于光动力疗法（PDT），其中所述PDT包括：（a）向所述动物施用包含所述光敏剂的组合物; 和（b）光活化所述光敏剂，并且其中通过使用（i） - （iv）中的一种或多种来防止或减少所述PDT的副作用（例如疼痛和/或红斑）：（i）所述组合物包含浓度小于10％wt（例如0.5至8％wt）的光敏剂，（ii）所述组合物在所述光活化前施用少于2小时（例如30分钟至90分钟），（iii）所述光活化是用光通量小于50mW / cm 2（例如5〜40mW / cm 2）的光源进行，（iv）进行所述的光活化用阳光照射。优选地，通过使用（iii）或（iv）与（i）和/或（ii）组合来防止或减少PDT的副作用。

6. 发明申请

WO9818500A3 Improvements in or relating to diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂的改进或与之相关
公开(公告)号：WO9818500A3
公开(公告)日：1998-07-23
申请号：PCT/GB9702953
申请日：1997-10-28
申请人： MARDSEN JOHN CHRISTOPHER , NYCOMED IMAGING AS , KLAVENESS JO , RONGVED PAL , HOEGSET ANDERS , TOLLESHAUG HELGE , CUTHBERSON ALAN , GODAL ASLAK , HOFF LARS , GOGSTAD GEIR , BRYN KLAUS , NAEVESTAD ANNE , LOEVHAUG DAGFINN , HELLEBUST HALLDIS , SOLBAKKEN MAGNE
发明人： KLAVENESS JO , RONGVED PAL , HOEGSET ANDERS , TOLLESHAUG HELGE , CUTHBERTSON ALAN , GODAL ASLAK , HOFF LARS , GOGSTAD GEIR , BRYN KLAUS , NAEVESTAD ANNE , LOEVHAUG DAGFINN , HELLBUST HALLDIS , SOLBAKKEN MAGNE
IPC分类号： A61K9/12 , A61K20060101 , A61K31/40 , A61K45/00 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K51/00 , A61K51/04 , A61K51/08 , A61K51/10 , A61K51/12
CPC分类号： A61K49/0056 , A61K47/542 , A61K47/549 , A61K47/55 , A61K47/554 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0054 , A61K49/0091 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：可靶向的诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

7. 发明申请

WO9818500A8 IMPROVEMENTS IN OR RELATING TO DIAGNOSTIC/THERAPEUTIC AGENTS 审中-公开
标题翻译：诊断/治疗药物的改善或相关
公开(公告)号：WO9818500A8
公开(公告)日：1999-11-25
申请号：PCT/GB9702953
申请日：1997-10-28
申请人： MARSDEN JOHN CHRISTOPHER , NYCOMED IMAGING AS , KLAVENESS JO , RONGVED PAAL , HOEGSET ANDERS , TOLLESHAUG HELGE , CUTHBERTSON ALAN , GODAL ASLAK , HOFF LARS , GOGSTAD GEIR , BRYN KLAUS , NAEVESTAD ANNE , LOEVHAUG DAGFINN , HELLEBUST HALLDIS , SOLBAKKEN MAGNE
发明人： KLAVENESS JO , RONGVED PAAL , HOEGSET ANDERS , TOLLESHAUG HELGE , CUTHBERTSON ALAN , GODAL ASLAK , HOFF LARS , GOGSTAD GEIR , BRYN KLAUS , NAEVESTAD ANNE , LOEVHAUG DAGFINN , HELLEBUST HALLDIS , SOLBAKKEN MAGNE
IPC分类号： A61K9/12 , A61K20060101 , A61K31/40 , A61K45/00 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K51/00 , A61K51/04 , A61K51/08 , A61K51/10 , A61K51/12
CPC分类号： A61K49/0056 , A61K47/542 , A61K47/549 , A61K47/55 , A61K47/554 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0054 , A61K49/0091 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

8. 发明申请

WO9818498A3 Improvements in or relating to diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂的改进或与之相关
公开(公告)号：WO9818498A3
公开(公告)日：1998-07-16
申请号：PCT/GB9702958
申请日：1997-10-28
申请人： MARSDEN JOHN CHRISTOPHER , NYCOMED IMAGING AS , KLAVENESS JO , RONGVED PAL , HOGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , CUTHBERTSON ALAN , LOVHAUG DAGFINN , SOLBAKKEN MAGNE
发明人： KLAVENESS JO , RONGVED PAL , HOEGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , CUTHBERTSON ALAN , LOEVHAUG DAGFINN , SOLBAKKEN MAGNE
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0091 , A61K49/223 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generated material, in which the reporter is coupled or linked to one or more non-bioactive vectors.

9. 发明申请

WO9818495A2 IMPROVEMENTS IN OR RELATING TO DIAGNOSTIC/THERAPEUTIC AGENTS 审中-公开
标题翻译：诊断/治疗药物的改善或相关
公开(公告)号：WO9818495A2
公开(公告)日：1998-05-07
申请号：PCT/GB9702955
申请日：1997-10-28
申请人： MARSDEN JOHN CHRISTOPHER , NYCOMED IMAGING AS , KLAVENESS JO , RONGVED PAAL , HOEGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , LOEVHAUG DAGFINN , SOLBAKKEN MAGNE , CUTHBERTSON ALAN
发明人： KLAVENESS JO , RONGVED PAAL , HOEGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , LOEVHAUG DAGFINN , SOLBAKKEN MAGNE , CUTHBERTSON ALAN
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12 , A61K51/10
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/55 , A61K47/554 , A61K47/6925 , A61K49/0043 , A61K49/0054 , A61K49/0091 , A61K49/223 , A61K51/04 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said reporter being conjugated to one or more non-proteinaceous, non-peptide and non-polysaccharide vectors.
摘要翻译：可靶向的诊断和/或治疗活性剂，例如超声造影剂，包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述报道分子与一种或多种非蛋白质，非肽和非多糖载体缀合。

10. 发明申请

WO9955837A3 IMPROVEMENTS IN OR RELATING TO SEPARATION PROCESSES 审中-公开
标题翻译：对分离过程的改进或相关
公开(公告)号：WO9955837A3
公开(公告)日：2000-02-10
申请号：PCT/GB9901317
申请日：1999-04-28
申请人： NYCOMED IMAGING AS , CUTHBERTSON ALAN , RONGVED PAAL , LOEVHAUG DAGFINN , FJERDINGSTAD HEGE , SOLBAKKEN MAGNE , GODAL ASLAK
发明人： CUTHBERTSON ALAN , RONGVED PAAL , LOEVHAUG DAGFINN , FJERDINGSTAD HEGE , SOLBAKKEN MAGNE , GODAL ASLAK
IPC分类号： G01N33/487 , A61K49/22 , B01D19/02 , B03D1/00 , B03D1/02 , B03D1/14 , C07K16/12 , C07K16/18 , C07K16/28 , C12N5/00 , C12N5/06 , C12N5/10 , G01N33/543 , B01F17/00 , B03D1/016 , G01N33/48
CPC分类号： G01N33/5432 , A61K49/223 , B03D1/00 , B03D1/02 , B03D1/14 , B03D1/247 , B03D2203/003 , C07K16/1271 , C07K16/2821 , C07K16/2854 , C07K16/2896 , G01N2405/04
摘要： Separation of target material from a liquid sample is achieved by coupling the target to targetable encapsulated gas microbubbles, allowing the microbubbles and coupled target to float to the surface of the sample to form a floating microbubble/target layer, and separating this layer from the sample. In a positive separation process the microbubbles are then removed from the target, e.g. by bursting. In a negative separation process target-free sample material is recovered following separation of the floating layer. The method may also be used diagnostically to detect the presence of a disease marker in a sample. Novel separation apparatus is also described.
摘要翻译：目标材料与液体样品的分离是通过将目标物与可靶向包封的气体微泡耦合来实现的，允许微泡和偶联的目标物漂浮到样品表面以形成浮动微泡/目标层，并将该层与样品分离。在正分离过程中，然后从目标物中除去微泡。通过爆裂。在负分离过程中，在浮选层分离后回收无目标样品材料。该方法也可以在诊断上用于检测样品中疾病标志物的存在。还描述了新颖的分离装置。

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