专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CA2244924A1 NON-NUCLEOTIDE PHOSPHOROUS ESTER OLIGOMERS 未知
公开(公告)号：CA2244924A1
公开(公告)日：1997-08-07
申请号：CA2244924
申请日：1997-01-22
申请人： PHARMAGENICS INC
发明人： FATHI REZA , RUDOLPH MORRIS J , GENTLES ROBERT G , COOK ALAN F
IPC分类号： C07F9/24 , C07F9/38 , C07F9/547 , C07F9/553 , C07F9/6509 , C07F9/6561 , C07H15/18
摘要： A phosphorus ester oligomer having structure (I) wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B1 and B2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labelling group, a protecting group, a phosphoramidate or a phosphomonoester; R1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R1 is independently selected from the group consisting of a condensation product of (i) a nonvicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether, a purine or pyrimidine substituted 1,2diol or a disubstituted heterocycle; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality; (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a nonvicinal or alicyclic diol, any of which can further include a detectable label, and n is at least one. Preferred R1 moieties include condensation products of heterocyclic diols, alicyclic diols, and polycyclic diols. Also the non-nucleotide monomers thereof, combinatorial library mixtures of the oligomers and the use of the oligomers as selective target-binding compounds.

2. 发明专利

AU1753297A Non-nucleotide phosphorous ester oligomers 未知
公开(公告)号：AU1753297A
公开(公告)日：1997-08-22
申请号：AU1753297
申请日：1997-01-22
申请人： PHARMAGENICS INC
发明人： GENTLES ROBERT G , COOK ALAN F , RUDOLPH MORRIS J , FATHI REZA
IPC分类号： C07F9/08 , A61K31/66 , A61K31/661 , A61K31/6615 , C07B61/00 , C07F9/141 , C07F9/143 , C07F9/145 , C07F9/24 , C07F9/572 , C07F9/58 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/6539 , C07F9/655 , C07F9/6561

3. 发明公开

EP0880532A4 NON-NUCLEOTIDE PHOSPHOROUS ESTER OLIGOMERS 失效
标题翻译： NON-核苷酸磷酸酯低聚物
公开(公告)号：EP0880532A4
公开(公告)日：1999-06-09
申请号：EP97933585
申请日：1997-01-22
申请人： PHARMAGENICS INC
发明人： GENTLES ROBERT G , COOK ALAN F , RUDOLPH MORRIS J , FATHI REZA
IPC分类号： C07F9/08 , A61K31/66 , A61K31/661 , A61K31/6615 , C07B61/00 , C07F9/141 , C07F9/143 , C07F9/145 , C07F9/24 , C07F9/572 , C07F9/58 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/6539 , C07F9/655 , C07F9/6561
CPC分类号： C07F9/65616 , C07F9/1411 , C07F9/143 , C07F9/145 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/65062 , C07F9/650958 , C07F9/6539 , C07F9/65515 , C07F9/6561 , C40B40/00 , Y02P20/55
摘要： A phosphorus ester oligomer having structure (I) wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B1 and B2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labelling group, a protecting group, a phosphoramidate or a phosphomonoester; R1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R1 is independently selected from the group consisting of a condensation product of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether, a purine or pyrimidine substituted 1,2-diol or a disubstituted heterocycle; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality; (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least one. Preferred R1 moieties include condensation products of heterocyclic diols, alicyclic diols, and polycyclic diols. Also the non-nucleotide monomers thereof, combinatorial library mixtures of the oligomers and the use of the oligomers as selective target-binding compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式