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1. 发明申请

WO2011152779A1 METHOD FOR DECISION SUPPORT IN ALLERGY DIAGNOSIS 审中-公开
标题翻译：在过敏诊断中的决策支持方法
公开(公告)号：WO2011152779A1
公开(公告)日：2011-12-08
申请号：PCT/SE2011/050664
申请日：2011-05-27
申请人： PHADIA AB , ANDERSSON, Karl , MATSSON, Per
发明人： ANDERSSON, Karl , MATSSON, Per
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G06F19/34 , G01N33/68 , G01N2800/24
摘要： A method of providing a clinical decision support in allergy diagnosis comprises the steps of: a) providing a body fluid sample from a patient, b) selecting (1 10) a plurality of allergens to be tested for in the sample, c) determining (120) for each allergen the concentration in the sample of at least one immunoglobulin directed against the allergen, d) transforming (130) each determined immunoglobulin concentration to a clinical effect value on a normalized scale common to allergens in general, e) assigning to each allergen tested for, based on known cross-reactivity information for the allergen, an allergen specificity value, representing the degree of cross-reactivity for the allergen, and f) presenting (140) determined clinical effect and allergen specificity values for each allergen, or a group or groups of the allergens. A computer-implemented method, a computer program product, and a patient information carrier device containing a diagnosis result are also disclosed.
摘要翻译：在过敏诊断中提供临床决定支持的方法包括以下步骤：a）从患者提供体液样品，b）在样品中选择（110）待测试的多种变应原，c）确定（ 120）对于每种变应原，至少一种针对变应原的免疫球蛋白的样品中的浓度，d）将所测定的每种免疫球蛋白浓度转化（130）至通常与变应原共有的归一化量值的临床效应值，e）分配给每个基于已知的变应原交叉反应性信息测试过敏原，表达变应原特异性值，表示变应原的交叉反应性程度，以及f）呈现（140）确定的每种变应原的临床效果和变应原特异性值，或一组或一组过敏原。还公开了一种计算机实现的方法，计算机程序产品和包含诊断结果的患者信息载体装置。

2. 发明申请

WO2009070122A1 A NOVEL METHOD FOR ASSESSING IF SYMPTOMS IN A PATIENT ARE RELATED TO A HYPERSENSITIVITY TO A SPECIFIC ALLERGEN 审中-公开
标题翻译：用于评估患者症状的新方法与特异性过敏原的超敏性相关
公开(公告)号：WO2009070122A1
公开(公告)日：2009-06-04
申请号：PCT/SE2008/051385
申请日：2008-12-01
申请人： PHADIA AB , SÖDERSTRÖM, Lars , AHLSTEDT, Staffan , MATSSON, Per , CUSTOVIC, Adnan
发明人： SÖDERSTRÖM, Lars , AHLSTEDT, Staffan , MATSSON, Per , CUSTOVIC, Adnan
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6854 , G01N2800/24
摘要： The present invention relates to the field of allergic diseases, and especially to methods for assessing if symptoms in a patient are related to a hypersensitivity to a specific allergen. Furthermore the invention relates to a computer program product comprising means for controlling the steps of said methods for use with an apparatus for analysis of binding assays. The invention also relates to such an apparatus.
摘要翻译：本发明涉及过敏性疾病领域，尤其涉及用于评估患者症状与特异性变应原过敏有关的方法。此外，本发明涉及一种计算机程序产品，其包括用于控制与用于分析结合测定的装置一起使用的所述方法的步骤的装置。本发明还涉及这种装置。

3. 发明申请

WO2013039450A1 CALIBRATION REAGENT AND METHOD 审中-公开
标题翻译：校准试剂和方法
公开(公告)号：WO2013039450A1
公开(公告)日：2013-03-21
申请号：PCT/SE2012/050977
申请日：2012-09-14
申请人： PHADIA AB , ELFVERSON, Göran , MATSSON, Per , NYSTRAND, Mats
发明人： ELFVERSON, Göran , MATSSON, Per , NYSTRAND, Mats
IPC分类号： G01N33/68 , G01N33/96 , C07K16/00
CPC分类号： G01N33/5302 , C07K16/00 , G01N33/6854 , G01N33/96
摘要： The present invention relates to a method for calibrating a multiplex assay, comprising: adding a calibration reagent to a solid phase on which a plurality of capturing agents are immobilised, adding a detection molecule which has a capacity to bind to the calibration reagent, detecting bound detection molecule, thereby creating a calibration curve, wherein the calibration reagent comprises at least two different binding molecules, wherein each binding molecule has a capacity to bind specifically to a capturing agent immobilised on the solid phase and a capacity to bind to a detection molecule. Further provided is a multiplex assay system comprising such a calibration reagent.
摘要翻译：本发明涉及一种用于校准多重测定的方法，包括：向固定有多个捕获剂的固相添加校准试剂，加入具有结合校准试剂的能力的检测分子，检测结合检测分子，从而产生校准曲线，其中校准试剂包含至少两种不同的结合分子，其中每个结合分子具有特异性结合固定在固相上的捕获剂和与检测分子结合的能力的能力。还提供了包含这种校准试剂的多重测定系统。

4. 发明申请

WO2007063423A1 TWO STEP LATERAL FLOW ASSAY METHODS AND DEVICES 审中-公开
标题翻译：两步法横向流动分析方法和装置
公开(公告)号：WO2007063423A1
公开(公告)日：2007-06-07
申请号：PCT/IB2006/003976
申请日：2006-05-23
申请人： PHADIA AB , RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
发明人： RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/558 , G01N33/543 , G01N33/6854 , G01N2800/24 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/821 , Y10T436/25125 , Y10T436/255
摘要： Lateral flow assay devices and methods for detecting a first member of a specific binding pair in a sample which comprises a plurality of nonspecific binding pair members are adapted for two step determinations. In one embodiment, a two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location The two step method further comprises allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and is dried on the lateral flow matrix at a location upstream of the delivery of the filtered sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a location downstream of the first location. Further embodiments comprise additional lateral flow immunoassay devices and methods for identifying IgE antibodies in a sample.
摘要翻译：用于检测包含多个非特异性结合对成员的样品中的特异性结合对的第一成员的侧流测定装置和方法适于两步测定。在一个实施方案中，用于鉴定样品中的IgE抗体的两步横向流动测定方法包括将样品应用于装置的样品端口，其中所述装置适于将样品递送至具有多种IgE抗原的横向流动基质固定在第一位置的相应位置处的物质。所述两步法还包括使样品沿横向流动基质通过固定化的多种IgE抗原物质行进到第一位置下游的第二位置，将液体缓冲液施加到侧流基质以调动适于结合抗IgE抗体的标记试剂，并在侧向流动基质上在过滤样品递送至侧流基质的上游位置处干燥，并允许由液体缓冲剂移动的标记试剂行进沿着横向流动基质通过固定化的多个IgE抗原物种到达第一位置下游的位置。进一步的实施方式包括用于鉴定样品中的IgE抗体的附加横向流动免疫测定装置和方法。

5. 发明申请

WO2012025077A3 VERFAHREN ZUR SCHNELLEN SEROLOGISCHEN DIAGNOSTIK EINES SALMONELLENSUBTYPS 审中-公开
公开(公告)号：WO2012025077A3
公开(公告)日：2012-03-01
申请号：PCT/DE2011/001409
申请日：2011-07-06
申请人： BIOSERV ANALYTIK UND MEDIZINPRODUKTE GMBH , MEYER, Udo , STEINMANN, Alain , FAHLANDT, Heike , FIEDLER, Raimund , MATSSON, Per , SCHULZ, Babette
发明人： MEYER, Udo , STEINMANN, Alain , FAHLANDT, Heike , FIEDLER, Raimund , MATSSON, Per , SCHULZ, Babette
IPC分类号： G01N33/569 , G01N33/558
摘要： Die Erfindung betrifft ein diagnostisches Verfahren zur Erkennung einer Salmonelleninfektion bzw. Salmonellenkontamination. Anwendungsgebiete sind die Medizin, Veterinärmedizin und verschiedene Zweige der Industrie. Das Ziel der Erfindung besteht darin, einen zuverlässigen Test zum Nachweis von Salmonellen zu entwickeln. Ihr liegt die Aufgabe zugrunde, ein Verfahren aufzubauen, welches einen möglichst frühen Nachweis ermöglicht und alle humanpathogenen Serovare erfasst. Das erfindungsgemäße diagnostische Verfahren zur Erkennung eines Salmonellensubtyps ist dadurch gekennzeichnet, dass in Exkreten von Patienten/Tieren, Schlachtkörpern, Eiern und Lebens-/Futtermitteln der spezielle Salmonellen-Serotyp durch eine Kombination einer multiplen Anzahl von spezifischen Antikörpern gegen H- und O-Antigene in einem immunologischen 1-/2-Schritt-Verfahren eindeutig und in wesentlich kürzerer Zeit als derzeit möglich, bestimmt wird.

6. 发明授权

EP2756312B1 CALIBRATION REAGENT AND METHOD 有权
标题翻译：校准试剂和方法
公开(公告)号：EP2756312B1
公开(公告)日：2016-04-20
申请号：EP12775854.8
申请日：2012-09-14
申请人： Phadia AB
发明人： ELFVERSON, Göran , MATSSON, Per , NYSTRAND, Mats
IPC分类号： G01N33/96 , G01N33/68 , G01N33/53 , C07K16/00
CPC分类号： G01N33/5302 , C07K16/00 , G01N33/6854 , G01N33/96

7. 发明公开

EP3743919A1 METHOD FOR THE HARMONIZATION OF ASSAY RESULTS 审中-实审
公开(公告)号：EP3743919A1
公开(公告)日：2020-12-02
申请号：EP19706807.5
申请日：2019-01-22
申请人： Phadia AB
发明人： MATSSON, Per , ANDERSSON, Karl , BERNARDO, Joseph
IPC分类号： G16H10/40 , G06F5/01

8. 发明公开

EP2577308A1 METHOD FOR DECISION SUPPORT IN ALLERGY DIAGNOSIS 审中-公开
标题翻译：决策支持在过敏诊断中的方法
公开(公告)号：EP2577308A1
公开(公告)日：2013-04-10
申请号：EP11790083.7
申请日：2011-05-27
申请人： Phadia AB
发明人： ANDERSSON, Karl , MATSSON, Per
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G06F19/34 , G01N33/68 , G01N2800/24
摘要： A method of providing a clinical decision support in allergy diagnosis comprises the steps of: a) providing a body fluid sample from a patient, b) selecting (1 10) a plurality of allergens to be tested for in the sample, c) determining (120) for each allergen the concentration in the sample of at least one immunoglobulin directed against the allergen, d) transforming (130) each determined immunoglobulin concentration to a clinical effect value on a normalized scale common to allergens in general, e) assigning to each allergen tested for, based on known cross-reactivity information for the allergen, an allergen specificity value, representing the degree of cross-reactivity for the allergen, and f) presenting (140) determined clinical effect and allergen specificity values for each allergen, or a group or groups of the allergens. A computer-implemented method, a computer program product, and a patient information carrier device containing a diagnosis result are also disclosed.
摘要翻译：在过敏诊断中提供临床决策支持的方法包括以下步骤：a）提供来自患者的体液样品，b）选择（110）样品中要测试的多种过敏原，c）确定（ 120）针对每种过敏原的至少一种针对过敏原的免疫球蛋白的样品中的浓度，d）将每种测定的免疫球蛋白浓度转化（130）到一般归因于过敏原常用规格化等级的临床效应值，e）基于过敏原的已知交叉反应性信息，过敏原特异性值，代表过敏原的交叉反应性程度，和f）呈现（140）确定的每种过敏原的临床效果和过敏原特异性值，或一组或多组过敏原。还公开了包含诊断结果的计算机实现的方法，计算机程序产品和患者信息载体设备。

9. 发明公开

EP1891447A1 TWO STEP LATERAL FLOW ASSAY METHODS AND DEVICES 有权
标题翻译：方法及装置有两个台阶的侧向流试验
公开(公告)号：EP1891447A1
公开(公告)日：2008-02-27
申请号：EP06847250.5
申请日：2006-05-23
申请人： Phadia AB
发明人： RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/558 , G01N33/543 , G01N33/6854 , G01N2800/24 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/821 , Y10T436/25125 , Y10T436/255
摘要： Lateral flow assay devices and methods for detecting a first member of a specific binding pair in a sample which comprises a plurality of nonspecific binding pair members are adapted for two step determinations. In one embodiment, a two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location The two step method further comprises allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and is dried on the lateral flow matrix at a location upstream of the delivery of the filtered sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a location downstream of the first location. Further embodiments comprise additional lateral flow immunoassay devices and methods for identifying IgE antibodies in a sample.

10. 发明公开

EP2238457A1 A NOVEL METHOD FOR ASSESSING IF SYMPTOMS IN A PATIENT ARE RELATED TO A HYPERSENSITIVITY TO A SPECIFIC ALLERGEN 审中-公开
标题翻译：用于评估症状可能的关联的新方法，在患者与过度敏感到过敏原特异性
公开(公告)号：EP2238457A1
公开(公告)日：2010-10-13
申请号：EP08853942.4
申请日：2008-12-01
申请人： Phadia AB
发明人： SÖDERSTRÖM, Lars , AHLSTEDT, Staffan , MATSSON, Per , CUSTOVIC, Adnan
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6854 , G01N2800/24
摘要： The present invention relates to the field of allergic diseases, and especially to methods for assessing if symptoms in a patient are related to a hypersensitivity to a specific allergen. Furthermore the invention relates to a computer program product comprising means for controlling the steps of said methods for use with an apparatus for analysis of binding assays. The invention also relates to such an apparatus.

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