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1. 发明申请

WO2007063423A1 TWO STEP LATERAL FLOW ASSAY METHODS AND DEVICES 审中-公开
标题翻译：两步法横向流动分析方法和装置
公开(公告)号：WO2007063423A1
公开(公告)日：2007-06-07
申请号：PCT/IB2006/003976
申请日：2006-05-23
申请人： PHADIA AB , RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
发明人： RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/558 , G01N33/543 , G01N33/6854 , G01N2800/24 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/821 , Y10T436/25125 , Y10T436/255
摘要： Lateral flow assay devices and methods for detecting a first member of a specific binding pair in a sample which comprises a plurality of nonspecific binding pair members are adapted for two step determinations. In one embodiment, a two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location The two step method further comprises allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and is dried on the lateral flow matrix at a location upstream of the delivery of the filtered sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a location downstream of the first location. Further embodiments comprise additional lateral flow immunoassay devices and methods for identifying IgE antibodies in a sample.
摘要翻译：用于检测包含多个非特异性结合对成员的样品中的特异性结合对的第一成员的侧流测定装置和方法适于两步测定。在一个实施方案中，用于鉴定样品中的IgE抗体的两步横向流动测定方法包括将样品应用于装置的样品端口，其中所述装置适于将样品递送至具有多种IgE抗原的横向流动基质固定在第一位置的相应位置处的物质。所述两步法还包括使样品沿横向流动基质通过固定化的多种IgE抗原物质行进到第一位置下游的第二位置，将液体缓冲液施加到侧流基质以调动适于结合抗IgE抗体的标记试剂，并在侧向流动基质上在过滤样品递送至侧流基质的上游位置处干燥，并允许由液体缓冲剂移动的标记试剂行进沿着横向流动基质通过固定化的多个IgE抗原物种到达第一位置下游的位置。进一步的实施方式包括用于鉴定样品中的IgE抗体的附加横向流动免疫测定装置和方法。

2. 发明公开

EP1891447A1 TWO STEP LATERAL FLOW ASSAY METHODS AND DEVICES 有权
标题翻译：方法及装置有两个台阶的侧向流试验
公开(公告)号：EP1891447A1
公开(公告)日：2008-02-27
申请号：EP06847250.5
申请日：2006-05-23
申请人： Phadia AB
发明人： RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/558 , G01N33/543 , G01N33/6854 , G01N2800/24 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/821 , Y10T436/25125 , Y10T436/255
摘要： Lateral flow assay devices and methods for detecting a first member of a specific binding pair in a sample which comprises a plurality of nonspecific binding pair members are adapted for two step determinations. In one embodiment, a two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location The two step method further comprises allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and is dried on the lateral flow matrix at a location upstream of the delivery of the filtered sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a location downstream of the first location. Further embodiments comprise additional lateral flow immunoassay devices and methods for identifying IgE antibodies in a sample.

3. 发明授权

EP1891447B1 TWO STEP LATERAL FLOW ASSAY METHODS AND DEVICES 有权
标题翻译：方法及装置有两个台阶的侧向流试验
公开(公告)号：EP1891447B1
公开(公告)日：2011-07-06
申请号：EP06847250.5
申请日：2006-05-23
申请人： Phadia AB
发明人： RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/558 , G01N33/543 , G01N33/6854 , G01N2800/24 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/821 , Y10T436/25125 , Y10T436/255
摘要： Lateral flow assay devices and methods for detecting a first member of a specific binding pair in a sample which comprises a plurality of nonspecific binding pair members are adapted for two step determinations. In one embodiment, a two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location The two step method further comprises allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and is dried on the lateral flow matrix at a location upstream of the delivery of the filtered sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a location downstream of the first location. Further embodiments comprise additional lateral flow immunoassay devices and methods for identifying IgE antibodies in a sample.

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