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1. 发明专利

IL291650A Polyheterocyclic modulators of sting (stimulator of interferon genes) 未知
公开(公告)号：IL291650A
公开(公告)日：2022-05-01
申请号：IL29165022
申请日：2022-03-23
申请人： PFIZER , ANDREW FENSOME , ETHAN LAWRENCE FISHER , KETAN S GAJIWALA , CHAN WOO HUH , MEHRAN JALAIE , INDRAWAN JAMES MCALPINE , RYAN PATMAN , EUGENE YUANJIN RUI , TUAN PHONG TRAN , MARTIN JAMES WYTHES , LEI ZHANG , DAHUI ZHOU
发明人： ANDREW FENSOME , ETHAN LAWRENCE FISHER , KETAN S GAJIWALA , CHAN WOO HUH , MEHRAN JALAIE , INDRAWAN JAMES MCALPINE , RYAN PATMAN , EUGENE YUANJIN RUI , TUAN PHONG TRAN , MARTIN JAMES WYTHES , LEI ZHANG , DAHUI ZHOU
摘要： Compounds of the general formula (I), or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

2. 发明专利

IL291650D0 Polyheterocyclic modulators of sting (stimulator of interferon genes) 未知
公开(公告)号：IL291650D0
公开(公告)日：2022-05-01
申请号：IL29165022
申请日：2022-03-23
申请人： PFIZER , ANDREW FENSOME , ETHAN LAWRENCE FISHER , KETAN S GAJIWALA , CHAN WOO HUH , MEHRAN JALAIE , INDRAWAN JAMES MCALPINE , RYAN PATMAN , EUGENE YUANJIN RUI , TUAN PHONG TRAN , MARTIN JAMES WYTHES , LEI ZHANG , DAHUI ZHOU
发明人： ANDREW FENSOME , ETHAN LAWRENCE FISHER , KETAN S GAJIWALA , CHAN WOO HUH , MEHRAN JALAIE , INDRAWAN JAMES MCALPINE , RYAN PATMAN , EUGENE YUANJIN RUI , TUAN PHONG TRAN , MARTIN JAMES WYTHES , LEI ZHANG , DAHUI ZHOU
IPC分类号： A61K31/4196 , A61K31/424 , A61K31/427 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/5386 , A61K38/21 , A61K39/395 , A61K47/68 , A61P35/00
摘要： Compounds of the general formula (I), or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

3. 发明专利

IL289877D0 Imidazo[4,5-c]pyridine derivatives as toll-like receptor agonists 未知
公开(公告)号：IL289877D0
公开(公告)日：2022-03-01
申请号：IL28987722
申请日：2022-01-16
申请人： PFIZER , OMAR AHMAD , ANDREW FENSOME , ETHAN LAWRENCE FISHER , ERIK ALPHIE LACHAPELLE , RAYOMAND J UNWALLA , JUN XIAO , LEI ZHANG
发明人： OMAR AHMAD , ANDREW FENSOME , ETHAN LAWRENCE FISHER , ERIK ALPHIE LACHAPELLE , RAYOMAND J UNWALLA , JUN XIAO , LEI ZHANG
IPC分类号： A61K31/437 , A61P35/00
摘要： The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

4. 发明专利

IL248277D0 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yl amides 未知
公开(公告)号：IL248277D0
公开(公告)日：2016-11-30
申请号：IL24827716
申请日：2016-10-09
申请人： PFIZER , LEI ZHANG , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRIAN THOMAS ONEILL , GABRIELA BARREIRO , ERIK ALPHIE LACHAPELLE , BRUCE NELSEN ROGERS
发明人： LEI ZHANG , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRIAN THOMAS O'NEILL , GABRIELA BARREIRO , ERIK ALPHIE LACHAPELLE , BRUCE NELSEN ROGERS
IPC分类号： C07D20060101
摘要： and the variable R1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

5. 发明专利

IL237537A Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks 未知
公开(公告)号：IL237537A
公开(公告)日：2020-05-31
申请号：IL23753715
申请日：2015-03-03
申请人： DOW AGROSCIENCES LLC , SANGAMO THERAPEUTICS INC , STEVEN R WEBB , WILLIAM MICHAEL AINLEY , DMITRY Y GUSCHIN , JEFFREY C MILLER , PON SAMUEL , LEI ZHANG
发明人： STEVEN R WEBB , WILLIAM MICHAEL AINLEY , DMITRY Y GUSCHIN , JEFFREY C MILLER , PON SAMUEL , LEI ZHANG
IPC分类号： A01H1/06 , A01H5/00 , A01H5/10 , C12N5/04 , C12N5/10 , C12N9/22 , C12N15/10 , C12N15/66 , C12N15/82 , C12N15/90
摘要： Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.

6. 发明申请

US20120208969A1 ZIEGLER-NATTA CATALYSTS DOPED WITH NON-GROUP IV METAL CHLORIDES 有权
标题翻译： ZIEGLER-NATTA催化剂与非IV族金属氯化物反应
公开(公告)号：US20120208969A1
公开(公告)日：2012-08-16
申请号：US13028393
申请日：2011-02-16
申请人： LEI ZHANG , David Knoeppel
发明人： LEI ZHANG , David Knoeppel
IPC分类号： C08F4/602 , B01J31/14
CPC分类号： C08F4/6421 , C08F10/00 , C08F10/02 , C08F110/02 , C08F2410/03 , C08F4/6557 , C08F4/6574 , C08F2500/04 , C08F2500/07 , C08F2500/11 , C08F2500/12 , C08F2500/17 , C08F2500/18 , C08F2500/20 , C08F2500/23 , C08F2500/26
摘要： Ziegler-Natta catalysts, processes of forming the same and using the same are described herein. The process generally includes contacting a metal component with a magnesium dihalide support material to form a Ziegler-Natta catalyst precursor; contacting the support material with a dopant including a non-Group IV metal halide to form a doped catalyst precursor; and activating the doped catalyst precursor by contact with an organoaluminum compound to form a Ziegler-Natta catalyst.
摘要翻译：齐格勒 - 纳塔催化剂，其形成方法和使用它们的方法在本文中描述。该方法通常包括使金属组分与二卤化镁载体材料接触以形成齐格勒 - 纳塔催化剂前体; 使载体材料与包含非IV族金属卤化物的掺杂剂接触以形成掺杂的催化剂前体; 并通过与有机铝化合物接触来活化掺杂的催化剂前体以形成齐格勒 - 纳塔催化剂。

7. 发明申请

US20120202955A1 ZIEGLER-NATTA CATALYST COMPOSITION WITH CONTROLLED MORPHOLOGY 审中-公开
标题翻译： ZIEGLER-NATTA催化剂组合物与控制形态
公开(公告)号：US20120202955A1
公开(公告)日：2012-08-09
申请号：US13022021
申请日：2011-02-07
申请人： LEI ZHANG , Kenneth Blackmon , David Rauscher
发明人： LEI ZHANG , Kenneth Blackmon , David Rauscher
IPC分类号： C08F4/60
CPC分类号： C08F10/00 , C08F110/02 , C08F4/6557 , C08F2500/04 , C08F2500/11 , C08F2500/12 , C08F2500/17 , C08F2500/18 , C08F2500/20 , C08F2500/23 , C08F2500/26
摘要： Catalyst Systems, processes of forming the same and polymers and polymerization processes are described herein. The process of forming the catalyst system generally includes providing a first compound including a magnesium dialkoxide and aluminum alkoxide: contacting the first compound with a first agent and a second agent to form a solution of reaction product “A”, the first agent including a titanating agent and the second agent including a first metal halide; contacting the solution of reaction product “A” with a third agent to form a solid reaction product “B”, the third agent including a second metal halide: contacting the solid reaction product “B” with a fourth agent to form a solid reaction product “C”, the fourth agent including a third metal halide: optionally contacting the solid reaction product “C” with a fifth agent to form a solid reaction product “D”, the fifth agent including a fourth metal halide; and contacting the solid reaction product “C” or “D” with a sixth agent to form a catalyst component, the sixth agent including a first organoaluminum compound.
摘要翻译：催化剂体系，其形成方法，聚合物和聚合方法在本文中描述。形成催化剂体系的方法通常包括提供包含二烷氧基镁和烷氧化铝的第一化合物：使第一化合物与第一试剂和第二试剂接触以形成反应产物“A”的溶液，第一试剂包括滴定试剂和第二试剂包括第一金属卤化物; 使反应产物“A”的溶液与第三试剂接触以形成固体反应产物“B”，第三试剂包括第二金属卤化物：使固体反应产物“B”与第四试剂接触以形成固体反应产物 “C”，第四剂包括第三金属卤化物：任选地使固体反应产物“C”与第五试剂接触以形成固体反应产物“D”，第五试剂包括第四金属卤化物; 并使固体反应产物“C”或“D”与第六试剂接触以形成催化剂组分，第六试剂包括第一有机铝化合物。

8. 发明申请

US20090172602A1 TECHNIQUE THAT ENHANCES THE MANIPULATION OF AN HTML TREE PRESENTATION BY USING AN ARRAY REPRESENTATION OF THE HIERARCHICAL PATH OF A TREE NODE 有权
标题翻译：通过使用一个树节点的分层路径的阵列表示来增强对HTML TREE演示的操纵的技术
公开(公告)号：US20090172602A1
公开(公告)日：2009-07-02
申请号：US11968278
申请日：2008-01-02
申请人： TREVETT B. CHUSING , LEI ZHANG , JIAN ZHU
发明人： TREVETT B. CHUSING , LEI ZHANG , JIAN ZHU
IPC分类号： G06F3/048 , G06F3/00
CPC分类号： G06F17/2247 , G06F17/2241
摘要： The present invention discloses a method for manipulating the presentation of an AJAX tree using an array representing the hierarchical path of a tree node. Such a method can begin with the receipt of a user-request to expand a selected tree node of an AJAX tree in a Web page. Next, it can be determined if the tree node is present in the existing path array. When the tree node is present in the existing path array, the existing path array can be modified for the selected tree node. A new path array can be requested from the AJAX engine when the tree node does not exist in the existing path array. A path array handler can be invoked to expand the AJAX tree using the existing path array.
摘要翻译：本发明公开了一种使用表示树节点的分层路径的阵列来操纵AJAX树的呈现的方法。这种方法可以从接收用户请求开始，以扩展Web页面中的AJAX树的选定的树节点。接下来，可以确定树节点是否存在于现有路径数组中。当现有路径数组中存在树节点时，可以为所选树节点修改现有路径数组。当树节点不存在于现有路径数组中时，可以从AJAX引擎请求新的路径数组。可以调用路径数组处理程序以使用现有的路径数组来扩展AJAX树。

9. 发明申请

US20120208970A1 HEAT-TREATED ZIEGLER-NATTA CATALYSTS FOR ETHYLENE POLYMERIZATION 有权
标题翻译：用于乙烯聚合的热处理ZIEGLER-NATTA催化剂
公开(公告)号：US20120208970A1
公开(公告)日：2012-08-16
申请号：US13028390
申请日：2011-02-16
申请人： LEI ZHANG , David Knoeppel
发明人： LEI ZHANG , David Knoeppel
IPC分类号： C08F4/642 , B01J31/38
CPC分类号： C08F10/00 , C08F110/02 , C08F4/6557 , C08F2500/04 , C08F2500/11 , C08F2500/12 , C08F2500/17 , C08F2500/18 , C08F2500/20 , C08F2500/23 , C08F2500/26
摘要： Catalyst systems, processes of forming the same and polymers formed therefrom are described herein. The processes of forming the catalyst systems generally include contacting a blend of an alkyl magnesium compound and an organoaluminum compound with an alcohol to form a magnesium dialkoxide compound; contacting the magnesium dialkoxide compound with a first agent to form a solution of reaction product “A”, the first agent including a halogenating/titanating agent; contacting the solution of reaction product “A” with a second agent to form a solid reaction product “B”, the second agent including a blend of a first metal halide and a metal alkoxide; contacting the solid reaction product “B” with a third agent to form a solid reaction product “C”, the third agent including a second metal halide; contacting the solid reaction product “C” with a fourth agent to form a solid reaction product “D”, the fourth agent including a third metal halide; contacting the solid reaction product “D” with a fifth agent to form a catalyst component, the fifth agent including a reducing agent; and heating an intermediate selected from reaction product “A”, reaction product “B”, reaction product “C”, reaction product “D” and combinations thereof to form a heat-treated catalyst that results in a shear response and a molecular weight distribution for a polymer produced by the heat-treated catalyst that are greater than a shear response and a molecular weight distribution for a polymer produced by an identical non-heat-treated catalyst.
摘要翻译：本文描述了催化剂体系，其形成方法和由其形成的聚合物。形成催化剂体系的方法通常包括使烷基镁化合物和有机铝化合物的混合物与醇接触以形成二烷氧基镁化合物; 使二烷氧基镁化合物与第一试剂接触以形成反应产物“A”的溶液，第一试剂包括卤化/钛化剂; 使反应产物“A”的溶液与第二试剂接触以形成固体反应产物“B”，第二试剂包括第一金属卤化物和金属醇盐的共混物; 使固体反应产物“B”与第三试剂接触以形成固体反应产物“C”，第三试剂包括第二金属卤化物; 使固体反应产物“C”与第四试剂接触以形成固体反应产物“D”，第四试剂包括第三金属卤化物; 使固体反应产物“D”与第五试剂接触以形成催化剂组分，第五试剂包括还原剂; 并加热选自反应产物“A”，反应产物“B”，反应产物“C”，反应产物“D”及其组合的中间体，以形成导致剪切响应和分子量分布的热处理催化剂对于由热处理催化剂制备的聚合物，该聚合物大于由相同的非热处理催化剂制备的聚合物的剪切响应和分子量分布。

10. 发明申请

US20120133158A1 SEALING FASTENER 失效
标题翻译：密封紧固件
公开(公告)号：US20120133158A1
公开(公告)日：2012-05-31
申请号：US13014732
申请日：2011-01-27
申请人： LEI ZHANG
发明人： LEI ZHANG
IPC分类号： E05C19/00
CPC分类号： B65D63/1081 , Y10T292/48 , Y10T292/507
摘要： A plastic sealing fastener includes a fixing member, a latching strip fixed on the fixing member and a cover mounted on the fixing member. The fixing member defines a locking hole through which the latching strip passes. The fixing member forms a plurality of elastic teeth locking the latching strip in the locking hole. The cover defines a covering hole communicating with the locking hole through which the latching strip passes. A diameter of the covering hole is less than that of the locking hole.
摘要翻译：塑料密封紧固件包括固定构件，固定在固定构件上的闩锁条和安装在固定构件上的盖。固定构件限定锁定孔通过的锁定孔。固定构件形成将锁定条锁定在锁定孔中的多个弹性齿。盖子限定了与锁定孔通过的锁定孔连通的覆盖孔。覆盖孔的直径小于锁定孔的直径。

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