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1. 发明专利

IL248277D0 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yl amides 未知
公开(公告)号：IL248277D0
公开(公告)日：2016-11-30
申请号：IL24827716
申请日：2016-10-09
申请人： PFIZER , LEI ZHANG , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRIAN THOMAS ONEILL , GABRIELA BARREIRO , ERIK ALPHIE LACHAPELLE , BRUCE NELSEN ROGERS
发明人： LEI ZHANG , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRIAN THOMAS O'NEILL , GABRIELA BARREIRO , ERIK ALPHIE LACHAPELLE , BRUCE NELSEN ROGERS
IPC分类号： C07D20060101
摘要： and the variable R1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

2. 发明专利

IL257203A 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors 未知
公开(公告)号：IL257203A
公开(公告)日：2020-08-31
申请号：IL25720318
申请日：2018-01-29
申请人： PFIZER , CHRISTOPHER JOHN HELAL , PATRICK ROBERT VERHOEST , LAURA ANN MCALLISTER , ADAM MATTHEW GILBERT , JUSTIN IAN MONTGOMERY , DOUGLAS SCOTT JOHNSON , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRUCE NELSEN ROGERS , STEVEN VICTOR ONEIL , DAMIEN WEBB
发明人： CHRISTOPHER JOHN HELAL , PATRICK ROBERT VERHOEST , LAURA ANN MCALLISTER , ADAM MATTHEW GILBERT , JUSTIN IAN MONTGOMERY , DOUGLAS SCOTT JOHNSON , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRUCE NELSEN ROGERS , STEVEN VICTOR O'NEIL , DAMIEN WEBB
IPC分类号： C07F9/6561
摘要： and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

3. 发明专利

IL257203D0 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors 未知
公开(公告)号：IL257203D0
公开(公告)日：2018-03-29
申请号：IL25720318
申请日：2018-01-29
申请人： PFIZER , CHRISTOPHER JOHN HELAL , PATRICK ROBERT VERHOEST , LAURA ANN MCALLISTER , ADAM MATTHEW GILBERT , JUSTIN IAN MONTGOMERY , DOUGLAS SCOTT JOHNSON , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRUCE NELSEN ROGERS , STEVEN VICTOR ONEIL , DAMIEN WEBB
发明人： CHRISTOPHER JOHN HELAL , PATRICK ROBERT VERHOEST , LAURA ANN MCALLISTER , ADAM MATTHEW GILBERT , JUSTIN IAN MONTGOMERY , DOUGLAS SCOTT JOHNSON , MICHAEL AARON BRODNEY , ELIZABETH MARY BECK , CHRISTOPHER RYAN BUTLER , BRUCE NELSEN ROGERS , STEVEN VICTOR O'NEIL , DAMIEN WEBB
IPC分类号： C07D20060101
摘要： and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

4. 发明申请

US20140336176A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS 审中-公开
标题翻译：异构化合物及其作为多巴胺D1配体使用
公开(公告)号：US20140336176A1
公开(公告)日：2014-11-13
申请号：US14339123
申请日：2014-07-23
申请人： PFIZER INC.
发明人： JENNIFER ELIZABETH DAVOREN , AMY BETH DOUNAY , IVAN VIKTOROVICH EFREMOV , DAVID LAWRENCE FIRMAN GRAY , SCOT RICHARD MENTE , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , CHAKRAPANI SUBRAMANYAM , LEI ZHANG
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D401/04 , C07D401/14 , C07D519/00
摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides of the foregoing; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, salts or N-oxides, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, impulsivity, compulsive gambling, overeating, autism spectrum disorder, MCI, age-related cognitive decline, dementia, RLS, Parkinson's disease, Huntington's chorea, anxiety, depression, MDD, TRD, and bipolar disorder.
摘要翻译：本发明部分提供式I化合物及其药学上可接受的盐和上述的N-氧化物; 制备过程; 中间体用于制备; 和含有这些化合物，盐或N-氧化物的组合物及其用于治疗D1介导的（或D1相关）疾病的用途，包括例如精神分裂症（例如，其认知和负面症状），认知障碍（例如，认知障碍相关精神分裂症，AD，PD或药物治疗），ADHD，冲动，强迫性赌博，暴饮暴食，孤独症谱系障碍，MCI，年龄相关认知衰退，痴呆，RLS，帕金森病，亨廷顿舞蹈病，焦虑，抑郁，MDD，TRD 和双相情感障碍。

5. 发明申请

US20140128374A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS 有权
公开(公告)号：US20140128374A1
公开(公告)日：2014-05-08
申请号：US14072563
申请日：2013-11-05
申请人： PFIZER INC.
发明人： JENNIFER ELIZABETH DAVOREN , AMY BETH DOUNAY , IVAN VIKTOROVICH EFREMOV , DAVID LAWRENCE FIRMAN GRAY , SCOT RICHARD MENTE , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , CHAKRAPANI SUBRAMANYAM , LEI ZHANG
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D401/04 , C07D401/14 , C07D519/00
摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides of the foregoing; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, salts or N-oxides, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, impulsivity, compulsive gambling, overeating, autism spectrum disorder, MCI, age-related cognitive decline, dementia, RLS, Parkinson's disease, Huntington's chorea, anxiety, depression, MDD, TRD, and bipolar disorder.

6. 发明申请

US20190002439A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS 审中-公开
公开(公告)号：US20190002439A1
公开(公告)日：2019-01-03
申请号：US16123072
申请日：2018-09-06
申请人： PFIZER INC.
发明人： MICHAEL AARON BRODNEY , JENNIFER ELIZABETH DAVOREN , AMY BETH DOUNAY , IVAN VIKTOROVICH EFREMOV , DAVID LAWRENCE FIRMAN GRAY , MICHAEL ERIC GREEN , JACLYN LOUISE HENDERSON , CHEWAH LEE , SCOT RICHARD MENTE , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , LEI ZHANG
IPC分类号： C07D401/14 , A61K31/513 , A61K31/501 , A61K31/506 , C07D405/14 , C07D403/12 , C07D401/12 , A61K31/444
CPC分类号： C07D401/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/513 , C07D401/12 , C07D403/12 , C07D405/14
摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), and Parkinson's disease.

7. 发明申请

US20180065943A1 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS 审中-公开
公开(公告)号：US20180065943A1
公开(公告)日：2018-03-08
申请号：US15808242
申请日：2017-11-09
申请人： PFIZER INC.
发明人： CHRISTOPHER RYAN BUTLER , LAURA ANN MCALLISTER , ELIZABETH MARY BECK , MICHAEL AARON BRODNEY , ADAM MATTHEW GILBERT , CHRISTOPHER JOHN HELAL , DOUGLAS SCOTT JOHNSON , JUSTIN IAN MONTGOMERY , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , PATRICK ROBERT VERHOEST , DAMIEN WEBB
IPC分类号： C07D295/14 , C07D405/14 , C07D413/14 , C07D515/10 , C07D471/08 , C07D211/48 , C07D487/04 , C07D471/10 , C07D401/12 , C07D491/107 , C07D498/10 , C07D403/04 , C07D401/04 , C07D401/14 , C07D493/10 , C07D405/12 , C07F9/6561
CPC分类号： C07D295/14 , C07D211/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/107 , C07D493/10 , C07D498/10 , C07D515/10 , C07F9/6561
摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

8. 发明申请

US20170057947A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS 审中-公开
标题翻译：异构化合物及其作为多巴胺D1配体使用
公开(公告)号：US20170057947A1
公开(公告)日：2017-03-02
申请号：US15349075
申请日：2016-11-11
申请人： PFIZER INC.
发明人： MICHAEL AARON BRODNEY , JENNIFER ELIZABETH DAVOREN , AMY BETH DOUNAY , IVAN VIKTOROVICH EFREMOV , DAVID LAWRENCE FIRMAN GRAY , MICHAEL ERIC GREEN , JACLYN LOUISE HENDERSON , CHEWAH LEE , SCOT RICHARD MENTE , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , LEI ZHANG
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12
CPC分类号： C07D401/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/513 , C07D401/12 , C07D403/12 , C07D405/14
摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, impulsivity, compulsive gambling, overeating, autism spectrum disorder, MCl, age-related cognitive decline, dementia, RLS, Parkinson's disease, Huntington's chorea, anxiety, depression, MDD, TRD, bipolar disorder, chronic apathy, anhedonia, chronic fatigue, post-traumatic stress disorder, seasonal affective disorder, social anxiety disorder, post-partum depression, serotonin syndrome, substance abuse and drug dependence, drug abuse relapse, Tourette's syndrome, tardive dyskinesia, drowsiness, excessive daytime sleepiness, cachexia, inattention, sexual dysfunction, migraine, SLE, hyperglycemia, atherosclerosis, dislipidemia, obesity, diabetes, sepsis, post-ischemic tubular necrosis, renal failure, hyponatremia, resistant edema, narcolepsy, hypertension, congestive heart failure, postoperative ocular hypotonia, sleep disorders, and pain.
摘要翻译：及其药学上可接受的盐; 制备过程; 中间体用于制备; 和含有这些化合物或盐的组合物及其用于治疗D1介导的（或D1相关）疾病的用途，包括例如精神分裂症（例如，其认知和负面症状），认知障碍（例如，与精神分裂症相关的认知障碍，AD ，PD或药物治疗），ADHD，冲动性，强迫性赌博，暴饮暴食，孤独症谱系障碍，MCl，年龄相关认知衰退，痴呆，RLS，帕金森病，亨廷顿舞蹈症，焦虑症，抑郁症，MDD，TRD，双相情感障碍，慢性冷漠，慢性疲劳，创伤后应激障碍，季节性情绪障碍，社会焦虑症，产后抑郁症，血清素综合征，药物滥用和毒品依赖，药物滥用复发，Tourette综合征，迟发性运动障碍，嗜睡，白天过度嗜睡，恶病质，注意力不集中，性功能障碍，偏头痛，SLE，高血糖症，动脉粥样硬化，血脂异常，肥胖，糖尿病，败血症，缺血后小管坏死，肾衰竭，低钠血症，抗性水肿，发作性睡病，高血压，充血性心力衰竭，术后眼睛低血压，睡眠障碍和疼痛。

9. 发明申请

US20180346477A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS 审中-公开
公开(公告)号：US20180346477A1
公开(公告)日：2018-12-06
申请号：US16100668
申请日：2018-08-10
申请人： PFIZER INC.
发明人： DAVID LAWRENCE FIRMAN GRAY , LEI ZHANG , JENNIFER ELIZABETH DAVOREN , AMY BETH DOUNAY , IVAN VIKTOROVICH EFREMOV , CHEWAH LEE , SCOT RICHARD MENTE , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , CHAKRAPANI SUBRAMANYAM
IPC分类号： C07D491/048 , C07D498/04 , C07D471/04
CPC分类号： C07D491/048 , C07D471/04 , C07D498/04
摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.

10. 发明申请

US20180072750A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS 审中-公开
公开(公告)号：US20180072750A1
公开(公告)日：2018-03-15
申请号：US15822493
申请日：2017-11-27
申请人： PFIZER INC.
发明人： DAVID LAWRENCE FIRMAN GRAY , LEI ZHANG , JENNIFER ELIZABETH DAVOREN , AMY BETH DOUNAY , IVAN VIKTOROVICH EFREMOV , CHEWAH LEE , SCOT RICHARD MENTE , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , CHAKRAPANI SUBRAMANYAM
IPC分类号： C07D491/048 , C07D498/04 , C07D471/04
CPC分类号： C07D491/048 , C07D471/04 , C07D498/04
摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.

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