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1. 发明申请

WO2010037395A3 MHC MULTIMERS IN CANCER VACCINES AND IMMUNE MONITORING 审中-公开
标题翻译：癌症疫苗中的MHC多聚体和免疫监测
公开(公告)号：WO2010037395A3
公开(公告)日：2010-05-20
申请号：PCT/DK2009050255
申请日：2009-10-01
申请人： DAKO DENMARK AS , BRIX LISELOTTE , SCHOELLER JOERGEN , PEDERSEN HENRIK
发明人： BRIX LISELOTTE , SCHOELLER JOERGEN , PEDERSEN HENRIK
IPC分类号： C07K14/705 , A61K39/00 , A61K47/48 , A61P35/00 , G01N33/569
CPC分类号： A61K39/0011 , A61K47/6901 , C07K14/705 , C07K14/70539 , G01N33/56972
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising cancer antigenic peptides and uses there of.
摘要翻译：本发明涉及MHC-肽复合物及其在诊断，治疗或针对个体疾病的疫苗中的用途。更具体地，本发明公开了包含癌抗原肽并在其中使用的MHC复合物。

2. 发明申请

WO2005095336A3 NOVEL METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF VITAMIN D ANALOGUES 审中-公开
标题翻译：制备中间体用于维生素D类似物合成的新方法
公开(公告)号：WO2005095336A3
公开(公告)日：2005-11-10
申请号：PCT/DK2005000203
申请日：2005-03-23
申请人： LEO PHARMA AS , HANSEN ERIK TORNGAARD , SABROE THOMAS PETER , CALVERLEY MARTIN JOHN , PEDERSEN HENRIK , DEUSSEN HEINZ-JOSEF WILHELM
发明人： HANSEN ERIK TORNGAARD , SABROE THOMAS PETER , CALVERLEY MARTIN JOHN , PEDERSEN HENRIK , DEUSSEN HEINZ-JOSEF WILHELM
IPC分类号： C07B37/00 , C07C401/00
CPC分类号： C07C401/00 , C07C2601/02 , C07D333/72
摘要： The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.
摘要翻译：本发明涉及用于制备可用于合成cacipotriol的中间体的新方法。本发明进一步涉及用所述方法产生的中间体用于制造卡泊三醇或卡泊三醇一水合物的用途。

3. 发明申请

WO2004083427A3 LIGATIONAL ENCODING OF SMALL MOLECULES 审中-公开
标题翻译：小分子的编码
公开(公告)号：WO2004083427A3
公开(公告)日：2005-02-17
申请号：PCT/DK2004000195
申请日：2004-03-22
申请人： NUEVOLUTION AS , FRANCH THOMAS , JACOBSEN SOEREN NYBOE , RASMUSSEN TORBEN , NEVE SOEREN , PEDERSEN HENRIK , GOULIAEV ALEX HAAHR
发明人： FRANCH THOMAS , JACOBSEN SOEREN NYBOE , RASMUSSEN TORBEN , NEVE SOEREN , PEDERSEN HENRIK , GOULIAEV ALEX HAAHR
IPC分类号： C12N15/10 , C12P21/02
CPC分类号： C07H21/04 , C12N15/1068 , C12P21/02 , C40B40/06 , C40B50/04
摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.
摘要翻译：本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关联的抗密码子，和ii）将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。

4. 发明申请

WO2004001042A3 MICROARRAYS DISPLAYING ENCODED MOLECULES 审中-公开
标题翻译：微阵列显示编码分子
公开(公告)号：WO2004001042A3
公开(公告)日：2004-03-18
申请号：PCT/DK0300417
申请日：2003-06-20
申请人： NUEVOLUTION AS , FRESKGAARD PER-OLA , PEDERSEN HENRIK
发明人： FRESKGAARD PER-OLA , PEDERSEN HENRIK
IPC分类号： C07H21/00 , C12N15/10 , C12P21/02 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2563/185
摘要： Disclosed is a microarray comprising a plurality of single stranded nucleic acid probes immobilized in discrete areas of a solid support, said probes being hybridised to a library of complexes, wherein each complex comprises an encoded molecule and a template which codes for said molecule, said template comprising a number of codons which codes for chemical entities which upon reaction form a reaction product which at least partly form part of the encoded molecule.
摘要翻译：公开了一种微阵列，其包含固定在固体支持物的离散区域中的多个单链核酸探针，所述探针与复合物文库杂交，其中每个复合物包含编码分子和编码所述分子的模板，所述模板包括编码化学实体的多个密码子，其在反应时形成至少部分形成编码分子的一部分的反应产物。

5. 发明申请

WO2013026501A3 AUTOMATED ROOT CAUSE ANALYSIS 审中-公开
标题翻译：自动原因分析
公开(公告)号：WO2013026501A3
公开(公告)日：2013-07-04
申请号：PCT/EP2011072316
申请日：2011-12-09
申请人： SIEMENS AG , PEDERSEN HENRIK
发明人： PEDERSEN HENRIK
IPC分类号： F01D17/02 , F01D21/00 , F02C9/00 , G01M15/00 , G05B13/02 , G05B23/02 , G06Q10/04 , G06Q10/06 , G07C3/00
CPC分类号： G05B23/02 , F01D17/02 , F01D21/00 , F01D21/003 , F02C9/00 , G05B23/0278 , G06Q10/0631 , G07C3/00
摘要： Automated root cause analysis for a complex product with the following steps: Monitoring the product (2); Detecting a product misbehaviour (3); Forming a misbehaviour pattern (5) with timeslots of normal operation and timeslots of misbehaviour operation (6); Comparing timeslots of the misbehaviour pattern (5) to corresponding timeslots (9) of channels (8) of information in at least one database relating to the product; Measuring how close the misbehaviour pattern (5) fits to the information; and Automatically identifying the best fit.
摘要翻译：通过以下步骤对复杂产品进行自动根本原因分析：监控产品（2）; 检测产品不当行为（3）; 形成不正当行为模式（5）与正常运行时间和不当行为时间（6）; 将不正当行为模式（5）的时隙与至少一个与产品相关的数据库中的信息（8）的相应时隙（9）进行比较; 衡量不当行为模式（5）对信息的接近程度; 并自动识别最佳配合。

6. 发明申请

WO2008116468A8 MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES 审中-公开
标题翻译： MHC肽复合物及其在感染性疾病中的应用
公开(公告)号：WO2008116468A8
公开(公告)日：2011-03-24
申请号：PCT/DK2008000118
申请日：2008-03-26
申请人： DAKO DENMARK AS , SCHOELLER JOERGEN , PEDERSEN HENRIK , BRIX LISELOTTE
发明人： SCHOELLER JOERGEN , PEDERSEN HENRIK , BRIX LISELOTTE
IPC分类号： C07K14/705 , A61K38/17 , A61K39/00 , A61K47/48 , A61P31/00 , G01N33/50
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K49/1896 , G01N33/56905 , G01N33/56911 , G01N33/56972 , G01N33/56977 , G01N33/574 , G01N2333/70539 , G01N2800/24
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC- peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.
摘要翻译：公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物是非常强大的工具，例如，在治疗和诊断领域。本发明一般涉及治疗领域，包括治疗方法和治疗组合物。本发明还包括MHC复合物和MHC多聚体的样品安装用途。

7. 发明申请

WO2008116468A3 MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES 审中-公开
标题翻译： MHC肽复合物及其在感染性疾病中的应用
公开(公告)号：WO2008116468A3
公开(公告)日：2008-12-04
申请号：PCT/DK2008000118
申请日：2008-03-26
申请人： DAKO DENMARK AS , SCHOELLER JOERGEN , PEDERSEN HENRIK , BRIX LISELOTTE
发明人： SCHOELLER JOERGEN , PEDERSEN HENRIK , BRIX LISELOTTE
IPC分类号： C07K14/705 , A61K38/17 , A61K39/00 , A61K47/48 , A61P31/00 , G01N33/50
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K49/1896 , G01N33/56905 , G01N33/56911 , G01N33/56972 , G01N33/56977 , G01N33/574 , G01N2333/70539 , G01N2800/24
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC- peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.
摘要翻译：公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物是非常强大的工具，例如，在治疗和诊断领域。本发明一般涉及治疗领域，包括治疗方法和治疗组合物。本发明还包括MHC复合物和MHC多聚体的样品安装用途。

8. 发明申请

WO2007062664A2 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES 审中-公开
标题翻译：用于大型图书馆有效合成的酶编码方法
公开(公告)号：WO2007062664A2
公开(公告)日：2007-06-07
申请号：PCT/DK2006000685
申请日：2006-12-01
申请人： NUEVOLUTION AS , FRANCH THOMAS , LUNDORF MIKKEL DYBRO , JAKOBSEN SOEREN NYBOE , OLSEN EVA KAMPMANN , ANDERSEN ANNE LEE , HOLTMANN ANETTE , HANSEN ANDERS HOLM , SOERENSEN ANDERS MALLING , GOLDBECH ANNE , DE LEON DAEN , KALDOR DITTE KIVSMOSE , SLOEK FRANK ABILGAARD , HUSEMOEN GITTE NYSTRUP , DOLBERG JOHANNES , JENSEN KIM BIRKEBAEK , PETERSEN LENE , NOERREGAARD-MADSEN MADS , GODSKESEN MICHAEL ANDERS , GLAD SANNE SCHROEDER , NEVE SOEREN , THISTED THOMAS , KRONBORG TINE TITILOLA AKINLEM , SAMS CHRISTIAN , FELDING JAKOB , FRESKGAARD PER-OLA , GOULIAEV ALEX HAAHR , PEDERSEN HENRIK
发明人： FRANCH THOMAS , LUNDORF MIKKEL DYBRO , JAKOBSEN SOEREN NYBOE , OLSEN EVA KAMPMANN , ANDERSEN ANNE LEE , HOLTMANN ANETTE , HANSEN ANDERS HOLM , SOERENSEN ANDERS MALLING , GOLDBECH ANNE , DE LEON DAEN , KALDOR DITTE KIVSMOSE , SLOEK FRANK ABILGAARD , HUSEMOEN GITTE NYSTRUP , DOLBERG JOHANNES , JENSEN KIM BIRKEBAEK , PETERSEN LENE , NOERREGAARD-MADSEN MADS , GODSKESEN MICHAEL ANDERS , GLAD SANNE SCHROEDER , NEVE SOEREN , THISTED THOMAS , KRONBORG TINE TITILOLA AKINLEM , SAMS CHRISTIAN , FELDING JAKOB , FRESKGAARD PER-OLA , GOULIAEV ALEX HAAHR , PEDERSEN HENRIK
IPC分类号： C12N15/10 , C12Q1/68 , C40B40/06 , C40B50/06
CPC分类号： C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译：公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标添加的引发位点是a）在化学反应位点与一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。

9. 发明申请

WO2005087918A9 FUNGAL LIPOLYTIC ENZYMES 审中-公开
标题翻译：真菌脂肪酶
公开(公告)号：WO2005087918A9
公开(公告)日：2006-08-24
申请号：PCT/IB2005000875
申请日：2005-03-10
申请人： DANISCO , BRUNSTEDT JANNE , MIKKELSEN JOERN DALGAARD , PEDERSEN HENRIK , SOEE JOERN BORCH
发明人： BRUNSTEDT JANNE , MIKKELSEN JOERN DALGAARD , PEDERSEN HENRIK , SOEE JOERN BORCH
IPC分类号： C12N9/00 , A21D8/04 , A23C19/032 , A23K1/165 , A23K1/18 , A23L1/03 , A23L1/105 , A23L1/16 , A23L1/24 , C11B3/00 , C12N9/18
CPC分类号： A21D8/042 , A23C19/0328 , A23D7/02 , A23K20/189 , A23K50/75 , A23L7/107 , A23L7/109 , A23L7/111 , A23L27/60 , A23L29/06 , C11B3/003 , C12N9/18 , C12P7/62 , C12P19/44 , C12Y301/01
摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipidAriglyceride hydrolysing activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolysing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID No. 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.
摘要翻译：与甘油三酸酯相比，极性脂质的活性比例更高的真菌野生型脂肪分解酶，其中该酶优选具有至少4个磷脂酸甘油酯水解活性比。优选地，根据本发明的脂肪分解酶具有糖脂：甘油三酯水解活性比至少为1.5。在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID No.1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列，与其具有至少90％的同一性。本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ SEQ ID No.5所示核苷酸序列的核酸第7号; （b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

10. 发明申请

WO2004110964A3 ENCODED MOLECULES BY TRANSLATION (EMT) 审中-公开
标题翻译：编码分子通过翻译（EMT）
公开(公告)号：WO2004110964A3
公开(公告)日：2005-03-31
申请号：PCT/DK2004000416
申请日：2004-06-15
申请人： NUEVOLUTION AS , PEDERSEN HENRIK , FRANCH THOMAS
发明人： PEDERSEN HENRIK , FRANCH THOMAS
IPC分类号： C07B61/00 , C12N15/10 , C12N15/67
CPC分类号： C12N15/1062 , C12N15/1068 , C12N15/67
摘要： The present invention is directed to methods for the synthesis, selection, amplification and isolation of templated molecules having desirable properties. The invention makes it possible to synthesise a variety of different templated molecules other than alpha-peptides and modified alpha-peptides. In particular, the present invention enables synthesis of templated molecules such as beta -, ϒ -, ϖ peptides, carbopeptoids, vinylogous peptides, oligoanthrilamides, oligoureas, azapeptides (azatides), oligocarbamates, PNA, oligopyrrolinones, vinylogous sulfonamidopeptide, peptoids, azapeptoids and hydrazino peptides. It is possible in accordance with the methods of the invention to synthesise templated molecules comprising heterocyclic components, such as coumarins and quinolones, pyrazolone, isoxazolone, pyrimidiones, phtalhydrazides, diketopiperazines, hydantoins, and benzodiazepines.
摘要翻译：本发明涉及用于合成，选择，扩增和分离具有所需性质的模板分子的方法。本发明使得可以合成除α-肽和修饰的α-肽以外的各种不同的模板分子。特别地，本发明能够合成模板分子，例如β - ，Υ-，π肽，卡皮派，血液肽，寡聚甲酰胺，寡聚脲，azapeptides（azatides），oligocarbamates，PNA，oligopyrrolinones，vinylogous sulfamidopeptide，peptoids，azapeptoids和hydrazino 肽。可以根据本发明的方法合成包含杂环成分的模板分子，例如香豆素和喹诺酮类，吡唑啉酮，异恶唑酮，嘧啶，邻苯二甲酰肼，二酮哌嗪，乙内酰脲和苯并二氮杂。

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