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1. 发明申请

WO2010037395A3 MHC MULTIMERS IN CANCER VACCINES AND IMMUNE MONITORING 审中-公开
标题翻译：癌症疫苗中的MHC多聚体和免疫监测
公开(公告)号：WO2010037395A3
公开(公告)日：2010-05-20
申请号：PCT/DK2009050255
申请日：2009-10-01
申请人： DAKO DENMARK AS , BRIX LISELOTTE , SCHOELLER JOERGEN , PEDERSEN HENRIK
发明人： BRIX LISELOTTE , SCHOELLER JOERGEN , PEDERSEN HENRIK
IPC分类号： C07K14/705 , A61K39/00 , A61K47/48 , A61P35/00 , G01N33/569
CPC分类号： A61K39/0011 , A61K47/6901 , C07K14/705 , C07K14/70539 , G01N33/56972
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising cancer antigenic peptides and uses there of.
摘要翻译：本发明涉及MHC-肽复合物及其在诊断，治疗或针对个体疾病的疫苗中的用途。更具体地，本发明公开了包含癌抗原肽并在其中使用的MHC复合物。

2. 发明申请

WO2009039854A3 MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS 审中-公开
公开(公告)号：WO2009039854A3
公开(公告)日：2009-04-02
申请号：PCT/DK2008/000339
申请日：2008-09-29
申请人： DAKO DENMARK A/S , SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
发明人： SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
IPC分类号： C07K14/705 , A61K47/48 , A61K39/00 , A61K38/17 , G01N33/50 , A61P31/00
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.

3. 发明申请

WO2009003493A2 COMPILED METHODS FOR ANALYSING AND SORTING SAMPLES 审中-公开
标题翻译：用于分析和分析样品的编译方法
公开(公告)号：WO2009003493A2
公开(公告)日：2009-01-08
申请号：PCT/DK2008/050168
申请日：2008-07-03
申请人： DAKO DENMARK A/S , JACOBSEN, Kivin , PEDERSEN, Henrik , BRIX, Liselotte , LOHSE, Jesper , SCHØLLER, Jørgen , JAKOBSEN, Tina
发明人： JACOBSEN, Kivin , PEDERSEN, Henrik , BRIX, Liselotte , LOHSE, Jesper , SCHØLLER, Jørgen , JAKOBSEN, Tina
IPC分类号： C07K14/705 , A61K47/48 , A61K39/00 , A61K38/17 , G01N33/50
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K47/665 , B82Y5/00 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要： The present invention relates to the fields of analysis, diagnostics, prognostics, standardization, characterization and enumeration of entities such as biological cells, as well as therapeutical applications. Accordingly, the present invention in preferred aspects is directed to methods for the detection and/or analysis and/or isolation and optionally further manipulation of entities, such as cells, particles, and supra-molecular structures.
摘要翻译：本发明涉及诸如生物细胞的实体以及治疗应用的分析，诊断，预测，标准化，表征和计数的领域。因此，本发明在优选方面涉及用于检测和/或分析和/或分离和任选地进一步操纵诸如细胞，颗粒和超分子结构的实体的方法。

4. 发明申请

WO2010009735A9 COMBINATORIAL ANALYSIS AND REPAIR 审中-公开
标题翻译：组合分析与修复
公开(公告)号：WO2010009735A9
公开(公告)日：2010-07-29
申请号：PCT/DK2009050185
申请日：2009-07-22
申请人： DAKO DENMARK AS , CHEMGENE HOLDING APS , PEDERSEN HENRIK , BRIX LISELOTTE
发明人： PEDERSEN HENRIK , BRIX LISELOTTE
IPC分类号： G01N33/00
CPC分类号： A61K39/0011 , A61K39/0225 , A61K2039/5158 , A61K2039/55505 , A61K2039/55566 , A61K2039/6006 , C12N2710/16122 , C12N2710/16222

5. 发明申请

WO2010037402A1 MOLECULAR VACCINES FOR INFECTIOUS DISEASE 审中-公开
标题翻译：感染性疾病的分子疫苗
公开(公告)号：WO2010037402A1
公开(公告)日：2010-04-08
申请号：PCT/DK2009/050262
申请日：2009-10-02
申请人： DAKO DENMARK A/S , SCHØLLER, Jørgen , PEDERSEN, Henrik , BRIX, Liselotte
发明人： SCHØLLER, Jørgen , PEDERSEN, Henrik , BRIX, Liselotte
IPC分类号： A61K38/17 , A61K39/00 , A61K47/48 , A61P31/04 , A61P31/18 , C07K14/705
CPC分类号： A61K39/00 , A61K38/00 , A61K39/12 , A61K39/21 , A61K47/61 , A61K47/646 , A61K2039/5154 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55516 , A61K2039/55583 , A61K2039/6087 , A61K2039/625 , C07K14/70539 , C12N2740/16134 , C12N2740/16234 , Y02A50/464 , Y02A50/487 , Y02A50/489 , Y02A50/491
摘要： The present invention relates to methods for construction of pharmamers i.e. vaccine components characterized by their multimerization domain and the attached biologically active molecules, and their use in preparation of vaccines that contains the pharmamers alone or in combination with other molecules. The individual molecules of the construct can be bound to each other or the multimerization domain(s) by covalent or non-covalent bonds, directly or via linkers. The invention further relates to the use of such preparations in vaccine settings aimed to function as preventive/prophylactic or therapeutic vaccines in humans and animals.
摘要翻译：本发明涉及用于构建药剂的方法，即以其多聚化结构域和附着的生物活性分子为特征的疫苗组分及其在制备包含单独或与其它分子组合的药剂的疫苗中的用途。构建体的各个分子可以通过共价或非共价键直接或通过接头彼此结合或多聚化结构域。本发明还涉及在旨在作为人和动物中的预防/预防或治疗性疫苗的疫苗设置中使用这种制剂。

6. 发明申请

WO2010037395A2 MHC MULTIMERS IN CANCER VACCINES AND IMMUNE MONITORING 审中-公开
标题翻译： MHC多抗在癌症疫苗和免疫监测中的应用
公开(公告)号：WO2010037395A2
公开(公告)日：2010-04-08
申请号：PCT/DK2009/050255
申请日：2009-10-01
申请人： DAKO DENMARK A/S , BRIX, Liselotte , SCHØLLER, Jørgen , PEDERSEN, Henrik
发明人： BRIX, Liselotte , SCHØLLER, Jørgen , PEDERSEN, Henrik
IPC分类号： C07K14/705 , A61K39/00 , A61K47/48 , G01N33/50 , A61P35/00
CPC分类号： A61K39/0011 , A61K47/6901 , C07K14/705 , C07K14/70539 , G01N33/56972
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising cancer antigenic peptides and uses there of.
摘要翻译：本发明涉及MHC-肽复合物及其在诊断，治疗或预防个体疾病中的用途。更具体地说，本发明公开了包含癌抗原肽的MHC复合物及其用途。

7. 发明申请

WO2009106073A2 MHC MULTIMERS IN BORRELIA DIAGNOSTICS AND DISEASE 审中-公开
标题翻译：波多黎各诊断和疾病中的MHC多态性
公开(公告)号：WO2009106073A2
公开(公告)日：2009-09-03
申请号：PCT/DK2008000451
申请日：2008-12-30
申请人： DAKO DENMARK AS , BRIX LISELOTTE , PEDERSEN HENRIK , SCHOLLER JORGEN
发明人： BRIX LISELOTTE , PEDERSEN HENRIK , SCHOLLER JORGEN
CPC分类号： C07K14/70539 , A61K39/0225 , G01N2333/70539
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules containing one or more Borrelia derived peptides are disclosed. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the sample-mounted use of MHC complexes and MHC multimers. Also comprised by the invention is the field of therapy and vaccine, including therapeutic/vaccine methods and therapeutic/vaccine compositions.
摘要翻译：公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。特别地，公开了包含一种或多种含有一种或多种疏螺旋体衍生肽的MHC分子的新型MHC复合物。向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如，在治疗和诊断领域。本发明一般涉及MHC复合物和MHC多聚体的样品安装使用。本发明还包括治疗和疫苗领域，包括治疗/疫苗方法和治疗/疫苗组合物。

8. 发明申请

WO2009039854A2 MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS 审中-公开
标题翻译： MHC多聚体结核病的诊断，疫苗和治疗药物
公开(公告)号：WO2009039854A2
公开(公告)日：2009-04-02
申请号：PCT/DK2008000339
申请日：2008-09-29
申请人： DAKO DENMARK AS , SCHOLLER JORGEN , BRIX LISELOTTE , PEDERSEN HENRIK , JAKOBSEN TINA
发明人： SCHOLLER JORGEN , BRIX LISELOTTE , PEDERSEN HENRIK , JAKOBSEN TINA
IPC分类号： C07K14/705 , G01N33/50 , G01N33/569
CPC分类号： C07K14/70539 , A61K39/0011 , A61K39/04 , A61K39/12 , A61K39/245 , A61K47/61 , A61K47/6425 , A61K2039/605 , A61K2039/6087 , A61K2039/625 , C12N2710/16134 , G01N33/56972 , G01N2333/35 , G01N2333/70539
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.
摘要翻译：本发明涉及MHC-肽复合物及其在诊断，治疗或预防个体疾病中的用途。更具体地说，本发明公开了包含结核分枝杆菌抗原肽的MHC复合物及其用途。

9. 发明申请

WO2009106073A3 MHC MULTIMERS IN BORRELIA DIAGNOSTICS AND DISEASE 审中-公开
公开(公告)号：WO2009106073A3
公开(公告)日：2009-09-03
申请号：PCT/DK2008/000451
申请日：2008-12-30
申请人： DAKO DENMARK A/S , BRIX, Liselotte , PEDERSEN, Henrik , SCHOLLER, Jorgen
发明人： BRIX, Liselotte , PEDERSEN, Henrik , SCHOLLER, Jorgen
IPC分类号： A61K39/02 , A61K47/48 , C07K14/705 , G01N33/569 , A61P31/04
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules containing one or more Borrelia derived peptides are disclosed. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the sample-mounted use of MHC complexes and MHC multimers. Also comprised by the invention is the field of therapy and vaccine, including therapeutic/vaccine methods and therapeutic/vaccine compositions.

10. 发明申请

WO2009039854A8 MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS 审中-公开
公开(公告)号：WO2009039854A8
公开(公告)日：2009-04-02
申请号：PCT/DK2008/000339
申请日：2008-09-29
申请人： DAKO DENMARK A/S , SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
发明人： SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
IPC分类号： C07K14/705 , A61K47/48 , A61K39/00 , A61K38/17 , G01N33/50 , A61P31/00
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.

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