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1. 发明申请

US20100081613A1 METHODS AND COMPOSITIONS FOR ENHANCING MEMORY 审中-公开
标题翻译：用于增强记忆的方法和组合
公开(公告)号：US20100081613A1
公开(公告)日：2010-04-01
申请号：US12414160
申请日：2009-03-30
申请人： Ottavio Arancio , Daniela Puzzo , Cristina Alberini , Paul Mathews
发明人： Ottavio Arancio , Daniela Puzzo , Cristina Alberini , Paul Mathews
IPC分类号： A61K38/16 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： A61K38/16
摘要： The invention is directed to methods for enhancing memory by administering low doses of beta amyloid peptide. The invention also encompasses methods for increasing synaptic plasticity in a subject which comprises administering to the subject low doses of beta amyloid peptide.
摘要翻译：本发明涉及通过施用低剂量的β淀粉样蛋白肽来增强记忆的方法。本发明还包括增加受试者突触可塑性的方法，其包括向受试者施用低剂量的β淀粉样蛋白肽。

2. 发明申请

US20050172344A1 Cell cultures from animal models of Alzheimer's disease for screening and testing drug efficacy 审中-公开
标题翻译：来自阿尔茨海默病动物模型的细胞培养物用于筛选和测试药物功效
公开(公告)号：US20050172344A1
公开(公告)日：2005-08-04
申请号：US10980922
申请日：2004-11-03
申请人： Ottavio Arancio , Paul Mathews , Stephen Schmidt , Ralph Nixon , Fortunato Battaglia , Fabrizio Trinchese , Shumin Liu
发明人： Ottavio Arancio , Paul Mathews , Stephen Schmidt , Ralph Nixon , Fortunato Battaglia , Fabrizio Trinchese , Shumin Liu
IPC分类号： A01K67/027 , C12N5/06 , G01N33/50 , G01N33/68
CPC分类号： G01N33/502 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , G01N33/5008 , G01N33/5014 , G01N33/5058 , G01N33/6896
摘要： The present invention describes a dissociated cell culture system comprising cells of the hippocampus, one of the brain areas affected by Alzheimer's Disease (AD) or amyloid beta-related diseases. This culture system comprises hippocampal neuronal and glial cells from animal models of AD, particularly, but not limited to, double transgenic mice expressing both the human APP mutation (K670N:M671L) (mAPP), and the human PS1 mutation (M146L) (mPS1), and serves as a powerful tool for the screening and testing of compounds and substances, e.g., drugs, for their ability to affect, treat, or prevent AD or β-amyloid-related diseases. The effects of a test substance on the cells in this culture system can be quantitatively assessed to determine if the test substance affects the cells biochemically and/or electrophysiologically, and/or optically, and/or immunocytochemically. The present in vitro culture system is advantageous for AD drug screening, because it is rapid and efficient. By contrast, even in the fastest animal model of AD, pathology does not start before the end of the second month. If such in vivo animal models are used, it is necessary to wait at least the two month time duration or longer to test for drug efficacy for AD treatment or prevention. At the same time the present invention provides a tool for production of amyloid-beta that can be used for electrophysiological, behavioral, and toxicological studies.
摘要翻译：本发明描述了解离的细胞培养系统，其包括海马细胞，受阿尔茨海默病（AD）或淀粉样蛋白β相关疾病影响的脑区之一。该培养系统包括来自AD的动物模型的海马神经元和神经胶质细胞，特别但不限于表达人APP突变（K670N：M671L）（mAPP）和人PS1突变（M146L）（mP1）的双转基因小鼠），并且用作筛选和测试化合物和物质（例如药物）对其影响，治疗或预防AD或β-淀粉样蛋白相关疾病的能力的有力工具。可以定量评估测试物质对该培养系统中细胞的影响，以确定测试物质是否通过生物化学和/或电生理学和/或光学和/或免疫细胞化学方法影响细胞。目前的体外培养体系对于AD药物筛选是有利的，因为它是快速和有效的。相比之下，即使在AD的最快动物模型中，病理学也不会在第二个月之前开始。如果使用这样的体内动物模型，则需要等待至少两个月的持续时间或更长时间来测试AD治疗或预防的药物功效。同时，本发明提供了可用于电生理，行为和毒理学研究的淀粉样蛋白-β生产工具。

3. 发明授权

US10163303B1 Cash slot machine augmented with secondary currency 有权
公开(公告)号：US10163303B1
公开(公告)日：2018-12-25
申请号：US14210030
申请日：2014-03-13
申请人： Andrew Pascal , Paul Mathews , Monty Kerr
发明人： Andrew Pascal , Paul Mathews , Monty Kerr
IPC分类号： G07F17/32
摘要： A method, apparatus, and computer readable storage to implement an augmented game system. A player can play an online game and accumulate loyalty points without have to pay cash. The player can enter a physical casino and play an electronic gaming machine which can retrieve the player's information from the online game including the number of loyalty points the player has and any other incentives or game add-ons the player would be entitled to. The player would then play a physical game on the electronic game normally (by depositing cash and playing) but the game play would be augmented by virtue of the player having the loyalty points or other incentives or add-ons. For example, the game can be augmented by giving the player a better paytable.

4. 发明授权

US09824537B1 Cash slot machine augmented with secondary currency 有权
公开(公告)号：US09824537B1
公开(公告)日：2017-11-21
申请号：US15131009
申请日：2016-04-17
申请人： Andrew Pascal , Paul Mathews , Monty Kerr
发明人： Andrew Pascal , Paul Mathews , Monty Kerr
IPC分类号： G07F17/32
CPC分类号： G07F17/3255 , G07F17/3246
摘要： A method, apparatus, and computer readable storage to implement an augmented game system. A player can play an online game and accumulate loyalty points without have to pay cash. The player can enter a physical casino and play an electronic gaming machine which can retrieve the player's information from the online game including the number of loyalty points the player has and any other incentives or game add-ons the player would be entitled to. The player would then play a physical game on the electronic game normally (by depositing cash and playing) but the game play would be augmented by virtue of the player having the loyalty points or other incentives or add-ons. For example, the game can be augmented by giving the player a better paytable.

5. 发明授权

US06813361B1 Non-contact audio fader control system and method 失效
标题翻译：非接触音频推子控制系统和方法
公开(公告)号：US06813361B1
公开(公告)日：2004-11-02
申请号：US10015249
申请日：2001-12-11
申请人： Philip R. Jeffs , Paul Mathews
发明人： Philip R. Jeffs , Paul Mathews
IPC分类号： H04B100
CPC分类号： H04H60/04
摘要： A non-contact fader control uses a movable permanent magnet and one or two Hall-effect sensors to provide a constant, direct current voltage output. Signal conditioning and digital control circuitry linearize the output and otherwise precondition the output for application to a voltage controlled amplifier for the control of audio output in an audio mixing board.
摘要翻译：非接触式推子控制器使用可移动永磁体和一个或两个霍尔效应传感器来提供恒定的直流电压输出。信号调理和数字控制电路将输出线性化，并以其他方式将输出预处理应用于压控放大器，以控制音频混合板中的音频输出。

6. 发明授权

US5354983A Object detector utilizing a threshold detection distance and suppression means for detecting the presence of a motor vehicle 失效
标题翻译：利用阈值检测距离的物体检测器和用于检测机动车辆的存在的抑制装置
公开(公告)号：US5354983A
公开(公告)日：1994-10-11
申请号：US508132
申请日：1990-04-10
申请人： Scott Juds , Paul Mathews
发明人： Scott Juds , Paul Mathews
IPC分类号： G01S7/491 , G01S17/93 , G01V9/04
CPC分类号： G01S17/936 , G01S7/4816 , G01S7/4918
摘要： A method and apparatus are disclosed which allow for the detection of an object (14) by the generation of a radiated beam (18) and a subsequent reflection by the object (14) of a portion (20) thereof. The detection of particulate object material (16) due to a reflection of a portion (22) of the generated beam (18) is minimized.
摘要翻译：公开了一种方法和装置，其允许通过产生辐射束（18）来检测物体（14），并且随后由物体（14）的一部分（20）反射。由于所产生的光束（18）的部分（22）的反射而对颗粒物体（16）的检测被最小化。

7. 发明授权

US11282336B1 Method, system, and apparatus for enabling players to earn tangible rewards on a social game 有权
公开(公告)号：US11282336B1
公开(公告)日：2022-03-22
申请号：US14144581
申请日：2013-12-31
申请人： Andrew Pascal , Paul Mathews , Monty Kerr
发明人： Andrew Pascal , Paul Mathews , Monty Kerr
IPC分类号： G06F17/00 , G07F17/32
摘要： A method, apparatus, and computer readable storage to implement an online casual casino games which provide a player an opportunity to earn loyalty points which are independent of outcomes of the casino games themselves. Loyalty points can be earned by advancing levels or wagering a certain amount in chips (typically with a non-cash value). Once enough loyalty points are earned, they can be redeemed for tangible goods and services.

8. 发明申请

US20060101532A1 Methods for the identification of compounds for the treatment of Alzheimer's disease 审中-公开
标题翻译：鉴定用于治疗阿尔茨海默病的化合物的方法
公开(公告)号：US20060101532A1
公开(公告)日：2006-05-11
申请号：US10983422
申请日：2004-11-08
申请人： Ralph Nixon , Anne Cataldo , Paul Mathews
发明人： Ralph Nixon , Anne Cataldo , Paul Mathews
IPC分类号： A01K67/027
CPC分类号： C07K14/4711 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , C07K14/705 , C07K14/72 , C12N9/14 , C12N9/6478 , C12N15/8509 , C12N2830/008 , G01N33/6896 , G01N2333/916 , G01N2500/10 , G01N2800/2821
摘要： The invention features methods for identifying compounds useful for the treatment of Alzheimer's disease. The invention also features methods of identifying genes involved in Alzheimer's disease pathology.
摘要翻译：本发明的特征在于鉴定可用于治疗阿尔茨海默病的化合物的方法。本发明还涉及鉴定涉及阿尔茨海默病病理学的基因的方法。

9. 发明授权

US06377167B1 Multi frequency photoelectric detection system 失效
标题翻译：多频光电检测系统
公开(公告)号：US06377167B1
公开(公告)日：2002-04-23
申请号：US09674215
申请日：2001-05-01
申请人： Scott Juds , Paul Mathews , Robert I Lewis
发明人： Scott Juds , Paul Mathews , Robert I Lewis
IPC分类号： B60Q100
CPC分类号： G01S17/936 , G01S7/4811 , G01S17/36 , G01S17/87 , G01S2013/9332
摘要： Collision avoidance apparatus (28, 30) is mounted on a host vehicle (20) to detect the presence of an adjacent vehicle (22) within a monitored zone (24, 26). A sensor module (30) includes a plurality of discrete sensor systems for monitoring unique portions of the monitored zone (24, 26), each of which comprises an emitter (52) emitting a fixed frequency modulated beam (58) of light energy (54) with a predetermined burst length into its unique portion of the monitored zone (24, 26), and a receiver (68) having a field of view (62), substantially aligned with emitted beam (58) to produce a fixed optical overlap area (A), and for sensing light energy (66) and generating a received signal. A frequency generator (48) produces two or more predetermined different fixed frequencies for use by the emitter (52) to emit beams (58) at each frequency. A phase shifter (70) produces a phase shifted reference signal with a different predetermined phase delay relationship to each fixed frequency. A mixer (72) mixes each received signal and each phase shifted reference signal to produce demodulation signals from for each frequency. A processor (40) receives and processes accoupled logic level detection signals generated by a limiter amplifier (76) for each discrete sensor system at each of the fixed frequencies to determine the presence of a vehicle (22) in the monitored zone (24, 26). The fixed frequency and the predetermined phase delay are chosen to produce a null received signal resulting from reflections of the emitted beam from uniformly distributed atmospheric backscatter within the optical overlap area (A).
摘要翻译：碰撞避免装置（28,30）安装在主车辆（20）上以检测在监视区域（24,26）内的相邻车辆（22）的存在。传感器模块（30）包括多个离散传感器系统，用于监测所监视区域（24,26）的独特部分，每个部分包括发射光（58）的发射器（52））具有预定的突发长度进入其被监视区域（24,26）的独特部分，以及具有与发射波束（58）基本对准的视场（62）的接收器（68），以产生固定的光学重叠区域（A），并且用于感测光能（66）并产生接收信号。频率发生器（48）产生两个或更多个预定的不同固定频率，供发射器（52）在每个频率下发射波束（58）。移相器（70）产生具有与每个固定频率不同的预定相位延迟关系的相移参考信号。混合器（72）将每个接收的信号和每个相移的参考信号混合以产生针对每个频率的解调信号。处理器（40）在每个固定频率处接收并处理由限幅放大器（76）产生的用于每个离散传感器系统的耦合逻辑电平检测信号，以确定车辆（22）在被监视区域（24,26）中的存在）。选择固定频率和预定相位延迟以产生由光重叠区域（A）内均匀分布的大气背散射的发射光束的反射产生的零接收信号。

10. 发明授权

US5675326A Method of determining optimal detection beam locations using reflective feature mapping 失效
标题翻译：使用反射特征映射确定最佳检测光束位置的方法
公开(公告)号：US5675326A
公开(公告)日：1997-10-07
申请号：US485099
申请日：1995-06-07
申请人： Scott Juds , Paul Mathews
发明人： Scott Juds , Paul Mathews
IPC分类号： G01S17/93 , G08G1/16
CPC分类号： G01S17/936
摘要： A method of defining a sensing system for detecting the presence of an object in a volume of space under surveillance by determining the optimal placement of a plurality of energy beams which are projected into the volume which comprises the steps of (A) placing the object at a preselected position within the space; (B) directing a plurality of sample beams of energy, which have a predetermined orientation, from a source onto the object; (C) detecting the reflections of the sample beam energy from points on the object by energy detectors; (D) recording the preselected position of the object, the predetermined orientation of sample beams, and the detection status of the energy detectors; (E) changing the equatorial and azimuthal angles of each of the beams and repeating steps (B), (C) and (D); (F) moving the source of the sample beams relative to the object; (G) repeating steps (B) through (F) to produce spatial maps of the locations at which the object is positioned when each of the energy detectors detect reflected sample beam energy; and (H) using the spatial maps so produced to select the optimal orientation of a set of energy beams which will maximize the detection probability of an object located in the volume of space under surveillance. This method is repeated for a plurality of different vehicles.
摘要翻译：一种定义感测系统的方法，用于通过确定投影到体积中的多个能量束的最佳布置来检测被监视的空间体内物体的存在，其包括以下步骤：（A）将物体放置在空间内的预选位置; （B）将具有预定取向的多个能量样本光束从源引导到物体上; （C）通过能量检测器检测物体上的点的样品束能量的反射; （D）记录物体的预选位置，样本光束的预定取向以及能量检测器的检测状态; （E）改变每个光束的赤道和方位角，重复步骤（B），（C）和（D）; （F）相对于物体移动样品光束的源; （G）重复步骤（B）至（F）以产生当每个能量检测器检测到反射的样品束能量时物体被放置的位置的空间图; 和（H）使用如此产生的空间图来选择一组能量束的最佳取向，这将最大化位于监视下的空间体积中的物体的检测概率。对于多个不同的车辆重复该方法。

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