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1. 发明授权

US06960681B2 Guanidinomethyl cyclohexane carboxylic acid ester derivatives 失效
标题翻译：胍基甲基环己烷羧酸酯衍生物
公开(公告)号：US06960681B2
公开(公告)日：2005-11-01
申请号：US10623135
申请日：2003-07-18
申请人： Osamu Kamoda , Hiromichi Fujiwara , Toshiharu Yanagi
发明人： Osamu Kamoda , Hiromichi Fujiwara , Toshiharu Yanagi
IPC分类号： A61K31/215 , A61K31/24 , C07C69/94 , C07C279/14 , C07C69/76
CPC分类号： C07C279/14 , A61K31/215 , A61K31/24 , C07C69/94 , C07C2601/14
摘要： The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori, and pharmaceutically acceptable salts thereof. In the general formula (VIII) X is hydrogen or halogen, Y is hydrogen or a substituted or unsubstituted aralkyloxycarbonyl group having 8-19 carbon atoms, Z is hydrogen, a substituted aralkyloxycarbonyl group having 8-19 carbon atoms or a substituted alkoxycarbonyyl group having 2-19 carbon atoms, except that X, Y and Z are all hydrogen.
摘要翻译：本发明涉及通式（Ⅷ）的新颖有价值的中间体化合物，其可用于制备包含抗菌作用的新化合物，特别是具有对幽门螺杆菌的强抗菌作用及其药学上可接受的盐。在通式（Ⅷ）中，X为氢或卤素，Y为氢或具有8-19个碳原子的取代或未取代的芳烷氧基羰基，Z为氢，具有8-19个碳原子的取代芳烷氧基羰基或取代的烷氧基羰基， 2-19个碳原子，除了X，Y和Z都是氢。

2. 发明授权

US06284791B1 Guanidinomethyl cyclohexane carboxylic acid ester derivatives 失效
标题翻译：胍基甲基环己烷羧酸酯衍生物
公开(公告)号：US06284791B1
公开(公告)日：2001-09-04
申请号：US08793728
申请日：1997-02-28
申请人： Osamu Kamoda , Hiromichi Fujiwara , Toshiharu Yanagi
发明人： Osamu Kamoda , Hiromichi Fujiwara , Toshiharu Yanagi
IPC分类号： A61K31215
CPC分类号： C07C279/14 , A61K31/215 , A61K31/24 , C07C69/94 , C07C2601/14
摘要： A compound represented by general formula (I-2) or a pharmaceutically acceptable acid-addition salt thereof, useful as an anti-microbial against Helicobacter pylori and as a medicinal composition for treating Helicobacter pylori infection, wherein Ar represents phenyl, biphenyl or naphthyl each having a at least one substituent selected from the group consisting of halogen, cyano, nitro, carboxy, C1-C18 alkyl, C1-C18 alkoxy, C3-C18 cycloalkyl, C7-C18 aralkyl, C8-C18 arylalkenyl, C7-C18 aralkyloxy, optionally substituted phenoxy, optionally substituted C2-C19 alkoxycarbonyl, and optionally substituted C8-C19 aralkyloxycarbonyl, provided the case where Ar represents phenyl substituted by halogen, cyano, nitro, carboxy, C1-C18 alkyl, optionally substituted C2-C19 alkoxycarbonyl or C8-C19 aralkyloxycarbonyl is expected.
摘要翻译：由通式（I-2）表示的化合物或其药学上可接受的酸加成盐可用作幽门螺杆菌的抗微生物剂和用作治疗幽门螺杆菌感染的药用组合物，其中Ar表示苯基，联苯基或萘基具有至少一个选自卤素，氰基，硝基，羧基，C 1 -C 18烷基，C 1 -C 18烷氧基，C 3 -C 18环烷基，C 7 -C 18芳烷基，C 8 -C 18芳基烯基，C 7 -C 18芳烷氧基，氰基，硝基，羧基，C 1 -C 18烷基，任意取代的C 2 -C 19烷氧基羰基或C 8 -C 19烷氧基羰基取代的苯基，任意取代的苯氧基，任意取代的C 2 -C 19烷氧羰基和任选取代的C 8 -C 19芳烷氧基羰基， C19芳烷氧基羰基是预期的。

3. 发明授权

US06831190B1 Guanidinomethyl cyclohexane carboxylic acid ester derivatives 失效
标题翻译：胍基甲基环己烷羧酸酯衍生物
公开(公告)号：US06831190B1
公开(公告)日：2004-12-14
申请号：US09721182
申请日：2000-11-22
申请人： Osamu Kamoda , Hiromichi Fujiwara , Toshiharu Yanagi
发明人： Osamu Kamoda , Hiromichi Fujiwara , Toshiharu Yanagi
IPC分类号： C07C6976
CPC分类号： C07C279/14 , A61K31/215 , A61K31/24 , C07C69/94 , C07C2601/14
摘要： The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori, and pharmaceutically acceptable salts thereof. In the general formula (VIII) X is hydrogen or halogen, Y is hydrogen or a substituted or unsubstituted aralkyloxycarbonyl group having 8-19 carbon atoms, Z is hydrogen, a substituted aralkyloxycarbonyl group having 8-19 carbon atoms or a substituted alkoxycarbonyyl group having 2-19 carbon atoms, except that X, Y and Z are all hydrogen.
摘要翻译：本发明涉及通式（Ⅷ）的新颖有价值的中间体化合物，其可用于制备包含抗菌作用的新化合物，特别是具有对幽门螺杆菌的强抗菌作用及其药学上可接受的盐。在通式（Ⅷ）中，X为氢或卤素，Y为氢或具有8-19个碳原子的取代或未取代的芳烷氧基羰基，Z为氢，具有8-19个碳原子的取代芳烷氧基羰基或取代的烷氧基羰基， 2-19个碳原子，除了X，Y和Z都是氢。

4. 发明授权

US5143935A Benzamide derivatives 失效
标题翻译：苯甲酸衍生物
公开(公告)号：US5143935A
公开(公告)日：1992-09-01
申请号：US777011
申请日：1991-10-16
申请人： Hiromichi Fujiwara , Akihiko Ogawa , Hideyo Sakiyama , Toshiaki Tamura
发明人： Hiromichi Fujiwara , Akihiko Ogawa , Hideyo Sakiyama , Toshiaki Tamura
IPC分类号： A61K31/40 , A61P1/00 , C07D207/14
CPC分类号： C07D207/14
摘要： A benzamide derivative represented by the formula: ##STR1## having a promoting activity of gastrointestinal tract and pharmacentical composition containing the same.

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