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1. 发明授权

US06685950B2 Methods of treating viral infections 有权
标题翻译：治疗病毒感染的方法
公开(公告)号：US06685950B2
公开(公告)日：2004-02-03
申请号：US09903013
申请日：2001-07-11
申请人： Olaf Weber , Tobias Schlapp , Angela Siegling , Andreas Knorr , Claudia Hirth-Dietrich , Gudrun Theiss
发明人： Olaf Weber , Tobias Schlapp , Angela Siegling , Andreas Knorr , Claudia Hirth-Dietrich , Gudrun Theiss
IPC分类号： A61K4500
CPC分类号： A61K35/76 , C12N2710/24232
摘要： The present invention relates to the use of strains of Parapoxvirus ovis as immunotherapeutic agents for immunodeficiencies of an infectious or non-infectious nature, and to the use of strains of Parapoxvirus ovis for treating tumor diseases and viral infections, and diseases which accompany them, and the use of strains of Parapoxvirus ovis for producing medicaments for use in humans and animals.
摘要翻译：本发明涉及副作用病毒ovis菌株作为感染性或非感染性免疫缺陷的免疫治疗剂的用途，以及使用Parapoxvirus ovis菌株治疗肿瘤疾病和病毒感染以及伴随它们的疾病的用途，以及使用副毒素病毒ovis菌株生产用于人和动物的药物。

2. 发明授权

US06632647B2 Use of strains of parapoxvirus ovis against organ fibrosis 有权
标题翻译：使用针对器官纤维化的副痘病毒ovis菌株
公开(公告)号：US06632647B2
公开(公告)日：2003-10-14
申请号：US09903005
申请日：2001-07-11
申请人： Claudia Hirth-Dietrich , Tobias Schlapp , Angela Siegling , Andreas Knorr , Olaf Weber , Gudrun Theiss
发明人： Claudia Hirth-Dietrich , Tobias Schlapp , Angela Siegling , Andreas Knorr , Olaf Weber , Gudrun Theiss
IPC分类号： C12N708
CPC分类号： A61K35/76 , A61K2039/5252 , C12N2710/24232
摘要： The present invention relates to the use, in humans, of inactivated parapoxviruses for the prophylaxis and treatment of diseases which are accompanied by an increased deposition of collagen, with it being possible for both internal organs, such as the liver, and the skin and its appended structures, to be affected. The invention relates, in particular, to liver fibrosis and/or liver cirrhosis consequent upon virus hepatitis, or to ethanol-induced liver diseases and to cystic fibrosis.
摘要翻译：本发明涉及在人类中用于预防和治疗伴随着胶原蛋白沉积增加的疾病的灭活的副代谢病毒，其中内脏器官例如肝脏和皮肤以及它们的可能性附加结构，受影响。本发明特别涉及由于病毒性肝炎引起的肝纤维化和/或肝硬化，或乙醇诱导的肝脏疾病和囊性纤维化。

3. 发明申请

US20060008471A1 Organ, tissue and cell-specific immuno-therapeutic for chronic viral infections and inflammatory, degenerative and proliferative diseases, in particular of the liver, and for cancer, based on a recombinant parapox virus 审中-公开
标题翻译：用于慢性病毒感染和炎性，退行性和增殖性疾病，特别是肝脏和癌症的器官，组织和细胞特异性免疫治疗，基于重组旁分泌病毒
公开(公告)号：US20060008471A1
公开(公告)日：2006-01-12
申请号：US11225508
申请日：2005-09-13
申请人： Olaf Weber , Angela Siegling , Tobias Schlapp
发明人： Olaf Weber , Angela Siegling , Tobias Schlapp
IPC分类号： A61K39/12
CPC分类号： C12N15/86 , C12N15/87 , C12N2710/24243
摘要： The present invention relates to the preparation and use of organ-specific, tissue-specific and/or cell-specific recombinant parapoxvirus ovis as a pathogen-specific and organ-specific, targeted immunotherapeutic agent for chronic viral infections and inflammatory, degenerative and proliferative diseases, in particular of the liver, and cancer.
摘要翻译：本发明涉及器官特异性，组织特异性和/或细胞特异性重组副痘病毒ovis作为慢性病毒感染和炎性，退行性和增殖性疾病的病原体特异性和器官特异性靶向免疫治疗剂的制备和用途，特别是肝脏和癌症。

4. 发明授权

US08357363B2 Recombinant proteins of parapoxvirus ovis and pharmaceutical compositions therefrom 有权
标题翻译：副作用的重组蛋白及其药物组合物
公开(公告)号：US08357363B2
公开(公告)日：2013-01-22
申请号：US10481112
申请日：2002-06-12
申请人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
发明人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： A61K39/155 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译：本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。

5. 发明授权

US08751101B2 Diagnosing a cooling subsystem of an engine system in response to dynamic pressure sensed in the subsystem 失效
标题翻译：根据子系统中感测到的动态压力，诊断发动机系统的冷却子系统
公开(公告)号：US08751101B2
公开(公告)日：2014-06-10
申请号：US13003377
申请日：2009-07-07
申请人： Olaf Weber , Wolfgang Wenzel
发明人： Olaf Weber , Wolfgang Wenzel
IPC分类号： F01P9/06
CPC分类号： G01M15/042 , F01P11/18 , F01P2025/04 , F01P2031/00 , F02B29/0493 , Y02T10/146
摘要： A method of diagnosing a cooling subsystem of an engine system in response a parameter extracted from dynamic hydraulic pressure sensed in the cooling subsystem, and products and systems using same.
摘要翻译：响应于从冷却子系统中感测到的动态液压提取的参数以及使用其的产品和系统来诊断发动机系统的冷却子系统的方法。

6. 发明申请

US20120330575A1 ESTIMATING ENGINE SYSTEM PARAMETERS BASED ON ENGINE CYLINDER PRESSURE 审中-公开
标题翻译：基于发动机气缸压力估算发动机系统参数
公开(公告)号：US20120330575A1
公开(公告)日：2012-12-27
申请号：US12442158
申请日：2007-10-05
申请人： Olaf Weber , John Shutty , Wolfgang Wenzel
发明人： Olaf Weber , John Shutty , Wolfgang Wenzel
IPC分类号： G01M15/08 , G06F19/00
CPC分类号： F02D41/22 , F01N3/0821 , F02B37/18 , F02B37/24 , F02D35/023 , F02D41/0007 , F02D2041/288 , F02D2200/025 , F02D2200/0408 , F02D2200/0416 , Y02T10/144 , Y02T10/40
摘要： A method includes sensing pressure within an engine cylinder, and estimating at least one other engine system parameter based on the sensed pressure. Another method includes designing an engine system, which includes one or more engine cylinder pressure sensors and one or more other engine system sensors. According to this method, the engine system is operated, and engine cylinder pressure is sensed using the engine cylinder pressure sensors, which are in communication with an engine cylinder of an engine of the engine system. Also, other engine system parameters are sensed to obtain at least one other engine system parameter using the other engine system sensors. The engine cylinder pressure is correlated to the at least one other engine system parameter, and engine cylinder pressure is used to replace or augment the at least one other engine system parameter that correlates to the engine cylinder pressure.
摘要翻译：一种方法包括感测发动机气缸内的压力，以及基于感测到的压力来估计至少一个其它发动机系统参数。另一种方法包括设计包括一个或多个发动机气缸压力传感器和一个或多个其它发动机系统传感器的发动机系统。根据该方法，发动机系统被操作，并且使用与发动机系统的发动机的发动机气缸连通的发动机气缸压力传感器感测发动机气缸压力。此外，感测其它发动机系统参数以使用其它发动机系统传感器获得至少一个其它发动机系统参数。发动机气缸压力与至少一个其它发动机系统参数相关联，并且发动机气缸压力用于替换或增加与发动机气缸压力相关的至少一个其它发动机系统参数。

7. 发明授权

US08227511B2 Substituted chromanol derivatives and their use 有权
标题翻译：取代的色原醇衍生物及其用途
公开(公告)号：US08227511B2
公开(公告)日：2012-07-24
申请号：US12225211
申请日：2007-03-07
申请人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
发明人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
IPC分类号： A61K31/352 , C07D311/04 , C07D311/96
CPC分类号： C07D311/22 , C07D311/96
摘要： The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译：本发明涉及取代的苯并二氢吡喃衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

8. 发明申请

US20110125361A1 DIAGNOSING A COOLING SUBSYSTEM OF AN ENGINE SYSTEM IN RESPONSE TO DYNAMIC PRESSURE SENSED IN THE SUBSYSTEM 失效
标题翻译：诊断发动机系统的冷却子系统对动力传感器在子系统中的响应
公开(公告)号：US20110125361A1
公开(公告)日：2011-05-26
申请号：US13003377
申请日：2009-07-07
申请人： Olaf Weber , Wolfgang Wenzel
发明人： Olaf Weber , Wolfgang Wenzel
IPC分类号： F01P9/00 , F01P3/20 , F02M25/07
CPC分类号： G01M15/042 , F01P11/18 , F01P2025/04 , F01P2031/00 , F02B29/0493 , Y02T10/146
摘要： A method of diagnosing a cooling subsystem of an engine system in response a parameter extracted from dynamic hydraulic pressure sensed in the cooling subsystem, and products and systems using same.
摘要翻译：响应于从冷却子系统中感测到的动态液压提取的参数以及使用其的产品和系统来诊断发动机系统的冷却子系统的方法。

9. 发明授权

US07897159B2 Parapoxviruses in combination with classical cytotoxic chemotherapeutic agents as biochemotherapy for the treatment of cancer 有权
标题翻译： Parapoxviruses与经典细胞毒性化学治疗剂结合用作治疗癌症的生物化学疗法
公开(公告)号：US07897159B2
公开(公告)日：2011-03-01
申请号：US12123360
申请日：2008-05-19
申请人： Olaf Weber
发明人： Olaf Weber
IPC分类号： A61K39/275
CPC分类号： A61K45/06 , A61K35/768 , C12N2710/24232 , A61K35/76 , A61K2300/00
摘要： The invention relates to a method for the production of a pharmaceutical composition for treating cancer by combining Parapoxvirus ovis with at least one anticancer agent. The invention furthermore relates to a method for treating a patient afflicted with cancer comprising the administration of Parapoxvirus ovis in combination with at least one anticancer agent.
摘要翻译：本发明涉及一种生产用于治疗癌症的药物组合物的方法，该药物组合物通过将副痘病毒与至少一种抗癌剂相结合。本发明还涉及治疗患有癌症的患者的方法，包括与至少一种抗癌剂组合施用副痘病毒ovis。

10. 发明申请

US20100300088A1 METHOD OF CONTROLLING A TURBOCHARGER 审中-公开
标题翻译：控制涡轮增压器的方法
公开(公告)号：US20100300088A1
公开(公告)日：2010-12-02
申请号：US12599316
申请日：2008-05-13
申请人： Volker Joergl , Olaf Weber
发明人： Volker Joergl , Olaf Weber
IPC分类号： F02D23/00
CPC分类号： F02B37/24 , F01P2060/02 , F02B37/164 , F02B39/16 , F02M26/05 , F02M26/06 , Y02T10/144
摘要： Another embodiment of the invention includes a method of controlling a turbocharger to achieve at least one of: produce air in excess of that required to operate a combustion engine at a specific power demand; control the flow of gas through the turbine; or control the turbine speed independent of boost pressure required to avoid specific speeds.
摘要翻译：本发明的另一实施例包括一种控制涡轮增压器以实现以下至少之一的方法：产生超过在特定功率需求下操作内燃机所需的空气的空气; 控制通过涡轮机的气体流量; 或者独立于避免特定速度所需的增压压力来控制涡轮速度。

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