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    • 5. 发明申请
    • BONE MATRIX COMPOSITIONS AND METHODS
    • 骨基质组合物和方法
    • WO2008157495A3
    • 2009-11-26
    • PCT/US2008067121
    • 2008-06-16
    • OSTEOTECH INCBEHNAM KEYVANWEI GUOBAOFORSYTH NANETTEBOYCE TODD MSHIMP LAWRENCE A
    • BEHNAM KEYVANWEI GUOBAOFORSYTH NANETTEBOYCE TODD MSHIMP LAWRENCE A
    • A61L27/36
    • A61L27/3695A61F2/28A61F2002/30059A61F2310/00359A61K35/00A61K35/32A61L27/3604A61L27/3608A61L27/3683A61L27/3834A61L27/54A61L2430/02A61L2430/40
    • Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
    • 提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。 可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性,成骨活性,软骨形成活性,伤口愈合活性,神经源性活性,收缩诱导活性,有丝分裂诱导活性,分化诱导活性,趋化活性,血管生成或血管发生活性,以及​​胞吐作用或内吞诱导活性。 在一个实施方案中,用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨,处理所述部分去矿物质的骨以破坏所述骨的胶原结构,以及任选地提供组织衍生的提取物,并将所述组织衍生的提取物加入到部分去矿物质 骨。 在另一个实施方案中,可植入的骨诱导和骨传导性组合物包含部分脱矿质骨,其中所述骨的胶原结构已被破坏,并且任选地包含组织衍生的提取物。