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1. 发明申请

WO2005107651A3 CELL PERMEABLE STRUCTURAL IMPLANT 审中-公开
标题翻译：细胞渗透性结构植入物
公开(公告)号：WO2005107651A3
公开(公告)日：2006-06-15
申请号：PCT/US2005015426
申请日：2005-05-04
申请人： OSTEOTECH INC , WINTERBOTTOM JOHN M , BELANEY RYAN , KNAACK DAVID , BOYCE TODD M , SHIMP LAWRENCE A , LEE SAMUEL , KAES DAVID
发明人： WINTERBOTTOM JOHN M , BELANEY RYAN , KNAACK DAVID , BOYCE TODD M , SHIMP LAWRENCE A , LEE SAMUEL , KAES DAVID
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/46 , C12N5/08
CPC分类号： A61F2/28 , A61F2/4644 , A61F2002/30062 , A61F2002/3093 , A61F2002/4645 , A61F2210/0004 , A61F2310/00179
摘要： An implant including a cell conducting phase and a binder phase. At least a portion of the surface of the implant includes the cell conducting phase, and the cell conducting phase defines a path from the surface of the implant to an interior of the implant.
摘要翻译：包括细胞传导相和粘结相的植入物。植入物的表面的至少一部分包括细胞传导相，并且细胞传导相限定从植入物表面到植入物内部的路径。

2. 发明申请

WO2004069890A3 POLYURETHANES FOR OSTEOIMPLANTS 审中-公开
标题翻译：聚氨酯泡沫塑料
公开(公告)号：WO2004069890A3
公开(公告)日：2005-09-09
申请号：PCT/US2004003233
申请日：2004-02-04
申请人： OSTEOTECH INC , KNAACK DAVID , WINTERBOTTOM JOHN M , KAES DAVID , BOYCE TODD M , SHIMP LAWRENCE A
发明人： KNAACK DAVID , WINTERBOTTOM JOHN M , KAES DAVID , BOYCE TODD M , SHIMP LAWRENCE A
IPC分类号： A61L27/18 , A61L27/46 , C08G18/10 , C08G18/36 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , A61K31/26 , A61K31/44
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译：生物基聚氨酯及其制备方法。聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。

3. 发明申请

WO2004014452A3 SYNTHESIS OF A BONE-POLYMER COMPOSITE MATERIAL 审中-公开
标题翻译：骨聚合物复合材料的合成
公开(公告)号：WO2004014452A3
公开(公告)日：2004-08-26
申请号：PCT/US0325417
申请日：2003-08-12
申请人： OSTEOTECH INC , SHIMP LAWRENCE A , WINTERBOTTOM JOHN M , BOYCE TODD M , KNAACK DAVID
发明人： SHIMP LAWRENCE A , WINTERBOTTOM JOHN M , BOYCE TODD M , KNAACK DAVID
IPC分类号： A61L27/26 , A61L27/36 , A61L27/46 , A61L27/48
CPC分类号： A61L27/48 , A61L27/3608 , A61L27/46 , A61L2430/02 , C08L89/00
摘要： A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.
摘要翻译：骨聚合物复合材料的制造方法。该方法包括以下步骤：提供多个骨颗粒，将骨颗粒与聚合物前体组合，并聚合聚合物前体。

4. 发明申请

WO2004014452A9 SYNTHESIS OF A BONE-POLYMER COMPOSITE MATERIAL 审中-公开
标题翻译：骨 - 聚合物复合材料的合成
公开(公告)号：WO2004014452A9
公开(公告)日：2004-06-10
申请号：PCT/US0325417
申请日：2003-08-12
申请人： OSTEOTECH INC , SHIMP LAWRENCE A , WINTERBOTTOM JOHN M , BOYCE TODD M , KNAACK DAVID
发明人： SHIMP LAWRENCE A , WINTERBOTTOM JOHN M , BOYCE TODD M , KNAACK DAVID
IPC分类号： A61L27/26 , A61L27/36 , A61L27/46 , A61L27/48 , A61L31/00
CPC分类号： A61L27/48 , A61L27/3608 , A61L27/46 , A61L2430/02 , C08L89/00
摘要： A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.
摘要翻译：一种生产骨 - 聚合物复合材料的方法。该方法包括以下步骤：提供多个骨颗粒，将骨颗粒与聚合物前体结合，并聚合该聚合物前体。

5. 发明申请

WO2007084610A3 POLYURETHANES FOR OSTEOIMPLANTS 审中-公开
标题翻译：聚氨酯泡沫塑料
公开(公告)号：WO2007084610A3
公开(公告)日：2008-01-10
申请号：PCT/US2007001326
申请日：2007-01-19
申请人： OSTEOTECH INC , KNAACK DAVID , WINTERBOTTOM JOHN , KAES DAVID R , BOYCE TODD M , SHIMP LAWRENCE A
发明人： KNAACK DAVID , WINTERBOTTOM JOHN , KAES DAVID R , BOYCE TODD M , SHIMP LAWRENCE A
IPC分类号： A61F2/28 , C08G18/10 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , C08K3/00
CPC分类号： A61L27/18 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K31/785 , A61L27/46 , A61L27/48 , C08G18/10 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04 , C08G18/36
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译：生物基聚氨酯及其制备方法。聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。

6. 发明申请

WO2005062868A3 TISSUE-DERIVED MESH FOR ORTHOPEDIC REGENERATION 审中-公开
标题翻译：用于正常再生的组织衍生网
公开(公告)号：WO2005062868A3
公开(公告)日：2006-06-22
申请号：PCT/US2004043016
申请日：2004-12-20
申请人： OSTEOTECH INC , GEREMAKIS PERRY A , GRASSO JENNIFER , KNAACK DAVID , LIN JO-WEN , SHIMP LAWRENCE A , WATERMAN ROBERT , WINTERBOTTOM JOHN M
发明人： GEREMAKIS PERRY A , GRASSO JENNIFER , KNAACK DAVID , LIN JO-WEN , SHIMP LAWRENCE A , WATERMAN ROBERT , WINTERBOTTOM JOHN M
IPC分类号： A61F2/28 , A61B17/00 , A61B17/06 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/36 , B29C47/36 , B29C67/02
CPC分类号： A61L27/3641 , A61B17/06166 , A61B2017/00004 , A61F2/0063 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2/4601 , A61F2/4644 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61F2310/00011 , A61F2310/00179 , A61F2310/00359 , A61L27/3608 , A61L27/3633 , A61L27/3645 , A61L27/3804 , A61L27/3843 , B29C67/02
摘要： An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.
摘要翻译：一种植入体，其包括基本上粘合的聚集体，其包含骨衍生的颗粒。粘合性通过机械互锁的成员维持，相邻骨衍生的颗粒通过与粘合剂的接合，热粘合，化学粘合或其中保留骨衍生的颗粒的基质材料相互接合。聚集体成形为一维或二维体。

7. 发明申请

WO2007084725A3 INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS 审中-公开
标题翻译：可注射和可修复的骨代替材料
公开(公告)号：WO2007084725A3
公开(公告)日：2009-04-16
申请号：PCT/US2007001540
申请日：2007-01-19
申请人： OSTEOTECH INC , WINTERBOTTOM JOHN , KAES DAVID R , TUNC DEGER C , BOYCE TODD M , KNAACK DAVID , RUSSELL JAMES , BHATTACHARYYA SUBHABRATA
发明人： WINTERBOTTOM JOHN , KAES DAVID R , TUNC DEGER C , BOYCE TODD M , KNAACK DAVID , RUSSELL JAMES , BHATTACHARYYA SUBHABRATA
IPC分类号： A61F2/00 , A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
摘要翻译：一种植物复合材料，其包含多种无机材料颗粒，骨替代材料，骨衍生材料或其任何组合; 以及与颗粒结合的聚合物材料。复合材料可以自然地模塑或流动，或者它可以是可模制的或可设定的。植入后，可以将复合材料设置成为植入物提供机械强度。本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为提供大多数矫形应用所需的机械强度。本发明还提供了使用和制备可模制和可流动的复合材料的方法。

8. 发明申请

WO2004032988A3 COUPLING AGENTS FOR ORTHOPEDIC BIOMATERIALS 审中-公开
标题翻译：用于正交生物材料的联接剂
公开(公告)号：WO2004032988A3
公开(公告)日：2004-05-27
申请号：PCT/US0331990
申请日：2003-10-08
申请人： OSTEOTECH INC , SHIMP LAWRENCE A , KNAACK DAVID
发明人： SHIMP LAWRENCE A , KNAACK DAVID
IPC分类号： A61L27/36 , A61L27/44 , A61L27/46
CPC分类号： A61L27/3821 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/3847 , A61L27/44 , A61L27/46 , A61L2430/02
摘要： The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
摘要翻译：本发明提供了一种用于制备骨 - 聚合物复合材料的方法，其中骨的矿物部分在被并入生物相容的聚合物基质之前用偶联剂处理。所得到的复合物可以原样使用或进一步加工以形成骨样植入物。

9. 发明专利

JP2011172953A Synthesis of bone-polymer composite material 审中-公开
标题翻译：骨聚合物复合材料的合成
公开(公告)号：JP2011172953A
公开(公告)日：2011-09-08
申请号：JP2011095408
申请日：2011-04-21
申请人： Osteotech Inc , オステオテックインコーポレーテッド
发明人： SHIMP LAWRENCE A , WINTERBOTTOM JOHN M , BOYCE TODD M , KNAACK DAVID
IPC分类号： A61L27/00 , A61L27/26 , A61L27/36 , A61L27/46 , A61L27/48
CPC分类号： A61L27/48 , A61L27/3608 , A61L27/46 , A61L2430/02 , C08L89/00
摘要： PROBLEM TO BE SOLVED: To provide bone-reinforced polymer matrix composites for use in orthopedic applications, and a synthesis method thereof.
SOLUTION: The source of the bone of the bone-reinforced polymer matrix composites may be autogenous, allogenic, xenogenic, or some combination of these; the bone particles obtained from one or more of cortical bone, cancellous bone, cortico-cancellous bone may be demineralized, nondemineralized, or a mixture of both demineralized and nondemineralized bone particles; the synthesis of composites includes steps of providing the bone particles, combining the bone particles with a polymer precursor in the form of a biodegradable or non-biodegradable polymer or copolymer or a copolymer of biodegradable and non-biodegradable polymers etc., and polymerizing the polymer precursor.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于矫形应用的骨增强聚合物基质复合材料及其合成方法。解决方案：骨增强聚合物基质复合材料的骨源可以是自体的，同种异体的，异种的，或这些的一些组合; 从皮质骨，松质骨，皮质松质骨中的一种或多种获得的骨颗粒可以被软化，非矿化，或脱矿质骨质和非矿化骨颗粒的混合物; 复合材料的合成包括提供骨颗粒，将骨颗粒与可生物降解或不可生物降解的聚合物或共聚物或可生物降解和不可生物降解的聚合物等的共聚物形式的聚合物前体组合并将聚合物聚合的步骤前体。版权所有（C）2011，JPO＆INPIT

10. 发明申请

WO03030956A2 IMPROVED BONE GRAFT 审中-公开
标题翻译：改进骨块
公开(公告)号：WO03030956A2
公开(公告)日：2003-04-17
申请号：PCT/US0232941
申请日：2002-10-15
申请人： OSTEOTECH INC
发明人： KNAACK DAVID , TRAIANEDES KATHY , DIEGMAN MICHELE , FORSYTH NANETTE , WINTERBOTTOM JOHN
IPC分类号： A61M31/00 , A61F2/28 , A61F2/30 , A61L27/00 , A61L27/22 , A61L27/36 , A61L27/50 , A61L27/54 , A61L27/58
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L27/227 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/505 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2430/02 , B33Y80/00
摘要： An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF- beta , BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteoinductive matrix compositions.
摘要翻译：提供了与稳定剂混合的改进的脱矿质骨基质（DBM）或其它基质组合物，其作为（1）扩散阻挡层，（2）酶抑制剂，（3）竞争性底物，或（4）掩蔽部分。扩散屏障作为屏障，以保护DBM中发现的骨诱导因子不被植入部位的蛋白水解酶和糖酵解酶降解。稳定剂可以是任何可生物降解的材料，例如淀粉，改性淀粉，纤维素，葡聚糖，聚合物，蛋白质和胶原蛋白。当稳定剂在体内降解或溶解时，诸如TGF-β，BMP和IGF的骨诱导因子被活化或暴露，并且活化因子用于将细胞从血管内空间募集到损伤部位并引起分化骨形成细胞。本发明还提供了制备，测试和使用本发明改进的骨诱导基质组合物的方法。

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