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1. 发明申请

WO2013032319A1 APPARATUS, SYSTEM AND METHOD FOR CONDITIONING AND PRESERVING AN ORGAN FROM A DONOR 审中-公开
标题翻译：用于调节和保存来自捐赠者的有机体的装置，系统和方法
公开(公告)号：WO2013032319A1
公开(公告)日：2013-03-07
申请号：PCT/NL2011/050603
申请日：2011-09-02
申请人： ORGAN ASSIST B.V. , VAN DER PLAATS, Arjan , RAKHORST, Gerhard
发明人： VAN DER PLAATS, Arjan , RAKHORST, Gerhard
IPC分类号： A01N1/02
CPC分类号： A01N1/0247
摘要： A donor organ treatment apparatus has a container for holding an organ and a perfusion liquid circuit. The perfusion circuit includes a supply conduit downstream of an oxygenator and a heat exchanger for supplying perfusion liquid from the oxygenator and the heat exchanger to an organ in the container and a return conduit upstream of the oxygenator and the heat exchanger for guiding perfusion liquid from the organ inside the container to the oxygenator and the heat exchanger. The supply conduit is provided with an outlet port coupling for connection to a perfusion catheter and the return conduit is provided with an inlet port coupling for connection to a return catheter. A method for successively perfusing an organ in-situ and ex-vivo with liquid circulating through the same perfusion circuit is also described.
摘要翻译：供体器官治疗装置具有用于保持器官和灌注液回路的容器。灌注回路包括在氧合器下游的供应管道和用于将来自氧合器和热交换器的灌注液体供应到容器中的器官和在氧合器和热交换器上游的返回管道的热交换器，用于引导灌注液体从容器内的器官到达氧合器和热交换器。供应管道设置有用于连接到灌注导管的出口端口，并且返回管道设置有用于连接到返回导管的入口端口联接件。还描述了通过同一灌注电路循环的液体原位和离体地依次灌注器官的方法。

2. 发明申请

WO2009041806A1 ORGAN TRANSPORT CONTAINER SYSTEM 审中-公开
标题翻译：有机运输集装箱系统
公开(公告)号：WO2009041806A1
公开(公告)日：2009-04-02
申请号：PCT/NL2007/050474
申请日：2007-09-28
申请人： ORGAN ASSIST B.V. , HUTZENLAUB, Jens Peter , SCHROEDER, Timm Michael , VAN DER PLAATS, Arjan , RAKHORST, Gerhard
发明人： HUTZENLAUB, Jens Peter , SCHROEDER, Timm Michael , VAN DER PLAATS, Arjan , RAKHORST, Gerhard
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0247 , A01N1/0273 , C12M21/08
摘要： An organ transport container system for storing and transporting therein an organ coupled to a perfusion system for preserving the viability of the organ for implantation by perfusing the organ with a perfusion liquid. The container system includes a cartridge for carrying the organ and a receptacle for holding a volume of the perfusion liquid and for removably holding therein the cartridge in a transport position. The cartridge has a holder for supporting the organ and relay conduit extending between an artery connector for sealingly connecting the relay conduit to an artery of the organ in the holder and an inlet. An outlet of a passage through the receptacle wall or bottom and the inlet are positioned and arranged such that the outlet and the inlet are sealingly coupled to each other when the cartridge is brought in the transport position, for allowing preservation liquid supplied via the supply conduit to be relayed to the artery via the relay conduit when the cartridge is in the transport position.
摘要翻译：一种器官输送容器系统，用于在其中存储和输送与灌注系统相连的器官，用于通过用灌注液灌注器官来保持用于植入的器官的存活力。容器系统包括用于携带器官的药筒和用于保持一定体积的灌注液体的容器，并用于将药筒可移除地保持在运送位置。药筒具有用于支撑在动脉连接器之间延伸的器官和继电器管道的保持器，用于将继电器导管密封地连接到保持器中的器官的动脉和入口。通过容器壁或底部和入口的通道的出口被定位和布置成使得当盒被带入运送位置时，出口和入口彼此密封地联接，以允许通过供应管道供应的保存液体当药筒处于运输位置时，通过继电器管道中继到动脉。

3. 发明申请

WO2007111495A1 A METHOD AND A SYSTEM FOR PROLONGATION OF THE VIABILITY OF A DONOR ORGAN 审中-公开
标题翻译：一种用于增强捐助机构可行性的方法和系统
公开(公告)号：WO2007111495A1
公开(公告)日：2007-10-04
申请号：PCT/NL2006/000158
申请日：2006-03-28
申请人： ORGAN ASSIST B.V. , RAKHORST, Gerhard , VAN DER PLAATS, Arjan , PLOEG, Rutger Jan
发明人： RAKHORST, Gerhard , VAN DER PLAATS, Arjan , PLOEG, Rutger Jan
IPC分类号： A01N1/02 , A61M25/00
CPC分类号： A01N1/0247 , A01N1/02
摘要： For post-mortem prolongation of the viability of an organ (7, 8, 50, 51) in a donor body, a flow of a solution is introduced from outside the body between a pair of barriers (21, 22) and a return flow including previously introduced quantities of the solution is led to the outside of the body. During a flushing phase, the flow including blood flushed out of the organ (7, 8, 50, 51) is discharged to a drain. Subsequently during a recirculation phase, solution returned from the body is cooled and/or oxygenated and recirculated from outside the body back into the body between the barriers. A system for carrying out the method is also described.
摘要翻译：对于供体体内器官（7,8,50,51）的活力的死后延长，溶液流从一对屏障（21,22）和回流包括以前介绍的数量的解决方案被引导到身体的外部。在冲洗阶段，包括从器官（7,8,50,51）冲出的血液的流量被排出到排水管。随后在再循环阶段，从身体返回的溶液被冷却和/或氧合并从身体外部再循环回到屏障之间的体内。还描述了用于执行该方法的系统。

4. 发明申请

WO2005009125A1 PORTABLE PRESERVATION APPARATUS FOR A DONOR ORGAN 审中-公开
标题翻译：便携式保存设备
公开(公告)号：WO2005009125A1
公开(公告)日：2005-02-03
申请号：PCT/NL2004/000539
申请日：2004-07-27
申请人： TECHNOLOGIESTICHTING STW , VAN DER PLAATS, Arjan , VERKERKE, Gijsbertus, Jacobus , RAKHORST, Gerhard , PLOEG, Rutger, Jan , 'T HART, Nils, Arnaud , LEUVENINK, Hendrik, Gerrit, Derk
发明人： VAN DER PLAATS, Arjan , VERKERKE, Gijsbertus, Jacobus , RAKHORST, Gerhard , PLOEG, Rutger, Jan , 'T HART, Nils, Arnaud , LEUVENINK, Hendrik, Gerrit, Derk
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0247 , A01N1/0273
摘要： A portable preservation apparatus of the cold storage type for a donor organ, comprising a cooling box provided with an organ chamber for receiving a donor organ in preservative fluid and a lid, wherein, on the side which operatively faces the organ chamber, the lid is provided with a connector which is detachably connected to the lid, which connector is provided with passages for one or more connecting pieces connected with the donor organ and one or more pipes connected with at least one perfusion pump, wherein the at least one perfusion pump is a miniature pump mounted at least partly in the lid and wherein the apparatus further comprises at least one oxygenator, an oxygen container, one or more electronic modules and a power supply module.
摘要翻译：一种用于供体器官的冷藏型便携式保存装置，包括设置有用于接收防腐液体中的供体器官的器官腔的冷却箱和盖子，其中，在操作性地面向器官腔室的一侧，盖子是设置有可拆卸地连接到盖的连接器，该连接器设置有用于与供体器官连接的一个或多个连接件的通道和与至少一个灌注泵连接的一个或多个管道，其中至少一个灌注泵是至少部分地安装在所述盖中的微型泵，其中所述装置还包括至少一个氧合器，氧气容器，一个或多个电子模块和电源模块。

5. 发明申请

WO2017044861A1 DEVICE FOR VASCULARIZED COMPOSITE ALLOTRANSPLANT PRESERVATION AND USE THEREOF 审中-公开
标题翻译：用于血管化复合材料保护的装置及其用途
公开(公告)号：WO2017044861A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/051122
申请日：2016-09-09
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , ORGAN ASSIST B.V.
发明人： CHAVES FONTES, Paulo, A. , VAN DER PLAATS, Arjan
IPC分类号： A01N1/00
CPC分类号： A01N1/0226 , A01N1/0247
摘要： Disclosed herein is a device for machine perfusion of an organ that includes a chamber including an organ support platform for supporting an organ and a perfusion circuit for providing an oxygenated perfusion fluid to the organ and carrying oxygen-depleted perfusion fluid away from the organ. The organ support platform includes perforations for fluid drainage. In some examples, the organ support platform is substantially horizontal. The device also includes a pump for circulating the perfusion fluid through the perfusion circuit, an oxygenating device in the perfusion circuit to oxygenate the perfusion fluid, and a temperature regulator for controlling the temperature of the perfusion fluid in the perfusion circuit. The device in some examples also includes a vascular perfusion cannula through which the perfusion fluid can flow to an organ placed on the organ support platform. Also disclosed are methods of perfusing an organ utilizing the machine perfusion devices.
摘要翻译：本文公开了一种用于机器灌注器官的装置，其包括包括用于支撑器官的器官支撑平台的腔室和用于向器官提供氧合灌注流体并将氧耗尽的灌注流体远离器官的灌注回路。器官支撑平台包括用于排液的穿孔。在一些示例中，器官支撑平台基本上是水平的。该装置还包括用于使灌注流体循环通过灌注回路的泵，用于使灌注流体充氧的灌注回路中的氧合装置，以及用于控制灌注回路中灌注流体温度的温度调节器。在一些示例中的装置还包括血管灌注插管，灌注流体可以通过该套管流动到放置在器官支撑平台上的器官。还公开了使用机器灌注装置灌注器官的方法。

6. 发明申请

WO2020145814A1 AN APPARATUS AND A METHOD FOR EX-VIVO MEASUREMENT OF PERFORMANCE OF A DONOR HEART 审中-公开
公开(公告)号：WO2020145814A1
公开(公告)日：2020-07-16
申请号：PCT/NL2019/050013
申请日：2019-01-10
申请人： ORGAN ASSIST B.V. , RIJKSUNIVERSITEIT GRONINGEN , ACADEMISCH ZIEKENHUIS GRONINGEN
发明人： NIJHUIS, Foppe , VAN DER PLAATS, Arjan , ERASMUS, Michiel Elardus
IPC分类号： A01N1/02
摘要： An apparatus (1) for ex-vivo measurement of performance of a donor heart (2) has a heart holder (6) in a receptacle (7) for holding a human donor heart and a bag (17) for placement into a left ventricle of the heart. The bag has a bag interior space communicating with an interior space of a fluid tight, compressible and expandable container (19). The apparatus further includes a sensor (21) for measuring compression and expansion of the container. Using the apparatus, cardiac output can be measured by measuring expansion and contraction of the container. A method for ex-vivo measurement of performance of a donor heart is also described. The method may include controlling the preload and/or the afterload.

7. 发明公开

EP3908110A1 AN APPARATUS AND A METHOD FOR EX-VIVO MEASUREMENT OF PERFORMANCE OF A DONOR HEART 审中-公开
公开(公告)号：EP3908110A1
公开(公告)日：2021-11-17
申请号：EP19719632.2
申请日：2019-01-10
申请人： Organ Assist B.V. , RIJKSUNIVERSITEIT GRONINGEN , Academisch Ziekenhuis Groningen
发明人： NIJHUIS, Foppe , VAN DER PLAATS, Arjan , ERASMUS, Michiel Elardus
IPC分类号： A01N1/02

8. 发明授权

EP2009986B1 A METHOD AND A SYSTEM FOR PROLONGATION OF THE VIABILITY OF A DONOR ORGAN 失效转让
标题翻译：延长DONORORGANEN的存活率的方法和系统
公开(公告)号：EP2009986B1
公开(公告)日：2015-04-22
申请号：EP06732965.6
申请日：2006-03-28
申请人： Organ Assist B.V.
发明人： RAKHORST, Gerhard , VAN DER PLAATS, Arjan , PLOEG, Rutger Jan
IPC分类号： A01N1/02 , A61M25/00
CPC分类号： A01N1/0247 , A01N1/02

9. 发明公开

EP2750499A1 APPARATUS, SYSTEM AND METHOD FOR CONDITIONING AND PRESERVING AN ORGAN FROM A DONOR 有权转让
标题翻译：设备，系统和方法进行冷却和保护策略的供体的学。
公开(公告)号：EP2750499A1
公开(公告)日：2014-07-09
申请号：EP11757967.2
申请日：2011-09-02
申请人： Organ Assist B.V.
发明人： VAN DER PLAATS, Arjan , RAKHORST, Gerhard
IPC分类号： A01N1/02
CPC分类号： A01N1/0247
摘要： A donor organ treatment apparatus has a container for holding an organ and a perfusion liquid circuit. The perfusion circuit includes a supply conduit downstream of an oxygenator and a heat exchanger for supplying perfusion liquid from the oxygenator and the heat exchanger to an organ in the container and a return conduit upstream of the oxygenator and the heat exchanger for guiding perfusion liquid from the organ inside the container to the oxygenator and the heat exchanger. The supply conduit is provided with an outlet port coupling for connection to a perfusion catheter and the return conduit is provided with an inlet port coupling for connection to a return catheter. A method for successively perfusing an organ in-situ and ex-vivo with liquid circulating through the same perfusion circuit is also described.

10. 发明授权

EP2750499B1 APPARATUS, SYSTEM AND METHOD FOR CONDITIONING AND PRESERVING AN ORGAN FROM A DONOR 有权转让
标题翻译：设备，系统和方法进行冷却和保护策略的供体的学。
公开(公告)号：EP2750499B1
公开(公告)日：2016-07-20
申请号：EP11757967.2
申请日：2011-09-02
申请人： Organ Assist B.V.
发明人： VAN DER PLAATS, Arjan , RAKHORST, Gerhard
IPC分类号： A01N1/02
CPC分类号： A01N1/0247

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