专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2017044861A1 DEVICE FOR VASCULARIZED COMPOSITE ALLOTRANSPLANT PRESERVATION AND USE THEREOF 审中-公开
标题翻译：用于血管化复合材料保护的装置及其用途
公开(公告)号：WO2017044861A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/051122
申请日：2016-09-09
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , ORGAN ASSIST B.V.
发明人： CHAVES FONTES, Paulo, A. , VAN DER PLAATS, Arjan
IPC分类号： A01N1/00
CPC分类号： A01N1/0226 , A01N1/0247
摘要： Disclosed herein is a device for machine perfusion of an organ that includes a chamber including an organ support platform for supporting an organ and a perfusion circuit for providing an oxygenated perfusion fluid to the organ and carrying oxygen-depleted perfusion fluid away from the organ. The organ support platform includes perforations for fluid drainage. In some examples, the organ support platform is substantially horizontal. The device also includes a pump for circulating the perfusion fluid through the perfusion circuit, an oxygenating device in the perfusion circuit to oxygenate the perfusion fluid, and a temperature regulator for controlling the temperature of the perfusion fluid in the perfusion circuit. The device in some examples also includes a vascular perfusion cannula through which the perfusion fluid can flow to an organ placed on the organ support platform. Also disclosed are methods of perfusing an organ utilizing the machine perfusion devices.
摘要翻译：本文公开了一种用于机器灌注器官的装置，其包括包括用于支撑器官的器官支撑平台的腔室和用于向器官提供氧合灌注流体并将氧耗尽的灌注流体远离器官的灌注回路。器官支撑平台包括用于排液的穿孔。在一些示例中，器官支撑平台基本上是水平的。该装置还包括用于使灌注流体循环通过灌注回路的泵，用于使灌注流体充氧的灌注回路中的氧合装置，以及用于控制灌注回路中灌注流体温度的温度调节器。在一些示例中的装置还包括血管灌注插管，灌注流体可以通过该套管流动到放置在器官支撑平台上的器官。还公开了使用机器灌注装置灌注器官的方法。

2. 发明申请

WO2015042602A1 BIOMARKERS RELATED TO ORGAN FUNCTION 审中-公开
标题翻译：与机关功能相关的生物标志
公开(公告)号：WO2015042602A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/057049
申请日：2014-09-23
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , CHAVES FONTES, Paulo, A. , KELLUM, John, A.
发明人： CHAVES FONTES, Paulo, A. , KELLUM, John, A.
IPC分类号： C12Q1/68
CPC分类号： G01N33/6863 , C12Q1/6883 , C12Q2600/158 , G01N33/6866 , G01N33/6869 , G01N2333/525 , G01N2333/5406 , G01N2333/5412 , G01N2333/5421 , G01N2333/5428 , G01N2333/5434 , G01N2333/545 , G01N2333/56 , G01N2333/57 , G01N2570/00 , G01N2800/085 , G01N2800/50 , G01N2800/60
摘要： Disclosed herein are methods of identifying biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) that can be used to predict organ or tissue function or dysfunction. In some embodiments, the methods include ex vivo perfusion of the organ or tissue, collection of samples from the organ or tissue (for example, perfusate, fluids produced by the organ (such as bile or urine), or tissue biopsies) and measuring the level of one or more biomarkers in the sample. It is also disclosed herein that an analysis of biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) present in a biological sample from an organ, tissue, or subject can be used to identify whether the organ, tissue, or subject is at risk for (or has) organ dysfunction or organ failure.
摘要翻译：本文公开了可用于预测器官或组织功能或功能障碍的生物标志物（例如基因（例如RNA或mRNA），蛋白质和/或小分子）的方法。在一些实施方案中，所述方法包括器官或组织的离体灌注，来自器官或组织（例如，灌注液，由器官（如胆汁或尿液）产生的流体）或组织活组织检查）的样品的收集，并测量样品中一种或多种生物标志物的水平。本文还公开了可以使用存在于来自器官，组织或受试者的生物样品中的生物标志物（例如RNA或mRNA），蛋白质和/或小分子的分析来鉴定是否器官，组织或受试者处于（或具有）器官功能障碍或器官衰竭的风险中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式