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1. 发明申请

WO2012071461A2 METHOD OF MAKING AND USING FLUORESCENT-TAGGED NANOPARTICLES AND MICROARRAYS 审中-公开
标题翻译：制备和使用荧光标记纳米颗粒和微米阵列的方法
公开(公告)号：WO2012071461A2
公开(公告)日：2012-05-31
申请号：PCT/US2011061936
申请日：2011-11-22
申请人： OREGON STATE , YAN MINGDI , WANG XIN , JAYAWARDENA H S N
发明人： YAN MINGDI , WANG XIN , JAYAWARDENA H S N
IPC分类号： G01N33/533 , A61K47/48 , C12Q1/68 , G01N33/551 , G01N33/68
CPC分类号： G01N33/587 , A61K49/0043 , A61K49/0052 , A61K49/0054 , A61K49/0065 , A61K49/0093 , G01N2400/00 , Y10T436/143333
摘要： Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern using statistical analysis to produce score plots illustrating the level of differentiation and/or classification. Also disclosed are methods for making perhalophenylazide-derived nanoparticle probes, individually or by using a microarray technique. Particular embodiments concern methods for using the perhalophenylazide-derived nanoparticle probes to diagnose, detect, and/or treat a disease. Kits comprising the perhalophenylazide-derived nanoparticle probes are also disclosed.
摘要翻译：所公开的实施方案涉及使用全卤代苯酰叠氮衍生的纳米粒子探针或多种这样的探针来区分和分类一个或多个靶标。具体实施方式涉及使用统计分析来产生说明分化和/或分类水平的分数图。还公开了单独地或通过使用微阵列技术来制备来自perhalophenylazide的纳米粒子探针的方法。具体实施方式涉及使用来自过氯化苯酰基化物的纳米粒子探针来诊断，检测和/或治疗疾病的方法。还公开了包含来自perhalophenylazide的纳米粒子探针的试剂盒。

2. 发明申请

WO03087206A8 PATTERNED POLYMERIC STRUCTURES, PARTICULARLY MICROSTRUCTURES, AND METHODS FOR MAKING SAME 审中-公开
标题翻译：特征聚合物结构，特殊微结构及其制备方法
公开(公告)号：WO03087206A8
公开(公告)日：2005-03-17
申请号：PCT/US0224675
申请日：2002-08-01
申请人： OREGON STATE , YAN MINGDI , BARTLETT MICHELE
发明人： YAN MINGDI , BARTLETT MICHELE
IPC分类号： B01J20/285 , B01J20/281 , B01J20/283 , C08K20060101 , C08K3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N30/88 , H01L21/31 , C08K
CPC分类号： C40B60/14 , B01J2219/00432 , B01J2219/00443 , B01J2219/00531 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C40B40/10 , G03F7/0035 , G03F7/008 , G03F7/012 , G03F7/11
摘要： Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.
摘要翻译：公开了将聚合物材料直接或通过连接分子粘附到基底上的方法。可以使用这些方法容易地形成结构，例如微结构，包括微孔和微孔阵列。在一些实施方案中，提供了由聚合材料完全形成的微结构，使得可以调整微结构的化学和物理性能。例如，提供具有包含极性聚合物材料的底部的微孔和包含非极性聚合物材料的阱侧/顶部。生物化学试剂可以很容易地传递到这种“智能井”，因为井底对于试剂的内在吸引力和阱侧/顶部之间的固有排斥结合起来将试剂引导到井。

3. 发明申请

WO2008156510A3 METHOD FOR FUNCTIONALIZING MATERIALS AND DEVICES COMPRISING SUCH MATERIALS 审中-公开
标题翻译：用于功能化材料的方法和包含这种材料的装置
公开(公告)号：WO2008156510A3
公开(公告)日：2009-04-23
申请号：PCT/US2008003348
申请日：2008-03-12
申请人： STATE OF OREGON ACTING BY & TH , YAN MINGDI , RAMSTROEM OLOF , LIU LI-HONG
发明人： YAN MINGDI , RAMSTROEM OLOF , LIU LI-HONG
IPC分类号： G01N33/53
CPC分类号： G01N33/5434 , C01P2002/82 , C01P2002/86 , C01P2004/04 , C08J7/047 , C08J7/065 , C08J7/12 , C08J7/16 , C09C1/24 , C09C1/3072 , C09C1/42 , C09C1/46 , G01N33/54346
摘要： Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, devices surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide.
摘要翻译：公开了包括功能化材料的装置以及用于制造和使用这些装置的方法的实施例。示例性装置包括眼科装置，纳米颗粒，石英晶体微量平衡，微阵列和纳米复合材料。在具体实施方案中，装置表面用单体和/或聚合物（通常为碳水化合物单体和/或聚合物）进行改性。公开了制造和使用这种装置的方法的实施例。使用官能化的全卤代叠氮基，单体和/或聚合物共价键合到表面上。在一些实施方案中，装置表面用全卤代苯偶酰胺官能化。随后使用全卤代苯偶酰共价键将一种或多种单体和/或聚合物共价结合到装置表面。在其它实施方案中，单体和/或聚合物用官能化的全卤代叠氮化物衍生化。然后，衍生化的单体和/或聚合物使用全卤代苯偶酰共价键合到器件表面。

4. 发明专利

AU2002367868A1 PATTERNED POLYMERIC STRUCTURES, PARTICULARLY MICROSTRUCTURES, AND METHODS FOR MAKING SAME 未知
公开(公告)号：AU2002367868A1
公开(公告)日：2003-10-27
申请号：AU2002367868
申请日：2002-08-01
申请人： OREGON STATE
发明人： YAN MINGDI , BARTLETT MICHELE
IPC分类号： B01J20/285 , B01J20/281 , B01J20/283 , C08K20060101 , C08K3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N30/88 , H01L21/31
摘要： Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

5. 发明公开

EP0731909A4 SENSORS EMPLOYING INTERFERENCE OF ELECTROMAGNETIC WAVES PASSING THROUGH WAVEGUIDES HAVING FUNCTIONALIZED SURFACES 失效
标题翻译：使用之间的干扰电磁波传感器是通过与表面官能扩频纤维
公开(公告)号：EP0731909A4
公开(公告)日：1997-09-03
申请号：EP94909569
申请日：1994-02-07
申请人： OREGON STATE
发明人： WYBOURNE MARTIN N , KEANA JOHN F W , CAI SUI XIONG , YAN MINGDI , WU JONG
IPC分类号： C08J7/12 , B01J19/08 , C01B31/04 , C08F8/34 , C23C16/02 , G01N21/27 , G01N21/45 , G01N21/64 , G01N21/75 , G01N21/77 , G01N33/543 , G01N33/566 , G03F7/20 , H01L21/368 , G01N21/41
CPC分类号： G01N21/7703 , C08F8/32 , G01N33/54373 , G01N2021/7779 , G01N2201/0873 , G03F7/2041 , C08F8/30 , C08F112/08
摘要： Chemical and biosensors are disclosed. An optical waveguide (11) is used to conduct electromagnetic radiation by total internal reflection in parallel through a reference waveguide portion (12) and at least one analyte waveguide portion (14). The electromagnetic radiation is then converged into an exit beam. The external surface of at least the analyte portion is covalently modified, or functionalized, relative to the reference portion. Resulting interaction of the functionalized surface with molecules comprising an analyte causes a phase change in the electromagnetic radiation passing through the analyte portion relative to the reference portion sufficient to generate a corresponding and measurable interference pattern in the exit beam.

6. 发明公开

EP1576040A4 PATTERNED POLYMERIC STRUCTURES, PARTICULARLY MICROSTRUCTURES, AND METHODS FOR MAKING SAME 有权
标题翻译：结构的聚合物结构，包括微结构及其制造方法
公开(公告)号：EP1576040A4
公开(公告)日：2008-12-10
申请号：EP02806828
申请日：2002-08-01
申请人： OREGON STATE
发明人： YAN MINGDI , BARTLETT MICHELE
IPC分类号： B01J20/285 , G03F7/00 , B01J20/281 , B01J20/283 , C08K20060101 , C08K3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N30/88 , G03F7/008 , G03F7/012 , G03F7/11 , H01L21/31
CPC分类号： C40B60/14 , B01J2219/00432 , B01J2219/00443 , B01J2219/00531 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C40B40/10 , G03F7/0035 , G03F7/008 , G03F7/012 , G03F7/11
摘要： Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such 'smart wells' because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

7. 发明公开

EP0680623A4 CHEMICAL FUNCTIONALIZATION OF SURFACES. 失效
标题翻译：方法功能化底物。
公开(公告)号：EP0680623A4
公开(公告)日：1996-07-24
申请号：EP94909487
申请日：1994-01-21
申请人： OREGON STATE
发明人： KEANA JOHN F W , WYBOURNE MARTIN N , CAI SUI XIONG , YAN MINGDI
IPC分类号： C08J7/12 , B01J19/08 , C01B31/04 , C08F8/34 , C23C16/02 , G01N21/45 , G01N21/77 , G01N33/543 , G03F7/20 , H01L21/368 , G03C5/00
CPC分类号： G01N33/54373 , C08F8/32 , G01N21/7703 , G01N2201/0873 , G03F7/2041 , Y10S430/143 , C08F8/30 , C08F112/08

8. 发明专利

AU2002367868A8 Patterned polymeric structures, particularly microstructures, and methods for making same 未知
公开(公告)号：AU2002367868A8
公开(公告)日：2003-10-27
申请号：AU2002367868
申请日：2002-08-01
申请人： OREGON STATE
发明人： YAN MINGDI , BARTLETT MICHELE
IPC分类号： B01J20/285 , G03F7/00 , B01J20/281 , B01J20/283 , C08K20060101 , C08K3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N30/88 , G03F7/004 , H01L21/31
摘要： Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

9. 发明专利

AU3306295A Chemical functionalisation of polymers 未知
公开(公告)号：AU3306295A
公开(公告)日：1995-12-14
申请号：AU3306295
申请日：1995-10-04
申请人： OREGON STATE
发明人： KEANA JOHN F W , WYBOURNE MARTIN N , CAI SUI XIONG , MANOJ KANSKAR , YAN MINGDI
IPC分类号： C08F8/30

10. 发明专利

AT541237T 未知
公开(公告)号：AT541237T
公开(公告)日：2012-01-15
申请号：AT02806828
申请日：2002-08-01
申请人： OREGON STATE
发明人： YAN MINGDI , BARTLETT MICHELE
IPC分类号： B01J20/285 , G03F7/00 , B01J20/281 , B01J20/283 , C08K20060101 , C08K3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N30/88 , G03F7/008 , G03F7/012 , G03F7/11 , H01L21/31
摘要： Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

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