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1. 发明申请

WO2008156510A3 METHOD FOR FUNCTIONALIZING MATERIALS AND DEVICES COMPRISING SUCH MATERIALS 审中-公开
标题翻译：用于功能化材料的方法和包含这种材料的装置
公开(公告)号：WO2008156510A3
公开(公告)日：2009-04-23
申请号：PCT/US2008003348
申请日：2008-03-12
申请人： STATE OF OREGON ACTING BY & TH , YAN MINGDI , RAMSTROEM OLOF , LIU LI-HONG
发明人： YAN MINGDI , RAMSTROEM OLOF , LIU LI-HONG
IPC分类号： G01N33/53
CPC分类号： G01N33/5434 , C01P2002/82 , C01P2002/86 , C01P2004/04 , C08J7/047 , C08J7/065 , C08J7/12 , C08J7/16 , C09C1/24 , C09C1/3072 , C09C1/42 , C09C1/46 , G01N33/54346
摘要： Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, devices surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide.
摘要翻译：公开了包括功能化材料的装置以及用于制造和使用这些装置的方法的实施例。示例性装置包括眼科装置，纳米颗粒，石英晶体微量平衡，微阵列和纳米复合材料。在具体实施方案中，装置表面用单体和/或聚合物（通常为碳水化合物单体和/或聚合物）进行改性。公开了制造和使用这种装置的方法的实施例。使用官能化的全卤代叠氮基，单体和/或聚合物共价键合到表面上。在一些实施方案中，装置表面用全卤代苯偶酰胺官能化。随后使用全卤代苯偶酰共价键将一种或多种单体和/或聚合物共价结合到装置表面。在其它实施方案中，单体和/或聚合物用官能化的全卤代叠氮化物衍生化。然后，衍生化的单体和/或聚合物使用全卤代苯偶酰共价键合到器件表面。

2. 发明申请

WO0220435A3 GENERATION OF COMBINATORIAL LIBRARIES AND ASSESSMENT THEREOF BY DECONVOLUTION 审中-公开
标题翻译：组合文库的生成及其解析评估
公开(公告)号：WO0220435A3
公开(公告)日：2002-06-06
申请号：PCT/EP0110170
申请日：2001-09-04
申请人： THERASCOPE AG , LEHN JEAN MARIE , RAMSTROEM OLOF , BUNYAPAIBOONSRI TARIDOPORN
发明人： LEHN JEAN-MARIE , RAMSTROEM OLOF , BUNYAPAIBOONSRI TARIDOPORN
IPC分类号： G01N33/15 , A61K45/00 , C07B61/00 , C07C211/63 , C07C243/34 , C12Q1/44 , C12Q1/527 , C40B20/06 , C40B40/02 , C40B50/06 , G01N33/53
CPC分类号： C40B50/04
摘要： The present invention deals with a method for the generation of a dynamic combinatorial library of ligands for a given target, capable of binding at least two functionalities, which method comprises the following steps: (i) selecting a set of n molecules carrying functionalities which may bind to the target, which molecules are capable of reversibly binding to each other under formation of an entity, n being an integer ≥ 1; (ii) mixing together said set of said n molecules; (iii) subjecting the mixture to conditions allowing a reversible bond formation and cleavage under formation of entities carrying different combinations of functionalities, until equilibrium is reached; (iv) optionally transforming the said entities into ligands; (v) repeating steps (i) to (iv) n-times, each time a different molecule of said set of n molecules being omitted; (vi) assessing the ability of each of the mixtures obtained to bind to a given target.
摘要翻译：本发明涉及用于产生能够结合至少两种官能度的给定靶标的配体的动态组合文库的方法，该方法包括以下步骤：（i）选择一组携带结合到靶上，所述分子在形成实体时能够彼此可逆地结合，n是≥1的整数; （ii）将所述一组所述n个分子混合在一起; （iii）使混合物经受允许可逆键形成和在形成携带不同功能组合的实体下形成的裂解的条件，直至达到平衡; （iv）任选地将所述实体转化成配体; （v）每次重复步骤（i）至（iv）n次，所述n个分子组中的不同分子被省略; （vi）评估获得的每种混合物结合给定靶标的能力。

3. 发明申请

WO0164605A3 GENERATION AND SCREENING OF A DYNAMIC COMBINATORIAL LIBRARY 审中-公开
标题翻译：动态组合图书馆的生成与筛选
公开(公告)号：WO0164605A3
公开(公告)日：2001-12-27
申请号：PCT/EP0102310
申请日：2001-03-01
申请人： THERASCOPE AG , LEHN JEAN MARIE , RAMSTROEM OLOF
发明人： LEHN JEAN-MARIE , RAMSTROEM OLOF
IPC分类号： C07H15/04 , A61K47/48 , C07B61/00 , C07H15/203 , C07H15/207 , C07H15/22 , G01N33/53 , G01N33/531
CPC分类号： G01N33/531 , C07H15/203 , C40B40/00 , G01N33/5308
摘要： The present invention concerns a method for selectively establishing a dynamic combinatorial library of ligands for a target which binds at least two functionalities, which method comprises the following steps: selecting a plurality of functionalities which upon combination with each other are capable of forming an entity which may bind to the at least two functionalities in the target; selecting at least one spacer group to be located between the at least two functionalities, which spacer group is of an appropriate size and/or flexibility to allow the functionalities to fit into the binding sites on the target and allowing a reversible bond formation and cleavage; creating discrete ligands by linking at least two identical or different functionalities by at least one spacer group or; linking the functionalities to fragments of the spacer group which contain functions allowing the said reversible bond formation under formation of the spacer group and cleavage of it; mixing together a plurality of different discrete ligands and/or different functionalities; subjecting the mixture to conditions allowing a reversible bond formation and cleavage; adding the target to the mixture; identifying the functionality combinations which are most appropriate for the formation of a complex between the target and the active molecule. In a further embodiment of the invention, the target is added when the discrete ligands are mixed together, in order to be present when the scrambling takes place.
摘要翻译：本发明涉及一种用于选择性地建立结合至少两个功能的靶的配体的动态组合文库的方法，该方法包括以下步骤：选择多个相互组合的能够形成一个实体的实体，可能与目标中的至少两个功能结合; 选择位于所述至少两个官能团之间的至少一个间隔基团，所述间隔基团具有适当大小和/或柔性，以使所述官能团适合于靶上的结合位点并允许可逆键的形成和切割; 通过将至少两个相同或不同的官能团连接至少一个间隔基团来产生离散的配体; 将所述官能团连接到间隔基团的片段上，所述间隔基团包含在间隔基团形成期间形成所述可逆键并使其断裂的功能; 将多个不同的离散配体和/或不同的官能团混合在一起; 使混合物经受允许可逆键形成和裂解的条件; 将混合物的目标加入; 鉴定最适合于靶和活性分子之间复合物形成的功能组合。在本发明的另一个实施方案中，当离散配体混合在一起时，加入靶，以便在发生加扰时存在。

4. 发明专利

SE9704919L 未知
公开(公告)号：SE9704919L
公开(公告)日：1999-03-15
申请号：SE9704919
申请日：1997-12-30
申请人： RAMSTROEM OLOF
发明人： RAMSTROEM OLOF
IPC分类号： C07J1/00 , C07K1/04 , C40B40/10 , C07B53/00

5. 发明专利

SE509863C2 未知
公开(公告)号：SE509863C2
公开(公告)日：1999-03-15
申请号：SE9704919
申请日：1997-12-30
申请人： RAMSTROEM OLOF
发明人： RAMSTROEM OLOF
IPC分类号： C07J1/00 , C07K1/04 , C40B40/10 , C07B53/00

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