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1. 发明申请

WO03040696A3 METHOD FOR TRANSFORMING PHASE SPECTRA OBTAINED BY THERMAL GRADIENT SPECTROMETRY TO ABSORPTION SPECTRA 审中-公开
标题翻译：通过热梯度光谱法测定吸收光谱的相位谱的方法
公开(公告)号：WO03040696A3
公开(公告)日：2003-07-10
申请号：PCT/US0236363
申请日：2002-11-12
申请人： OPTISCAN BIOMEDICAL CORP , BRAIG JAMES R , HALL W DALE , BARNES CASPER W , GABLE JENNIFER H
发明人： BRAIG JAMES R , HALL W DALE , BARNES CASPER W , GABLE JENNIFER H
IPC分类号： A61B5/00 , G01N21/17 , G01N21/35 , G01N21/71
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1491 , G01N21/1717 , G01N21/35 , G01N21/3577 , G01N21/71
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks (K) and reference wavelengths(J, L). The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.
摘要翻译：提供了用于确定材料样品中的分析物浓度的装置和方法。在样品中诱导调制温度梯度，并在所选的分析物吸收峰（K）和参考波长（J，L）上测量发射的红外辐射。调制温度梯度由表面温度调制控制。一个实施例提供了将表面温度调制与测量的红外辐射的调制相关联的传递函数。在所寻求的分析物的存在下检测传递函数的相位和幅度差异。测量，相关和处理与分析物浓度有关的这些相位和幅度差异，以确定材料样品中的分析物浓度。另一个实施方案提供了一种用于将热相谱转化为吸收光谱的方法，用于一致地测定样品中的分析物浓度。

2. 发明申请

WO2006088771A2 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
标题翻译：用于分析身体液体样品的装置和方法
公开(公告)号：WO2006088771A2
公开(公告)日：2006-08-24
申请号：PCT/US2006004928
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
发明人： HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
IPC分类号： A61B5/15 , A61B5/00 , A61M5/172 , G01N33/487
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength ?. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.
摘要翻译：提供了一种用于在将输注液注入患者体内时监测患者体液的预定参数的装置。该装置包括输注管线和构造成用于插入患者血管的导管以及连接在输注液源和输注管线和导管之间的可逆输液泵。该装置还包括体液传感器组件，其安装成与输注管线流体连通并且包括第一传感器和样品池。第一传感器提供指示输注管线中存在的任何流体的预定参数的信号。样品池对于包含波长λ的光是基本上透射的。所述装置还包括控制器，所述控制器被配置为沿向前方向操作所述输注泵，以便将所述输注流体泵送通过所述输注管线和导管以输注到所述患者体内。控制器被配置为间歇地中断其在向前方向上的输液泵的操作，以在向后的方向上操作输注泵，以便通过导管和输注管线从患者抽取体液样品。从患者抽出的体液样品被设置成使得体液样品的第一部分与体液传感器组件的第一传感器感测接触，并且体液样品的第二部分设置在样品池内的体液传感器组件。控制器还被配置为监测由体液传感器组件的第一传感器提供的信号，并且检测指示体液样品到达第一传感器的信号的变化。响应于检测体液样品到达第一传感器，控制器被配置为在向后的方向停止输注泵的操作。当体液样品与第一传感器感测接触时，由第一传感器产生的信号提供患者体液的预定参数的指示。

3. 发明申请

WO2006088771A9 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
标题翻译：用于分析身体液体样品的装置和方法
公开(公告)号：WO2006088771A9
公开(公告)日：2007-12-21
申请号：PCT/US2006004928
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
发明人： HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
IPC分类号： A61B5/15 , A61B5/00 , A61M5/142 , A61M5/172 , G01N33/487
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid wh
摘要翻译：提供一种用于监测患者体液的预定参数的装置，

4. 发明申请

WO2006088792A3 METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES 审中-公开
标题翻译：用于检测多个分析仪的方法和装置
公开(公告)号：WO2006088792A3
公开(公告)日：2007-03-01
申请号：PCT/US2006005027
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , STERLING BERNHARD B , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
发明人： STERLING BERNHARD B , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
IPC分类号： A61B5/15
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus (10) for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end (11) configured to maintain fluid communication with a bodily fluid in a patient and at least one pump (203) intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer (140) positioned to analyze at least a portion of the sample and measure the presence of two or more analytes . Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer.
摘要翻译：一种用于分析体液组成的装置（10）。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端部（11），以及间歇地可操作以从患者抽取体液样本的至少一个泵（203）。该装置还包括流体分析器（140），其定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。公开了用于分离血浆和血清和光谱分析仪的进一步手段。

5. 发明申请

WO2006047182A8 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENTS 审中-公开
标题翻译：在具有干扰的样品中测定分析物浓度的方法和装置
公开(公告)号：WO2006047182A8
公开(公告)日：2006-12-14
申请号：PCT/US2005037606
申请日：2005-10-21
申请人： OPTISCAN BIOMEDICAL CORP , HALL W DALE
发明人： HALL W DALE
IPC分类号： G06F19/00 , G01N33/50
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of know analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有一定范围的已知分析物和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

6. 发明申请

WO2006047182A2 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENT 审中-公开
标题翻译：用于确定样品中的分析物浓度的方法和装置
公开(公告)号：WO2006047182A2
公开(公告)日：2006-05-04
申请号：PCT/US2005037606
申请日：2005-10-21
申请人： OPTISCAN BIOMEDICAL CORP , HALL W DALE
发明人： HALL W DALE
IPC分类号： G01N19/00
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of know analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有一定范围的已知分析物和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

7. 发明专利

AU2002356913B2 Reagent-less whole-blood glucose meter 未知
公开(公告)号：AU2002356913B2
公开(公告)日：2006-09-28
申请号：AU2002356913
申请日：2002-11-06
申请人： OPTISCAN BIOMEDICAL CORP
发明人： CORTELLA JULIAN M , ZHENG PENG , GABLE JENNIFER H , AGOSTINO MARK D , GAFFNEY ROBERT D , HARTSTEIN PHILIP C , MUNROW MIKE A , HALL W DALE , BRAIG JAMES R , STERLING BERNHARD B , KLONOFF DAVID C , SHEILL JANE J , SMITH HEIDI M , GOLDBERGER DANIEL S , RULE PETER , WITTE KENNETH G , LI KENNETH I , FENNELL MARTIN J
IPC分类号： A61B5/00 , G01N33/49 , A61B5/145 , A61B5/1455 , G01N21/35 , G01N33/66
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

8. 发明公开

EP1805499A4 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENT 审中-公开
标题翻译：方法和设备的探测器，厘定分析物浓度的干扰物质
公开(公告)号：EP1805499A4
公开(公告)日：2010-07-21
申请号：EP05815567
申请日：2005-10-21
申请人： OPTISCAN BIOMEDICAL CORP
发明人： HALL W DALE , STERLING BERNHARD B , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , KEENAN RICHARD
IPC分类号： G01N19/00 , G01N33/50
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127

9. 发明专利

CA2465889C REAGENT-LESS WHOLE-BLOOD GLUCOSE METER 未知
公开(公告)号：CA2465889C
公开(公告)日：2009-06-02
申请号：CA2465889
申请日：2002-11-06
申请人： OPTISCAN BIOMEDICAL CORP
发明人： RULE PETER , GOLDBERGER DANIEL S , HALL W DALE , GABLE JENNIFER H , MUNROW MIKE A , BRAIG JAMES R , SMITH HEIDI M , SHEILL JANE J , WITTE KENNETH G , FENNELL MARTIN J , STERLING BERNHARD B , CORTELLA JULIAN M , ZHENG PENG , GAFFNEY ROBERT D , AGOSTINO MARK D , HARTSTEIN PHILIP C , LI KENNETH I , KLONOFF DAVID C
IPC分类号： G01N21/35 , G01N33/49 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/151 , G01N1/44 , G01N21/03 , G01N33/66
摘要： A reagentless whole-blood analyte detection system (200, 400, 450, 1000, 110 0) that is capable of being deployed near a patient has a source (220) capable of emitting a beam of radiation that includes a spectral band. The whole-blood system (200, 400, 450, 1000, 1100) also has at least one detector (250, 1152 , 1154) in an optical path of the beam. The whole-blood system (200, 400, 450, 1000, 1100) also has a housing (402, 452) that is configured to house the source (220) and the detector(s) (250, 1152, 1154). The whole-blood system (200, 400, 450, 1000, 1100) also has a sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) that is situated in the optical path of the beam. The sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) has a sample cell (242, 310, 610, 810) and a sample cell wall (244, 330, 335) that does not eliminate transmittance of the beam of radiation in the spectral band.

10. 发明专利

CA2597705A1 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 未知
公开(公告)号：CA2597705A1
公开(公告)日：2006-08-24
申请号：CA2597705
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP
发明人： WESCHLER MARK , WITTE KENNETH G , BRAIG JAMES R , KEENAN RICHARD , RULE PETER , CALLICOAT DAVID N , HALL W DALE , GABLE JENNIFER H
IPC分类号： A61B5/15 , A61B5/00 , A61M5/142 , A61M5/172 , G01N33/487

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