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1. 发明申请

WO2011031351A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 审中-公开
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：WO2011031351A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/033794
申请日：2010-05-05
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter
发明人： RULE, Peter
IPC分类号： A61B5/00
CPC分类号： G10L21/0208 , A61M5/168 , A61M5/1723
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e g insulin, dextrose, etc ) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

2. 发明申请

WO2006088785A1 ANALYTE DETECTION SYSTEM WITH DISTRIBUTED SENSING 审中-公开
标题翻译：分布式感知分析检测系统
公开(公告)号：WO2006088785A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005005
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
发明人： BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
IPC分类号： A61B5/15 , A61M1/36
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，采样组件用于主分析器。主分析器构造成通过从主分析器延伸的第一流体通道感测从患者获得的体液中的分析物。采样组件包括与主分析器分离并且包括至少一个传感器的仪器部分。仪器部分可移除地与第一流体通道接合。所述至少一个传感器与第一流体通道感应接合，使得至少一个传感器可感测第一流体通道内的流体的特性。

3. 发明申请

WO2006086019A2 METHODS OF TREATING DIABETES 审中-公开
标题翻译：治疗糖尿病的方法
公开(公告)号：WO2006086019A2
公开(公告)日：2006-08-17
申请号：PCT/US2005037699
申请日：2005-10-21
申请人： OPTISCAN BIOMEDICAL CORP , RULE PETER
发明人： RULE PETER
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455
摘要： A method of treating a diabetic condition of a patient comprises providing a glucose detection system which is portable and usable by the patient, and which is configured to measure glucose levels with a standard error of less than about 30 mg/dL. The method further comprises making a plurality of measurements of the patient's glucose level with the portable, patient-usable glucose detection system. The method further comprises administering a diabetes treatment to the patient based on one or more of the measurements of the patient's glucose level.
摘要翻译：治疗患者的糖尿病状况的方法包括提供便携式且可由患者使用的葡萄糖检测系统，并且该葡萄糖检测系统被配置成以小于约30mg / dL的标准误差测量葡萄糖水平。该方法还包括利用便携式患者可用葡萄糖检测系统对患者的葡萄糖水平进行多次测量。该方法进一步包括基于患者葡萄糖水平的一个或多个测量结果对患者施用糖尿病治疗。

4. 发明申请

WO2004016171A9 DEVICE AND METHOD FOR IN VITRO DETERMINATION OF ANALYTE CONCENTRATIONS WITHIN BODY FLUIDS 审中-公开
标题翻译：用于体内测定体内分析物浓度的装置和方法
公开(公告)号：WO2004016171A9
公开(公告)日：2005-03-17
申请号：PCT/US0325352
申请日：2003-08-12
申请人： OPTISCAN BIOMEDICAL CORP , BRAIG JAMES R , RULE PETER , HARTSTEIN PHILIP C
发明人： BRAIG JAMES R , RULE PETER , HARTSTEIN PHILIP C
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/15 , A61B5/151 , A61B5/157 , G01N21/03 , G01N21/35 , G01N33/49 , G01N33/493 , G01N33/50
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/15136 , A61B5/1514 , A61B5/157 , A61B2562/0295 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

5. 发明申请

WO2004062493A1 WEARABLE DEVICE FOR MEASURING ANALYTE CONCENTRATION 审中-公开
标题翻译：用于测量分析仪浓度的可测装置
公开(公告)号：WO2004062493A1
公开(公告)日：2004-07-29
申请号：PCT/US2003/041579
申请日：2003-12-30
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/14532 , A61B5/1455
摘要： An analyte detection system includes a first wearable module, a detector, and a processor. The first wearable module has an optical input through which electromagnetic radiation may enter said first wearable module. The first wearable module is configured to be worn on and engage a living wearer’s body such that electromagnetic radiation omitted by the body of the wearer can enter the first wearable module via the optical input. The detector is in optical communication with the optical input. The processor is in communication with the detector. The processor is configured to estimate the concentration of an analyte in the wearer’s tissue based on the emitted electromagnetic radiation.
摘要翻译：分析物检测系统包括第一耐磨模块，检测器和处理器。第一可佩戴模块具有光学输入，电磁辐射可通过该输入进入所述第一可穿戴模块。第一可穿戴模块被配置为佩戴在活体佩戴者的身体上并使其接合，使得佩戴者的身体省略的电磁辐射可经由光学输入进入第一佩戴模块。检测器与光学输入端光学通信。处理器与检测器通信。处理器被配置为基于发射的电磁辐射来估计穿着者组织中的分析物的浓度。

6. 发明申请

WO2003030731A3 METHOD AND APPARATUS FOR IMPROVING CLINICAL ACCURACY OF ANALYTE MEASUREMENTS 审中-公开
公开(公告)号：WO2003030731A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032281
申请日：2002-10-09
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
发明人： BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
IPC分类号： A61B5/00
摘要： Herein is described a system that includes a processing circuit for identifying possible zone D errors among estimated blood glucose concentration values. The system converts estimated blood glucose concentration values which are identified as possible zone D errors into adjusted blood glucose concentration values which are lower in blood glucose concentration magnitude than their corresponding estimated blood glucose concentration values, thereby decreasing the occurrence of zone D errors. Herein is also disclosed a method for improving the clinical accuracy of an analyte concentration measurement. One method includes a first act of computing an estimated analyte concentration having an associated first error that is clinically significant and a second act of processing the estimated analyte concentration to generate an adjusted analyte concentration having a second error that is clinically insignificant.

7. 发明申请

WO2003005894A1 STANDARD FOR NON-INVASIVE OPTICAL MEASUREMENT SYSTEMS 审中-公开
标题翻译：无入射光学测量系统的标准
公开(公告)号：WO2003005894A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/021888
申请日：2002-07-09
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , CORTELLA, Julian, M. , MUNROW, Mike , WITTE, Kenneth, G. , SMITH, Heidi, M. , HARTSTEIN, Philip, C. , HERRERA, Roger, O. , RULE, Peter
发明人： BRAIG, James, R. , CORTELLA, Julian, M. , MUNROW, Mike , WITTE, Kenneth, G. , SMITH, Heidi, M. , HARTSTEIN, Philip, C. , HERRERA, Roger, O. , RULE, Peter
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B2560/0233
摘要： In accordance with one embodiment there is provided a method of providing a known spectrum to a noninvasive optical detection system of the type having a window for receiving infrared energy. The method comprises affixing a standard to the window. The standard comprises a body formed from a material having known and stable spectral properties. The method further comprises placing at least a portion of the body directly against the window, and operating the optical detection system to detect an emission spectrum of the body. In accordance with another embodiment an infrared spectrometer comprises a window for receiving infrared energy. The window has an exposed surface. The infrared spectrometer further comprises a standard comprising a body formed of a material having known and stable spectral properties. At least part of the body is removably disposed directly against the exposed surface of the window.
摘要翻译：根据一个实施例，提供了一种向具有用于接收红外能量的窗口的类型的无创光学检测系统提供已知光谱的方法。该方法包括将标准附加到窗口。该标准包括由具有已知且稳定的光谱性质的材料形成的主体。该方法还包括将身体的至少一部分直接放置在窗户上，并且操作光学检测系统以检测身体的发射光谱。根据另一实施例，红外光谱仪包括用于接收红外能量的窗口。窗户有一个暴露的表面。红外光谱仪还包括标准，其包括由具有已知且稳定的光谱性质的材料形成的主体。身体的至少一部分可拆卸地直接设置在窗户的暴露表面上。

8. 发明申请

WO2007073392A1 ANALYTE DETECTION SYSTEM AND METHOD WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER 审中-公开
标题翻译：分析仪检测系统和方法与定期抽样和体液分析仪
公开(公告)号：WO2007073392A1
公开(公告)日：2007-06-28
申请号：PCT/US2006/005113
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter
发明人： BRAIG, James, R. , RULE, Peter
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/1486 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B2562/0295 , A61M5/14232 , A61M2005/1726 , A61M2230/201 , G01N27/3271 , G01N33/49
摘要： Described is a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system (203) is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element (9520) is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system (334) is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.
摘要翻译：描述了一种用于分析患者的体液的系统，包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。泵系统（203）联接到流体输送网络。泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体运输网络通过患者终点。至少一个电化学测试元件位于流体输送网络的流体输送点附近。电化学测试元件（9520）定位成接收由流体输送网络输送到输送点的体液的一部分。分析物检测系统（334）被配置为接收测试元件并且测量体液部分中的至少一种分析物。

9. 发明申请

WO2006091426A2 METHODS AND APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID 审中-公开
标题翻译：提取和分析一种体液的方法和装置
公开(公告)号：WO2006091426A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/005112
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , CALLICOAT, David N. , GABLE, Jennifer H. , BRAIG, James R. , LI, Kenneth I. , WITTE, Kenneth G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard A.
发明人： CALLICOAT, David N. , GABLE, Jennifer H. , BRAIG, James R. , LI, Kenneth I. , WITTE, Kenneth G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard A.
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system 334, 1700 and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The drawn portion is separated into a first component of the bodily fluid, while the analyte detection system 334, 1700 remains in fluid communication with the patient. The analyte detection system 334, 1700 analyzes the first component to measure a concentration of an analyte.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括建立分析物检测系统334,1700与患者体液之间的流体连通。体液的一部分从患者身上抽出。被拉伸的部分被分离成体液的第一组分，而分析物检测系统334,1700与患者保持流体连通。分析物检测系统334,1700分析第一组分以测量分析物的浓度。

10. 发明申请

WO2006088771A2 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
标题翻译：用于分析身体液体样品的装置和方法
公开(公告)号：WO2006088771A2
公开(公告)日：2006-08-24
申请号：PCT/US2006004928
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
发明人： HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
IPC分类号： A61B5/15 , A61B5/00 , A61M5/172 , G01N33/487
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength ?. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.
摘要翻译：提供了一种用于在将输注液注入患者体内时监测患者体液的预定参数的装置。该装置包括输注管线和构造成用于插入患者血管的导管以及连接在输注液源和输注管线和导管之间的可逆输液泵。该装置还包括体液传感器组件，其安装成与输注管线流体连通并且包括第一传感器和样品池。第一传感器提供指示输注管线中存在的任何流体的预定参数的信号。样品池对于包含波长λ的光是基本上透射的。所述装置还包括控制器，所述控制器被配置为沿向前方向操作所述输注泵，以便将所述输注流体泵送通过所述输注管线和导管以输注到所述患者体内。控制器被配置为间歇地中断其在向前方向上的输液泵的操作，以在向后的方向上操作输注泵，以便通过导管和输注管线从患者抽取体液样品。从患者抽出的体液样品被设置成使得体液样品的第一部分与体液传感器组件的第一传感器感测接触，并且体液样品的第二部分设置在样品池内的体液传感器组件。控制器还被配置为监测由体液传感器组件的第一传感器提供的信号，并且检测指示体液样品到达第一传感器的信号的变化。响应于检测体液样品到达第一传感器，控制器被配置为在向后的方向停止输注泵的操作。当体液样品与第一传感器感测接触时，由第一传感器产生的信号提供患者体液的预定参数的指示。

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