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1. 发明申请

WO2005072268A3 TREATMENT OF DEGENERAATIVE CARTILAGE CONDITIONS IN A MAMMAL WITH GLYCOSIDASE INHIBITORS 审中-公开
标题翻译：糖苷酶抑制剂治疗哺乳动物退行性软骨病变
公开(公告)号：WO2005072268A3
公开(公告)日：2005-10-20
申请号：PCT/US2005002017
申请日：2005-01-20
申请人： OPTIMER PHARMACEUTICALS INC , ICHIKAWA YOSHITAKA , SHUE YOUE-KONG , ORIDA NORMAN K , LOTZ MARTIN , WONG CHI-HUEY , OKUMU FRANKLIN W , HWANG SAN-BAO
发明人： ICHIKAWA YOSHITAKA , SHUE YOUE-KONG , ORIDA NORMAN K , LOTZ MARTIN , WONG CHI-HUEY , OKUMU FRANKLIN W , HWANG SAN-BAO
IPC分类号： A61K9/00 , A61K31/40 , A61K31/435 , A61K31/55 , A61K31/70 , A61K45/06
CPC分类号： A61K45/06 , A61K9/0019 , A61K31/00 , A61K31/336 , A61K31/40 , A61K31/4015 , A61K31/435 , A61K31/445 , A61K31/4745 , A61K31/55 , A61K31/70 , A61K31/7008 , A61K2300/00
摘要： This invention relates to treating, preventing, and lessening the severity of conditions selected from the group consisting of osteoarthritis, rheumatoid arthritis, synovitis, subchondral bone edema, and cartilage degradation with administration of glycosidase inhibitors.
摘要翻译：本发明涉及治疗，预防和减轻选自由骨关节炎，类风湿性关节炎，滑膜炎，软骨下骨水肿和软骨降解引起的糖苷酶抑制剂组成的组中的病症的严重性。

2. 发明申请

WO2005051326A3 TREATMENT OF A CONDITION IN A MAMMAL WITH ADMINISTRATION OF COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：处理化合物管理的一个条件及其使用方法
公开(公告)号：WO2005051326A3
公开(公告)日：2007-10-11
申请号：PCT/US2004039680
申请日：2004-11-23
申请人： OPTIMER PHARMACEUTICALS INC , SCRIPPS RESEARCH INST , ICHIKAWA YOSHITAKA , OKUMU FRANKLIN W , LOTZ MARTIN
发明人： ICHIKAWA YOSHITAKA , OKUMU FRANKLIN W , LOTZ MARTIN
IPC分类号： A61K31/70 , A61K20060101
CPC分类号： A61K31/70 , A61K31/13 , A61K31/16 , A61K31/7008 , A61K31/7052
摘要： This invention relates to methods of treating, preventing, and lessening the severity of conditions or diseases selected from the group consisting of osteoarthritis (OA), rheumatoid arthritis, synovitis, subchondral bone edema, and cartilage degradation ("OA and related disorders") with administration of an aminosugar derivative and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及治疗，预防和减轻选自骨关节炎（OA），类风湿性关节炎，滑膜炎，软骨下骨水肿和软骨降解（“OA和相关疾病”）的病症或疾病的严重性的方法，其中施用氨基糖衍生物及其药学上可接受的盐。

3. 发明专利

CA2553866A1 TREATMENT OF DEGENERATIVE CARTILAGE CONDITIONS IN A MAMMAL WITH GLYCOSI DASE INHIBITORS 未知
公开(公告)号：CA2553866A1
公开(公告)日：2005-08-11
申请号：CA2553866
申请日：2005-01-20
申请人： OPTIMER PHARMACEUTICALS INC
发明人： WONG CHI-HUEY , SHUE YOUE-KONG , OKUMU FRANKLIN W , ICHIKAWA YOSHITAKA , LOTZ MARTIN , ORIDA NORMAN K
IPC分类号： A61K31/55 , A61K9/00 , A61K31/40 , A61K31/435 , A61K31/70 , A61K45/06
摘要： This invention relates to treating, preventing, and lessening the severity o f conditions selected from the group consisting of osteoarthritis, rheumatoid arthritis, synovitis, subchondral bone edema, and cartilage degradation with administration of glycosidase inhibitors.

4. 发明专利

CA2540586A1 TREATMENT OF A CONDITION IN A MAMMAL WITH ADMINISRATION OF AMINOSUGAR AND USES THEREOF 未知
公开(公告)号：CA2540586A1
公开(公告)日：2005-04-21
申请号：CA2540586
申请日：2004-09-30
申请人： OPTIMER PHARMACEUTICALS INC
发明人： SHUE YOUE-KONG , OKUMU FRANKLIN W , LOTZ MARTIN , SHIKHMAN ALEXANDER R
IPC分类号： A61K31/70 , A01N25/00 , C07H5/04 , C08B37/08

5. 发明专利

CA2546861A1 TREATMENT OF A CONDITION IN A MAMMAL WITH ADMINISTRATION OF COMPOUNDS AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2546861A1
公开(公告)日：2005-06-09
申请号：CA2546861
申请日：2004-11-23
申请人： OPTIMER PHARMACEUTICALS INC
发明人： LOTZ MARTIN , OKUMU FRANKLIN W , ICHIKAWA YOSHITAKA
IPC分类号： A61K31/7008 , A61K20060101 , A61P19/02
摘要： This invention relates to methods of treating, preventing, and lessening the severity of conditions or diseases selected from the group consisting of osteoarthritis (OA), rheumatoid arthritis, synovitis, subchondral bone edema , and cartilage degradation ("OA and related disorders") with administration o f an aminosugar derivative and pharmaceutically acceptable salts thereof.

6. 发明公开

EP1691779A4 TREATMENT OF A CONDITION IN A MAMMAL WITH ADMINISTRATION OF COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：一个条件均与化合物的给药及其使用方法治疗哺乳动物
公开(公告)号：EP1691779A4
公开(公告)日：2009-01-21
申请号：EP04812241
申请日：2004-11-23
申请人： OPTIMER PHARMACEUTICALS INC , SCRIPPS RESEARCH INST
发明人： ICHIKAWA YOSHITAKA , OKUMU FRANKLIN W , LOTZ MARTIN
IPC分类号： A61K31/70 , A61K20060101
CPC分类号： A61K31/70 , A61K31/13 , A61K31/16 , A61K31/7008 , A61K31/7052

7. 发明公开

EP1670486A4 TREATMENT OF A CONDITION IN A MAMMAL WITH ADMINISRATION OF AMINOSUGAR AND USES THEREOF 审中-公开
标题翻译：的病症的IN随给药氨基糖和治疗哺乳动物使用它们的
公开(公告)号：EP1670486A4
公开(公告)日：2009-04-01
申请号：EP04789289
申请日：2004-09-30
申请人： OPTIMER PHARMACEUTICALS INC , SCRIPPS RESEARCH INST
发明人： SHUE YOUE-KONG , OKUMU FRANKLIN W , SHIKHMAN ALEXANDER R , LOTZ MARTIN
IPC分类号： A61K31/70 , A61P19/02
CPC分类号： A61K31/70 , A61K2300/00

8. 发明公开

EP1713485A4 TREATMENT OF DEGENERATIVE CARTILAGE CONDITIONS IN A MAMMAL WITH GLYCOSIDASE INHIBITORS 审中-公开
标题翻译：软骨退变疾病的治疗哺乳动物葡糖苷酶抑制剂
公开(公告)号：EP1713485A4
公开(公告)日：2007-09-19
申请号：EP05706017
申请日：2005-01-20
申请人： OPTIMER PHARMACEUTICALS INC , SCRIPPS RESEARCH INST
发明人： ICHIKAWA YOSHITAKA , SHUE YOUE-KONG , ORIDA NORMAN K , LOTZ MARTIN , WONG CHI-HUEY , OKUMU FRANKLIN W
IPC分类号： A61K31/55 , A61K9/00 , A61K31/40 , A61K31/435 , A61K31/70 , A61K45/06
CPC分类号： A61K45/06 , A61K9/0019 , A61K31/00 , A61K31/336 , A61K31/40 , A61K31/4015 , A61K31/435 , A61K31/445 , A61K31/4745 , A61K31/55 , A61K31/70 , A61K31/7008 , A61K2300/00

9. 发明申请

WO2008131742A3 MODIFIED POTATO FLAKES OR MODIFIED POTATO GRANULATE, METHOD FOR THE PRODUCTION THEREOF, AND USES THEREOF 审中-公开
标题翻译：改性马铃薯片或改性马铃薯颗粒，其制备方法和应用
公开(公告)号：WO2008131742A3
公开(公告)日：2009-02-12
申请号：PCT/DE2008000712
申请日：2008-04-25
申请人： EMSLAND STAERKE GMBH , LOTZ MARTIN , BORGHUIS JOHANNES B , SCHAIPER FRANK , FRANCKE CHRISTIAN
发明人： LOTZ MARTIN , BORGHUIS JOHANNES B , SCHAIPER FRANK , FRANCKE CHRISTIAN
IPC分类号： A23L1/308 , A23L1/2165
CPC分类号： A23L33/21 , A23L19/15 , A23L19/19 , A23V2002/00 , A23V2200/3324
摘要： The invention relates to a method for producing modified potato flakes or modified potato granulate. Said method comprises the following steps: a) potatoes are washed; b) the peels and any dirt are removed; c) the potatoes are optionally cut into small pieces; d) the potatoes are optionally blanched; e) the potatoes are optionally cooled if step d) is carried out; f) the potatoes are pressure-cooked; g) the pressure-cooked potatoes are strained or mashed; h) other additives are optionally added as dietary fibers; and i) the obtained puree is dried. Dietary fibers are added in at least one additional step after step b) and before step i) and are mixed in an essentially homogeneous manner into a product obtained at that time of the process. Also disclosed are modified potato flakes or potato granulates produced according to said method as well as the use thereof.
摘要翻译：本发明涉及一种用于改性马铃薯薄片或改性的马铃薯颗粒的制备方法，包括以下步骤：a）洗涤马铃薯; b）除去壳和可能的杂质; c）任选地，马铃薯的自由切割; d）任选地漂白的马铃薯; E）土豆，当步骤d）的任选的冷却进行; F）蒸汽烹调土豆; 克）使蒸汽煮土豆和MUSE; 1H）任选的加入除纤维材料的其它添加剂; 以及i）干燥获得的沉思，其中）至少纤维材料被添加进一步的步骤，并在存在于步骤b后的过程的加成产物时混合基本上均匀）和步骤i之前; 此后产生的被修饰马铃薯薄片或马铃薯颗粒及其用途。

10. 发明申请

WO2008052501B1 METHOD OF OBTAINING PLANT PROTEIN FRACTIONS WITH A MEDIUM MOLECULAR WEIGHT, PLANT PROTEIN FRACTION, AND ITS USE 审中-公开
标题翻译：用于获得植物蛋白组分的方法平均分子量，植物蛋白组分及其用途
公开(公告)号：WO2008052501B1
公开(公告)日：2008-07-03
申请号：PCT/DE2007001723
申请日：2007-09-24
申请人： EMSLAND STAERKE GMBH , LOTZ MARTIN , EGGENGOOR GEROLD
发明人： LOTZ MARTIN , EGGENGOOR GEROLD
IPC分类号： A23L1/305 , A23J1/00 , A23J1/12 , A23J1/14 , A23K1/14 , A61K8/64 , C07K1/30 , C07K14/415
CPC分类号： A61K8/645 , A23J1/006 , A23K10/35 , A23K20/147 , A23L33/185 , A61Q19/00 , C07K1/30 , C07K14/415 , Y02P60/877
摘要： The invention relates to a method of preparing a coagulated plant protein fraction with a medium molecular weight of between 14 to 97, comprising: providing fruit juice in aqueous solution; precipitating a high-molecular-weight plant protein fraction whose bulk has a molecular weight of from above 100 to 600, by adjusting an acidic pH and/or a temperature above room temperature, and mechanically separating the fraction precipitated thus; precipitating a medium-molecular-weight coagulated plant protein fraction under warm conditions by treating, at pH 2 to 7, preferably pH 3 to 6, especially preferably pH 4 to 5, and between 60 to 90°C, preferably at approximately 80°C, the solution obtained after separation of the high-molecular-weight plant protein fraction and mechanically separating the medium-molecular-weight coagulated plant protein fraction with a molecular weight of between approximately 14 to 97, with the bulk of the molecular weight distribution being between 20 to 60; if appropriate, washing the resulting medium-molecular-weight coagulated plant protein fraction by at least one step involving slurrying with water at a neutral or acidic pH above the precipitation pH at room temperature or a temperature below the precipitation temperature, and mechanically separating the medium-molecular-weight coagulated plant protein fraction; and, if appropriate, drying the washed plant protein fraction; and to the use of the plant protein fraction as foodstuff, food additive, additive in pharmaceuticals, animal feed, in cosmetics, as industrial protein, as adhesive.
摘要翻译：本发明涉及一种用于制备的凝固植物蛋白馏分与14 97之间的平均分子量：提供在水溶液中的果汁; 高分子量的植物蛋白质级分，其本体具有的分子量为约100至600的，通过调节酸性pH值和/或高于室温，如此沉淀馏分的机械分离的温度的情况下; 情况下，中等分子量凝结在所述热植物蛋白质级分通过在pH 2的pH 4处理高分子量的植物蛋白级分分离后得到的溶液至7，优选pH 3至6，更优选为5，60〜90℃，优选在约80 ℃，并具有分子量在约14至97中，其中，所述分子量分布的20之间以60的焦点位于所述介质分子量凝固植物蛋白质级分的机械分离; 如果需要，通过至少一次洗涤所得到的中等分子量的凝固植物蛋白质级分在中性或酸性pH的沉淀pH值以上与水浆化，在室温下或低于沉淀温度和中等分子量的凝固植物蛋白质级分的机械分离的温度; 和任选干燥经洗涤的植物蛋白级分，并使用植物蛋白质级分的作为食品，食品添加剂，药物添加剂，动物食品，化妆品，作为技术蛋白质，如粘合剂。

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