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1. 发明申请

WO2012151481A1 COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACITIVATION 审中-公开
标题翻译：用于抑制MASP-2依赖性补充活性的组合物
公开(公告)号：WO2012151481A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036509
申请日：2012-05-04
申请人： OMEROS CORPORATION , DUDLER, Thomas , GOMBOTZ, Wayne, R. , PARENT, James, Brian , TEDFORD, Clark, E. , KAVLIE, Anita , HAGEMANN, Urs, Beat , REIERSEN, Herald , KIPRIJANOV, Sergej
发明人： DUDLER, Thomas , GOMBOTZ, Wayne, R. , PARENT, James, Brian , TEDFORD, Clark, E. , KAVLIE, Anita , HAGEMANN, Urs, Beat , REIERSEN, Herald , KIPRIJANOV, Sergej
IPC分类号： A61K39/395 , C07K16/40 , C12N15/13 , C12N15/63 , C12P21/08 , C12N5/10 , C12N1/19
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N9/6424 , C12Y304/21104
摘要： The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-2 dependent complement activation. In one aspect, the invention provides an isolated human monoclonal antibody, or antigen binding fragment thereof, that binds to human MASP-2, comprising:(i) a heavy chain variable region comprising CDR-HI, CDR-H2 and CDR-H3 sequences; and (ii) a light chain variable region comprising CDR-LI, CDR-L2 and CDR-L3, wherein the heavy chain variable region CDR-H3 sequence comprises an amino acid sequence set with factor B in forming additional alternative pathway C3 convertase (C3bBb). The alternative pathway C3 convertase is stabilized by the binding of properdin. Properdin extends the alternative pathway C3 convertase half-life six to ten fold. Addition of C3b to the alternative pathway C3 convertase leads to the formation of the alternative pathway C5 convertase.
摘要翻译：本发明涉及抗MASP-2抑制性抗体和包含用于抑制MASP-2依赖性补体活化的不良作用的抗体的组合物。一方面，本发明提供了与人MASP-2结合的分离的人单克隆抗体或其抗原结合片段，其包含：（i）包含CDR-HI，CDR-H2和CDR-H3序列的重链可变区 ; 和（ii）包含CDR-L1，CDR-L2和CDR-L3的轻链可变区，其中重链可变区CDR-H3序列包含设置有因子B的氨基酸序列，形成另外的替代途径C3转化酶（C3bBb ）。替代途径C3转化酶通过适体素的结合而稳定。 Properdin将替代途径C3转化酶半衰期延长至10倍。将C3b加入替代途径C3转化酶导致替代途径C5转化酶的形成。

2. 发明申请

WO2012076883A1 ANTI CCR4 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗体CCR4抗体及其用途
公开(公告)号：WO2012076883A1
公开(公告)日：2012-06-14
申请号：PCT/GB2011/052421
申请日：2011-12-07
申请人： AFFITECH RESEARCH AS , HAGEMANN, Urs Beat , GRIEP, Remko Albert , REIERSEN, Herald , KIPRIJANOV, Sergej Michailovic , RIGBY, Barbara
发明人： HAGEMANN, Urs Beat , GRIEP, Remko Albert , REIERSEN, Herald , KIPRIJANOV, Sergej Michailovic
IPC分类号： C07K16/28 , G01N33/574 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , G01N2333/7158
摘要： The present disclosure provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage - derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.
摘要翻译：本公开提供结合人类CC趋化因子受体4（CCR4）的细胞外结构域中的表位并且能够抑制巨噬细胞衍生的趋化因子（MDC）和/或胸腺和激活调节的趋化因子（TARC）的结合的抗体，到CCR4。还提供了免疫缀合物和包含此类抗体的组合物，以及涉及这种抗体的方法和用途，特别是在医学和诊断领域。

3. 发明申请

WO2010097589A1 METHOD FOR SCREENING PHAGE DISPLAY LIBRARIES AGAINST EACH OTHER 审中-公开
标题翻译：用于筛选噬菌体的方法显示每个其他图书馆
公开(公告)号：WO2010097589A1
公开(公告)日：2010-09-02
申请号：PCT/GB2010/000340
申请日：2010-02-26
申请人： AFFITECH RESEARCH AS , REIERSEN, Herald , LØSER, Geir, Åge , HAGEMANN, Urs, Beat , OWEN, Deborah
发明人： REIERSEN, Herald , LØSER, Geir, Åge , HAGEMANN, Urs, Beat
IPC分类号： C12N15/10
CPC分类号： C12N15/1037 , C40B40/08 , C40B50/06
摘要： The present invention relates to a method for screening phage display libraries against each other. In particular, the invention relates to a method for screening at least two phage display libraries against each other to identify and/or select one or more interacting binding partners or binding molecules making up such interacting binding partners. Kits providing two bispecific phage display libraries are also provided.
摘要翻译：本发明涉及一种筛选噬菌体展示文库的方法。特别地，本发明涉及一种筛选至少两个噬菌体展示文库相互抵抗以识别和/或选择构成这种相互作用的结合配偶体的一个或多个相互作用的结合配偶体或结合分子的方法。还提供了提供两个双特异性噬菌体展示文库的试剂盒。

4. 发明申请

WO2006038021A1 METHODS FOR ANTIBODY LIBRARY SCREENING 审中-公开
标题翻译：抗体库筛选方法
公开(公告)号：WO2006038021A1
公开(公告)日：2006-04-13
申请号：PCT/GB2005/003865
申请日：2005-10-07
申请人： AFFITECH AS , OWEN, Deborah, Jane , STASSAR, Marike, Josée, Janneke, Gertrud , REIERSEN, Herald
发明人： STASSAR, Marike, Josée, Janneke, Gertrud , REIERSEN, Herald
IPC分类号： G01N33/68
CPC分类号： C12N15/1086
摘要： The present invention provides a method of screening a library of molecules to identify and/or select one or more members thereof which are candidate binding partners for one or more ligands comprising: a) contacting an expression library in solution with one or more ligands; b) capturing ligands which have become bound to one or more members of the expression library onto a solid phase; and c) detecting the presence of a ligand, thereby detecting the presence of one or more members of the expression library which are candidate binding partners for the ligand.
摘要翻译：本发明提供了筛选分子文库以鉴定和/或选择一种或多种成员的方法，所述成员是一种或多种配体的候选结合配偶体，其包含：a）使溶液中的表达文库与一种或多种配体接触; b）捕获已经与表达文库的一个或多个成员结合到固相上的配体; 和c）检测配体的存在，从而检测作为配体的候选结合配偶体的表达文库的一个或多个成员的存在。

5. 发明申请

WO2006038022A1 METHODS FOR ANTIBODY LIBRARY SCREENING 审中-公开
标题翻译：抗体库筛选方法
公开(公告)号：WO2006038022A1
公开(公告)日：2006-04-13
申请号：PCT/GB2005/003866
申请日：2005-10-07
申请人： AFFITECH AS , OWEN, Deborah, Jane , STASSAR, Marike, Josée, Janneke, Gertrud , REIERSEN, Herald
发明人： STASSAR, Marike, Josée, Janneke, Gertrud , REIERSEN, Herald
IPC分类号： G01N33/68
CPC分类号： C40B30/04 , C12N15/1086
摘要： The present invention provides an improved method of screening a library of molecules to identify or select one or more members thereof which are candidate binding partners for one or more target entities: (a) contacting an expression library with one or more target entities; (b) subjecting said target entities to at least one washing step; (c) separating target entities which have become bound to one or more members of the expression library from unbound members of the expression library by separation through an organic phase, thereby separating candidate binding partners for said target entities from other library members.
摘要翻译：本发明提供了一种筛选分子文库以鉴定或选择一个或多个成员的改进方法，所述成员是一个或多个目标实体的候选结合配偶体：（a）使表达文库与一个或多个目标实体接触; （b）对所述目标实体进行至少一个洗涤步骤; （c）通过分离有机相分离已经从表达文库的未结合成员绑定到表达文库的一个或多个成员的目标实体，从而将所述目标实体的候选绑定伙伴与其他库成员分离。

6. 发明申请

WO2004056995A1 PROCESS FOR PRODUCING AN IN VITRO PEPTIDE EXPRESSION LIBRARY 审中-公开
标题翻译：生产体外肽表达图谱的方法
公开(公告)号：WO2004056995A1
公开(公告)日：2004-07-08
申请号：PCT/GB2002/005909
申请日：2002-12-23
申请人： AFFITECH AS , OWEN, Deborah , MARVIK, Ole, Jørgen , REIERSEN, Herald , BREKKE, Ole, Henrik
发明人： MARVIK, Ole, Jørgen , REIERSEN, Herald , BREKKE, Ole, Henrik
IPC分类号： C12N15/10
CPC分类号： C12N15/1075
摘要： The present invention provides a method of producing a peptide expression library which displays a plurality of different peptides, wherein displayed peptides coupled to the genetic material encoding them, said method comprising the following steps: (a) preparing a library of nucleic acid molecules wherein each member of the library comprises a nucleotide sequence encoding a nucleic acid binding amino acid sequence, an oligonucleotide tag and a nucleotide sequence encoding the peptide which is to be displayed said nucleic acid binding sequence being capable of coupling to the nucleic acid molecule which encodes it; (b) attaching said library or a subpopulation thereof to one or more solid supports, wherein said attachment occurs by specific hybridisation of the oligonucleotide tag of a library member to a complementary tag which is attached to a solid support or a discrete area of a solid support so that each solid support or discrete area of a solid support has attached a distinct type of individual library members; and (c) translating the library members. Nucleic acid and peptide expression libraries and the members thereof form yet further aspects of the invention, as do kits comprising these libraries and members thereof. Further aspects involve the use of said libraries to screen and identify peptides or proteins or other entities exhibiting desired properties or the use of said library to screen against another library.
摘要翻译：本发明提供了一种产生肽表达文库的方法，其显示多个不同的肽，其中显示的肽与编码它们的遗传物质偶联，所述方法包括以下步骤：（a）制备核酸分子文库，其中每个文库成员包括编码核酸结合氨基酸序列的核苷酸序列，寡核苷酸标签和编码该肽的核苷酸序列，该核苷酸序列将显示所述核酸结合序列，其能够与编码该核酸结合序列的核酸分子偶联; （b）将所述文库或其亚群连接至一种或多种固体支持物，其中所述附着通过文库成员的寡核苷酸标签与附着于固体支持物或固体的离散区域的互补标签的特异性杂交而发生支撑，使得固体支持物的每个固体支持物或离散区域附着有不同类型的单个文库成员; 和（c）翻译图书馆成员。核酸和肽表达文库及其成员形成本发明的进一步方面，以及包含这些文库及其成员的试剂盒。进一步的方面涉及使用所述文库来筛选和鉴定显示所需性质的肽或蛋白质或其他实体或使用所述文库筛选另一文库。

7. 发明授权

EP2704743B1 COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACITIVATION 有权
公开(公告)号：EP2704743B1
公开(公告)日：2020-03-11
申请号：EP12779347.9
申请日：2012-05-04
申请人： Omeros Corporation
发明人： DUDLER, Thomas , GOMBOTZ, Wayne, R. , PARENT, James, Brian , TEDFORD, Clark, E. , KAVLIE, Anita , HAGEMANN, Urs, Beat , REIERSEN, Herald , KIPRIJANOV, Sergej
IPC分类号： C07K16/40 , A61K39/395 , C12N15/13 , C12N15/63 , C12P21/08 , C12N5/10 , C12N1/19

8. 发明公开

EP3725811A3 COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-实审
公开(公告)号：EP3725811A3
公开(公告)日：2021-01-27
申请号：EP19215429.2
申请日：2012-05-04
申请人： Omeros Corporation
发明人： DUDLER, Thomas , GOMBOTZ, Wayne R. , PARENT, James Brian , TEDFORD, Clark E. , KAVLIE, Anita , HAGEMANN, Urs Beat , REIERSEN, Herald , KIPRIJANOV, Sergej
IPC分类号： C07K16/40 , A61K39/395
摘要： The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-2 dependent complement activation.

9. 发明公开

EP3725811A2 COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-实审
公开(公告)号：EP3725811A2
公开(公告)日：2020-10-21
申请号：EP19215429.2
申请日：2012-05-04
申请人： Omeros Corporation
发明人： DUDLER, Thomas , GOMBOTZ, Wayne R. , PARENT, James Brian , TEDFORD, Clark E. , KAVLIE, Anita , HAGEMANN, Urs Beat , REIERSEN, Herald , KIPRIJANOV, Sergej
IPC分类号： C07K16/40 , A61K39/395
摘要： The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-2 dependent complement activation.

10. 发明公开

EP2704743A1 COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACITIVATION 有权
标题翻译：抑制MASP-2依赖补充激活的组合物
公开(公告)号：EP2704743A1
公开(公告)日：2014-03-12
申请号：EP12779347.9
申请日：2012-05-04
申请人： Omeros Corporation
发明人： DUDLER, Thomas , GOMBOTZ, Wayne, R. , PARENT, James, Brian , TEDFORD, Clark, E. , KAVLIE, Anita , HAGEMANN, Urs, Beat , REIERSEN, Herald , KIPRIJANOV, Sergej
IPC分类号： A61K39/395 , C07K16/40 , C12N15/13 , C12N15/63 , C12P21/08 , C12N5/10 , C12N1/19
摘要： The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-2 dependent complement activation.
摘要翻译：本发明涉及抗MASP-2抑制性抗体和包含此类抗体的组合物，用于抑制MASP-2依赖性补体活化的不利影响。在一个方面，本发明提供了结合人MASP-2的分离的人单克隆抗体或其抗原结合片段，其包含：（i）包含CDR-H1，CDR-H2和CDR-H3序列的重链可变区 ; 和（ii）包含CDR-L1，CDR-L2和CDR-L3的轻链可变区，其中所述重链可变区CDR-H3序列包含与因子B一起形成另外的旁路途径C3转化酶的氨基酸序列（C3bBb ）。替代途径C3转化酶通过血清灭菌蛋白的结合而稳定。 Properdin将替代途径C3转化酶半衰期延长六至十倍。向旁路途径C3转化酶添加C3b导致旁路途径C5转化酶的形成。

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