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1. 发明授权

US06932091B2 Method for surgically restoring coronary blood vessels 有权
标题翻译：手术恢复冠状动脉血管的方法
公开(公告)号：US06932091B2
公开(公告)日：2005-08-23
申请号：US10618897
申请日：2003-07-14
申请人： O. Howard Frazier , Stephen R. Igo
发明人： O. Howard Frazier , Stephen R. Igo
IPC分类号： A61B17/22 , A61F2/00 , A61F2/86 , A61B19/00
CPC分类号： A61F2/86 , A61B17/22 , A61B2017/320741 , A61F2220/0008 , A61F2220/0016 , A61F2220/0058 , A61F2250/0067
摘要： A method for surgically restoring a coronary artery having an atheroma, to more normal structure by making an arteriotomy incision over the length of the atheroma, extracting plaque, inserting stent into the coronary artery at the incision and closing the coronary artery over the stent with sutures. An extravascular drug delivery material is applied over the stent implantation site to inhibit thrombosis and smooth muscle cell proliferation.
摘要翻译：一种通过在动脉粥样化纤维长度上进行动脉切开术切除手术将具有动脉粥样硬化的冠状动脉手术恢复到更正常的结构的方法，提取斑块，在切口处将支架插入冠状动脉并用支架缝合冠状动脉。血管外药物递送材料应用于支架植入部位以抑制血栓形成和平滑肌细胞增殖。

2. 发明授权

US5827216A Method and apparatus for accessing the pericardial space 失效
标题翻译：用于获取心包空间的方法和装置
公开(公告)号：US5827216A
公开(公告)日：1998-10-27
申请号：US484299
申请日：1995-06-07
申请人： Stephen R. Igo , James W. Meador , Ruben Trono
发明人： Stephen R. Igo , James W. Meador , Ruben Trono
IPC分类号： A61B17/00 , A61B17/22 , A61B17/30 , A61B17/34 , A61M1/00 , A61N1/05 , A61N1/30
CPC分类号： A61M1/0058 , A61B17/00234 , A61N1/0587 , A61B17/3468 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00269 , A61B2017/22038 , A61B2017/306 , A61B2017/3488 , A61B2018/00392
摘要： A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within the tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within the needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through the needle for the slow and/or sustained delivery of the therapeutic agents into the pericardial cavity.
摘要翻译：一种用于获取心包空间的心包穿刺装置和方法。本发明包括插入经皮管，其尖端具有定位在前心包膜上方并与之接触的孔。在管内引入真空，在该孔内形成心包泡。管内的引导针头前进以刺穿心包泡，同时避免与心外膜接触。然后可以将针内的中空细丝或心电线或柔性导线推入所述心包腔。导丝可以用于将心包内导管引导到心包空间中，用于将选定的治疗剂注射或输注到心包空间中以治疗各种心脏和血管疾病。可以通过针头注射控制的药物释放材料，用于将治疗剂缓慢和/或持续递送到心包腔中。

3. 发明授权

US5957880A Extracorporeal circulation apparatus and method 失效
标题翻译：体外循环装置及方法
公开(公告)号：US5957880A
公开(公告)日：1999-09-28
申请号：US28220
申请日：1998-02-23
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61M1/16 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3666 , A61M2202/0275
摘要： Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.
摘要翻译：体外流路（例如心肺旁路机）中的患者血液与至少一个在电路泵上游的一种或多种一氧化氮进料接触，以提供有效抑制活化的血液中的一氧化氮浓度的血小板，并且通过使用体外循环的程序来减少患者的全身炎症。

4. 发明授权

US5634895A Apparatus and method for transpericardial delivery of fluid 失效
标题翻译：用于心包传递液体的装置和方法
公开(公告)号：US5634895A
公开(公告)日：1997-06-03
申请号：US486104
申请日：1995-06-07
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61F2/82 , A61M25/10 , A61M25/14 , A61M29/02 , A61M37/00 , A61N1/05 , A61N1/30 , A61B17/36
CPC分类号： A61M25/104 , A61M25/10 , A61M37/00 , A61N1/0587 , A61N1/30 , A61N1/303 , A61N1/306 , A61M2025/105 , A61M2210/122 , A61M25/1002 , A61M29/02
摘要： Method and apparatus for treating blood vessels in a mammal, particularly humans, especially coronary blood vessels, for vascular thrombosis and angioplasty restenosis, thereby to decrease incidence of vessel rethrombosis, unstable angina and myocardial infarction, by administering a conager of an endothelium-derived bioactive agent, especially a nitrovasodilator, including one or more of nitric oxide or a nitric oxide donor agent, such as sodium nitroprusside and nitroglycerin, to an extravascular treatment site at a therapeutically effective dosage rate.
摘要翻译：用于治疗哺乳动物，特别是人，特别是冠状血管的血管，用于血管血栓形成和血管成形术再狭窄的方法和装置，从而通过施用内皮衍生的生物活性物质的同位素来减少血管重血症，不稳定型心绞痛和心肌梗塞的发生率药剂，特别是硝基血管扩张剂，其包括一种或多种一氧化氮或一氧化氮供体试剂，例如硝普钠和硝酸甘油，以治疗有效的剂量率向血管外治疗部位。

5. 发明授权

US5725492A Extracorporeal circulation apparatus and method 失效
公开(公告)号：US5725492A
公开(公告)日：1998-03-10
申请号：US610622
申请日：1996-03-04
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61M1/16 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3666 , A61M2202/0275
摘要： Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.

6. 发明授权

US5681278A Coronary vasculature treatment method 失效
标题翻译：冠脉脉管系统治疗方法
公开(公告)号：US5681278A
公开(公告)日：1997-10-28
申请号：US264458
申请日：1994-06-23
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61F2/82 , A61M25/10 , A61M25/14 , A61M29/02 , A61M37/00 , A61N1/05 , A61N1/30 , A61M31/00
CPC分类号： A61M25/104 , A61M25/10 , A61M37/00 , A61N1/0587 , A61N1/30 , A61N1/303 , A61N1/306 , A61M2025/105 , A61M2210/122 , A61M25/1002 , A61M29/02
摘要： Method and apparatus for treating blood vessels in a mammal, particularly humans, especially coronary blood vessels, for vascular thrombosis and angioplasty restenosis, thereby to decrease incidence of vessel rethrombosis, unstable angina and myocardial infarction, by administering a conager of an endothelium-derived bioactive agent, especially a nitrovasodilator, including one or more of nitric oxide or a nitric oxide donor agent, such as sodium nitroprusside and nitroglycerin, to an extravascular treatment site at a therapeutically effective dosage rate.
摘要翻译：用于治疗哺乳动物，特别是人，特别是冠状血管的血管，用于血管血栓形成和血管成形术再狭窄的方法和装置，从而通过施用内皮衍生的生物活性物质的同位素来减少血管重血症，不稳定型心绞痛和心肌梗塞的发生率药剂，特别是硝基血管扩张剂，其包括一种或多种一氧化氮或一氧化氮供体试剂，例如硝普钠和硝酸甘油，以治疗有效的剂量率向血管外治疗部位。

7. 发明授权

US06666844B1 Method and apparatus for accessing the pericardial space 失效
标题翻译：用于获取心包空间的方法和装置
公开(公告)号：US06666844B1
公开(公告)日：2003-12-23
申请号：US09625900
申请日：2000-07-26
申请人： Stephen R. Igo , James W. Meador , Ruben Trono
发明人： Stephen R. Igo , James W. Meador , Ruben Trono
IPC分类号： A61M500
CPC分类号： A61M1/0058 , A61B17/00234 , A61B17/3468 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00269 , A61B2017/22038 , A61B2017/306 , A61B2017/3488 , A61B2018/00392 , A61N1/0587
摘要： A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within said tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within said needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through said needle for the slow and/or sustained delivery of said therapeutic agents into said pericardial cavity.
摘要翻译：一种用于获取心包空间的心包穿刺装置和方法。本发明包括插入经皮管，其尖端具有定位在前心包膜上方并与之接触的孔。在所述管内引入真空，在该孔内形成心包泡。管内的引导针头前进以刺穿心包泡，同时避免与心外膜接触。然后可将所述针内的中空细丝或心电线或柔性导线推入所述心包腔内。导丝可以用于将心包内导管引导到心包空间中，用于将选定的治疗剂注射或输注到心包空间中以治疗各种心脏和血管疾病。可以通过所述针头注射控制的药物释放材料，用于将所述治疗剂缓慢和/或持续递送到所述心包腔中。

8. 发明授权

US6162195A Method and apparatus for accessing the pericardial space 失效
公开(公告)号：US6162195A
公开(公告)日：2000-12-19
申请号：US158024
申请日：1998-09-21
申请人： Stephen R. Igo , James W. Meador , Ruben Trono
发明人： Stephen R. Igo , James W. Meador , Ruben Trono
IPC分类号： A61B17/00 , A61B17/22 , A61B17/30 , A61B17/34 , A61M1/00 , A61N1/05 , A61M5/178
CPC分类号： A61M1/0058 , A61B17/00234 , A61B17/3468 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00269 , A61B2017/22038 , A61B2017/306 , A61B2017/3488 , A61B2018/00392 , A61N1/0587
摘要： A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within said tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within said needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through said needle for the slow and/or sustained delivery of said therapeutic agents into said pericardial cavity.

9. 发明授权

US5900433A Vascular treatment method and apparatus 失效
标题翻译：血管治疗方法及装置
公开(公告)号：US5900433A
公开(公告)日：1999-05-04
申请号：US765711
申请日：1996-12-23
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61K31/155 , A61K31/21 , A61K31/5575 , A61M31/00 , A61K31/215 , A61K31/19
CPC分类号： A61K31/5575 , A61K31/155 , A61K31/21 , A61M31/00 , A61M2210/125
摘要： This invention relates to the method of use of a congener of an endothelium-derived bioactive composition of matter, which comprises administering said congener percutaneously to a site proximately adjacent the exterior of a coronary blood vessel at a therapeutically effective dosage.
摘要翻译： PCT No.PCT / US95 / 09055 Sec。 371日期：1996年12月23日 102（e）日期1996年12月23日PCT提交1995年6月23日PCT公布。第WO96 / 00112号公报日本1996年1月4日本发明涉及使用内皮衍生的物质生物活性组合物的同类物质的方法，其包括以治疗有效剂量经皮给予所述同源物至邻近冠状动脉血管外部的部位。

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