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1. 发明授权

US5827216A Method and apparatus for accessing the pericardial space 失效
标题翻译：用于获取心包空间的方法和装置
公开(公告)号：US5827216A
公开(公告)日：1998-10-27
申请号：US484299
申请日：1995-06-07
申请人： Stephen R. Igo , James W. Meador , Ruben Trono
发明人： Stephen R. Igo , James W. Meador , Ruben Trono
IPC分类号： A61B17/00 , A61B17/22 , A61B17/30 , A61B17/34 , A61M1/00 , A61N1/05 , A61N1/30
CPC分类号： A61M1/0058 , A61B17/00234 , A61N1/0587 , A61B17/3468 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00269 , A61B2017/22038 , A61B2017/306 , A61B2017/3488 , A61B2018/00392
摘要： A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within the tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within the needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through the needle for the slow and/or sustained delivery of the therapeutic agents into the pericardial cavity.
摘要翻译：一种用于获取心包空间的心包穿刺装置和方法。本发明包括插入经皮管，其尖端具有定位在前心包膜上方并与之接触的孔。在管内引入真空，在该孔内形成心包泡。管内的引导针头前进以刺穿心包泡，同时避免与心外膜接触。然后可以将针内的中空细丝或心电线或柔性导线推入所述心包腔。导丝可以用于将心包内导管引导到心包空间中，用于将选定的治疗剂注射或输注到心包空间中以治疗各种心脏和血管疾病。可以通过针头注射控制的药物释放材料，用于将治疗剂缓慢和/或持续递送到心包腔中。

2. 发明授权

US5957880A Extracorporeal circulation apparatus and method 失效
标题翻译：体外循环装置及方法
公开(公告)号：US5957880A
公开(公告)日：1999-09-28
申请号：US28220
申请日：1998-02-23
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61M1/16 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3666 , A61M2202/0275
摘要： Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.
摘要翻译：体外流路（例如心肺旁路机）中的患者血液与至少一个在电路泵上游的一种或多种一氧化氮进料接触，以提供有效抑制活化的血液中的一氧化氮浓度的血小板，并且通过使用体外循环的程序来减少患者的全身炎症。

3. 发明授权

US5634895A Apparatus and method for transpericardial delivery of fluid 失效
标题翻译：用于心包传递液体的装置和方法
公开(公告)号：US5634895A
公开(公告)日：1997-06-03
申请号：US486104
申请日：1995-06-07
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61F2/82 , A61M25/10 , A61M25/14 , A61M29/02 , A61M37/00 , A61N1/05 , A61N1/30 , A61B17/36
CPC分类号： A61M25/104 , A61M25/10 , A61M37/00 , A61N1/0587 , A61N1/30 , A61N1/303 , A61N1/306 , A61M2025/105 , A61M2210/122 , A61M25/1002 , A61M29/02
摘要： Method and apparatus for treating blood vessels in a mammal, particularly humans, especially coronary blood vessels, for vascular thrombosis and angioplasty restenosis, thereby to decrease incidence of vessel rethrombosis, unstable angina and myocardial infarction, by administering a conager of an endothelium-derived bioactive agent, especially a nitrovasodilator, including one or more of nitric oxide or a nitric oxide donor agent, such as sodium nitroprusside and nitroglycerin, to an extravascular treatment site at a therapeutically effective dosage rate.
摘要翻译：用于治疗哺乳动物，特别是人，特别是冠状血管的血管，用于血管血栓形成和血管成形术再狭窄的方法和装置，从而通过施用内皮衍生的生物活性物质的同位素来减少血管重血症，不稳定型心绞痛和心肌梗塞的发生率药剂，特别是硝基血管扩张剂，其包括一种或多种一氧化氮或一氧化氮供体试剂，例如硝普钠和硝酸甘油，以治疗有效的剂量率向血管外治疗部位。

4. 发明授权

US5725492A Extracorporeal circulation apparatus and method 失效
公开(公告)号：US5725492A
公开(公告)日：1998-03-10
申请号：US610622
申请日：1996-03-04
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61M1/16 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3666 , A61M2202/0275
摘要： Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.

5. 发明授权

US5681278A Coronary vasculature treatment method 失效
标题翻译：冠脉脉管系统治疗方法
公开(公告)号：US5681278A
公开(公告)日：1997-10-28
申请号：US264458
申请日：1994-06-23
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61F2/82 , A61M25/10 , A61M25/14 , A61M29/02 , A61M37/00 , A61N1/05 , A61N1/30 , A61M31/00
CPC分类号： A61M25/104 , A61M25/10 , A61M37/00 , A61N1/0587 , A61N1/30 , A61N1/303 , A61N1/306 , A61M2025/105 , A61M2210/122 , A61M25/1002 , A61M29/02
摘要： Method and apparatus for treating blood vessels in a mammal, particularly humans, especially coronary blood vessels, for vascular thrombosis and angioplasty restenosis, thereby to decrease incidence of vessel rethrombosis, unstable angina and myocardial infarction, by administering a conager of an endothelium-derived bioactive agent, especially a nitrovasodilator, including one or more of nitric oxide or a nitric oxide donor agent, such as sodium nitroprusside and nitroglycerin, to an extravascular treatment site at a therapeutically effective dosage rate.
摘要翻译：用于治疗哺乳动物，特别是人，特别是冠状血管的血管，用于血管血栓形成和血管成形术再狭窄的方法和装置，从而通过施用内皮衍生的生物活性物质的同位素来减少血管重血症，不稳定型心绞痛和心肌梗塞的发生率药剂，特别是硝基血管扩张剂，其包括一种或多种一氧化氮或一氧化氮供体试剂，例如硝普钠和硝酸甘油，以治疗有效的剂量率向血管外治疗部位。

6. 发明授权

US06666844B1 Method and apparatus for accessing the pericardial space 失效
标题翻译：用于获取心包空间的方法和装置
公开(公告)号：US06666844B1
公开(公告)日：2003-12-23
申请号：US09625900
申请日：2000-07-26
申请人： Stephen R. Igo , James W. Meador , Ruben Trono
发明人： Stephen R. Igo , James W. Meador , Ruben Trono
IPC分类号： A61M500
CPC分类号： A61M1/0058 , A61B17/00234 , A61B17/3468 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00269 , A61B2017/22038 , A61B2017/306 , A61B2017/3488 , A61B2018/00392 , A61N1/0587
摘要： A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within said tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within said needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through said needle for the slow and/or sustained delivery of said therapeutic agents into said pericardial cavity.
摘要翻译：一种用于获取心包空间的心包穿刺装置和方法。本发明包括插入经皮管，其尖端具有定位在前心包膜上方并与之接触的孔。在所述管内引入真空，在该孔内形成心包泡。管内的引导针头前进以刺穿心包泡，同时避免与心外膜接触。然后可将所述针内的中空细丝或心电线或柔性导线推入所述心包腔内。导丝可以用于将心包内导管引导到心包空间中，用于将选定的治疗剂注射或输注到心包空间中以治疗各种心脏和血管疾病。可以通过所述针头注射控制的药物释放材料，用于将所述治疗剂缓慢和/或持续递送到所述心包腔中。

7. 发明授权

US6162195A Method and apparatus for accessing the pericardial space 失效
公开(公告)号：US6162195A
公开(公告)日：2000-12-19
申请号：US158024
申请日：1998-09-21
申请人： Stephen R. Igo , James W. Meador , Ruben Trono
发明人： Stephen R. Igo , James W. Meador , Ruben Trono
IPC分类号： A61B17/00 , A61B17/22 , A61B17/30 , A61B17/34 , A61M1/00 , A61N1/05 , A61M5/178
CPC分类号： A61M1/0058 , A61B17/00234 , A61B17/3468 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00269 , A61B2017/22038 , A61B2017/306 , A61B2017/3488 , A61B2018/00392 , A61N1/0587
摘要： A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within said tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within said needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through said needle for the slow and/or sustained delivery of said therapeutic agents into said pericardial cavity.

8. 发明授权

US5900433A Vascular treatment method and apparatus 失效
标题翻译：血管治疗方法及装置
公开(公告)号：US5900433A
公开(公告)日：1999-05-04
申请号：US765711
申请日：1996-12-23
申请人： Stephen R. Igo , James W. Meador
发明人： Stephen R. Igo , James W. Meador
IPC分类号： A61K31/155 , A61K31/21 , A61K31/5575 , A61M31/00 , A61K31/215 , A61K31/19
CPC分类号： A61K31/5575 , A61K31/155 , A61K31/21 , A61M31/00 , A61M2210/125
摘要： This invention relates to the method of use of a congener of an endothelium-derived bioactive composition of matter, which comprises administering said congener percutaneously to a site proximately adjacent the exterior of a coronary blood vessel at a therapeutically effective dosage.
摘要翻译： PCT No.PCT / US95 / 09055 Sec。 371日期：1996年12月23日 102（e）日期1996年12月23日PCT提交1995年6月23日PCT公布。第WO96 / 00112号公报日本1996年1月4日本发明涉及使用内皮衍生的物质生物活性组合物的同类物质的方法，其包括以治疗有效剂量经皮给予所述同源物至邻近冠状动脉血管外部的部位。

9. 发明授权

US5409117A Liquid specimen vessel 失效
标题翻译：液体样品容器
公开(公告)号：US5409117A
公开(公告)日：1995-04-25
申请号：US227040
申请日：1994-04-13
申请人： James W. Meador
发明人： James W. Meador
IPC分类号： A61B10/00 , A61B19/02 , A61M1/00
CPC分类号： A61B10/007 , B01L3/505 , A61B2010/0009 , A61B2050/0064 , A61B2050/0076
摘要： A liquid vessel provides a means of assuring uncontaminated, multiple specimens of a liquid. Two containers are connected side-by-side by a retainer which accepts a detachable funnel assembly that directs liquid into each container. The retainer includes both a flexible serpentine connector loosely connecting collar portions of the retainer fitted to each container and a rigid portion fixing the spacing of the containers. Each container includes an bellows-like sidewall flexure, and when the funnel is removed, each is closed by a closure that includes another bellows-like sidewall flexure, a nozzle facing away from and basally open to the floor of the container, and a stiff basal projection extending to the floor of the container. Coupling members on the floor underside of the containers enable coupling of the floors of the two containers after the rigid portion of the retainer is severed. Pushing the closure of one of the containers reduces intra-chamber pressure in that container and if the containers are coupled increases intra-chamber pressure in the coupled other container. The reduced pressure prevents discharge of specimen from the one container when a nozzle in the closure of that container is opened. Compressing the volume of the container with the opened nozzle discharges an aliquot of specimen from that container through the opened nozzle.
摘要翻译：液体容器提供了确保未受污染的多个液体样本的方法。两个容器通过保持器并排连接，保持器接受将液体引导到每个容器中的可拆卸漏斗组件。保持器包括松紧地连接装配到每个容器的保持器的套环部分的柔性蛇形连接器和固定容器间隔的刚性部分。每个容器包括波纹管状的侧壁弯曲部，并且当漏斗被移除时，每个都由封闭件封闭，该封闭件包括另一个波纹管状的侧壁弯曲部，背向容器的底部并且基本上向容器底部开口的喷嘴，基底突起延伸到容器的地板上。在容器的刚性部分被切断之后，容器底面上的联接构件能联接两个容器的地板。推动其中一个容器的封闭件减小该容器中的室内压力，并且如果容器联接则增加了联接的其他容器中的室内压力。当打开该容器的封闭件中的喷嘴时，减小的压力防止样品从一个容器中排出。用打开的喷嘴压缩容器的体积，通过打开的喷嘴将样品的等分试样从该容器排出。

10. 发明授权

US07351234B2 Urine collection and disposal system 失效
公开(公告)号：US07351234B2
公开(公告)日：2008-04-01
申请号：US10962687
申请日：2004-10-12
申请人： Richard B. Finger , James W. Meador
发明人： Richard B. Finger , James W. Meador
IPC分类号： A61M1/00 , A61F5/44
CPC分类号： A61G9/00
摘要： A urine collection and disposal system and method applies subatmospheric pressure to a receptacle open to atmospheric pressure which has a urine outlet in fluid communication with a source of subatmospheric pressure. The receptacle receives urine in the receptacle from a urine donor and removes the urine from the receptacle, transporting the removed urine to a reservoir under the force of a pressure differential between atmospheric pressure at the receptacle and subatmospheric pressure at the reservoir. The reservoir urine is discharged at atmospheric pressure, for disposal, from the reservoir while maintaining the reservoir at subatmospheric pressure. A plurality of the receptacles allows simultaneously providing urine to the reservoir from more than one of the receptacles. Sanitizing fluid may be supplied intermediate the receptacle and the reservoir for transport to the reservoir under the force of the pressure differential between atmospheric and subatmospheric.

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