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1. 发明申请

WO2005069762A2 BACILLUS LICHENIFORMIS CHROMOSOME 审中-公开
标题翻译： BACILLUS LICHENIFORMIS染色体
公开(公告)号：WO2005069762A2
公开(公告)日：2005-08-04
申请号：PCT/US2004/037204
申请日：2004-11-05
申请人： NOVOZYMES INC. , NOVOZYMES A/S
发明人： BERKA, Randy , REY, Michael , RAMAIYA, Preethi , ANDERSEN, Jens Tonne , RASMUSSEN, Michael Dolberg , OLSEN, Peter Bjarke
IPC分类号： C07K14/32 , C12Q1/68
CPC分类号： C12Q1/689 , C07K14/32
摘要： The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods for producing biologically active substances encoded by the genes and to methods of using the isolated genes of the complete chromosome of Bacillus licheniformis.
摘要翻译：本发明涉及地衣芽孢杆菌的完整染色体的分离的多核苷酸。本发明还涉及编码生物活性物质的地衣芽孢杆菌染色体和包含该基因的核酸构建体，载体和宿主细胞的分离基因以及用于产生由该基因编码的生物活性物质的方法和使用地衣芽孢杆菌完整染色体的分离基因。

2. 发明公开

EP1706721A2 BACILLUS LICHENIFORMIS CHROMOSOME 审中-公开
标题翻译：地衣芽孢杆菌染色体
公开(公告)号：EP1706721A2
公开(公告)日：2006-10-04
申请号：EP04810533.2
申请日：2004-11-05
申请人： Novozymes, Inc. , Novozymes A/S
发明人： BERKA, Randy , REY, Michael , RAMAIYA, Preethi , ANDERSEN, Jens Tonne , RASMUSSEN, Michael Dolberg , OLSEN, Peter Bjarke
IPC分类号： G01N15/00
CPC分类号： C12Q1/689 , C07K14/32
摘要： The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods for producing biologically active substances encoded by the genes and to methods of using the isolated genes of the complete chromosome of Bacillus licheniformis.

3. 发明公开

EP3420104A1 IMPROVED NEXT-GENERATION SEQUENCING 审中-公开
公开(公告)号：EP3420104A1
公开(公告)日：2019-01-02
申请号：EP17711816.3
申请日：2017-02-23
申请人： Novozymes A/S
发明人： NELSON, Beth , MALTEN, Marco , POULSEN, Thomas Agersten , BARGISEN, Michael , RAMAIYA, Preethi
IPC分类号： C12Q1/68 , C12N15/10

4. 发明公开

EP3362574A1 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 有权
公开(公告)号：EP3362574A1
公开(公告)日：2018-08-22
申请号：EP16790471.3
申请日：2016-10-12
申请人： Novozymes A/S
发明人： NELSON, Beth , SVENDSEN, Allan , SRIVASTAVA, Vivek , MALTEN, Marco , POULSEN, Thomas A. , RAMAIYA, Preethi , GUPTA, Shikha , RAO, Vasudeva P. , BALUMURI, Padmavathi
IPC分类号： C12P19/02 , C12P19/20 , C12N9/34
CPC分类号： C12Y302/01003 , C12N9/2428 , C12P19/02 , C12P19/14 , C12P19/20
摘要： The present invention relates to glucoamylase variants having an increase in specific activity and/or an increase in melting temperature measured by TSA of at least 0.5 degrees Celsius, and further wherein the variants have at least at least 85%, at least 90%, at least 95% identity, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

5. 发明申请

WO2017147294A1 IMPROVED NEXT-GENERATION SEQUENCING 审中-公开
标题翻译：改进的下一代测序
公开(公告)号：WO2017147294A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/019134
申请日：2017-02-23
申请人： NOVOZYMES A/S , NELSON, Beth
发明人： NELSON, Beth , MALTEN, Marco , POULSEN, Thomas Agersten , BARGISEN, Michael , RAMAIYA, Preethi
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6806 , C12N15/1093 , C12Q1/6869 , C12Q2525/191 , C12Q2535/119 , C12Q2535/122 , C12Q2563/179 , C12Q2565/514 , C12Q2521/301
摘要： The present invention enables the determination by NGS of the full nucleotide sequence of one or more polynucleotides of interest that are more than 800 bp in length after only one round of PCR amplification and subsequent fragmentation by adding at least one known oligonucleotide index to at least one end of each polynucleotide to produce elongated polynucleotides, wherein each known oligonucleotide index added to each polynucleotide is unique; fragmenting the elongated polynucleotides; sequencing the resulting fragments with paired forward and reverse reads using bridge amplification and next-generation sequencing; sorting the paired sequences based on the known oligonucleotide; and performing manual or in silico assembly of the sorted paired sequences, thereby providing the full coding sequence of each of the multitude of polynucleotides.
摘要翻译：本发明使得能够通过NGS确定一个或多个目标多核苷酸的全长核苷酸序列长度超过800bp，仅经过一轮PCR扩增和随后的片段化，通过至少添加对每个多核苷酸的至少一个末端的一个已知的寡核苷酸索引以产生伸长的多核苷酸，其中添加到每个多核苷酸的每个已知的寡核苷酸索引是独特的; 片段化伸长的多核苷酸; 使用桥扩增和下一代测序对所得片段进行成对正向和反向读取测序; 基于已知的寡核苷酸对成对序列进行分类; 并对所分类的成对序列进行手工或计算机组装，从而提供多种多核苷酸中的每一种的完整编码序列。

6. 发明申请

WO2018015443A1 IMPROVED FILAMENTOUS FUNGAL HOST 审中-公开
标题翻译：改进的丝状真菌宿主
公开(公告)号：WO2018015443A1
公开(公告)日：2018-01-25
申请号：PCT/EP2017/068242
申请日：2017-07-19
申请人： NOVOZYMES A/S
发明人： KOJIMA, Kaihei , TERAMOTO, Hiroshi , RAMAIYA, Preethi
IPC分类号： C07K14/38 , C12P21/02 , C12N15/80
摘要： The instant invention relates to filamentous fungal host cells producing and secreting a heterologous polypeptide of interest, said mutant host cell comprising and expressing a mutated ireA gene or a homologue thereof encoding a modified IreA polypeptide or a homologue thereof, said modified IreA polypeptide or homologue thereof comprising amino acid substitutions in 5 positions corresponding to positions 81 and 84 in the Aspergillus niger IreA amino acid sequence shown in SEQ ID NO:16, as well as methods of producing a polypeptide of interest in said cells and methods for constructing said cells.
摘要翻译：本发明涉及产生和分泌感兴趣的异源多肽的丝状真菌宿主细胞，所述突变宿主细胞包含并表达突变的ireA基因或其同源物，所述突变的ireA基因或其同源物编码修饰的IreA多肽或其同源物，所述修饰的IreA多肽或其同源物在对应于SEQ ID NO：16所示的黑曲霉IreA氨基酸序列中的位置81和84的5个位置中包含氨基酸取代，以及在所述细胞中产生目的多肽的方法和构建所述细胞的方法。

7. 发明申请

WO2017066255A1 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：葡糖淀粉酶变体和编码多核苷酸的多核苷酸
公开(公告)号：WO2017066255A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056549
申请日：2016-10-12
申请人： NOVOZYMES A/S , NELSON, Beth
发明人： NELSON, Beth , SVENDSEN, Allan , SRIVASTAVA, Vivek , MALTEN, Marco , POULSEN, Thomas A. , RAMAIYA, Preethi , GUPTA, Shikha , RAO, Vasudeva P. , BALUMURI, Padmavathi
IPC分类号： C12P19/02 , C12P19/20 , C12N9/34
CPC分类号： C12N9/2428 , C12P19/02 , C12P19/14 , C12P19/20 , C12Y302/01003
摘要： The present invention relates to glucoamylase variants having an increase in specific activity and/or an increase in melting temperature measured by TSA of at least 0.5 degrees Celsius, and further wherein the variants have at least at least 85%, at least 90%, at least 95% identity, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及葡糖淀粉酶变体，其通过TSA测量的比活性增加和/或熔解温度增加至少0.5摄氏度，并且另外其中变体具有至少85 与SEQ ID NO：1的氨基酸序列具有至少90％，至少90％，至少95％同一性，至少96％，至少97％，至少98％，或至少99％，但小于100％编号：3。本发明还涉及编码变体的多核苷酸; 包含所述多核苷酸的核酸构建体，载体和宿主细胞; 以及使用这些变体的方法。

8. 发明公开

EP3487873A1 IMPROVED FILAMENTOUS FUNGAL HOST 有权
公开(公告)号：EP3487873A1
公开(公告)日：2019-05-29
申请号：EP17748673.5
申请日：2017-07-19
申请人： Novozymes A/S
发明人： KOJIMA, Kaihei , TERAMOTO, Hiroshi , RAMAIYA, Preethi
IPC分类号： C07K14/38 , C12P21/02 , C12N15/80

9. 发明申请

WO2008066931A3 BACILLUS LICHENIFORMIS CHROMOSOME 审中-公开
公开(公告)号：WO2008066931A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/024746
申请日：2007-11-29
申请人： NOVOZYMES, INC. , BERKA, Randy , REY, Michael , RAMAIYA, Preethi
发明人： BERKA, Randy , REY, Michael , RAMAIYA, Preethi
IPC分类号： C07K14/32 , C07K14/195 , C12N15/31
摘要： The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis SJ1904 (ATCC PTA-7992). The present invention also relates to isolated polynucleotides of the chromosome of Bacillus licheniformis SJ1904 that encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing biologically active substances encoded by the polynucleotides and to methods of using the isolated polynucleotides of the complete chromosome of Bacillus licheniformis SJ1904.

10. 发明公开

EP2099818A2 BACILLUS LICHENIFORMIS CHROMOSOME 审中-公开
标题翻译：地衣芽孢杆菌染色体
公开(公告)号：EP2099818A2
公开(公告)日：2009-09-16
申请号：EP07853214.0
申请日：2007-11-29
申请人： Novozymes Inc.
发明人： BERKA, Randy , REY, Michael , RAMAIYA, Preethi
IPC分类号： C07K14/32 , C07K14/195 , C12N15/31
CPC分类号： C12N1/20 , C07K14/32 , C12R1/10
摘要： The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis SJ1904 (ATCC PTA-7992). The present invention also relates to isolated polynucleotides of the chromosome of Bacillus licheniformis SJ1904 that encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing biologically active substances encoded by the polynucleotides and to methods of using the isolated polynucleotides of the complete chromosome of Bacillus licheniformis SJ1904.

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