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1. 发明专利

JP2007252946A Medicament inhaler 有权
标题翻译：药物吸入
公开(公告)号：JP2007252946A
公开(公告)日：2007-10-04
申请号：JP2007138192
申请日：2007-05-24
申请人： Norton Healthcare Ltd , ノートンヘルスケアーリミテッドNorton Healthcare Ltd.
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M13/00 , A61M15/00 , G06M1/24
CPC分类号： A61M15/0045 , A61M15/0008 , A61M15/0048 , A61M15/0065 , A61M15/0068 , A61M15/0078 , A61M15/0086 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2206/16 , G06M1/04 , G06M1/246
摘要： PROBLEM TO BE SOLVED: To provide a dry powdered medicament inhaler which can meter the dose of medicament and count the number of doses remaining in the inhaler.
SOLUTION: The inhaler comprises a mouthpiece, a delivery passage which directs an air flow generated by inhalation toward a direction allowing the flow to go through the mouthpiece, a channel extended from the delivery passage, and a reservoir 14 to contain medicament. The reservoir comprises an administration port connected to the channel, a cup contained in the channel and located movable between the administration port and the delivery passage, a cup spring biasing the cup against the administration port and one of the passages, and a yoke 68 movably positioned between at least two positions. The yoke is connected to the cup. When the yoke is positioned at one of the two positions at least, it prevents the cup from moving. When the yoke is positioned at the other one of the two positions at least, it has a rachet allowing the cup to move.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供可以计量药物剂量并计数吸入器中剩余剂量的干粉状药物吸入器。解决方案：吸入器包括接口管，输送通道，其将由吸入产生的空气流引向允许流动通过接口管的方向，从输送通道延伸的通道和容纳器14以容纳药物。储存器包括连接到通道的管理端口，容纳在通道中并且位于可在管理端口和输送通道之间移动的杯子，将杯子偏置在配给口和其中一个通道中的杯形弹簧以及可移动的轭68 位于至少两个位置之间。轭连接到杯子。当轭架至少位于两个位置中的一个位置时，它防止杯子移动。当轭架至少位于两个位置中的另一个位置时，它具有允许杯子移动的抽水壶。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2007289716A Medicament inhaler 有权
标题翻译：药物吸入
公开(公告)号：JP2007289716A
公开(公告)日：2007-11-08
申请号：JP2007138191
申请日：2007-05-24
申请人： Norton Healthcare Ltd , ノートンヘルスケアーリミテッドNorton Healthcare Ltd.
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M13/00 , A61M15/00 , G06M1/24
CPC分类号： A61M15/0045 , A61M15/0008 , A61M15/0048 , A61M15/0065 , A61M15/0068 , A61M15/0078 , A61M15/0086 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2206/16 , G06M1/04 , G06M1/246
摘要： PROBLEM TO BE SOLVED: To provide a medicament inhaler, metering a dose of medicament, controlling the pressure of a medicament reservoir and counting a dose remaining in the inhaler.
SOLUTION: This inhaler 10 includes: mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses; and a dose counting system indicating the number of doses remaining in the inhaler.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供药物吸入器，计量剂量的药物，控制药物储存器的压力并计数吸入器中剩余的剂量。解决方案：该吸入器10包括：机械剂量计量系统，其以离散量或剂量分配用于患者吸入的干粉状药物;压力释放系统，其管理吸入器的药物储存器内的压力以确保始终分配的剂量; 以及指示吸入器中剩余的剂量数量的剂量计数系统。版权所有（C）2008，JPO＆INPIT

3. 发明申请

WO0197889A9 DE-AGGLOMERATOR FOR BREATH-ACTUATED DRY POWDER INHALER 审中-公开
标题翻译：用于呼吸干燥粉末吸入器的脱胶机
公开(公告)号：WO0197889A9
公开(公告)日：2003-03-06
申请号：PCT/US0120091
申请日：2001-06-23
申请人： IVAX CORP , NORTON HEALTHCARE LTD
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M15/00 , G06M1/24
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0045 , A61M15/0048 , A61M15/0068 , A61M15/0091 , A61M2202/064 , A61M2206/16 , G06M1/246
摘要： A de-agglomerator is provided for use with a breath-actuated dry powder inhaler for breaking up aggregates and micronizing particles of dry powder prior to inhalation of the powder by a patient using the inhaler. The de-agglomerator includes an inner wall defining a swirl chamber extending along an axis from a first end to a second end, a dry powder supply port, an inlet port, and an outlet port. The supply port is in the first end of the swirl chamber for providing fluid communication between a dry powder delivery passageway of an inhaler and the first end of the swirl chamber. The inlet port is in the inner wall of the swirl chamber adjacent to the first end of the swirl chamber and provides fluid communication between a region exterior to the de-agglomerator and the swirl chamber. The outlet port provides fluid communication between the second end of the swirl chamber and a region exterior to the de-agglomerator, whereby a breath induced low pressure at the outlet port causes air flows into the swirl chamber through the dry powder supply port and the inlet port. The air flows collide with each other and with the wall of the swirl chamber prior to exiting through the outlet port, such that any powder entrained in the air flows is broken down and micronized. The de-agglomerator further includes vanes at the first end of the swirl chamber for creating additional collisions and impacts of entrained powder.
摘要翻译：提供去聚集器用于呼吸致动的干粉吸入器，用于在使用吸入器的患者吸入粉末之前破碎聚集体并粉碎干粉颗粒。除凝器包括限定从第一端延伸到第二端的旋转室的内壁，干粉供给口，入口端口和出口。供应口位于涡流室的第一端，用于在吸入器的干粉输送通道和涡流室的第一端之间提供流体连通。入口位于涡流室的内壁中，与涡旋室的第一端相邻，并且在去附聚器外部的区域与涡流室之间提供流体连通。出口端口提供涡流室的第二端和去附聚器外部的区域之间的流体连通，由此在出口处的呼吸引起的低压使空气通过干粉供给口和入口进入涡流室港口。空气流在离开出口之前相互碰撞并与涡流室的壁碰撞，使得夹带在空气流中的任何粉末被分解并微粉化。除凝器还包括在涡流室的第一端处的叶片，用于产生夹带的粉末的附加碰撞和撞击。

4. 发明申请

WO0197889A2 DE-AGGLOMERATOR FOR BREATH-ACTUATED DRY POWDER INHALER 审中-公开
标题翻译：用于呼吸干燥粉末吸入器的脱胶机
公开(公告)号：WO0197889A2
公开(公告)日：2001-12-27
申请号：PCT/US0120091
申请日：2001-06-23
申请人： IVAX CORP , NORTON HEALTHCARE LTD
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M15/00 , G06M1/24
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0045 , A61M15/0048 , A61M15/0068 , A61M15/0091 , A61M2202/064 , A61M2206/16 , G06M1/246
摘要： A de-agglomerator is provided for use with a breath-actuated dry powder inhaler for breaking up aggregates and micronizing particles of dry powder prior to inhalation of the powder by a patient using the inhaler. The de-agglomerator includes an inner wall defining a swirl chamber extending along an axis from a first end to a second end, a dry powder supply port, an inlet port, and an outlet port. The supply port is in the first end of the swirl chamber for providing fluid communication between a dry powder delivery passageway of an inhaler and the first end of the swirl chamber. The inlet port is in the inner wall of the swirl chamber adjacent to the first end of the swirl chamber and provides fluid communication between a region exterior to the de-agglomerator and the swirl chamber. The outlet port provides fluid communication between the second end of the swirl chamber and a region exterior to the de-agglomerator, whereby a breath induced low pressure at the outlet port causes air flows into the swirl chamber through the dry powder supply port and the inlet port. The air flows collide with each other and with the wall of the swirl chamber prior to exiting through the outlet port, such that any powder entrained in the air flows is broken down and micronized. The de-agglomerator further includes vanes at the first end of the swirl chamber for creating additional collisions and impacts of entrained powder.
摘要翻译：提供去聚集器用于呼吸致动的干粉吸入器，用于在使用吸入器的患者吸入粉末之前破碎聚集体并粉碎干粉颗粒。除凝器包括限定从第一端延伸到第二端的旋转室的内壁，干粉供给口，入口端口和出口。供应口位于涡流室的第一端，用于在吸入器的干粉输送通道和涡流室的第一端之间提供流体连通。入口位于涡流室的内壁中，与涡旋室的第一端相邻，并且在去附聚器外部的区域与涡流室之间提供流体连通。出口端口提供涡流室的第二端和去附聚器外部的区域之间的流体连通，由此在出口处的呼吸引起的低压使空气通过干粉供给口和入口进入涡流室港口。空气流在离开出口之前相互碰撞并与涡流室的壁碰撞，使得夹带在空气流中的任何粉末被分解并微粉化。除凝器还包括在涡流室的第一端处的叶片，用于产生夹带的粉末的附加碰撞和撞击。

5. 发明申请

WO0200281A3 MEDICAMENT INHALER 审中-公开
标题翻译：药物吸入
公开(公告)号：WO0200281A3
公开(公告)日：2003-01-03
申请号：PCT/US0120098
申请日：2001-06-23
申请人： IVAX CORP , NORTON HEALTHCARE LTD
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M13/00 , A61M15/00 , G06M1/24
CPC分类号： A61M15/0045 , A61M15/0008 , A61M15/0048 , A61M15/0065 , A61M15/0068 , A61M15/0078 , A61M15/0086 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2206/16 , G06M1/04 , G06M1/246
摘要： A new and improved inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses remaining in the inhaler.
摘要翻译：新的改进的吸入器包括准确和一致的机械剂量计量系统，其分配用于患者吸入的离散量或剂量的干燥粉末药物，压力释放系统，其管理吸入器的药物储存器内的压力以确保一致分配的剂量，以及剂量计数系统，指示吸入器中剩余的剂量数。

6. 发明申请

WO2005034833A2 DRY POWDER INHALATION APPARATUS 审中-公开
标题翻译：干粉吸入装置
公开(公告)号：WO2005034833A2
公开(公告)日：2005-04-21
申请号：PCT/US2004032160
申请日：2004-10-02
申请人： IVAX CORP , NORTON HEALTHCARE LTD , BARNEY BRIAN , O'LEARY DAVID , STRIEBIG RACHEL
发明人： BARNEY BRIAN , O'LEARY DAVID , STRIEBIG RACHEL
IPC分类号： A61J20060101 , A61M15/00 , A61M16/00 , A61J
CPC分类号： A61M15/0091 , A61M15/0026 , A61M15/0065 , A61M15/0068 , A61M15/0096 , A61M2016/0024 , A61M2202/064 , A61M2205/583 , A61M2205/8206
摘要： The invention relates to dry powder inhalation apparatus usually operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device (4) normally held adjacent a reservoir for receiving medicament in a cup or receptacle (15) and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device (4) is achieved by a yoke acting on an abutment (16) thereof. Spillage of medicament in the apparatus is avoided.
摘要翻译：本发明涉及通常由用户的呼吸操作的干粉吸入装置，其在用户的多次致动期间提供药物的受控和平滑的转移。用于实现这种受控和平稳转移的装置的机构包括通常保持在容器附近的装置（4），用于接收在杯子或容器（15）中的药物，并且其通常可以横向于装置的纵向轴线移动到输送通道的装置。设备（4）的这种身体移动通过作用在其基台（16）上的轭来实现。避免了药物在装置中的溢出。

7. 发明申请

WO0200280A2 PRE-METERED DOSE MAGAZINE FOR BREATH-ACTUATED DRY POWDER INHALER 审中-公开
标题翻译：用于呼吸动力干粉吸入器的预测剂量杂志
公开(公告)号：WO0200280A2
公开(公告)日：2002-01-03
申请号：PCT/US0120097
申请日：2001-06-23
申请人： IVAX CORP , NORTON HEALTHCARE LTD
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M1/00 , A61M15/00 , G06M1/24
CPC分类号： G06M1/272 , A61M1/0001 , A61M15/0008 , A61M15/0045 , A61M15/0048 , A61M15/0068 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2206/16 , G06M1/248
摘要： A pre-metered dose assembly for consistently supplying precise doses of medicament is provided for a breath-actuated dry powder inhaler. The assembly includes a cap defining a dry powder delivery passageway for providing air to dry powder supply port of a swirl chamber of a breath-actuated dry powder inhaler, and a magazine including a plurality of reservoirs for holding pre-metered doses of dry powder. One of the magazine and the cap is movable with respect to the other of the magazine and the cap for sequentially positioning the reservoirs within the delivery passageway of the cap. A breath-induced low pressure at an outlet port of the swirl chamber of the inhaler causes an air flow through the dry powder delivery passageway of the assembly and into the dry powder supply port of the swirl chamber that entrains dry powder from the reservoir positioned in the passageway for inhalation by a patient using the inhaler. The present disclosure also provides a breath-actuated dry powder inhaler including the pre-metered dose assembly in combination with a de-agglomerator for breaking up aggregates and micronizing particles of dry powder prior to inhalation of the powder by a patient.
摘要翻译：为呼吸驱动的干粉吸入器提供了用于持续供应精确剂量的药物的预计量剂量组件。该组件包括限定用于向呼气致动干粉吸入器的涡流室的干粉供应端口提供空气的干粉输送通道的盖以及包括用于保持预先计量剂量的干粉的多个储存器的储存盒。弹匣和盖中的一个可相对于弹匣和盖中的另一个移动，以便顺序地将储存器定位在盖的输送通道内。吸入器的涡流室的出口处的呼吸引起的低压引起空气流过组件的干粉输送通道并进入涡流室的干粉供应端口，该涡流室的干粉供应端口将干粉从位于用吸入器吸入病人的通道。本发明还提供了一种呼吸驱动的干粉吸入器，其包括预计量剂量组件与解凝器，用于在患者吸入粉末之前破碎聚集体和微粉化干粉颗粒。

8. 发明公开

EP1667627A4 DRY POWDER INHALATION APPARATUS 有权转让
标题翻译： TROCKENPULVER-INHALIERGERÄT
公开(公告)号：EP1667627A4
公开(公告)日：2010-04-28
申请号：EP04793913
申请日：2004-10-02
申请人： NORTON HEALTHCARE LTD
发明人： BARNEY BRIAN , O'LEARY DAVID , STRIEBIG RACHEL
IPC分类号： A61M11/00 , A61J20060101 , A61M15/00 , A61M16/00
CPC分类号： A61M15/0091 , A61M15/0026 , A61M15/0065 , A61M15/0068 , A61M15/0096 , A61M2016/0024 , A61M2202/064 , A61M2205/583 , A61M2205/8206

9. 发明专利

ES2317916T5 Depósito de dosis previamente medidas para inhalador de polvo seco activado por la respiración 未知
公开(公告)号：ES2317916T5
公开(公告)日：2016-12-21
申请号：ES01948660
申请日：2001-06-23
申请人： NORTON HEALTHCARE LTD
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M15/00 , A61M1/00 , G06M1/24

10. 发明专利

ES2559760T3 Desaglomerador para inhalador de polvo seco accionado por respiración 未知
公开(公告)号：ES2559760T3
公开(公告)日：2016-02-15
申请号：ES10002414
申请日：2001-06-23
申请人： NORTON HEALTHCARE LTD
发明人： KEANE LAWRENCE , O'LEARY DAVID
IPC分类号： A61M15/00 , G06M1/24
摘要： Un desaglomerador (10) para su uso con un inhalador de polvo seco accionado por respiración que incluye un pasadizo de administración de polvo seco y un depósito de polvo seco para exponer una cantidad predeterminada de polvo seco al pasadizo de administración de polvo seco, el desaglomerador que comprende: una pared interna (12) que define una cámara de turbulencia (14) que se extiende a lo largo de un eje (A) desde un primer extremo hasta un segundo extremo; un puerto de suministro de polvo seco (22) en el primer extremo (18) de la cámara de turbulencia (14) para proporcionar una comunicación de fluidos entre un pasadizo de administración de polvo seco de un inhalador y el primer extremo (18) de la cámara de turbulencia (14); al menos un puerto de entrada (24) en la pared interna (12) de la cámara de turbulencia (14) adyacente al primer extremo (18) de la cámara de turbulencia (14) que proporciona una comunicación de fluidos entre una región exterior al desaglomerador y el primer extremo (18) de la cámara de turbulencia (14); un puerto de salida (32) que proporciona una comunicación de fluidos entre el segundo extremo (20) de la cámara de turbulencia (14) y una región exterior al desaglomerador (10); y paletas (26) en el primer extremo (18) de la cámara de turbulencia (14) que se extienden al menos en parte hacia fuera de forma radial desde el eje (A) de la cámara, cada una de las paletas (26) que tiene una superficie oblicua orientada al menos en parte en una dirección transversal al eje (A); por lo que una presión baja inducida por respiración en el puerto de salida (32) provoca flujos de aire en la cámara de turbulencia (14) a través del puerto de suministro de polvo seco (22) y del puerto de entrada (24), caracterizado por que la cámara de turbulencia (14) incluye áreas de sección transversal generalmente circulares dispuestas coaxialmente alrededor del eje (A) y el al menos un puerto de entrada (24) se extiende en una dirección sustancialmente transversal al eje (A) y sustancialmente tangencial a las áreas de sección transversal circular.

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