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1. 发明授权

US08912010B2 Thyroxine immunoassay using fluorescent particles 有权
标题翻译：使用荧光颗粒进行甲状腺素免疫测定
公开(公告)号：US08912010B2
公开(公告)日：2014-12-16
申请号：US13610497
申请日：2012-09-11
申请人： Noriyuki Kasagi , Junichi Katada , Tadahiro Matsuno
发明人： Noriyuki Kasagi , Junichi Katada , Tadahiro Matsuno
IPC分类号： G01N33/544 , G01N33/53 , C07K1/04 , G01N33/543 , G01N33/78 , G01N33/58
CPC分类号： G01N33/54373 , G01N33/54306 , G01N33/585 , G01N33/78
摘要： Provided are a base plate and a method for thyroxine immunoassay, which are capable of decreasing the signal change rate caused by temperature change in a high-sensitivity immunoassay method for thyroxine. A base plate for thyroxine immunoassay which has a conjugate of thyroxine or a derivative thereof and albumin immobilized thereon, and in which the ratio of the molecule number of thyroxine or a derivative thereof to the molecule number of albumin in the immobilized conjugate, is disclosed.
摘要翻译：本发明提供甲状腺素免疫测定法的基板和甲基荧光素免疫测定方法，能够降低甲状腺素的高灵敏度免疫测定法中的温度变化引起的信号变化率。公开了一种甲状腺素免疫测定的基板，其具有甲状腺素或其衍生物和固定在其上的白蛋白的缀合物，其中甲状腺素或其衍生物的分子数与固定化缀合物中白蛋白的分子数之比。

2. 发明授权

US08524864B2 Method for producing conjugate of thyroxine and albumin 失效
标题翻译：生产甲状腺素和白蛋白缀合物的方法
公开(公告)号：US08524864B2
公开(公告)日：2013-09-03
申请号：US13213585
申请日：2011-08-19
申请人： Noriyuki Kasagi , Tadahiro Matsuno
发明人： Noriyuki Kasagi , Tadahiro Matsuno
IPC分类号： C07K1/107 , C07K14/76
CPC分类号： A61K47/643
摘要： It is an object of the present invention to provide a method for producing a conjugate of thyroxine and albumin with higher purity. The present invention provides a method for producing a conjugate of thyroxine and albumin which comprises: step (a) of converting a carboxyl group in thyroxine having a carboxyl group to be linked to albumin into an active ester and allowing the thyroxine to react with albumin, so as to prepare a conjugate of thyroxine and albumin; and step (b) of purifying the conjugate with the use of an acidic mixed aqueous solvent in which the thyroxine having a carboxyl group to be linked to albumin is dissolved but albumin is not precipitated.
摘要翻译：本发明的目的是提供一种制备高纯度甲状腺素和白蛋白缀合物的方法。本发明提供了一种生产甲状腺素和白蛋白缀合物的方法，其包括：将具有与白蛋白连接的羧基的甲状腺素中的羧基转化成活性酯的步骤（a），并使甲状腺素与白蛋白反应，以制备甲状腺素和白蛋白的缀合物; 和使用其中与白蛋白连接的具有羧基的甲状腺素溶解但不沉淀白蛋白的酸性混合水性溶剂来纯化缀合物的步骤（b）。

3. 发明授权

US09296814B2 Antibody against human TSH and canine TSH 有权
标题翻译：抗人TSH和犬TSH的抗体
公开(公告)号：US09296814B2
公开(公告)日：2016-03-29
申请号：US13592802
申请日：2012-08-23
申请人： Noriyuki Kasagi , Yuya Watanabe
发明人： Noriyuki Kasagi , Yuya Watanabe
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , C07K2317/33 , C07K2317/92
摘要： It is an object of the present invention to provide an antibody that recognizes a canine TSH and binds thereto, without obtaining a large amount of canine TSH antigen. The present invention provides a monoclonal antibody produced by a hybridoma having Accession No. FERM BP-11490.
摘要翻译：本发明的目的是提供一种识别犬TSH并与之结合的抗体，而不需要大量的犬TSH抗原。本发明提供由登录号为FERM BP-11490的杂交瘤产生的单克隆抗体。

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