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    • 9. 发明授权
    • Biopolymer optical analysis device and method
    • 生物聚合物光学分析装置及方法
    • US09562809B2
    • 2017-02-07
    • US13812801
    • 2011-07-21
    • Satoshi OzawaTakashi AnazawaRena AkahoriSatoshi TakahashiTakeshi OhuraMasashi Kiguchi
    • Satoshi OzawaTakashi AnazawaRena AkahoriSatoshi TakahashiTakeshi OhuraMasashi Kiguchi
    • G01J3/02B82Y5/00B82Y15/00G01N33/487G01N21/65
    • G01J3/0267B82Y5/00B82Y15/00C12Q1/6869G01N21/658G01N33/48721C12Q2565/631C12Q2565/632
    • The present invention provides a device and method for analyzing the characteristics of a biopolymer with excellent mechanical stability, high spatial resolution and sensitivity using a simple device construction. Specifically, the Raman scattered light of a biopolymer is measured and the properties of monomer units forming the biopolymer are analyzed by using a biopolymer property analysis chip (100a) characterized by comprising: a solid substrate (110); at least one nanopore (120) disposed in the solid substrate (110); and one or more electrically conductive thin films (130a, 130b) disposed on the solid substrate (110). The biopolymer property analysis chip (100a) is characterized in that the electrically conductive thin films (130a, 130b) are disposed partially on the solid substrate (110) where the nanopore (120) is formed and a biopolymer which has penetrated into the nanopore (120) is caused to generate Raman scattered light by means of irradiation with external light.
    • 本发明提供一种使用简单的装置结构分析具有优异机械稳定性,高空间分辨率和灵敏度的生物聚合物的特性的装置和方法。 具体地,测量生物聚合物的拉曼散射光,并通过使用生物聚合物性质分析芯片(100a)分析形成生物聚合物的单体单元的性质,其特征在于包括:固体基材(110); 设置在所述固体基板(110)中的至少一个纳米孔(120); 以及设置在固体基板(110)上的一个或多个导电薄膜(130a,130b)。 生物聚合物性质分析芯片(100a)的特征在于,导电薄膜(130a,130b)部分地设置在形成有纳米孔(120)的固体基板(110)上,并且已经渗透到纳米孔中的生物聚合物 120)通过外部光照射产生拉曼散射光。