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    • 9. 发明申请
    • METHOD OF PRODUCING AROMATIC AMINO COMPOUNDS
    • 生产芳族氨基化合物的方法
    • US20110257404A1
    • 2011-10-20
    • US13123098
    • 2010-01-25
    • Norimasa YokoyamaMakoto NagaokaKazunori Togashi
    • Norimasa YokoyamaMakoto NagaokaKazunori Togashi
    • C07D401/14C07D209/82C07C65/03C07C213/08
    • C07D209/86C07C209/10C07C2603/18C07D249/08C07D401/14C07C211/55
    • [Problem] To provide a method of producing an aromatic amino compound by using a primary or secondary amine compound and a halogenated aromatic compound as starting materials, and relying upon the Ullmann reaction, the method being capable of obtaining the highly pure aromatic amino compound in high yields and inexpensively.[Means for Solution] A method of producing an aromatic amino compound by using a primary or secondary amine compound having an aromatic ring group and a halogenated aromatic compound as starting materials, reacting the amine compound with the halogenated aromatic compound in the presence of a copper catalyst and a base so as to produce the aromatic amino compound having a structure in which an aromatic ring group derived from the halogenated aromatic compound is coupled to the amino group of the amine compound, wherein the amine compound and the halogenated aromatic compound are reacted together under a condition where an aromatic oxycarboxylic acid having a hydroxyl group and a hydroxycarbonyl group that are bonded to neighboring carbon atoms, is made present together with the copper catalyst and the base.
    • [问题]为了提供通过使用伯胺或仲胺化合物和卤代芳族化合物作为原料制备芳香族氨基化合物的方法,依赖于乌尔曼反应,该方法能够获得高纯度芳香族氨基化合物 产量高,成本低廉。 [解决方案]通过使用具有芳环基和卤代芳族化合物的伯胺或仲胺化合物作为起始原料制备芳族氨基化合物的方法,使胺化合物与卤代芳族化合物在铜的存在下反应 催化剂和碱,以产生具有这样一种结构的芳族氨基化合物,其中衍生自卤代芳族化合物的芳族环基团与胺化合物的氨基偶合,其中胺化合物和卤代芳族化合物一起反应 在具有与相邻碳原子键合的羟基和羟基羰基的芳族羟基羧酸的情况下,与铜催化剂和碱一起存在。
    • 10. 发明授权
    • Method of producing aromatic amino compounds
    • 制备芳香族氨基化合物的方法
    • US08735626B2
    • 2014-05-27
    • US13123098
    • 2010-01-25
    • Norimasa YokoyamaMakoto NagaokaKazunori Togashi
    • Norimasa YokoyamaMakoto NagaokaKazunori Togashi
    • C07C211/00C07C59/00C07C65/21
    • C07D209/86C07C209/10C07C2603/18C07D249/08C07D401/14C07C211/55
    • A method of producing an aromatic amino compound using a primary or secondary amine compound and a halogenated aromatic compound as starting materials, and relying upon the Ullmann reaction, the method being capable of obtaining the highly pure aromatic amino compound in high yields and inexpensively. A primary or secondary amine compound having an aromatic ring group and a halogenated aromatic compound as starting materials, are reacted with the halogenated aromatic compound in the presence of copper catalyst and base to produce the aromatic amino compound having a structure in which an aromatic ring group derived from the halogenated aromatic compound is coupled to the amino group of the amine compound, wherein the amine compound and the halogenated aromatic compound are reacted together such that an aromatic oxycarboxylic acid having a hydroxyl group and a hydroxycarbonyl group bonded to neighboring carbon atoms, is present together with the copper catalyst and the base.
    • 使用伯胺或仲胺化合物和卤代芳族化合物作为原料制备芳香族氨基化合物的方法,依赖乌尔曼反应,该方法能够以高收率和低成本获得高纯度芳香族氨基化合物。 具有芳环基团和卤代芳族化合物作为起始原料的伯胺或仲胺化合物与卤化芳族化合物在铜催化剂和碱存在下反应,生成具有芳环基团的芳族氨基化合物 来自卤代芳香族化合物的胺化合物的氨基与胺化合物的氨基偶联,其中胺化合物和卤代芳香族化合物反应,使得具有与相邻碳原子键合的羟基和羟基羰基的芳族羟基羧酸为 与铜催化剂和碱一起存在。