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1. 发明授权

US09018444B2 Non-diffusing plant virus vector 有权
标题翻译：非扩散植物病毒载体
公开(公告)号：US09018444B2
公开(公告)日：2015-04-28
申请号：US13057818
申请日：2009-08-07
申请人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
发明人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
IPC分类号： C12N15/83 , C12N15/33 , C12N15/82 , C12N15/86
CPC分类号： C12N15/8203 , C12N15/86 , C12N2770/14043
摘要： The present invention is to provide a novel non-diffusing plant virus vector wherein virus vector infection and proliferation are possible only in a recombinant plant transformed with a gene necessary for viral proliferation, thereby enabling avoidance of unintended diffusion of a recombinant virus, a selective and specific expression system therefor, and a method of expression thereof which comprises combining a non-diffusing virus vector lacking a gene involved in intercellular movement of a cucumber mosaic virus (CMV) genome and a transgenic plant transformed with the lacked gene involved in intercellular movement for the non-diffusing virus vector to establish infection and proliferation selectively and specifically in the transgenic plant.
摘要翻译：本发明提供一种新的非扩散性植物病毒载体，其中病毒载体的感染和增殖仅在用病毒增殖所必需的基因转化的重组植物中是可能的，从而能够避免重组病毒的非预期扩散，选择性和特异性表达系统及其表达方法，其包括将缺乏参与黄瓜花叶病毒（CMV）基因组的细胞间运动的基因的非扩散病毒载体与转基因植物相结合，转基因植物参与细胞间移动非扩散病毒载体在转基因植物中选择性和特异性地建立感染和增殖。

2. 发明申请

US20110138497A1 Non-Diffusing Plant Virus Vector 有权
标题翻译：非扩散植物病毒载体
公开(公告)号：US20110138497A1
公开(公告)日：2011-06-09
申请号：US13057818
申请日：2009-08-07
申请人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
发明人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
IPC分类号： A01H1/06 , C12N15/63 , A01H5/00
CPC分类号： C12N15/8203 , C12N15/86 , C12N2770/14043
摘要： The present invention is to provide a novel non-diffusing plant virus vector wherein virus vector infection and proliferation are possible only in a recombinant plant transfected with a gene necessary for viral proliferation, thereby enabling avoidance of unintended diffusion of a recombinant virus, a selective and specific expression system therefor, and a method of expression thereof which comprises combining a non-diffusing virus vector lacking a gene involved in intercellular movement of a cucumber mosaic virus (CMV) genome and a transgenic plant transfected with the lacked gene involved in intercellular movement for the non-diffusing virus vector to establish infection and proliferation selectively and specifically in the transgenic plant.
摘要翻译：本发明提供一种新的非扩散性植物病毒载体，其中病毒载体的感染和增殖仅在用病毒增殖所必需的基因转染的重组植物中是可能的，从而能够避免重组病毒的非预期扩散，选择性和特异性表达系统及其表达方法，其包括将缺少涉及黄瓜花叶病毒（CMV）基因组的细胞间运动的基因的非扩散病毒载体与转染有参与细胞间移动的缺失基因的转基因植物组合非扩散病毒载体在转基因植物中选择性和特异性地建立感染和增殖。

3. 发明申请

US20070143877A1 Plant virus vector 有权
标题翻译：植物病毒载体
公开(公告)号：US20070143877A1
公开(公告)日：2007-06-21
申请号：US10562227
申请日：2004-06-25
申请人： Chikara Masuta , Takeshi Matsumura , Noriko Itchoda
发明人： Chikara Masuta , Takeshi Matsumura , Noriko Itchoda
IPC分类号： A01H1/00 , C12N7/00
CPC分类号： C12N15/8203
摘要： A novel plant virus vector and a method of gene expression into plants are provided, and the present invention relates to a plant virus vector characterized in that a part of the sequence of the 2b region of the RNA2 molecule of the Cucumber mosaic virus (CMV) is deleted; the aforementioned plant virus vector characterized in that the region from the StuI site to the stop codon of the 2b ORF of pCY2, which is an infectious clone of CMV-Y RNA2, is deleted; and a method of gene expression in plants characterized in that a foreign gene is introduced so as to be stably expressed in a plant using the genetic recombinant. This vector is useful as a plant RNA vector for causing stable expression of foreign genes.
摘要翻译：提供了一种新型植物病毒载体和植物基因表达方法，本发明涉及植物病毒载体，其特征在于黄瓜花叶病毒（CMV）的RNA2分子的2b区的一部分序列，被删除上述植物病毒载体的特征在于缺失了作为CMV-Y RNA2的感染性克隆的pCY2的2b ORF的StuI位点至终止密码子的区域; 以及植物中的基因表达方法，其特征在于引入外源基因，以便使用遗传重组体在植物中稳定表达。该载体可用作引起外源基因稳定表达的植物RNA载体。

4. 发明授权

US07632676B2 Plant virus vector 有权
标题翻译：植物病毒载体
公开(公告)号：US07632676B2
公开(公告)日：2009-12-15
申请号：US10562227
申请日：2004-06-25
申请人： Chikara Masuta , Takeshi Matsumura , Noriko Itchoda
发明人： Chikara Masuta , Takeshi Matsumura , Noriko Itchoda
IPC分类号： C12N15/00 , A01H1/00 , C12N15/82 , C12N15/87
CPC分类号： C12N15/8203
摘要： A novel plant virus vector and a method of gene expression into plants are provided, and the present invention relates to a plant virus vector characterized in that a part of the sequence of the 2b region of the RNA2 molecule of the Cucumber mosaic virus (CMV) is deleted; the aforementioned plant virus vector characterized in that the region from the StuI site to the stop codon of the 2b ORF of pCY2, which is an infectious clone of CMV-Y RNA2, is deleted; and a method of gene expression in plants characterized in that a foreign gene is introduced so as to be stably expressed in a plant using the genetic recombinant. This vector is useful as a plant RNA vector for causing stable expression of foreign genes.
摘要翻译：提供了一种新型植物病毒载体和植物基因表达方法，本发明涉及植物病毒载体，其特征在于黄瓜花叶病毒（CMV）的RNA2分子的2b区的一部分序列，被删除上述植物病毒载体的特征在于缺失了作为CMV-Y RNA2的感染性克隆的pCY2的2b ORF的StuI位点至终止密码子的区域; 以及植物中的基因表达方法，其特征在于引入外源基因，以便使用遗传重组体在植物中稳定表达。该载体可用作引起外源基因稳定表达的植物RNA载体。

5. 发明申请

US20090004227A1 Peroral Vaccine Carrier System 审中-公开
标题翻译：口服疫苗载体系统
公开(公告)号：US20090004227A1
公开(公告)日：2009-01-01
申请号：US11628535
申请日：2005-06-07
申请人： Takeshi Matsumura , Akira Ito , Shigeki Kobayashi , Katsumi Kume , Keizo Ito , Noriko Itchoda , Chihiro Sugimoto
发明人： Takeshi Matsumura , Akira Ito , Shigeki Kobayashi , Katsumi Kume , Keizo Ito , Noriko Itchoda , Chihiro Sugimoto
IPC分类号： A61K39/00 , A01H5/00 , C07H21/04 , A61P31/00
CPC分类号： A61K36/81 , A61K38/00 , A61K2039/517 , A61K2039/542 , C12N15/8258 , C12N2770/16022
摘要： The present invention provides a system in which a recombinant plant expressing a target peptide is orally administered to thereby achieve exertion of the function of the peptide, along with the genetically recombinant plant, and the present invention relates to a carrier system for oral administration of a target peptide by oral administration of a plant (potato) that expresses a target peptide by expressing for example a fused gene obtained by fusing the LRE1 gene coding for the immunogenic peptide LRE1 derived from the Leucocytozoon caulleryi 2nd-generation schizont with a Norwalk virus coat protein gene, along with the relevant genetically recombinant plant, and thus, in the present invention the orally administered target peptide can reach an intended destination (such as the intestinal mucosa) without being decomposed in the digestive tract, so that the function of the target peptide can be induced.
摘要翻译：本发明提供了一种系统，其中口服施用表达目标肽的重组植物，从而与遗传重组植物一起实现肽的功能的运用，本发明涉及一种口服给药的载体体系通过口服表达目标肽的植物（马铃薯），通过表达例如通过将编码来源于白细胞介素2代裂殖体的免疫原性肽LRE1的LRE1基因与诺瓦克病毒外壳蛋白融合获得的融合基因，基因以及相关的遗传重组植物，因此在本发明中，口服给药的目标肽可以在消化道中不分解而达到预期的目的地（例如肠粘膜），从而靶肽的功能可以诱导。

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