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1. 发明授权

EP2414844B1 FIBROSIS BIOMARKER ASSAY 有权
标题翻译：生物标志物囊性纤维化
公开(公告)号：EP2414844B1
公开(公告)日：2014-12-10
申请号：EP10715752.1
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

2. 发明公开

EP2414844A2 FIBROSIS BIOMARKER ASSAY 有权
标题翻译：生物标志物囊性纤维化
公开(公告)号：EP2414844A2
公开(公告)日：2012-02-08
申请号：EP10715752.1
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

3. 发明公开

EP3173792A3 CRP NEO-EPITOPE FIBROSIS ASSAY 有权
公开(公告)号：EP3173792A3
公开(公告)日：2017-07-05
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprising conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:
contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and
measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV,
collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

4. 发明授权

EP3173792B1 CRP NEO-EPITOPE FIBROSIS ASSAY 有权
公开(公告)号：EP3173792B1
公开(公告)日：2019-06-12
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68

5. 发明公开

EP3578664A1 COLLAGEN IV NEO-EPITOPE FIBROSIS ASSAY 审中-实审
公开(公告)号：EP3578664A1
公开(公告)日：2019-12-11
申请号：EP19174151.1
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： C12Q1/00 , G01N33/68
摘要： Methods of diagnosis or of quantitation of fibrosis comprising conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:
contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

6. 发明公开

EP3173792A2 CRP NEO-EPITOPE FIBROSIS ASSAY 有权
标题翻译： CRP NEO-表位纤维化测定
公开(公告)号：EP3173792A2
公开(公告)日：2017-05-31
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprising conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:
contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and
measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV,
collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.
摘要翻译：诊断或定量纤维化的方法包括进行免疫测定以测量天然存在于bioflui样品中的含有新表位的蛋白质片段，并且将所述患者中所述测量值在正常水平以上的升高与纤维化的存在或程度相关联。所述免疫测定法通过包括以下步骤的方法进行：使天然存在于所述样品中的蛋白质片段与免疫学结合配偶体接触，所述免疫学结合配偶体与通过蛋白酶裂解蛋白质形成的新表位反应并测量肽片段与所述免疫学结合的结合程度其中所述蛋白质是III型胶原蛋白，I型胶原蛋白，IV型胶原蛋白，V型胶原蛋白或VI型胶原蛋白，弹性蛋白，双糖链蛋白聚糖，核心蛋白聚糖，lumican，多功能蛋白聚糖，基底膜蛋白聚糖， neurocan，短裂解蛋白，纤维调节蛋白，serglycin，多配体聚糖，β聚糖，波形蛋白或C反应蛋白。

7. 发明申请

WO2010115749A2 FIBROSIS BIOMARKER ASSAY 审中-公开
标题翻译： FIBROSIS BIOMARKER测定
公开(公告)号：WO2010115749A2
公开(公告)日：2010-10-14
申请号：PCT/EP2010/054096
申请日：2010-03-29
申请人： NORDIC BIOSCIENCE A/S , VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
发明人： VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.
摘要翻译：诊断或定量纤维化的方法包括进行免疫测定以测量天然存在于生物流体样品中的含有蛋白质片段的蛋白质片段，并将所述患者中所述患者的高度高于正常水平与所述纤维化的存在或程度相关联。免疫测定通过以下方法进行，该方法包括：使天然存在于所述样品中的蛋白片段与免疫结合配偶体接触，所述免疫结合配偶体与通过蛋白酶切割蛋白质形成的新表位反应，并测量肽片段与所述免疫结合的结合程度其中所述蛋白质是III型胶原，I型胶原，IV型胶原，V型胶原或VI型胶原蛋白，弹性蛋白，双糖链蛋白聚糖，核心蛋白聚糖，多巴胺，多聚核苷酸，神经鞘蛋白，短纤维蛋白原，纤维调节蛋白，血清蛋白，syndecan，betaglycan，波形蛋白或C反应蛋白。

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