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1. 发明公开

EP3173792A3 CRP NEO-EPITOPE FIBROSIS ASSAY 有权
公开(公告)号：EP3173792A3
公开(公告)日：2017-07-05
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprising conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:
contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and
measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV,
collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

2. 发明授权

EP3173792B1 CRP NEO-EPITOPE FIBROSIS ASSAY 有权
公开(公告)号：EP3173792B1
公开(公告)日：2019-06-12
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68

3. 发明公开

EP3578664A1 COLLAGEN IV NEO-EPITOPE FIBROSIS ASSAY 审中-实审
公开(公告)号：EP3578664A1
公开(公告)日：2019-12-11
申请号：EP19174151.1
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： C12Q1/00 , G01N33/68
摘要： Methods of diagnosis or of quantitation of fibrosis comprising conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:
contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

4. 发明公开

EP3173792A2 CRP NEO-EPITOPE FIBROSIS ASSAY 有权
标题翻译： CRP NEO-表位纤维化测定
公开(公告)号：EP3173792A2
公开(公告)日：2017-05-31
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprising conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:
contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and
measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV,
collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.
摘要翻译：诊断或定量纤维化的方法包括进行免疫测定以测量天然存在于bioflui样品中的含有新表位的蛋白质片段，并且将所述患者中所述测量值在正常水平以上的升高与纤维化的存在或程度相关联。所述免疫测定法通过包括以下步骤的方法进行：使天然存在于所述样品中的蛋白质片段与免疫学结合配偶体接触，所述免疫学结合配偶体与通过蛋白酶裂解蛋白质形成的新表位反应并测量肽片段与所述免疫学结合的结合程度其中所述蛋白质是III型胶原蛋白，I型胶原蛋白，IV型胶原蛋白，V型胶原蛋白或VI型胶原蛋白，弹性蛋白，双糖链蛋白聚糖，核心蛋白聚糖，lumican，多功能蛋白聚糖，基底膜蛋白聚糖， neurocan，短裂解蛋白，纤维调节蛋白，serglycin，多配体聚糖，β聚糖，波形蛋白或C反应蛋白。

5. 发明申请

WO2019121345A1 SPARC ASSAY 审中-公开
公开(公告)号：WO2019121345A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/084841
申请日：2018-12-13
申请人： NORDIC BIOSCIENCE A/S
发明人： KEHLET, Stephanie, Nina , ØRSNES-LEEMING, Diana , KARSDAL, Morten
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57423 , C07K16/18 , C07K2317/34 , G01N33/57484 , G01N2800/52
摘要： The present invention relates to an assay for detecting secreted proteome acidic and rich in cysteine (SPARC), and more specifically to its use in evaluating lung cancer.

6. 发明申请

WO2018167132A1 LYSYL OXIDASE LIKE-2 ASSAY 审中-公开
公开(公告)号：WO2018167132A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/056364
申请日：2018-03-14
申请人： NORDIC BIOSCIENCE A/S
发明人： ORSNES-LEEMING, Diana , KARSDAL, Morten , NIELSEN, Signe, Holm
IPC分类号： C07K16/40
摘要： The present invention relates to an antibody, wherein the antibody specifically binds to the N-terminus of Lysyl Oxidase Like-2 (LOXL2), and its use in a method of immunoassay for detecting or quantitating LOXL2 in a sample. The method may be used to evaluate LOXL2-associated diseases, and may also be used to evaluate the efficacy of anti-LOXL2 therapeutics.

7. 发明申请

WO2018050671A1 NIDOGEN-1 FRAGMENTS ASSAY 审中-公开
标题翻译： NIDOGEN-1片段测定
公开(公告)号：WO2018050671A1
公开(公告)日：2018-03-22
申请号：PCT/EP2017/072973
申请日：2017-09-13
申请人： NORDIC BIOSCIENCE A/S
发明人： WILLUMSEN, Nicholas , BAGER, Cecilie, Liv , BAY JENSEN, Anne-Cecilie , QUILEZ-ALVAREZ, Antonio , KARSDAL, Morten , ORSNES-LEEMING, Diana , MANON-JENSEN, Tina
IPC分类号： C07K14/78 , C12Q1/37 , G01N33/574
摘要： A method of diagnosis or of quantitation of cancer comprising obtaining a patient biofluid sample, conducting an immunoassay to measure fragments of Nidogen-1 having an N- or C-terminal neo-epitope formed by cleavage of Nidogen-1 by Cathepsin-S, said fragments being naturally present in said sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of cancer.
摘要翻译：一种诊断或定量癌症的方法，其包括获得患者生物流体样品，进行免疫测定以测量具有通过裂解Nidogen形成的N或C末端新表位的Nidogen-1的片段 -1，所述片段天然存在于所述样品中，并且将所述患者中的所述测量值在正常水平以上的升高与癌症的存在或程度相关联。

8. 发明申请

WO2017134172A1 COMBINED BIOMARKER MEASUREMENT OF FIBROSIS 审中-公开
标题翻译：纤维瘤的联合生物标志物测定
公开(公告)号：WO2017134172A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052271
申请日：2017-02-02
申请人： NORDIC BIOSCIENCE A/S
发明人： GENOVESE, Federica , NIELSEN, Mette, Juul , LARSEN, Lisa , OERSNES-LEEMING, Diane, Julie , KARSDAL, Morten
IPC分类号： G01N33/577 , G01N33/68
CPC分类号： G01N33/6887 , G01N33/577 , G01N2333/78 , G01N2800/085 , G01N2800/52 , G01N2800/7052
摘要： Provided herein is a sandwich immunoassay for detecting cross-linked PIIINP that has at least two strands of PIIINP joined together by inter-strand cross-linking each having a C-terminal neo-epitope of PIIINP that is generated by N-protease cleavage of intact type III procollagen. A biological sample having the cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody and then by a second monoclonal antibody, both specifically reactive with a neoepitope in the C-terminal sequence of PIIINP, and then binding of the second monoclonal antibody is determined. Also provided is a method for evaluating the efficacy of an antagonist drug targeting lysyl oxidases via the immunoassay and a kit containing a solid support binding the first monoclonal antibody and containing the second monoclonal antibody.
摘要翻译：本文提供了用于检测交联PIIINP的夹心免疫测定法，其具有通过链间交联连接在一起的至少两条PIIINP链，每条链具有PIIINP的C端新表位，其是由完整的III型前胶原的N-蛋白酶切割产生。使具有交联的PIIINP的生物样品与第一表面结合的单克隆抗体接触，然后通过第二单克隆抗体与PIIINP的C末端序列中的新表位特异性反应，然后结合第二单克隆抗体决心，决意，决定。还提供了一种通过免疫测定评估靶向赖氨酰氧化酶的拮抗剂药物的功效的方法和一种含有结合第一单克隆抗体并含有第二单克隆抗体的固体支持物的试剂盒。

9. 发明申请

WO2002097121A1 METHOD FOR ASSAYING OSTEOCLAST RECRUITMENT AND RESORPTION 审中-公开
标题翻译：测定骨质疏松症和再吸收的方法
公开(公告)号：WO2002097121A1
公开(公告)日：2002-12-05
申请号：PCT/DK2002/000361
申请日：2002-05-28
申请人： NORDIC BIOSCIENCE A/S , KARSDAL, Morten , ENGSIG, Michael
发明人： KARSDAL, Morten , ENGSIG, Michael
IPC分类号： C12Q1/02
CPC分类号： G01N33/5047 , C12N5/0643 , C12N2501/185 , C12N2501/22 , C12N2501/25 , C12N2503/00 , G01N33/5008 , G01N33/502 , G01N33/5029 , G01N33/5044 , G01N2500/00
摘要： This invention relates to a method for separation of the differentiation process and the process of recruitment of mammalian osteoclasts comprising an initial culture period, cultivating a CD-14 positive monocyte cell culture, followed by detachment of the osteoclasts from the substratum and subsequent reseeding of the osteoclasts in an appropriate recruitment assay, in the presence of differention factors as RANKL and M-CSF.
摘要翻译：本发明涉及一种用于分离分化过程的方法和哺乳动物破骨细胞的募集方法，其包括初始培养期，培养CD-14阳性单核细胞培养物，随后将破骨细胞从基质中分离出来，随后重新加入破骨细胞在适当的招募测定中，在分化因子存在下作为RANKL和M-CSF。

10. 发明申请

WO2021043945A1 ASSAY FOR ASSESSING HEART FAILURE 审中-公开
公开(公告)号：WO2021043945A1
公开(公告)日：2021-03-11
申请号：PCT/EP2020/074685
申请日：2020-09-03
申请人： NORDIC BIOSCIENCE A/S
发明人： SUN, Shu , REESE-PETERSEN, Alexander, Lynge , GENOVESE, Federica , KARSDAL, Morten
IPC分类号： G01N33/68 , C07K16/18
摘要： Disclosed herein are immunoassays, in particular immunoassays for detecting and/or monitoring cardiovascular disease, such as heart failure. Also disclosed are monoclonal antibodies and kits for use in said assays. The assays, antibodies and kits target a C-terminal epitope of type XXVIII collagen.

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