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1. 发明授权

US5763205A Producing pure chondroitinase ABC from Proteus vulgaris ATCC 6896 失效
标题翻译：从普通变形菌ATCC 6896生产纯软骨素酶ABC
公开(公告)号：US5763205A
公开(公告)日：1998-06-09
申请号：US443675
申请日：1995-05-18
申请人： Nobukazu Hashimoto , Hideo Mochizuki , Akio Hamai
发明人： Nobukazu Hashimoto , Hideo Mochizuki , Akio Hamai
IPC分类号： A61K38/43 , A61K38/00 , C12N9/16 , C12N9/20 , C12N9/88 , C12N9/44
CPC分类号： C12N9/88 , A61K38/00 , G03C2001/0471 , Y10S435/873
摘要： A crystallizable, purified chondroitinase ABC having a molecular weight of about 100,000 dalton by the measurement of the SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and the measurement by the gel permeation chromatography method, having alanine as the N-terminal amino acid and proline as the C-terminal amino acid is disclosed. A process for the purification of the crystallizable purified chondroitinase ABC comprising removing nucleic acid from an surfactant solution extract obtained from cells of chondroitinase ABC-producing microorganisms and chromatographically treating by concentration gradient elution using a weak cation exchange resin or a strong cation exchange resin is disclosed. A composition comprising a chondroitinase and serum albumin, gelatin, or a nonionic surfactant is disclosed. The enzyme is isolated from Proteus vulgaris ATCC 6896.
摘要翻译：通过SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE）的测量和通过凝胶渗透色谱法测定的具有约100,000道尔顿分子量的可结晶纯化的软骨素酶ABC，其具有丙氨酸作为N-末端氨基酸和脯氨酸因为公开了C-末端氨基酸。公开了一种纯化可结晶纯化软骨素酶ABC的方法，包括从由软骨素酶ABC产生的微生物的细胞获得的表面活性剂溶液提取物中除去核酸，并使用弱阳离子交换树脂或强阳离子交换树脂进行色谱法处理。。公开了包含软骨素酶和血清白蛋白，明胶或非离子表面活性剂的组合物。该酶从普通变形杆菌ATCC 6896中分离。

2. 发明授权

US06184023B2 Chondroitinase, process for preparing the same, and pharmaceutical composition comprising the same 失效
标题翻译：软骨素酶，其制备方法和包含其的药物组合物
公开(公告)号：US06184023B2
公开(公告)日：2001-02-06
申请号：US08888530
申请日：1997-07-07
申请人： Nobukazu Hashimoto , Hideo Mochizuki , Akio Hamai
发明人： Nobukazu Hashimoto , Hideo Mochizuki , Akio Hamai
IPC分类号： C12N988
CPC分类号： C12N9/88 , A61K38/00 , G03C2001/0471 , Y10S435/873
摘要： A crystallizable, purified chondroitinase ABC having a molecular weight of about 100,000 dalton by the measurement of the SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and the measurement by the gel permeation chromatography method, having alanine as the N-terminal amino acid and proline as the C-terminal amino acid. A process for the purification of the crystallizable purified chondroitinase ABC comprising removing nucleic acid from an surfactant solution extract obtained from cells of chondroitinase ABC-producing microorganisms and chromatographically treating by concentration gradient elution using a weak cation exchange resin or a strong cation exchange resin. A composition comprising a chondroitinase and serum albumin, gelatin, or a nonionic surfactant.
摘要翻译：通过SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE）的测量和通过凝胶渗透色谱法测定的具有约100,000道尔顿分子量的可结晶纯化的软骨素酶ABC，其具有丙氨酸作为N-末端氨基酸和脯氨酸作为C末端氨基酸。一种用于纯化可结晶的纯化软骨素酶ABC的方法，包括从获自软骨素酶ABC微生物的细胞获得的表面活性剂溶液提取物中除去核酸，并使用弱阳离子交换树脂或强阳离子交换树脂进行色谱法处理。包含软骨素酶和血清白蛋白，明胶或非离子表面活性剂的组合物。

3. 发明授权

US5496718A Chondroitinase ABC isolated from proteus vulgaris ATCC 6896 失效
标题翻译：从普通寻常型ATCC 6896中分离的软骨素酶ABC
公开(公告)号：US5496718A
公开(公告)日：1996-03-05
申请号：US082853
申请日：1993-06-23
申请人： Nobukazu Hashimoto , Hideo Mochizuki , Akio Hamai
发明人： Nobukazu Hashimoto , Hideo Mochizuki , Akio Hamai
IPC分类号： A61K38/43 , A61K38/00 , C12N9/16 , C12N9/20 , C12N9/88 , C01G17/04 , C12N1/12
CPC分类号： C12N9/88 , A61K38/00 , G03C2001/0471 , Y10S435/873
摘要： A crystallizable, purified chondroitinase ABC having a molecular weight of about 100,000 dalton by the measurement of the SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and the measurement by the gel permeation chromatography method, having alanine as the N-terminal amino acid and proline as the C-terminal amino acid. A process for the purification of the crystallizable purified chondroitinase ABC comprising removing nucleic acid from an surfactant solution extract obtained from cells of chondroitinase ABC-producing microorganisms and chromatographically treating by concentration gradient elution using a weak cation exchange resin or a strong cation exchange resin. A composition comprising a chondroitinase and serum albumin, gelatin, or a nonionic surfactant. The chondroitinase ABC is isolated from Proteus vulgaris ATCC 6896.
摘要翻译：通过SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE）的测量和通过凝胶渗透色谱法测定的具有约100,000道尔顿分子量的可结晶纯化的软骨素酶ABC，其具有丙氨酸作为N-末端氨基酸和脯氨酸作为C末端氨基酸。一种用于纯化可结晶的纯化软骨素酶ABC的方法，包括从获自软骨素酶ABC微生物的细胞获得的表面活性剂溶液提取物中除去核酸，并使用弱阳离子交换树脂或强阳离子交换树脂进行色谱法处理。包含软骨素酶和血清白蛋白，明胶或非离子表面活性剂的组合物。软骨素酶ABC从普通变形杆菌ATCC 6896中分离。

4. 发明申请

US20060032768A1 Prefilled injector package and sterilizing or disinfecting method therefor 审中-公开
标题翻译：预填注射器包装及其消毒或消毒方法
公开(公告)号：US20060032768A1
公开(公告)日：2006-02-16
申请号：US11192528
申请日：2005-07-29
申请人： Akio Hamai , Kenji Miyamoto , Hiroki Kano , John Shea
发明人： Akio Hamai , Kenji Miyamoto , Hiroki Kano , John Shea
IPC分类号： B65D83/10 , A61M5/00
CPC分类号： A61L2/07 , A61B50/30 , A61B2050/314 , A61L2/04 , A61M5/001 , A61M5/002 , A61M2005/3132
摘要： The present invention relates to a prefilled injector package comprising a prefilled injector having a syringe body filled with a medicinal preparation; and a packaging material for hermetically packaging the prefilled injector, the packaging material being brought into close contact with at least the syringe body; and a method for sterilizing or disinfecting the prefilled injector package, which comprises the steps of packaging the prefilled injector with the packaging material such that the packaging material is brought into close contact with at least the syringe body; and heat-treating the prefilled injector package to simultaneously sterilize or disinfect an injector body and the medicinal preparation filled therein. According to the present invention, the injector body and the medicinal preparation filled therein is sterilized or disinfected at the same time by subjecting the prefilled injector package to only one heat treatment, and the deposition of water is prevented onto injection nozzle or cap upon sterilization using steam or hot water.
摘要翻译：本发明涉及一种预充式注射器包装，其包括预充式注射器，其具有填充有药物制剂的注射器主体; 以及用于气密地包装预充式注射器的包装材料，所述包装材料至少与所述注射器主体紧密接触; 以及用于对预充式注射器包装进行消毒或消毒的方法，其包括以下步骤：用包装材料包装预填充注射器，使得包装材料与至少注射器主体紧密接触; 并对预填充的注射器包装进行热处理，以同时对注射器主体和填充在其中的药剂进行灭菌或消毒。根据本发明，通过对预填充的注射器包装进行一次热处理，同时对注射器主体和其中填充的药剂进行灭菌或消毒，并且在灭菌时在喷嘴或盖上进行沉积蒸汽或热水。

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