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1. 发明授权

US4211898A Headphone with two resonant peaks for simulating loudspeaker reproduction 失效
标题翻译：具有两个谐振峰值的耳机，用于模拟扬声器再现
公开(公告)号：US4211898A
公开(公告)日：1980-07-08
申请号：US923206
申请日：1978-07-10
申请人： Nobuhisa Atoji , Takashi Matsumoto , Shoichi Kusumoto , Kazue Sato , Mitsuhiro Hasegawa
发明人： Nobuhisa Atoji , Takashi Matsumoto , Shoichi Kusumoto , Kazue Sato , Mitsuhiro Hasegawa
IPC分类号： H04R1/22 , H04R9/04 , H04M1/05 , H04R1/28
CPC分类号： H04R1/225 , H04R9/047
摘要： A headphone is designed to have two resonant peaks for simulating loudspeaker reproduction. The headphone comprises a housing in which an electroacoustic transducer with a diaphragm is positioned, wherein the housing is formed with a rearward cavity positioned adjacent to the diaphragm remote from the listener's ear to provide an acoustic compliance to the generated acoustic energy. In order to generate the two resonant peaks to simulate a sensation of realism as if the listener is hearing sound from a loudspeaker, the rearward cavity is communicated with the atmosphere through apertures. The acoustic compliance of the rearward cavity coacts with the apertures to produce two resonant peaks at frequencies corresponding to the frequencies of the peaks which occur in a signal from the loudspeaker.
摘要翻译：耳机设计为具有两个谐振峰值，用于模拟扬声器再现。耳机包括壳体，其中定位有具有隔膜的电声换能器，其中壳体形成有与隔离器相邻的向后腔，远离听者的耳朵，以提供与产生的声能的声学顺应性。为了产生两个谐振峰值以仿真听众听到来自扬声器的声音的真实感，后腔通过孔与大气连通。后腔的声学顺应性与孔隙共同作用，以产生在对应于来自扬声器的信号中出现的峰值的频率的频率处的两个谐振峰值。

2. 发明授权

US07838549B2 Linker compound, ligand conjugate, and production methods thereof 有权
标题翻译：接头化合物，配体缀合物及其制备方法
公开(公告)号：US07838549B2
公开(公告)日：2010-11-23
申请号：US10588612
申请日：2005-02-04
申请人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel , Masahiro Wakao
发明人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel , Masahiro Wakao
IPC分类号： A61K31/385 , C07D409/14
CPC分类号： C07H15/04 , C07D339/04 , G01N33/54353
摘要： The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.
摘要翻译：本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。连接体化合物为下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含三个以上的烃衍生链，其中所述烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。配体缀合物包括其中引入糖分子的连接体化合物。

3. 发明授权

US05998595A Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups 失效
标题翻译：叠氮基苄基衍生物，糖类化合物和保护羟基
公开(公告)号：US05998595A
公开(公告)日：1999-12-07
申请号：US961174
申请日：1997-10-30
申请人： Shoichi Kusumoto , Koichi Fukase
发明人： Shoichi Kusumoto , Koichi Fukase
IPC分类号： C07C247/16 , C07H15/18 , C07H15/203 , C07H1/00
CPC分类号： C07H15/18 , C07C247/16 , C07H15/203 , C07B2200/11 , Y02P20/55
摘要： Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.
摘要翻译：式（I）的叠氮基苄基衍生物，其中A是卤素原子，B是卤素原子或氢原子，X是与羟基反应的基团，使用所述衍生物保护羟基的方法和糖至少一个羟基的氢原子被叠氮基卤代苄基取代的化合物。根据本发明，提供了能够将基团引入到具有羟基的化合物中的新的衍生物，该基团即使在用于延长糖的目的的固相合成中也可用作稳定的羟基保护基在连续酸性条件下并在温和条件下除去; 通过使用所述衍生物保护的糖化合物; 以及使用所述衍生物保护羟基的方法。

4. 发明授权

US5548077A Method of producing a conjugate utilizing a 2-amino-pyridine compound 失效
标题翻译：使用2-氨基 - 吡啶化合物生产结合物的方法
公开(公告)号：US5548077A
公开(公告)日：1996-08-20
申请号：US311733
申请日：1994-09-23
申请人： Shoichi Kusumoto , Koichi Fukase , Sumihiro Hase
发明人： Shoichi Kusumoto , Koichi Fukase , Sumihiro Hase
IPC分类号： C07D213/74 , C07D213/75 , C07D213/02 , C07H17/02
CPC分类号： C07D213/74 , C07D213/75
摘要： 2-Aminopyridine derivatives having a bifunctional or unifunctional structure and capable of serving as reactants in synthetically converting organic compounds, such as carbohydrates, proteins, lipids or polymer resins, to desired conjugated structures suited for various purposes and detectable by fluorescence spectrometry with high sensitivity, a fluorescent labeling agent comprising the same, and methods of their production are disclosed.
摘要翻译：具有双官能或单官能结构并能够在合成转化的有机化合物如碳水化合物，蛋白质，脂质或聚合物树脂中的反应物的2-氨基吡啶衍生物转化成适用于各种目的的所需缀合结构并且可通过高灵敏度的荧光光谱法检测，公开了包含该荧光标记物的荧光标记物及其制备方法。

5. 发明申请

US20070213523A1 Linker Compound, Ligand Conjugate, and Production Methods Thereof 有权
标题翻译：连接剂化合物，配体结合物及其制备方法
公开(公告)号：US20070213523A1
公开(公告)日：2007-09-13
申请号：US10588612
申请日：2005-02-04
申请人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel , Masahiro Wakao
发明人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel , Masahiro Wakao
IPC分类号： C07D339/04 , C07H3/04 , C07H3/06
CPC分类号： C07H15/04 , C07D339/04 , G01N33/54353
摘要： The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.
摘要翻译：本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。连接体化合物为下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含三个以上的烃衍生链，其中所述烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。配体缀合物包括其中引入糖分子的连接体化合物。

6. 发明授权

US07320867B2 Linker compound, ligand, and producing method thereof 有权
标题翻译：接头化合物，配体及其制备方法
公开(公告)号：US07320867B2
公开(公告)日：2008-01-22
申请号：US10526775
申请日：2003-09-08
申请人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel
发明人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel
IPC分类号： G01N33/53 , G01N33/532 , C12P7/58 , C07K1/13
CPC分类号： C07H15/04 , A61K47/549 , C07D339/04 , C07D409/14 , Y10S435/961 , Y10S435/97
摘要： A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound
摘要翻译：连接体化合物具有下述通式（1）表示的结构，其中n为1〜6的整数，X为具有多支链结构部分的结构，包括三个或四个具有芳香族氨基的烃衍生物链末端的基团和骨架中的碳 - 氮键。配体包括连接体化合物和引入接头化合物的糖

7. 发明申请

US20060014220A1 Multipurpose linker compounds and ligands and process for producing the same 有权
标题翻译：多用途接头化合物和配体及其制备方法
公开(公告)号：US20060014220A1
公开(公告)日：2006-01-19
申请号：US10526938
申请日：2003-08-06
申请人： Yasuo Suda , Akio Arano , Hideki Hayashi , Shoichi Kusumoto , Michael Sobel
发明人： Yasuo Suda , Akio Arano , Hideki Hayashi , Shoichi Kusumoto , Michael Sobel
IPC分类号： G01N33/53 , C07H17/02
CPC分类号： C07D495/04 , C07H15/203 , G01N33/531 , G01N33/54353 , Y10S435/961 , Y10S435/97 , Y10S530/813
摘要： A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.
摘要翻译：通用的接头化合物具有由以下通式（1）表示的结构，其中Y具有由O或NH表示的结构，X具有用作多支链部分的结构，包括四个烃衍生物链，其各自具有芳族氨基，其末端可以具有或不具有碳 - 氮键。使用通用的接头化合物，糖分子可以二维排列在蛋白质分析支持物的表面上，具有高重现性。此外，配体包括通用连接体化合物和引入其中的糖分子。

8. 发明授权

US07183067B2 Versatile linker compound, ligand, and producing method thereof 有权
标题翻译：多功能接头化合物，配体及其制备方法
公开(公告)号：US07183067B2
公开(公告)日：2007-02-27
申请号：US10526938
申请日：2003-08-06
申请人： Yasuo Suda , Akio Arano , Hideki Hayashi , Shoichi Kusumoto , Michael Sobel
发明人： Yasuo Suda , Akio Arano , Hideki Hayashi , Shoichi Kusumoto , Michael Sobel
IPC分类号： G01N33/53 , G01N33/532 , G01N33/547 , C12P7/58 , C07K1/13
CPC分类号： C07D495/04 , C07H15/203 , G01N33/531 , G01N33/54353 , Y10S435/961 , Y10S435/97 , Y10S530/813
摘要： A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.
摘要翻译：通用的接头化合物具有由以下通式（1）表示的结构，其中Y具有由O或NH表示的结构，X具有用作多支链部分的结构，包括四个烃衍生物链，其各自具有芳族氨基，其末端可以具有或不具有碳 - 氮键。使用通用的接头化合物，糖分子可以二维排列在蛋白质分析支持物的表面上，具有高重现性。此外，配体包括通用连接体化合物和引入其中的糖分子。

9. 发明申请

US20060030699A1 Versatile linker compound and ligand, and method for preparation thereof 有权
标题翻译：通用接头化合物和配体，及其制备方法
公开(公告)号：US20060030699A1
公开(公告)日：2006-02-09
申请号：US10526775
申请日：2003-09-08
申请人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel
发明人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel
IPC分类号： C08B37/00
CPC分类号： C07H15/04 , A61K47/549 , C07D339/04 , C07D409/14 , Y10S435/961 , Y10S435/97
摘要： A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound.
摘要翻译：连接体化合物具有下述通式（1）表示的结构，其中n为1〜6的整数，X为具有多支链结构部分的结构，包括三个或四个具有芳香族氨基的烃衍生物链末端的基团和骨架中的碳 - 氮键。配体包括连接体化合物和引入接头化合物的糖。

10. 发明授权

US5386033A 2-aminopyridine compounds 失效
标题翻译： 2-氨基吡啶化合物
公开(公告)号：US5386033A
公开(公告)日：1995-01-31
申请号：US31476
申请日：1993-03-15
申请人： Shoichi Kusumoto , Sumihiro Hase , Koichi Fukase
发明人： Shoichi Kusumoto , Sumihiro Hase , Koichi Fukase
IPC分类号： C07D213/73 , C07D213/74 , C07D213/75 , C07H17/02 , C09K11/06 , G01N33/533 , C07D213/02
CPC分类号： C07D213/75 , C07D213/74 , Y02P20/55
摘要： 2-Aminopyridine derivatives having a bifunctional or unifunctional structure and capable of serving as reactants in synthetically converting organic compounds, such as carbohydrates, proteins, lipids or polymer resins, to desired conjugated structures suited for various purposes and detectable by fluorescence spectrometry with high sensitivity, a fluorescent labeling agent comprising the same, and methods of their production are disclosed.
摘要翻译：具有双官能或单官能结构并能够在合成转化的有机化合物如碳水化合物，蛋白质，脂质或聚合物树脂中的反应物的2-氨基吡啶衍生物转化成适用于各种目的的所需缀合结构并且可通过高灵敏度的荧光光谱法检测，公开了包含该荧光标记物的荧光标记物及其制备方法。

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