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1. 外观设计

USD561623S1 Sensor chip for biochemical analysis 有权
标题翻译：传感器芯片进行生化分析
公开(公告)号：USD561623S1
公开(公告)日：2008-02-12
申请号：US29266470
申请日：2006-09-22
申请人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Hideyuki Morimoto , Hiroyuki Ota , Masayasu Konishi , Yoshiyuki Kunuki
设计人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Hideyuki Morimoto , Hiroyuki Ota , Masayasu Konishi , Yoshiyuki Kunuki

2. 外观设计

USD561055S1 Flow channel member of sensor chip for biochemical analysis 有权
公开(公告)号：USD561055S1
公开(公告)日：2008-02-05
申请号：US29266477
申请日：2006-09-22
申请人： Nobuhiko Ogura , Hitoshi Shimizu , Yasunobu Sakaguchi , Masayasu Konishi
设计人： Nobuhiko Ogura , Hitoshi Shimizu , Yasunobu Sakaguchi , Masayasu Konishi

3. 外观设计

USD562165S1 Flow channel member of sensor chip for biochemical analysis 有权
标题翻译：传感器芯片流道成分进行生化分析
公开(公告)号：USD562165S1
公开(公告)日：2008-02-19
申请号：US29266469
申请日：2006-09-22
申请人： Nobuhiko Ogura , Hitoshi Shimizu , Yasunobu Sakaguchi , Masayasu Konishi
设计人： Nobuhiko Ogura , Hitoshi Shimizu , Yasunobu Sakaguchi , Masayasu Konishi

4. 外观设计

USD561053S1 Prism of sensor chip for biochemical analysis 有权
标题翻译：传感器芯片棱镜用于生化分析
公开(公告)号：USD561053S1
公开(公告)日：2008-02-05
申请号：US29266439
申请日：2006-09-21
申请人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Yoshiyuki Kunuki
设计人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Yoshiyuki Kunuki

5. 外观设计

USD561054S1 Prism of sensor chip for biochemical analysis 有权
公开(公告)号：USD561054S1
公开(公告)日：2008-02-05
申请号：US29266476
申请日：2006-09-22
申请人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Yoshiyuki Kunuki
设计人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Yoshiyuki Kunuki

6. 发明授权

US07715012B2 Sensor unit and assay method of assay in utilizing attenuated total reflection 失效
标题翻译：使用衰减全反射的传感器单元和测定方法
公开(公告)号：US07715012B2
公开(公告)日：2010-05-11
申请号：US12394298
申请日：2009-02-27
申请人： Nobuhiko Ogura , Hitoshi Shimizu , Koji Kuruma , Hisashi Ohtsuka , Tatsuo Fujikura , Shu Sato
发明人： Nobuhiko Ogura , Hitoshi Shimizu , Koji Kuruma , Hisashi Ohtsuka , Tatsuo Fujikura , Shu Sato
IPC分类号： G01N21/55
CPC分类号： G01N21/05 , G01N21/553 , G01N2021/0346 , G01N2021/058
摘要： A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio) chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.
摘要翻译：表面等离子体共振（SPR）测定系统的传感器单元包括透明电介质。薄膜具有第一表面和感测表面。第一表面与电介质连接以构成界面。感测表面回到第一个表面，用于检测（生物）化学反应。流动池块具有用于将样品流动到感测表面的流动通道。在界面处检查照明光的衰减全反射，分析配体和分析物之间的相互作用作为样品。流动通道包括与感测表面相对设置的第一内表面，以沿着该方式延伸以使样品在两者之间流动。第一内表面具有相对于感测表面限定的高度，并且在200-500微米的范围内。

7. 发明申请

US20090195784A1 Sensor Unit and Assay Method of Assay in Utilizing Attenuated Total Reflection 失效
标题翻译：传感器单元和使用衰减全反射测定方法
公开(公告)号：US20090195784A1
公开(公告)日：2009-08-06
申请号：US12394298
申请日：2009-02-27
申请人： Nobuhiko Ogura , Hitoshi Shimizu , Koji Kuruma , Hisashi Ohtsuka , Tatsuo Fujikura , Shu Sato
发明人： Nobuhiko Ogura , Hitoshi Shimizu , Koji Kuruma , Hisashi Ohtsuka , Tatsuo Fujikura , Shu Sato
IPC分类号： G01N21/55 , G01N21/05
CPC分类号： G01N21/05 , G01N21/553 , G01N2021/0346 , G01N2021/058
摘要： A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio) chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.
摘要翻译：表面等离子体共振（SPR）测定系统的传感器单元包括透明电介质。薄膜具有第一表面和感测表面。第一表面与电介质连接以构成界面。感测表面回到第一个表面，用于检测（生物）化学反应。流动池块具有用于将样品流动到感测表面的流动通道。在界面处检查照明光的衰减全反射，分析配体和分析物之间的相互作用作为样品。流动通道包括与感测表面相对设置的第一内表面，以沿着该方式延伸以使样品在两者之间流动。第一内表面具有相对于感测表面限定的高度，并且在200-500微米的范围内。

8. 发明授权

US06781143B2 Biochemical analysis data producing method, biochemical analysis data producing apparatus and stimulable phosphor sheet used therefor 失效
标题翻译：生物化学分析数据生成方法，生化分析数据生成装置和用于其的可刺激荧光粉片
公开(公告)号：US06781143B2
公开(公告)日：2004-08-24
申请号：US10116701
申请日：2002-04-05
申请人： Hitoshi Shimizu , Nobuhiko Ogura
发明人： Hitoshi Shimizu , Nobuhiko Ogura
IPC分类号： G03B4200
CPC分类号： G01T1/2014 , G01T1/2012 , G01T1/2985
摘要： A biochemical analysis data producing method includes the steps of exposing stimulable phosphor layer regions formed in a stimulable phosphor sheet and spaced from each other using standard light, irradiating the stimulable phosphor layer regions with a stimulating ray, detecting stimulated emission to produce correction data for the individual stimulable phosphor layer regions, superposing the stimulable phosphor sheet on a biochemical analysis unit including spot-like regions formed in the same pattern as that of the stimulable phosphor layer regions and selectively containing a radioactive labeling substance, exposing the stimulable phosphor layer regions to the radioactive labeling substance, scanning the stimulable phosphor layer regions with a stimulating ray, detecting stimulated emission to produce biochemical analysis data, and correcting the biochemical analysis data using the correction data. According to this biochemical analysis data producing method, it is possible to produce biochemical analysis data having excellent quantitative characteristics.
摘要翻译：生物化学分析数据生成方法包括以下步骤：使用标准光曝光形成在可刺激的荧光体片材中的可激发的荧光体层区域，并用刺激的光线照射可刺激的荧光体层区域，检测受激发射以产生校正数据单独的可刺激荧光体层区域，将可刺激的荧光体片材叠加在生物化学分析单元上，该生物化学分析单元包括以与可刺激的荧光体层区域相同的图案形成的斑点状区域，并选择性地含有放射性标记物质，将可刺激的荧光体层区域暴露于放射性标记物质，用刺激射线扫描可刺激的荧光体层区域，检测受激发射以产生生化分析数据，以及使用校正数据校正生化分析数据。根据该生化分析数据生成方法，能够生成具有优异的定量特性的生化分析数据。

9. 发明授权

US07348587B2 Method for producing biochemical analysis data and apparatus used therefor 失效
标题翻译：生化分析数据及其使用方法
公开(公告)号：US07348587B2
公开(公告)日：2008-03-25
申请号：US10175425
申请日：2002-06-20
申请人： Hitoshi Shimizu , Nobuhiko Ogura
发明人： Hitoshi Shimizu , Nobuhiko Ogura
IPC分类号： G03B42/08
CPC分类号： G01N21/76 , G01N21/6452 , G01N2021/6484
摘要： A method for producing biochemical analysis data includes the steps of collecting light selectively released from a plurality of light releasable regions two-dimensionally formed to be spaced apart from each other in a sample placed on a sample stage by a plurality of light guide member each of which is disposed to face one of the plurality of light releasable regions, leading the thus collected light to a light detector and photoelectrically detecting the light by the light detector. According to this method, it is possible to produce biochemical analysis data having high quantitative characteristics by photoelectrically detecting light emitted from a plurality of light releasable regions even in the case where the plurality of light releasable regions labeled with a labeling substance are formed in a sample at a high density.
摘要翻译：一种生化分析数据的制造方法，其特征在于，在多个导光部件中，通过多个导光部件收集从放置在样品台上的样品彼此间隔开的二维形成的多个可光释放区域中选择性地剥离的光其被设置为面对多个可光释放区域中的一个，将由此收集的光导向光检测器并通过光检测器光电检测光。根据该方法，即使在标记有标记物质的多个可光剥离区域形成在样品中的情况下，也可以通过光电检测从多个可光释放区域发出的光来生成具有高定量特性的生化分析数据以高密度。

10. 发明授权

US07170078B2 Biochemical analysis data producing method and scanner used therefor 失效
标题翻译：生化分析数据生成方法和扫描仪用于此
公开(公告)号：US07170078B2
公开(公告)日：2007-01-30
申请号：US10141555
申请日：2002-05-09
申请人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
发明人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
IPC分类号： G03B42/08
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/54373
摘要： A biochemical analysis data producing method includes the steps of selectively storing one of radiation energy and light energy in a plurality of stimulable phosphor layer regions two-dimensionally formed in a support of a stimulable phosphor sheet and spaced apart from each other, moving the stimulable phosphor sheet and a stimulating ray relative to each other in a main scanning direction and a sub-scanning direction, sequentially irradiating the plurality of stimulable phosphor layer regions so that energy of the stimulating ray projected onto the plurality of stimulable phosphor layer regions per unit area is higher than that projected on regions other than the plurality of stimulable phosphor layer regions, thereby exciting stimulable phosphor contained in the plurality of stimulable phosphor layer regions, and photoelectrically detecting stimulated emission released from the stimulable phosphor layer to produce biochemical analysis data. According to this method, it is possible to effectively prevent the stimulating ray from entering a neighboring stimulable phosphor layer region to be next stimulated as the stimulating ray is scanned and thus prevent stimulable phosphor contained in the neighboring stimulable phosphor layer region from being excited to release radiation energy or light energy stored therein, and, therefore, biochemical analysis data having an excellent quantitative characteristic can be produced in a desired manner.
摘要翻译：生物化学分析数据生成方法包括以下步骤：将辐射能量和光能中的一种选择性地存储在可激发的荧光体片的支撑体中二维地形成并且彼此间隔开的多个可刺激的荧光体层区域中，将可刺激的荧光体并且在主扫描方向和副扫描方向上相对于彼此产生刺激光线，顺序地照射多个可刺激的荧光体层区域，使得投影到每单位面积的多个可激发荧光体层区域上的刺激光线的能量为高于在多个可刺激的荧光体层区域以外的区域上投影的激光荧光体层，从而激发包含在多个可刺激的荧光体层区域中的可激发的荧光体，以及光电检测从可刺激的荧光体层释放的受激发射以产生生化分析数据。根据该方法，可以有效地防止刺激光线随着刺激射线被扫描而进入下一个被刺激的刺激性射线区域，从而防止相邻可刺激荧光体层区域中包含的可刺激的荧光体被激发释放辐射能量或光能存储在其中，因此可以以期望的方式产生具有优异定量特性的生化分析数据。

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